In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio-cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the Democratic Republic of Congo, and describe some lessons learned, related to the definition of acceptable representative, the role of independent witness and the impact of (...) socio-economic vulnerability. To ensure children's protection, consent is required by the parents or, in their absence, by a legally mandated representative. In our setting, children's responsibility is often entrusted permanently or temporarily to relatives or friends without a tribunal mandate. Hence, a notion of ‘culturally acceptable representative’ under supervision of the local Ethics Committee may be more suitable. To ensure protection of illiterate subjects, an independent witness is required to confirm that the consent was freely given. However, in low-literacy contexts, potential witnesses often don't have any previous relationship with patient and there may be power-unbalance in their relationship, rather than genuine dialogue. In poor communities, trial participation may be seen as an opportunity to secure access to healthcare. Poverty may also lead to ‘competition’ to access the research-related benefits, with a risk of disturbance at societal or household level. Adjusting consent procedures to sociocultural and socioeconomic realities is essential for fulfilling the underlying ethical principles. This requires a collaborative dialogue between researchers, regulators and ethics committees. (shrink)

The French school of theoretical biology has been mainly initiated in Poitiers during the sixties by scientists like J. Besson, G. Bouligand, P. Gavaudan, M. P. Schützenberger and R. Thom, launching many new research domains on the fractal dimension, the combinatorial properties of the genetic code and related amino-acids as well as on the genetic regulation of the biological processes. Presently, the biological science knows that RNA molecules are often involved in the regulation of complex genetic networks as effectors, e.g., (...) activators, inhibitors or hybrids. Examples of such networks will be given showing that there exist RNA “relics” that have played an important role during evolution and have survived in many genomes, whose probability distribution of their sub-sequences is quantified by the Shannon entropy, and the robustness of the dynamics of the networks they regulate can be characterized by the Kolmogorov–Sinaï dynamic entropy and attractor entropy. (shrink)

Information?rich environments are created to promote data use in schools for the purpose of self?evaluation and quality assurance. However, providing feedback does not guarantee that schools will actually put it to use. One of the main stumbling blocks relates to the interpretation and diagnosis of the information. This study examines the relationship between data literacy competences, support given in interpreting the information, actual use of the feedback and potential school improvement effect. A randomised field experiment with 188 school principals from (...) primary education was set up and a post?test was used to investigate the effects of a support initiative. The results revealed that a minority of schools invested significantly in the interpretation and diagnosis of the school performance feedback (SPF), despite the fact that most of the respondents showed an interest in the SPF report. In addition, data competence support and the subsequent use of feedback were found to be limited. (shrink)

Par son enseignement et par ses traductions de Kant, Jean-Pierre Fussler a influencé plusieurs générations d'étudiants. Croisant les approches, ce recueil de travaux en son honneur fait dialoguer perspectives kantiennes, lectures et relectures des œuvres de Kant, commentaires de son œuvre et études de sa réception contemporaine, mais aussi, plus généralement, questions éthiques, essais phénoménologiques et diverses études philosophiques qui s'accordent toutes sur la nécessité de la méthode, la diversité du rationalisme et les impératifs de la pensée critique."--Page (...) 4 of cover. (shrink)

A Study of the History and Philosophy of Category Theory Jean-Pierre Marquis. to say that objects are dispensable in geometry. What is claimed is that the specific nature of the objects used is irrelevant. To use the terminology already ...

Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our ...

Durante cuatro siglos, cristianos (de rito romano o visigótico), musulmanes y judíos coexistieron en la ciudad de Toledo. Pero tal coexistencia, antes de terminar de manera trágica, se caracterizó por muchos matices y atravesó circunstancias diversas. Cuando los llamados mozárabes (cristianos arabizados de rito visigótico) se fundieron en la masa cristiana de rito latino y lengua hispánica, después de dominar en la ciudad durante largo tiempo, los musulmanes (mudéjares), nunca muy numerosos, alcanzaron cierto apogeo en el siglo XIV, antes de (...) quedar parcialmente marginalizados en el XV. En cuanto a los judíos, debido al papel que desempeñaban en la gestión del dinero, fueron objeto de la ira y el furor popular, sobre todo en los siglos XIV y XV, incluso después de su conversión, fingida o sincera, a la fe cristiana. (shrink)

