Brain-Computer interfacing is a highly promising and fast developing field of modern life sciences. Recent advances in neuroscience together with progressing miniaturization in micro systems provide insights in structure and functioning of the human brain and enable connections of technical components to neuronal structures as well. This possibly offers a future therapy for paralysed patients through neuronal motor pros-theses. This paper identifies central ethical aspects which have to be considered in further progressing research in this scientific field and the development (...) of neuronal motor prostheses. (shrink)

Novel neurotechnologies like deep brain stimulation and brain-computer interfaces promise clinical benefits for severely suffering patients. Nevertheless, such electroceuticals raise several ethical issues on different levels: while on the level of clinical neuroethics issues with direct relevance for diagnosis and treatment have to be discussed, on the level of research neuroethics questions regarding research and development of these technological devices like investigating new targets and different diseases as well as thorough inclusion criteria are dealt with. On the level of theoretical (...) neuroethics more general questions are examined including anthropological considerations on “normal” human functioning as well as implications on personality, personal identity and authenticity. This paper presents a brief review on ethical issues of deep brain stimulation and brain computer interfacing and simultaneously introduces to this themed issue with thirteen contributions dealing from different perspectives with ethical implications of electroceuticals for the human brain. (shrink)

One of the most controversial areas of animal research is the use of nonhuman primates for fundamental research. At the centre of the controversy is the question of whether the benefits of research outweigh the harms. We argue that the evaluation of harms and benefits is highly problematic. We describe some common procedures in neurological research using nonhuman primates and the difficulties in evaluating the harm involved. Even if the harm could be quantified, it is unlikely that it could be (...) meaningfully aggregated over different procedures, let alone different animals. A similar problem arises for evaluating benefits. It is not clear how benefits could be quantified, and even if they could be, values for different aspects of expected benefits cannot be simply added up. Sorting harms and benefits in three or four categories cannot avoid the charge of arbitrariness and runs the risk of imposing its structure on the moral decision. The metaphor of weighing or balancing harms and benefits is inappropriate for the moral decision about whether to use nonhuman primates for research. Arguing that the harms and benefits in this context are incommensurable, we suggest describing the moral consideration of harms and benefits as a coherent trade-off. Such a decision does not require commensurability. It must be well-informed about the suffering involved and the potential benefits, it must be consistent with the legal, regulatory and institutional framework within which it is made, and it must cohere with other judgments in relevant areas. (shrink)

Nanomedicine promises unprecedented innovations for diagnosis and therapy as well as for predicting and preventing diseases. On the other hand it raises fears linked to new and unknown characteristics of nanoscale materials. Both, promises and fears, are closely linked to the realm of uncertainty. To a large extent it is currently not known which expectations could become reality and which suspected adverse events might come true. Medicine is quite familiar with decision-making under uncertainty. Rules and regulations for clinical research have (...) been developed to reduce possible harm for research participants without abandoning necessary investigations. Here we examine whether clinical research trials of nanomedicine need new regulations and conclude that the established rules should suffice. (shrink)

Harvesting human embryonic stem (hES) cells is a highly controversial field of research because it rests on the destruction of human embryos. Altering the procedure of nuclear transfer (NT) is suggested to generate hES cell lines without ethical obstacles by claiming that no embryo would be involved. While discussing the nature of an embryo and related central questions concerning their moral status and the respect they deserve, this paper argues that the entity created by somatic cell nuclear transfer (SCNT) or (...) altered nuclear transfer (ANT) is an embryo and has the same moral status as a natural embryo. Respect for the embryo is expressed by the ethical principles of proportionality, probability and subsidiarity. This paper argues that the human embryo should only be taken for research with high ranking goals, which are proven in animal experimentation and for which there are no alternatives. This makes ANT obsolete and shows that SCNT to produce hES cells is premature at the present time. (shrink)

Brain-Computer Interface (BCI) research and (future) applications raise important ethical issues that need to be addressed to promote societal acceptance and adequate policies. Here we report on a survey we conducted among 145 BCI researchers at the 4th International BCI conference, which took place in May–June 2010 in Asilomar, California. We assessed respondents’ opinions about a number of topics. First, we investigated preferences for terminology and definitions relating to BCIs. Second, we assessed respondents’ expectations on the marketability of different BCI (...) applications (BCIs for healthy people, BCIs for assistive technology, BCIs-controlled neuroprostheses and BCIs as therapy tools). Third, we investigated opinions about ethical issues related to BCI research for the development of assistive technology: informed consent process with locked-in patients, risk-benefit analyses, team responsibility, consequences of BCI on patients’ and families’ lives, liability and personal identity and interaction with the media. Finally, we asked respondents which issues are urgent in BCI research. (shrink)

