The generation of patterns and the diversity of cell types in a multicellular organism require differential gene regulation. At the heart of this process are enhancers or cis‐regulatory modules (CRMs), genomic regions that are bound by transcription factors (TFs) that control spatio‐temporal gene expression in developmental networks. To date, only a few CRMs have been studied in detail and the underlying cis‐regulatory code is not well understood. Here, we review recent progress on the genome‐wide identification of CRMs with chromatin immunoprecipitation (...) of TF‐DNA complexes followed by microarrays (ChIP‐on‐chip). We focus on two computational approaches that have succeeded in predicting the expression pattern driven by a CRM either based on TF binding site preferences and their expression levels, or quantitative analysis of CRM occupancy by key TFs. We also discuss the current limits of these methods and highlight some of the key problems that have to be solved to gain a more complete understanding of the structure and function of CRMs. (shrink)

In human languages, a palindrome reads the same forward as backward (e.g., ‘madam’). In regulatory DNA, a palindrome is an inverted sequence repeat that allows a transcription factor to bind as a homodimer or as a heterodimer with another type of transcription factor. Regulatory palindromes are typically imperfect, that is, the repeated sequences differ in at least one base pair, but the functional significance of this asymmetry remains poorly understood. Here, we review the use of imperfect palindromes in Drosophila photoreceptor (...) differentiation and mammalian steroid receptor signaling. Moreover, we discuss mechanistic explanations for the predominance of imperfect palindromes over perfect palindromes in these two gene regulatory contexts. Lastly, we propose to elucidate whether specific imperfectly palindromic variants have specific regulatory functions in steroid receptor signaling and whether such variants can help predict transcriptional outcomes as well as the response of individual patients to drug treatments. (shrink)

John Martin Fischer and Anthony L. Brueckner have argued that a person’s death is, in many cases, bad for him, whereas a person’s prenatal non-existence is not bad for him. Their suggestion relies on the idea that death deprives the person of pleasant experiences that it is rational for him to care about, whereas prenatal non-existence only deprives him of pleasant experiences that it is not rational for him to care about. In two recent articles in The Journal of Ethics, (...) I have objected that it is irrelevant what it is in fact rational for the person to care about. Fischer and Brueckner have replied to my critique. In this paper I respond to their latest pair of replies. (shrink)

The chapters in this timely volume aim to answer the growing interest in Arthur Schopenhauer’s logic, mathematics, and philosophy of language by comprehensively exploring his work on mathematical evidence, logic diagrams, and problems of semantics. Thus, this work addresses the lack of research on these subjects in the context of Schopenhauer’s oeuvre by exposing their links to modern research areas, such as the “proof without words” movement, analytic philosophy and diagrammatic reasoning, demonstrating its continued relevance to current discourse on logic. (...) -/- Beginning with Schopenhauer’s philosophy of language, the chapters examine the individual aspects of his semantics, semiotics, translation theory, language criticism, and communication theory. Additionally, Schopenhauer’s anticipation of modern contextualism is analyzed. The second section then addresses his logic, examining proof theory, metalogic, system of natural deduction, conversion theory, logical geometry, and the history of logic. Special focus is given to the role of the Euler diagrams used frequently in his lectures and their significance to broader context of his logic. In the final section, chapters discuss Schopenhauer’s philosophy of mathematics while synthesizing all topics from the previous sections, emphasizing the relationship between intuition and concept. -/- Aimed at a variety of academics, including researchers of Schopenhauer, philosophers, historians, logicians, mathematicians, and linguists, this title serves as a unique and vital resource for those interested in expanding their knowledge of Schopenhauer’s work as it relates to modern mathematical and logical study. (shrink)

The mechanistic view of computation contends that computational explanations are mechanistic explanations. Mechanists, however, disagree about the precise role that the environment – or the so-called “contextual level” – plays for computational explanations. We advance here two claims: Contextual factors essentially determine the computational identity of a computing system ; this means that specifying the “intrinsic” mechanism is not sufficient to fix the computational identity of the system. It is not necessary to specify the causal-mechanistic interaction between the system and (...) its context in order to offer a complete and adequate computational explanation. While the first claim has been discussed before, the second has been practically ignored. After supporting these claims, we discuss the implications of our contextualist view for the mechanistic view of computational explanation. Our aim is to show that some versions of the mechanistic view are consistent with the contextualist view, whilst others are not. (shrink)