Jean-Pierre Vernant delineates a compelling new vision of ancient Greece that takesus far from the calm and familiar images of Polykleitos and the Parthenon, and reveals a culture ofslavery, of blood sacrifice, of perpetual and ritualized warfare, of ceremonial hunting andecstasies.In his provocative discussions of various institutions and practices including war,marriage, and the city state, Vernant unveils a complex and previously unexplored intersection ofthe religious, social, and political structures of ancient Greece. He concludes with a genealogy ofthe study (...) of myth from antiquity to the present, and offers a critique of structuralism.Jean-PierreVernant is Professor Emeritus of Comparative Study of Ancient Religions at the College de France inParis. (shrink)

The relationship between the imaginary and the political has many aspects and it is not possible to address them all in this paper. We will choose to focus on the relationship between myth and national idea, on the one hand, and myth and political ideologies on the other. Before considering these questions, we will first present the work of Gilbert Durand from his articles “Le social et le mythique” and “La cité et les divisions du royaume” ; then we will (...) focus on the study of the two axes announced. This paper thus emphasizes the importance of the imaginary in politics and society. We will conclude with the current development, particularly in Western Europe, where myth no longer plays its unifying role for society. (shrink)

In a remarkable exchange between neuroscientist Jean-Pierre Changeux and philosopher Paul Ricoeur, this book explores the vexed territory between these...

Appartient-il au philosophe de fixer strictement la compréhension de notre concept d'art, ou doit-il limiter sa tâche à celle d'une clarification de ses usages? À cette question, les textes de Jean-Pierre Cometti réunis dans ce volume répondent en choisissant la voie d'une esthétique « minimale », qui renonce aux vertiges de l'ontologie et aux ambitions définitionnelle de la philosophie analytique de l'art, tout en prenant acte du caractère caduc des grands récits spéculatifs hérités de l'esthétique idéaliste ou des (...) mirages de la déconstruction. (shrink)

L’édition critique des œuvres de Moïse ben Sabbataï, philosophe juif actif (à Rome?) vers 1340, avait signalé, parmi d’autres sources latines lues dans les traductions en hébreu de son contemporain Juda de Rome, un exemplum présentant le sage athénien Solon sur son lit de mort en champion de la doctrine de l’élévation intellectuelle en vue de la vie éternelle. Cette note identifie comme sa source un chapitre d’Albert le Grand, De natura et origine animae II, 13, dont la traduction en (...) hébreu se trouve dans un ouvrage inédit de Juda de Rome, son Commentaire du Qaddīš et de la Qeduššāh. La traduction du chapitre est éditée, l’histoire de l’ exemplum reconstituée et son emploi par les trois auteurs, remis en contexte et interprété. (shrink)

Jean-Paul Sartre: Mind and Body, Word and Deed celebrates Sartre's polyvalence with an examination of Sartrean philosophy, literature, and politics. In four distinct yet related sections, twelve scholars from three continents examine Sartre's thought, writing and action over his long career. "Sartre and the Body" reappraises Sartre's work in dialogue with other philosophers past and present, including Maine de Biran, Maurice Merleau-Ponty and Didier Anzieu. "Sartre and Time" offers a first-hand account by Michel Contat of Sartre and Beauvoir working (...) together, and a "philosophy in practice" analysis by François Noudelmann. "Ideology and Politics" uses Sartrean notions of commitment and engagement to address modern and contemporary politics, including insights into Castro, De Gaulle, Sarkozy and Obama. Finally, an important but neglected episode of Sartre's life the visit that he and Beauvoir made to Japan in 1966 is narrated with verve and humour by Professor Suzuki Michihiko, who first met Sartre during that visit and remained in touch subsequently. Taken together, these twelve chapters make a strong case for the continued relevance of Sartre today. (shrink)