Ethical questions with regard to modern neurosciences have significant relevance because the human brain provides the organic basis for central aspects of our self-concept. Neuroethics identifies and reflects the ethical questions raised by modern neurosciences. Here we deal with ethical questions in the contexts of brain imaging techniques and several interventions into the human brain. Besides the central question how to preserve personal identity and higher cognitive functions we address specific ethical aspects of neurotechnology and neuroprosthetics as well as the (...) questions relevant in the context of neuroenhancement. (shrink)

Abstract:Brain–computer interfaces (BCIs) can enable communication for persons in severe paralysis including locked-in syndrome (LIS); that is, being unable to move or speak while aware. In cases of complete loss of muscle control, termed “complete locked-in syndrome,” a BCI may be the only viable solution to restore communication. However, a widespread ignorance regarding quality of life in LIS, current BCIs, and their potential as an assistive technology for persons in LIS, needlessly causes a harmful situation for this cohort. In addition (...) to their medical condition, these persons also face social barriers often perceived as more impairing than their physical condition. Through social exclusion, stigmatization, and frequently being underestimated in their abilities, these persons are being locked out in addition to being locked-in. In this article, we (1) show how persons in LIS are being locked out, including how key issues addressed in the existing literature on ethics, LIS, and BCIs for communication, such as autonomy, quality of life, and advance directives, may reinforce these confinements; (2) show how these practices violate the United Nations Convention on the Rights of Persons with Disabilities, and suggest that we have a moral responsibility to prevent and stop this exclusion; and (3) discuss the role of BCIs for communication as one means to this end and suggest that a novel approach to BCI research is necessary to acknowledge the moral responsibility toward the end users and avoid violating the human rights of persons in LIS. (shrink)

In this paper, we present and defend an analysis of harm that we call the Negative Influence on Well-Being Account (NIWA). We argue that NIWA has a number of significant advantages compared to its two main rivals, the Counterfactual Comparative Account (CCA) and the Causal Account (CA), and that it also helps explain why those views go wrong. In addition, we defend NIWA against a class of likely objections, and consider its implications for several questions about harm and its role (...) in normative theorizing. (shrink)

Ethical evaluation of deep brain stimulation as a treatment for Parkinson’s disease is complicated by results that can be described as involving changes in the patient’s identity. The risk of becoming another person following surgery is alarming for patients, caregivers and clinicians alike. It is one of the most urgent conceptual and ethical problems facing deep brain stimulation in Parkinson’s disease at this time. In our paper we take issue with this problem on two accounts. First, we elucidate what is (...) meant by “becoming another person” from a conceptual point of view. After critically discussing two broad approaches we concentrate on the notion of “individual identity” which centers on the idea of “core attitudes”. Subsequently we discuss several approaches to determine what distinguishes core attitudes from those that are more peripheral. We argue for a “foundational-function model” highlighting the importance of specific dependency relations between these attitudes. Our second aim is to comment on the possibility to empirically measure changes in individual identity and argue that many of the instruments now commonly used in selecting and monitoring DBS-patients are inappropriate for this purpose. Future research in this area is advised combining a conceptual and an empirical approach as a basis of sound ethical appraisal. (shrink)

This paper explores the complex relationship between the plant evolutionist G. Ledyard Stebbins and the animal evolutionist Theodosius Dobzhansky. The manner in which the plant evolution was brought into line, synthesized, or rendered consistent with the understanding of animal evolution (and especially insect evolution) is explored, especially as it culminated with the publication of Stebbins's 1950 book Variation and Evolution in Plants. The paper explores the multi-directional traffic of influence between Stebbins and Dobzhansky, but also their social and professional networks (...) that linked plant evolutionists like Stebbins with Edgar Anderson, Carl Epling, and the 'Carnegie team' of Jens Clausen, David Keck, and William Hiesey with collaborators on the animal side like I. Michael Lerner, Sewall Wright and L.C. Dunn and other 'architects' of the synthesis like Ernst Mayr, Julian Huxley and George Gaylord Simpson. The compatibility in training, work styles, methodologies, goals, field sites, levels of analysis, and even choice of organismic systems is explored between Stebbins and Dobzhansky. Finally, the extent to which coevolution between plants and insects is reflected in the relationship is explored, as is the power dynamic in the relationship between two of the most visible figures associated with the evolutionary synthesis. (shrink)