A pure time preference is a preference for something to occur at one point in time rather than another, merely because of when it occurs in time. Such preferences are widely regarded as paradigm examples of irrational preferences. However, Rosemary Lowry and Martin Peterson have recently argued that, for instance, a pure time preference to go to the opera tonight rather than next month may be rationally permissible, even if the amounts of intrinsic value realized in both cases are identical. (...) In this reply, we argue that Lowry and Peterson's argument is unsuccessful. (shrink)

A prominent objection to the counterfactual comparative account of harm is that it classifies as harmful some events that are, intuitively, mere failures to benefit. In an attempt to solve this problem, Duncan Purves has recently proposed a novel version of the counterfactual comparative account, which relies on a distinction between making upshots happen and allowing upshots to happen. In this response, we argue that Purves’s account is unsuccessful. It fails in cases where an action makes the subject occupy a (...) high well-being level though one of the available alternatives would have made it even higher. In fact, it fails even in some cases where each of the available alternatives to the action that was actually performed would have made the subject’s well-being level lower. (shrink)

Some forms of argumentation are best performed through words. However, there are also some forms of argumentation that may be best presented visually. Thus, this paper examines the virtues of visual argumentation. What makes visual argumentation distinct from verbal argumentation? What aspects of visual argumentation may be considered especially beneficial?

In a recent article, I criticized Anthony L. Brueckner and John Martin Fischer’s influential argument—appealing to the rationality of our asymmetric attitudes towards past and future pleasures—against the Lucretian claim that death and prenatal non-existence are relevantly similar. Brueckner and Fischer have replied, however, that my critique involves an unjustified shift in temporal perspectives. In this paper, I respond to this charge and also argue that even if it were correct, it would fail to defend Brueckner and Fischer’s proposal against (...) my critique. (shrink)

The paper examines Schopenhauer's logic lectures and the eristic dialectics of the manuscript remains in particular. The content of the logic lectures is briefly presented, then the characteristics are highlighted and finally Schopenhauer’s Euler diagrams are examined. The section on eristic dialectics summarizes the history of the text and its origin and reflects the content and order of the document.

This paper introduces a general logical framework for reasoning about diffusion processes within social networks. The new “Logic for Diffusion in Social Networks” is a dynamic extension of standard hybrid logic, allowing to model complex phenomena involving several properties of agents. We provide a complete axiomatization and a terminating and complete tableau system for this logic and show how to apply the framework to diffusion phenomena documented in social networks analysis.

In 1924 the artist Luise Staudinger issued a bronze medal featuring a portrait of Kant on one side and a famous passage from Kant on the other: “Two things fill the mind with ever new and increasing admiration and reverence […]: the starry heavens above me and the moral law within me.” To this Staudinger added an illustration of a naked young man kneeling with outstretched arms, described by the artist as a man in prayer. Yet this does not seem (...) to fit the meaning of Kant’s words. This paper shows that Luise Staudinger was implicitly referring to her father, Franz Staudinger. In his writings, Staudinger taught that he who truly lives up to the moral law always does what he ought to do out of his own free will and with devotion. It is in fact devotion (Hingabe) that is the key to Luise Staudinger’s illustration. The young man is not in prayer; instead, the figure symbolizes a state of mind, namely obedience to the moral law out of devotion to it. (shrink)

Ethical evaluation of deep brain stimulation as a treatment for Parkinson’s disease is complicated by results that can be described as involving changes in the patient’s identity. The risk of becoming another person following surgery is alarming for patients, caregivers and clinicians alike. It is one of the most urgent conceptual and ethical problems facing deep brain stimulation in Parkinson’s disease at this time. In our paper we take issue with this problem on two accounts. First, we elucidate what is (...) meant by “becoming another person” from a conceptual point of view. After critically discussing two broad approaches we concentrate on the notion of “individual identity” which centers on the idea of “core attitudes”. Subsequently we discuss several approaches to determine what distinguishes core attitudes from those that are more peripheral. We argue for a “foundational-function model” highlighting the importance of specific dependency relations between these attitudes. Our second aim is to comment on the possibility to empirically measure changes in individual identity and argue that many of the instruments now commonly used in selecting and monitoring DBS-patients are inappropriate for this purpose. Future research in this area is advised combining a conceptual and an empirical approach as a basis of sound ethical appraisal. (shrink)

The standard view of the value of death is the Deprivation Approach, according to which a person's death is bad for her insofar as she would have been better off without it. On the face of it, the Deprivation Approach sits much better with our normative intuitions about death than does the Epicurean view that death is never bad for the deceased. However, this issue is more complex and nuanced than it might appear.

