It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3′ untranslated regions (UTRs). The functionality of sites in the coding domain sequence (CDS), on the other hand, remains under discussion. Such sites have limited impact on target mRNA abundance and recent work suggests that miRNAs bind in the CDS to inhibit translation. What then could be the regulatory benefits of translation inhibition through CDS targeting compared to mRNA degradation following 3′ UTR binding? We propose that these (...) domain‐dependent effects serve to diversify the functional repertoire of post‐transcriptional gene expression control. Possible regulatory benefits may include tuning the time‐scale and magnitude of post‐transcriptional regulation, regulating protein abundance depending on or independently of the cellular state, and regulation of the protein abundance of alternative splice variants. Finally, we review emerging evidence that these ideas may generalize to RNA‐binding proteins beyond miRNAs and Argonaute proteins. (shrink)

Erratum to: Int J Semiot Law DOI 10.1007/s11196-015-9405-1Assurance de la qualité en traduction juridique: l’évaluation du processus, de la compétence et du produit dans la quête de l’équivalence.Le professeur Prieto Ramos propose un modèle holistique pour assurer la qualité de l’évaluation en traduction juridique. Fondée sur un cadre fonctionnaliste de la prise de décision, cette démarche passe par l’établissement d’une stratégie d’adéquation basée sur les paramètres juridiques et contextuels impliqués dans le processus de la traduction, de son produit au stade (...) de l’auto-révision et de l’évaluation, et dans la définition des critères d’évaluation et de la compétence attendus des traducteurs et des réviseurs. Ce modèle d’évaluation de la qualité devrait permettre d’améliorer la prédictibilité tout en réduisant la subjectivité et de hausser les standards de la pratique professionnelle de la traduction. (shrink)

_Being and Nothingness_ is without doubt one of the most significant books of the twentieth century. The central work by one of the world's most influential thinkers, it altered the course of western philosophy. Its revolutionary approach challenged all previous assumptions about the individual's relationship with the world. Known as 'the Bible of existentialism', its impact on culture and literature was immediate and was felt worldwide, from the absurd drama of Samuel Beckett to the soul-searching cries of the Beat poets. (...) _Being and Nothingness_ is one of those rare books whose influence has affected the mind-set of subsequent generations. Sixty years after its first publication, its message remains as potent as ever - challenging the reader to confront the fundamental dilemmas of human freedom, responsibility and action. (shrink)

It was to correct common misconceptions about his thought that Jean-Paul Sartre, the most dominent European intellectual of the post-World War II decades, accepted an invitation to speak on October 29, 1945, at the Club Maintenant in Paris. The unstated objective of his lecture (“Existentialism Is a Humanism”) was to expound his philosophy as a form of “existentialism,” a term much bandied about at the time. Sartre asserted that existentialism was essentially a doctrine for philosophers, though, ironically, he was (...) about to make it accessible to a general audience. The published text of his lecture quickly became one of the bibles of existentialism and made Sartre an international celebrity. The idea of freedom occupies the center of Sartre’s doctrine. Man, born into an empty, godless universe, is nothing to begin with. He creates his essence—his self, his being—through the choices he freely makes (“existence precedes essence”). Were it not for the contingency of his death, he would never end. Choosing to be this or that is to affirm the value of what we choose. In choosing, therefore, we commit not only ourselves but all of mankind. This book presents a new English translation of Sartre’s 1945 lecture and his analysis of Camus’s _The Stranger_, along with a discussion of these works by acclaimed Sartre biographer Annie Cohen-Solal. This edition is a translation of the 1996 French edition, which includes Arlette Elkaïm-Sartre’s introduction and a Q&A with Sartre about his lecture. (shrink)

It was to correct common misconceptions about his thought that Jean-Paul Sartre, the most dominent European intellectual of the post-World War II decades, accepted an invitation to speak on October 29, 1945, at the Club Maintenant in Paris. The unstated objective of his lecture was to expound his philosophy as a form of “existentialism,” a term much bandied about at the time. Sartre asserted that existentialism was essentially a doctrine for philosophers, though, ironically, he was about to make it (...) accessible to a general audience. The published text of his lecture quickly became one of the bibles of existentialism and made Sartre an international celebrity. The idea of freedom occupies the center of Sartre’s doctrine. Man, born into an empty, godless universe, is nothing to begin with. He creates his essence—his self, his being—through the choices he freely makes. Were it not for the contingency of his death, he would never end. Choosing to be this or that is to affirm the value of what we choose. In choosing, therefore, we commit not only ourselves but all of mankind. This book presents a new English translation of Sartre’s 1945 lecture and his analysis of Camus’s _The Stranger_, along with a discussion of these works by acclaimed Sartre biographer Annie Cohen-Solal. This edition is a translation of the 1996 French edition, which includes Arlette Elkaïm-Sartre’s introduction and a Q&A with Sartre about his lecture. (shrink)