Sous l'Ancien Regime, les champs semantiques de la preuve sont aussi complexes et plastiques que ses usages. La notion circule et innerve des pratiques tres diverses, parfois de maniere inattendue. La plaidoirie ou le requisitoire reorganisent les faits, creant des fables qui s'eloignent quelquefois de la realite et qui tendent a transformer la verite en mensonge et le mensonge en verite. Ces ressorts sont aussi ceux de la fiction qui exploite toutes les ressources de la probation ou preuve et signe (...) viennent a se confondre. Dans d'autres domaines, pour assurer le passage de liaisons necessaires entre des elements divers qui conduisent a la certitude, a l'analyse morale qui s'appuie sur des relations probables pour etablir l'innocence ou la culpabilite, il faut s'etre approprie un art de la demonstration qui, ayant traverse la metaphysique et les mathematiques, parvient au droit. Ce passage-la marque le role historiquement grandissant de la probabilite dans la prise de decision et dans la conception de la verite. Le present volume interroge les lineaments semantiques et les usages de la notion de preuve, du XVIe au XVIIIe siecle, essentiellement en France et en Grande-Bretagne. Les etudes qui le composent suggerent que ces divers usages constituent l'un des aspects du long processus de division des savoirs. Jean-Pierre Schandeler est charge de recherche CNRS a l'IRCL. Ses travaux portent sur les rapports entre l'histoire et les sciences morales et politiques au XVIIIe siecle. Nathalie Vienne-Guerrin est professeur a l'universite Paul-Valery Montpellier 3, specialiste de Shakespeare. Elle dirige l'Institut de Recherche sur la Renaissance, l'age Classique et les Lumieres (UMR 5186 du CNRS). (shrink)

Les observations des activités de jeux et de construction de jouets se concentrent sur l’âge préscolaire et primaire. Le début des activités ludiques des filles et garçons à l’extérieur de la maison, dans le domaine public, se situe vers l’âge de trois ans dans l’Anti-Atlas et en général au Maroc. Toutefois, l’on trouve des enfants plus petits dehors, lorsqu’ils sont pris en charge par des filles à l’âge de l’école primaire ou par des adolescentes, moins souvent par des garçons ou (...) adolescents : les observations concernent donc des filles de l’Anti-Atlas âgées de 2 à 8 ans, à quelques exceptions près, les jeux de faire semblant, les poupées et autres objets bricolés, et examinent l’impact des jouets industriels sur la fabrication de jouets par les enfants. (shrink)

Bd. 1. Allgemeine Themen. Iberische Halbinsel. Italien -- Bd. 2. Frankreich und Niederlande -- Bd. 3. England.

Jean-Pierre Dupuy, prophet of what he calls "enlightened doomsaying," has long warned that modern society is on a path to self-destruction. In this book, he pleads for a subversion of this crisis from within, arguing that it is our lopsided view of religion and reason that has set us on this course. In denial of our sacred origins and hubristically convinced of the powers of human reason, we cease to know our own limits: our disenchanted world leaves us (...) defenseless against a headlong rush into the abyss of global warming, nuclear holocaust, and the other catastrophes that loom on our horizon. Reviving the religious anthropology of Max Weber, Emile Durkheim, and Marcel Mauss and in dialogue with the work of René Girard, Dupuy shows that we must remember the world's sacredness in order to keep human violence in check. A metaphysical and theological detective, he tracks the sacred in the very fields where human reason considers itself most free from everything it judges irrational: science, technology, economics, political and strategic thought. In making such claims, The Mark of the Sacred takes on religion bashers, secularists, and fundamentalists at once. Written by one of the deepest and most versatile thinkers of our time, it militates for a world where reason is no longer an enemy of faith. (shrink)

« Toute activité se laisse discerner et définir dans la mesure où elle prend forme, où elle inscrit sa courbe dans l’espace et le temps. La vie agit essentiellement comme créatrice de formes. La vie est forme, et la forme est le mode de la vie » (Henri Focillon). Formes de la géométrie et du cosmos, formes de la vie et de la pensée, formes architecturales, musicales et littéraires, formes fixes ou métamorphoses : le concept de forme est omniprésent dans (...) les sciences et dans les arts. C’est à une exploration de cette notion de forme que le Collège de France a consacré en octobre 2011 son colloque multidisciplinaire de rentrée : sa définition en philosophie chez Platon et Aristote, ses applications en mathématiques et en astrophysique, en chimie et en biologie, ses conséquences en psychologie et en linguistique, en anthropologie, en droit et dans les arts. Ces débats ont été aussi l’occasion de se tourner vers des pensées où elle joue un rôle particulièrement important, comme le structuralisme de Claude Lévi-Strauss ou l’histoire de l’art d’André Chastel. Jean-Pierre Changeux est professeur honoraire au Collège de France, chaire de Communications cellulaires. Il a dirigé la publication de trois colloques précédents du Collège de France : La Vérité dans les sciences (2003), Gènes et culture (2003) et L’Homme artificiel(2007). Contributions de Antoine Compagnon, Claude Debru, Stanislas Dehaene, Mireille Delmas-Marty, Philippe Descola, Anne Fagot-Largeault, Marcel Hénaff, Michel Hochmann, Jean-Jacques Hublin, François-Bernard Mâche, Jean-François Mangin, Jean-Claude Pecker, Jacques Reisse, John Scheid, Jesper Svenbro. (shrink)