The counterfactual comparative account of harm (cca) faces well-known problems concerning preemption and omission. In a recent article in this journal, Daniel Immerman proposes a novel variant of cca, which he calls the worse than nothing account (wtna). According to Immerman, wtna nicely handles the preemption and omission problems. We seek to show, however, that wtna is not an acceptable account of harm. In particular, while wtna deals better than cca with some cases that involve preemption and omission, it has (...) implausible implications in other similar cases – cases that, moreover, pose no problems for cca. (shrink)

A particularly promising trail on the search for forgotten logic diagrams leads to Upper Lusatia in the 17th century, more precisely to Christian Weise and his students. Samuel Grosser, who later became rector in Görlitz, and Johann Christian Lange, who later became professor of logic at the University of Gießen, are the most prominent to have published remarkable logic diagrams. Even more remarkable, however, is the fact that Lange's interest in these diagrams ultimately gave rise to the idea of building (...) a logic machine. (shrink)

CL diagrams – the abbreviation of Cubus Logicus – are inspired by J.C. Lange’s logic machine from 1714. In recent times, Lange’s diagrams have been used for extended syllogistics, bitstring semantics, analogical reasoning and many more. The paper presents a method for testing statistical syllogisms (also called proportional syllogisms or inductive syllogisms) by using CL diagrams.

This article urges that what distinguishes dialectic from rhetoric in the Gorgias is their differing conceptions of definitions and argues that: (1) Dialectic centers on the nature of things, rhetoric on their qualities. (2) Dialectic is shown to differ from rhetoric in the inquiry through the application of collection and division. (3) Socrates’ definition and criticism of rhetoric flows from his conception of expertise, not his moral outlook.

With the introduction of the technique of auscultation in nineteenth-century medicine, the auditory became a most important means of producing diagnostic knowledge. The correct classification and interpretation of the sounds revealed by auscultation, however, remained an issue of negotiation and often controversy throughout the mid-nineteenth century. This article examines the codification of lung sounds within two cultural and geographic contexts: first, the original approach as it was developed by Laennec and his followers in Paris that came to be dominant in (...) French medicine, and second, the alternative approach that grew out of Joseph Skoda’s reception of Laennec’s method in Vienna and became widely adopted in the German-speaking world. On one hand, it will be argued that lung sound classifications attempted a standardization of the perception and the interpretation of auscultation sounds. On the other hand, it will be shown that the development of auscultation sounds was shaped by the local context in which it took place. This article seeks to shed light on the way in which auditory experiences were instrumentalized for epistemic purposes in medicine. Furthermore, it discusses the role of standardization both as a mechanism for the universalization of knowledge and as a contextually bounded practice. (shrink)

In this paper, we present and defend an analysis of harm that we call the Negative Influence on Well-Being Account (NIWA). We argue that NIWA has a number of significant advantages compared to its two main rivals, the Counterfactual Comparative Account (CCA) and the Causal Account (CA), and that it also helps explain why those views go wrong. In addition, we defend NIWA against a class of likely objections, and consider its implications for several questions about harm and its role (...) in normative theorizing. (shrink)

By now a consensus has emerged that people, when subjected to high-stakes decisions through automated decision systems, have a moral right to have these decisions explained to them. However, furnishing such explanations can be costly. So the right to an explanation creates what we call the cost problem: providing subjects of automated decisions with appropriate explanations of the grounds of these decisions can be costly for the companies and organisations that use these automated decision systems. In this paper, we explore (...) whether large language models could prove significant in overcoming the cost problem. We provide an initial case for believing that they can but only with serious ethical costs. (shrink)

A widely debated question in current research centres on determining the precursors to G. W. F. Hegel's theory of recognition. Until now Fichte, Rousseau and Aristotle have been discussed. However, the present paper analyses a further surprising correspondence between Marsilio Ficino's theory of love and Hegel's theory of recognition. Here it is shown that Hegel studied Ficino in 1793 and that we can discover syntactical, semantical, and structural vestiges of Ficino's De amore II 8 in Hegel's early fragments on religion (...) (1793) and love (1797), which are closely related to the general theory of recognition found in the Phenomenology of Spirit. Not only may this thesis be relevant for Hegel or Ficino scholarship, but it could also be a further indication that social theories with normative content are an integral characteristic of (early) modern self-consciousness. (shrink)