According to the standard version of the counterfactual comparative account of harm, an event is overall harmful for an individual if and only if she would have been on balance better off if it had not occurred. This view faces the “preemption problem.” In the recent literature, there are various ingenious attempts to deal with this problem, some of which involve slight additions to, or modifications of, the counterfactual comparative account. We argue, however, that none of these attempts work, and (...) that the preemption problem continues to haunt the counterfactual comparative account. (shrink)

According to epistemic two-dimensionalism, or simply two-dimensionalism, linguistic expressions are associated with two intensions, one of which represents an expression’s a priori implications. The author investigates the prospects of conceptual analysis on the basis of a two-dimensionalist theory of meaning. He discusses a number of arguments for and against two-dimensional semantics and argues that properly construed, two-dimensionalism provides a potent and plausible account of meaning. Against the background of this account, the author then goes on to assess the value of (...) conceptual analysis in philosophical practice, outlining its goals, its promises, but also its limitations. (shrink)

Possible-worlds accounts of mental or linguistic content are often criticized for being too coarse-grained. To make room for more fine-grained distinctions among contents, several authors have recently proposed extending the space of possible worlds by "impossible worlds". We argue that this strategy comes with serious costs: we would effectively have to abandon most of the features that make the possible-worlds framework attractive. More generally, we argue that while there are intuitive and theoretical considerations against overly coarse-grained notions of content, the (...) same kinds of considerations also prohibit an overly fine-grained individuation of content. An adequate notion of content, it seems, should have intermediate granularity. However, it is hard to construe a notion of content that meets these demands. Any notion of content, we suggest, must be either implausibly coarse-grained or implausibly fine-grained (or both). (shrink)

Suppose your evil sibling travels back in time, intending to lethally poison your grandfather during his infancy. Determined to save grandpa, you grab two antidotes and follow your sibling through the wormhole. Under normal circumstances, each antidote has a 50% chance of curing a poisoning. Upon finding young grandpa, poisoned, you administer the first antidote. Alas, it has no effect. The second antidote is your last hope. You administer it---and success: the paleness vanishes from grandpa's face, he is healed. As (...) you administered the first antidote, what was the chance that it would be effective? -/- This essay offers a systematic account of this case, and others like it. The central question is this: Given a certain time travel structure, what are the chances? In particular, I'll develop a theory about the connection between these chances and the chances in ordinary, time-travel-free contexts. Central to the account is a Markov condition involving the boundaries of spacetime regions. (shrink)

According to the “deprivation approach,” a person’s death is bad for her to the extent that it deprives her of goods. This approach faces the Lucretian problem that prenatal non-existence deprives us of goods just as much as death does, but does not seem bad at all. The two most prominent responses to this challenge—one of which is provided by Frederik Kaufman (inspired by Thomas Nagel) and the other by Anthony Brueckner and John Martin Fischer—claim that prenatal non-existence is relevantly (...) different from death. This paper criticizes these responses. (shrink)

In this article I discuss the question of whether a person’s existence can be better (or worse) for him than his non-existence. Recently, Nils Holtug and Melinda A. Roberts have defended an affirmative answer. These defenses, I shall argue, do not succeed. In different ways, Holtug and Roberts have got the metaphysics and axiology wrong. However, I also argue that a person’s existence can after all be better (or worse) for him than his non-existence, though for reasons other than those (...) provided by Holtug and Roberts. (shrink)

A prominent objection to the counterfactual comparative account of harm is that it classifies as harmful some events that are, intuitively, mere failures to benefit. In an attempt to solve this problem, Duncan Purves has recently proposed a novel version of the counterfactual comparative account, which relies on a distinction between making upshots happen and allowing upshots to happen. In this response, we argue that Purves’s account is unsuccessful. It fails in cases where an action makes the subject occupy a (...) high well-being level though one of the available alternatives would have made it even higher. In fact, it fails even in some cases where each of the available alternatives to the action that was actually performed would have made the subject’s well-being level lower. (shrink)

I raise two objections against Christian List and Peter Menzies' influential account of high-level causation. Improving upon some of Stephen Yablo's earlier work, I develop an alternative theory which evades both objections. The discussion calls into question List and Menzies' main contention, namely, that the exclusion principle, applied to difference-making, is false.