The Transcendence of the Ego may be regarded as a turning-point in the philosophical development of Jean-Paul Sartre. Prior to the writing of this essay, published in France in 1937, Sartre had been intimately acquainted with the phenomenological movement which originated in Germany with Edmund Husserl. It is a fundamental tenet of Husserl, the notion of a transcendent ego, which is here attacked by Sartre. This disagreement with Husserl has great importance for Sartre and facilitated the transition from phenomenology (...) to the doctrine of Being and Nothingness. (shrink)

A major event in the history of twentieth-century thought, Notebooks for a Ethics is Jean-Paul Sartre's attempt to develop an ethics consistent with the profound individualism of his existential philosophy. In the famous conclusion to Being and Nothingness , Sartre announced that he would devote his next philosophical work to moral problems. Although he worked on this project in the late 1940s, Sartre never completed it to his satisfaction, and it remained unpublished until after his death in 1980. Presented (...) here for the first time in English, the Notebooks reveal Sartre at his most productive, crafting a masterpiece of philosophical reflection that can easily stand alongside his other great works. Sartre grapples anew here with such central issues as "authenticity" and the relation of alienation and freedom to moral values. Exploring fundamental modes of relating to the Other--among them violence, entreaty, demand, appeal, refusal, and revolt--he articulates the necessary transition from individualism to historical consciousness. This work thus forms an important bridge between the early existentialist Sartre and the later Marxist social thinker of the Critique of Dialectical Reason . The Notebooks themselves are complemented here by two additional essays, one on "the good and subjectivity," the other on the oppression of blacks in the United States. With publication of David Pellauer's lucid translation, English-speaking readers will be able to appreciate this important contribution to moral philosophy and the history of ethics. Jean-Paul Sartre (1906-1980) was offered, but declined, the Nobel Prize for literature in 1964. His many works of fiction, drama, and philosophy include the monumental study of Flaubert, The Family Idiot , and The Freud Scenario , both published in translation by the University of Chicago Press. (shrink)

Jean-Paul Sartre was one of the most important philosophical and political thinkers of the twentieth century. His writings had a potency that was irresistible to the intellectual scene that swept post-war Europe, and have left a vital inheritance to contemporary thought. The central tenet of the Existentialist movement which he helped to found, whereby God is replaced by an ethical self, proved hugely attractive to a generation that had seen the horrors of Nazism, and provoked a revolution in post-war (...) thought and literature. In _What is Literature?_ Sartre the novelist and Sartre the philosopher combine to address the phenomenon of literature, exploring why we read, and why we write. (shrink)

First published in France in 1936 as a journal article, The Transcendence of the Ego was one of Jean-Paul Sartre's earliest philosophical publications. When it appeared, Sartre was still largely unknown, working as a school teacher in provincial France and struggling to find a publisher for his most famous fictional work, Nausea . The Transcendence of the Ego is the outcome of Sartre's intense engagement with the philosophy of Edmund Husserl, the founder of phenomenology. Here, as in many subsequent (...) writings, Sartre embraces Husserl's vision of phenomenology as the proper method for philosophy. But he argues that Husserl's conception of the self as an inner entity, 'behind' conscious experience is mistaken and phenomenologically unfounded. The Transcendence of the Ego offers a brilliant diagnosis of where Husserl went wrong, and a radical alternative account of the self as a product of consciousness, situated in the world. This essay introduces many of the themes central to Sartre's major work, Being and Nothingness : the nature of consciousness, the problem of self-knowledge, other minds, anguish. It demonstrates their presence and importance in Sartre's thinking from the very outset of his career. This fresh translation makes this classic work available again to students of Sartre, phenomenology, existentialism, and twentieth century philosophy. It includes a thorough and illuminating introduction by Sarah Richmond, placing Sartre's essay in its philosophical and historical context. (shrink)

A cornerstone of Sartre’s philosophy, _The Imaginary_ was first published in 1940. Sartre had become acquainted with the philosophy of Edmund Husserl in Berlin and was fascinated by his idea of the 'intentionality of consciousness' as a key to the puzzle of existence. Against this background, _The Imaginary_ crystallized Sartre's worldview and artistic vision. The book is an extended examination of the concepts of nothingness and freedom, both of which are derived from the ability of consciousness to imagine objects both (...) as they are and as they are not – ideas that would drive Sartre's existentialism and entire theory of human freedom. (shrink)

The result was the Critique of Dialectical Reason, an intellectual masterpiece of the twentieth century, now republished in two volumes with major original ...

Essays culled from two former books by the leading French exponent of this philosophy.