This paper is concerned with the content of the causal proportionality constraint. It investigates two general versions of the constraint, namely “horizontal” and “vertical” proportionality. Moreover, it discusses whether proportionality is considered an ontic or an epistemic, i.e. explanatory, constraint on causation in the context of some of the most prominent theories of causation. The following main claims are defended: (1) The horizontal (HP) and the vertical version (VP) of the proportionality constraint are logically independent. (2) HP is implied by (...) some prominent theories of causation, not by others. (3) None of the discussed popular theories of causation contradicts either HP or VP. (4) HP and VP are not ontic or epistemic principles as such; rather, whether they are ontic or epistemic depends on the theories chosen plus background assumptions about the existence of higher-level causes and their non-identity to lower-level ones. (shrink)

"Christentum im Atheismus" (Christianity in Atheism) analyses the history of the development of a normative ethic of imitation, mimesis and role model that sprang from Platonism and Christianity and was transformed in the atheistic or agnostic philosophy of modernity. The first volume describes the development of this ethics from antiquity to the Enlightenment using the example of several philosophical and theological writings.

Das folgende Essay erläutert, warum der Tod Gottes sowohl in einem konsequent theistischen System als auch bei atheistischen Denkern unausweichlich ist. Zur Beantwortung der Frage, wie Gott gestorben ist, werden hauptsächlich Autoren wie Friedrich W. Schelling , Friedrich Nietzsche und Peter Sloterdijk herangezogen. Da die Rede vom Tod Gottes den Verdacht erweckt, metaphorisch zu sein, werden wir mit Apoptose und Nekrose auch zwei unterschiedliche Metaphern anwenden, um den vorliegenden Sachverhalt zu beschreiben . Das letzte Kapitel fragt dann nach den Konsequenzen (...) von Gottes Tod für die heutige Ethik.The following essay describes the death of god as unavoidable in a consequent theistic as well as in an atheistic system. To answer the question: how god died, philosophers like Friedrich W. Schelling , Friedrich Nietzsche und Peter Sloterdijk were taken into consideration. For the matter of god’s death is suggestive of being metaphorical, we use two different metaphors to discuss the issue – apoptosis and necrosis . Finally the last chapter asks for the consequences of god’s death concerning nowadays ethics. (shrink)

The paper gives an overview of Arthur Schopenhauer's theory of rationality. For Schopenhauer, rationality is a human faculty based on language, which, in addition to language, is primarily concerned with knowledge or philosophy of science and practical action. For Schopenhauer, language is the umbrella term under which he subsumes logic and eristics. This paper will first introduce Schopenhauer's logic and clarify its connection to the philosophy of language. This is followed by eristic dialectics, which reflects on how one can protect (...) oneself from people who argue irrationally in a goal-oriented way. Schopenhauer's philosophy of mathematics belongs to the field of philosophy of science. Unlike many other authors of his time, Schopenhauer does not advocate a rationalist but a representationalist approach, which, however, includes a theory of rationality. Therefore, Schopenhauer's representationalist approach will finally be discussed, emphasizing its relationship to his theory of rationality. (shrink)

This paper presents an analysis of Seneca's 58th letter to Lucilius and Porphyry's Isagoge, which were the origin of the tree diagrams that became popular in philosophy and logic from the early Middle Ages onwards. These diagrams visualise the extent to which a concept can be understood as a category, genus, species or individual and what the method of dihairesis (division) means. The paper explores the dissimilarities between Seneca's and Porphyry's tree structures, scrutinising them through the perspective of modern graph (...) theory. Although traditional trees can be interpreted in a modern way, their terms and definitions defy modern standardisation. These distinctions are not only useful for differentiating between Seneca's and Porphyry's trees, but also for comprehending the evolution of this philosophical tradition. Thus the paper highlights the continued significance of these tree diagrams in analysing concepts and categories in philosophy and structuring objects and information in modern fields such as artificial intelligence, computer science, bioinformatics, graph theory, and many more. (shrink)

The mechanistic approach in the cognitive and biological sciences emphasizes that scientific explanations succeed by analyzing the mechanisms underlying phenomena across multiple levels. In this paper, we propose a formal strategy to establish such multi-level mechanistic models, which are foundational to mechanistic explanations. Our objectives are twofold: First, we introduce the novel "mLCA" (multi-Level Coincidence Analysis) script, which transforms binary data tables from tests on mechanistic systems into mechanistic models consistent with those tables. Second, we provide several philosophical insights derived (...) from the outcomes generated by this script and its underlying algorithm. Using illustrative examples, we defend the following claims: 1. Inference methods for generating mechanistic models generally require information on how causal factors are assigned to different levels within data tables generated by multi-level structures. 2. The mLCA script successfully produces appropriate mechanistic models from binary data tables, demonstrating the practical application of the philosophical mechanistic approach in the sciences. 3. The number of solutions generated by mLCA increases significantly as the number of relevant factors grows, reflecting adaptations in causal inference methods to meet the demands of multi-level mechanistic modeling. 4. Any further reduction of solutions, if possible, involves pragmatic considerations, a point that carries profound implications for the broader ambitions of the mechanistic approach. By addressing these points, our paper contributes both to the development of practical algorithmic tools and to a deeper philosophical understanding of multi-level mechanistic modeling. (shrink)