Que se passe-t-il dans le cerveau de l'artiste lorsque celui-ci crée? Quels mécanismes régissent l'activité cérébrale au moment de la contemplation d'un tableau? D'où vient cette étrange et si puissante émotion, le plaisir esthétique? Peut-on l'expliquer? Longtemps la création artistique est demeurée un mystère. Depuis une vingtaine d'années, cependant, grâce à l'apport des neurosciences et de la psychologie cognitive, loin de s'épaissir, le mystère peu à peu se dissipe. Explorateur du cerveau et grand collectionneur, c'est à une fantastique « aventure (...) philosophique» au cœur du processus créatif que nous convie Jean-Pierre Changeux, dans ce livre illustré par des chefs-d'œuvre peu connus de l'art français et étranger. (shrink)

This bibliographical review of the modelling of the mitotic apparatus covers a period of one hundred and twenty years, from the discovery of the bipolar mitotic spindle up to the present day. Without attempting to be fully comprehensive, it will describe the evolution of the main ideas that have left their mark on a century of experimental and theoretical research. Fol and Bütschli's first writings date back to 1873, at a time when Schleiden and Schwann's cell theory was rapidly gaining (...) ground throughout Germany. Both mitosis and chromosomes were to be discovered within the space of thirty years, along with the two key events in the animal and plant reproductive cycle, namely fecondation and meiosis. The mitotic pole, a term still in use to this day, was employed to describe a morphological fact which was noted as early as 1876, namely that the lines and the dots of the karyokinetic figure, with its spindle and asters, looks remarkably like the lines of force around a bar magnet. This was to lead to models designed to explain the movements of chromosomes which take place when the cell nucleus appears to cease to exist as an organelle during mitosis. The nature of those mechanisms and the origin of the forces behind the chromosomes' ordered movements were central to the debate. Auguste Prenant, in a remarkable bibliographical synthesis published in 1910, summed up the opposing viewpoints of the vitalists, on the one hand, who favoured the theory of contractility or extensility in spindle fibres, and of those who believed in models based on physical phenomena, on the other. The latter subdivided into two groups: some, like Bütschli, Rhumbler or Leduc, referred to diffusion, osmosis and superficial tension, whilst the others, led by Gallardo and Hartog, focussed on the laws of electromagnetism. Lillie, Kuwada and Darlington followed up this line of research. The mid-20th century was a major turning point. Most of the modelling mentioned above was criticized and fell into disuse after disappearing from research publications and textbooks.This marked the onset of a new era, as electron microscopes made possible the materialization and detailed study of the macromolecular elements of the fibres, filaments and microtubules of the cytoskeleton. The successive phases of (a) de Harven and Bernhard's 1956 discovery of the centriole's ultrastructure, (b) its identification with the basal body of the cilia and flagella, confirming the theory set out by Henneguy and von Lenhossek (1898–99), (c) the universal presence of microtubules in animal, vegetal and eukaryotic protist cells, (d) the polymerization-depolymerization induced reversible transformations of the tubulin pool in mitosing cells (Inoue, 1960), (e) ultrastructural comparative studies of the mitotic apparatus of eukaryotes illustrating the Pickett-Heaps integrating concept of the MTOC (microtubule-organizing centre), (f) the possibility ofin vitro experiments on mtocs or on microtubules, brings us upon the present day, which has seen the focus placed on the concept of motor-proteins (kinesin, dynein) and on cell cycle models. The latter are based on a close coincidence between the observable modifications of the mitotic apparatus and the periodic variations in intracellular concentrations of calcium or of certain enzymes (cyclins, Cdc2) during the main transitions of the cell cycle. (shrink)