In a recent article, I criticized Anthony L. Brueckner and John Martin Fischer’s influential argument—appealing to the rationality of our asymmetric attitudes towards past and future pleasures—against the Lucretian claim that death and prenatal non-existence are relevantly similar. Brueckner and Fischer have replied, however, that my critique involves an unjustified shift in temporal perspectives. In this paper, I respond to this charge and also argue that even if it were correct, it would fail to defend Brueckner and Fischer’s proposal against (...) my critique. (shrink)

This paper is concerned with the notions of supervenience and mechanistic constitution as they have been discussed in the philosophy of neuroscience. Since both notions essentially involve specific dependence and determination relations among properties and sets of properties, the question arises whether the notions are systematically connected and how they connect to science. In a first step, some definitions of supervenience and mechanistic constitution are presented and tested for logical independence. Afterwards, certain assumptions fundamental to neuroscientific inquiry are made explicit (...) in order to show that the presented definitions of supervenience are virtually uninteresting for theory construction in this field. In a third step, a new formulation of supervenience is developed that makes explicit reference to the notion of constitution and that bridges the gap between the philosophical concepts and explanatory practice in neuroscience. (shrink)

Derek Parfit famously defends a number of surprising views about "fission." One is that, in such a scenario, it is indeterminate whether I have survived or not. Another is that the fission case shows that it does not matter, in itself, whether I survive or not. Most critics of the first view contend that fission makes me cease to exist. Most opponents of the second view contend that fission does not preserve everything that matters in ordinary survival. In this paper (...) I shall provide a critique that does not rely on either of these contentions. There are other, interrelated reasons to reject Parfit's defense of the two theses. In particular, the availability of the following view creates trouble for Parfit: I determinately survive fission, but it is indeterminate which fission product I am. (shrink)

One increasingly popular approach to personal identity is called ‘animalism.’ Unfortunately, it is unclear just what the doctrine says. In this paper, I criticise several different ways of stating animalism, and put forward one formulation that I find more promising.

The counterfactual comparative account of harm (cca) faces well-known problems concerning preemption and omission. In a recent article in this journal, Daniel Immerman proposes a novel variant of cca, which he calls the worse than nothing account (wtna). According to Immerman, wtna nicely handles the preemption and omission problems. We seek to show, however, that wtna is not an acceptable account of harm. In particular, while wtna deals better than cca with some cases that involve preemption and omission, it has (...) implausible implications in other similar cases – cases that, moreover, pose no problems for cca. (shrink)

In this paper, we critically examine Molly Gardner’s favored solution to what she calls “the problem of justified harm.” We argue that Gardner’s view is false and that her arguments in support of it are unconvincing. Finally, we briefly suggest an alternative solution to the problem which avoids the difficulties that beset Gardner’s proposal.

This article defends three claims. First, that collection and division in the Phaedrus are described as procedures that underlie human speaking and thinking in general, as well as philosophical inquiry, and are not identified with either. Second, that what sets the dialectical use of these procedures apart from their ordinary use are philosophical suppositions independent of the procedures of collection and division themselves; for that reason, collection and division cannot be identified with dialectic as such. Third, that the second part (...) of the Phaedrus is concerned with the broader question how noble or beautiful speaking, in general, may be said to depend on dialectic as much as it is concerned with the question how rhetoric, as a kind of expertise, is related to dialectic. (shrink)