This article discusses the problem of global democracy, and why democratic legitimacy seems so difficult to attain at the global level. I start by arguing that the difficulties we experience when we try to widen the scope of democratic governance beyond the boundaries of individual states have nothing to do with the characteristics of global society, but result from the underlying assumption that a political community has to be bounded and based on consent in order for democratic legitimacy to be (...) possible. I then explore how this view came into being, arguing that the perennial paradoxes of democratic legitimacy are little but results of earlier and successful attempts to make the concept of political community coextensive with that of the nation. Finally, I argue that once we let go of the idea that political communities have to be bounded and based on consent in order to qualify as democratic ones, the paradox of democratic legitimacy will look like a category mistake rather than an inescapable obstacle to global democracy. Keywords : cosmopolitanism, democratic paradox, legitimacy, global governance (Published online: 7 November 2008) Citation: Ethics & Global Politics. Vol. 1, No. 4, 2008, pp. 159-174. DOI: 10.3402/egp.v1i4.1858. (shrink)

In Mathematiklehrbüchern und mathematischen Spezialabhandlungen tauchen bis heute immer wieder Themen und Thesen der Schopenhauerschen Elementargeometrie auf. Da Schopenhauers Geometrie bzw. Philosophie der Geometrie in ihrer Figuren- und damit Anschauungsbezogenheit im 19. und frühen 20. Jahrhundert exemplarisch galt, folgt die hier skizzenhaft dargestellte zweihundertjährige Rezeptionsgeschichte auch der von den mathematischen Paradigmen abhängenden Bewertung anschauungsbezogener Geometrien.

In his recent book, Death and the Afterlife, Samuel Scheffler argues that it matters greatly to us that there be other human beings long after our own deaths. In support of this “Afterlife Thesis,” as I call it, he provides a thought experiment—the “doomsday scenario”—in which we learn that, although we ourselves will live a normal life span, 30 days after our death the earth will be completely destroyed. In this paper I question this “doomsday scenario” support for Scheffler’s Afterlife (...) Thesis. In particular, I suggest that Scheffler has underestimated the importance of a good ending. (shrink)

Wie es scheint, hat Hume in Of personal identity die Identität der Person bestritten. Tatsächlich hat er lediglich eine falsche Auffassung von Person und Selbst kritisiert und daran anschließend zu erklären versucht, durch welche psychischen Mechanismen es zur Bildung dieser falschen „idea of self“ kommt. Diese Erklärung ist misslungen und von Hume im Appendix revoziert worden. Hume selbst hat dagegen einen vollkommen unspektakulären und alltäglichen Begriff der Person vertreten, wie in Of pride and humility so beiläufig wie überzeugend deutlich wird.

'It is quite different with the beautiful.' But what about it, then? According to Kant, this can only be revealed by analyzing the judgment by which we attribute beauty. Tracing the often-rocky path of this analysis, fraught with all sorts of pitfalls, in order to see how Kant arrives at the concept of beauty as a form of purposiveness without purpose, and what exactly this concept means, is still very rewarding. However, in doing so, it is important to defend Kant (...) against himself and to rid the core of his aesthetics of a great deal of incidental material that has nothing to do with the matter at hand. - In an appendix to this discussion of the "Critique of Aesthetic Judgment", the author demonstrates the close connection that exists between Kant's text and Hume's treatise 'On the Standard of Taste'." -- Provided by the publisher. (shrink)

IntroductionIf we were to identify the beginning of the study of visual argumentation, we would have to choose 1996 as the starting point. This was the year that Leo Groarke published “Logic, art and argument” in Informal logic, and it was the year that he and David Birdsell co-edited a special double issue of Argumentation and Advocacy on visual argumentation . Among other papers, the issue included Anthony Blair’s “The possibility and actuality of visual arguments”. It was also the year (...) that Gail J. Chryslee, Sonja K. Foss and Arthur L. Ranney published their short text on “The construction of claims in visual argumentation” , stating that even though theorists may know a great deal about the process of argumentation, “virtually none of this knowledge is applicable to visual argumentation […] because of the properties that distinguish visual imagery from discursive symbols” .Texts on visual rhetoric have been written as far back as the early 1980s, .. (shrink)