The aim of this paper is to clarify the role of category theory in the foundations of mathematics. There is a good deal of confusion surrounding this issue. A standard philosophical strategy in the face of a situation of this kind is to draw various distinctions and in this way show that the confusion rests on divergent conceptions of what the foundations of mathematics ought to be. This is the strategy adopted in the present paper. It is divided into 5 (...) sections. We first show that already in the set theoretical framework, there are different dimensions to the expression foundations of. We then explore these dimensions more thoroughly. After a very short discussion of the links between these dimensions, we move to some of the arguments presented for and against category theory in the foundational landscape. We end up on a more speculative note by examining the relationships between category theory and set theory. (shrink)

Anselm of Cantorbery wrote Proslogion, where is formulated the famous ‘Unum argumentum’ about the existence of God. This argument was been disputed and criticized by numerous logicians from an extensional view point. The classical predicate logic is not able to give a formal frame to develop an adequate analysis of this argument. According to us, this argument is not an ontological proof; it analyses the meaning of the “quo nihil maius cogitari posit”, a characterization of God, and establish, by absurd, (...) that “quod non posit cogitare non esse” by using the hypothesis: “to think in re” is taller than “to think in solo intelectu”. We discuss this relation and the difference between the meanings of the elementary predicates ‘to be in re’, ‘to be in intellectu’ and ‘to be in solo intellectu’. We propose a new logical approach of this ‘Unum argumentum’ of Anselm by using Curry’s Combinatory Logic. Indeed, Combinatory Logic is an abstract applicative formalism of operators applied to operands; in this formalism, the predicates, viewed as specific operators, can be composed and can be transformed, by an intrinsic way, into more complex predicates, by means of abstract operators, called “combinators”, studied by Combinatory Logic. We show that this formalism is a logical frame where it becomes possible to discuss and to formulate cognitive representations of the meanings of predicates used inside of the ‘Unum argumentum’ and to explain how the argument runs. (shrink)

Résumé L’article propose une analyse du phénomène de mobilisation des Lumières, c’est-à-dire de la réactivation récurrente de leurs notions (liberté, tolérance, progrès …) dans des moments d’affrontements idéologiques depuis le début du XXe siècle. L’étude s’appuie notamment sur les traductions de l’Esquisse d’un tableau historique des progrès de l’esprit humain de Condorcet (1795) dans le monde. Mais elle propose aussi l’analyse d’autres modes de convocation des idéaux des Lumières, par exemple dans le contexte d’actes terroristes qui visent précisément les valeurs (...) associées à la philosophie du XVIIIe siècle. En examinant la force mobilisatrice du « siècle de Voltaire » lors de crises aiguës, la présente contribution distingue et définit plusieurs formes de ces mobilisations. (shrink)

For the first time this volume makes Jean-Pierre Meunier's influential thoughts on the film experience available for an English-speaking readership. Introduced and commented by specialists in film studies and philosophy, Meunier's intricate phenomenological descriptions of the spectator's engagement with fiction films, documentaries and home movies can reach the wide audience they have deserved ever since their publication in French in 1969.

Tradução do livro: Sociologias da alimentação: os comedores e o espaço social alimentar. Florianópolis, Editora da UFSC, 2004, 311 páginas. Obra traduzida juntamente com Rossana Pacheco da Costa Proença e Carmen Silvia Rial. ISBN 85.328.0290-7. [Título original: Sociologies de l'alimentation: Les mangeurs et l'espace social alimentair. Obra publicada originalmente pela PUF, Paris, 2002. Edição original 288 páginas. ISBN: 213050643. Janeiro 2003, 2e édition. Etnologia-Antropologia].

Evaluative Semantics proposes a strongly postmodernist theory of cognition, ideology and discourse in which the structure and internal consistency of ideology resemble those of evaluative knowledge of the mind. The strength of this book is that it goes beyond purely theoretical claims to propose an original connectionist model of evaluative interpretation. Malrieu's new semantics makes a unique contribution to the literature of cognitive science, linguistics, and discourse analysis.