The epistemic arrow of time is the fact that our knowledge of the past seems to be both of a different kind and more detailed than our knowledge of the future. Just like with the other arrows of time, it has often been speculated that the epistemic arrow arises due to the second law of thermodynamics. In this paper, we investigate the epistemic arrow of time using a fully formal framework. We begin by defining a memory system as any physical (...) system whose present state can provide information about the state of the external world at some time other than the present. We then identify two types of memory systems in our universe, along with an important special case of the first type, which we distinguish as a third type of memory system. We show that two of these types of memory systems are time-symmetric, able to provide knowledge about both the past and the future. However, the third type of memory systems exploits the second law of thermodynamics, at least in all of its instances in our universe that we are aware of. The result is that in our universe, this type of memory system only ever provides information about the past. We also argue that human memory is of this third type, completing the argument. We end by scrutinizing the basis of the second law itself. This uncovers a previously unappreciated formal problem for common arguments that try to derive the second law from the “Past Hypothesis”, i.e., from the claim that the very early universe was in a state of extremely low entropy. Our analysis is indebted to prior work by one of us but expands and improves upon this work in several respects. (shrink)

A pure time preference is a preference for something to occur at one point in time rather than another, merely because of when it occurs in time. Such preferences are widely regarded as paradigm examples of irrational preferences. However, Rosemary Lowry and Martin Peterson have recently argued that, for instance, a pure time preference to go to the opera tonight rather than next month may be rationally permissible, even if the amounts of intrinsic value realized in both cases are identical. (...) In this reply, we argue that Lowry and Peterson's argument is unsuccessful. (shrink)

Abstract: The symmetry argument is an objection to the 'deprivation approach'– the account of badness favored by nearly all philosophers who take death to be bad for the one who dies. Frederik Kaufman's recent response to the symmetry argument is a development of Thomas Nagel's suggestion that we could not have come into existence substantially earlier than we in fact did. In this paper, I aim to show that Kaufman's suggestion fails. I also consider several possible modifications of his theory, (...) and argue that they are unsuccessful as well. (shrink)

Many have argued that there is something that is a priori about all necessary truths, including a posteriori necessities. According to a particularly popular claim of this kind, one can know a priori whether a sentence is G-necessary, i.e. whether it is either necessarily true or necessarily false. In this paper, I identify the most plausible version of this claim and I argue that it fails. My discussion also reveals, and depends upon, an important feature of putative natural kind terms (...) that has been widely overlooked. I conclude by outlining a proposal of what is really a priori about necessities. (shrink)

While in the beginning of the environmental debate, conflicts over environmental and technological issues had primarily been understood in terms of ‘‘risk’’, over the past two decades the relevance of ignorance, or nonknowledge, was emphasized. Referring to this shift of attention to nonknowledge the article presents two main findings: first, that in debates on what is not known and how to appraise it different and partly conflicting epistemic cultures of nonknowledge can be discerned and, second, that drawing attention to nonknowledge (...) in technology conflicts results in significant institutional effects and new constellations of actors in public debates. To illustrate and substantiate this political dynamics of nonknowledge we draw upon examples from the areas of agri-biotechnology and mobile phoning. In a first step, we develop in greater detail the concept of scientific cultures of nonknowledge and identify three such cultures involved in the social conflicts within the two areas. Subsequently, we analyze the specific dynamics of the politicisation of nonknowledge looking at the variety of actors involved and the pluralisation of perceptions and evaluations of what is not known. Then, we point out some of the institutional reactions to the political and cultural dynamics of scientific nonknowledge. We argue that the equal recognition of the diverse cultures of nonknowledge is a key prerequisite for socially legitimate and ‘‘robust’’ decision-making under conditions of politicised scientific nonknowledge. (shrink)

According to the “deprivation approach,” a person’s death is bad for her to the extent that it deprives her of goods. This approach faces the Lucretian problem that prenatal non-existence deprives us of goods just as much as death does, but does not seem bad at all. The two most prominent responses to this challenge—one of which is provided by Frederik Kaufman and the other by Anthony Brueckner and John Martin Fischer—claim that prenatal non-existence is relevantly different from death. This (...) paper criticizes these responses. (shrink)

In his recent book, Death and the Afterlife, Samuel Scheffler argues that it matters greatly to us that there be other human beings long after our own deaths. In support of this “Afterlife Thesis,” as I call it, he provides a thought experiment—the “doomsday scenario”—in which we learn that, although we ourselves will live a normal life span, 30 days after our death the earth will be completely destroyed. In this paper I question this “doomsday scenario” support for Scheffler’s Afterlife (...) Thesis. In particular, I suggest that Scheffler has underestimated the importance of a good ending. (shrink)