First published in France in 1936 as a journal article, The Transcendence of the Egowas one of Jean-Paul Sartre's earliest philosophical publications. When it appeared, Sartre was still largely unknown, working as a school teacher in provincial France and struggling to find a publisher for his most famous fictional work, Nausea. The Transcendence of the Egois the outcome of Sartre's intense engagement with the philosophy of Edmund Husserl, the founder of phenomenology. Here, as in many subsequent writings, Sartre embraces (...) Husserl's vision of phenomenology as the proper method for philosophy. But he argues that Husserl's conception of the self as an inner entity, 'behind' conscious experience is mistaken and phenomenologically unfounded. The Transcendence of the Egooffers a brilliant diagnosis of where Husserl went wrong, and a radical alternative account of the self as a product of consciousness, situated in the world. This essay introduces many of the themes central to Sartre's major work, Being and Nothingness: the nature of consciousness, the problem of self-knowledge, other minds, anguish. It demonstrates their presence and importance in Sartre's thinking from the very outset of his career. This fresh translation makes this classic work available again to students of Sartre, phenomenology, existentialism, and twentieth century philosophy. It includes a thorough and illuminating introduction by Sarah Richmond, placing Sartre's essay in its philosophical and historical context.t of consciousness, situated in the world. This essay introduces many of the themes central to Sartre's major work, Being and Nothingness: the nature of consciousness, the problem of self-knowledge, other minds, anguish. It demonstrates their presence and importance in Sartre's thinking from the very outset of his career. This fresh translation makes this classic work available again to students of Sartre, phenomenology, existentialism, and twentieth century philosophy. It includes a thorough and illuminating introduction by Sarah Richmond, placing Sartre's essay in its philosophical and historical context. (shrink)

"A driving force in all Sartre's writing is his serious desire to change the life of his reader." -- Iris Murdoch.

“He devoured her with his eyes.” This expression and many other signs point to the illusion common to both realism and idealism: to know is to eat. After a hundred years of academicism, French philosophy remains at that point. We have all read Brunschvicg, Lalande, and Meyerson,2 we have all believed that the spidery mind trapped things in its web, covered them with a white spit and slowly swallowed them, reducing them to its own substance. What is a table, a (...) rock, a house? Answer: a certain assemblage of “contents of consciousness,” a class of such contents. Oh digestive philosophy! Yet nothing seemed more obvious: is not the table the actual content of my perception? Is not my perception the present state of my consciousness? Nutrition, assimilation! Assimilation, Lalande said, of things to ideas, of ideas by ideas, of minds by minds. The corpulent skeletons of the world were picked clean by these diligent diastases: assimilation, unification, identification. The simplest and plainest among us vainly looked for something solid, something not just mental, but would encounter everywhere only a soft and very genteel mist: themselves. (shrink)

‘No matter how long I may look at an image, I shall never find anything in it but what I put there. It is in this fact that we find the distinction between an image and a perception.' - Jean-Paul Sartre L’Imagination was published in 1936 when Jean-Paul Sartre was thirty years old. Long out of print, this is the first English translation in many years. The Imagination is Sartre’s first full philosophical work, presenting some of the basic (...) arguments concerning phenomenology, consciousness and intentionality that were to later appear in his master works and be so influential in the course of twentieth-century philosophy. Sartre begins by criticising philosophical theories of the imagination, particularly those of Descartes, Leibniz and Hume, before establishing his central thesis. Imagination does not involve the perception of ‘mental images’ in any literal sense, Sartre argues, yet reveals some of the fundamental capacities of consciousness. He then reviews psychological theories of the imagination, including a fascinating discussion of the work of Henri Bergson. Sartre argues that the ‘classical conception’ is fundamentally flawed because it begins by conceiving of the imagination as being like perception and then seeks, in vain, to re-establish the difference between the two. Sartre concludes with an important chapter on Husserl’s theory of the imagination which, despite sharing the flaws of earlier approaches, signals a new phenomenological way forward in understanding the imagination. The Imagination is essential reading for anyone interested in the philosophy of Jean-Paul Sartre, phenomenology, and the history of twentieth-century philosophy. This new translation includes a helpful historical and philosophical introduction by Kenneth Williford and David Rudrauf. Also included is Maurice Merleau-Ponty’s important review of L’Imagination upon its publication in French in 1936. Translated by Kenneth Williford and David Rudrauf. (shrink)

'Search for a Method' is a separate and introductory essay published together with 'Critique of Dialectical Reason'.

First published in 1972. Routledge is an imprint of Taylor & Francis, an informa company.

_Colonialism and Neo-Colonialism_ is a classic critique of France's policies in Algeria in the 1950s and 1960s and inspired much subsequent writing on colonialism, post-colonialism, politics, and literature. It includes Sartre's celebrated preface to Fanon's classic _Wretched_ _of the Earth. Colonialism and Neo-Colonialism _ had a profound impact on French intellectual life, inspiring many other influential French thinkers and critics of colonialism such as Jean-Francois Lyotard, Frantz Fanon, Pierre Bourdieu and Jacques Derrida.

In a series of highly publicized articles in 1952, Jean-Paul Sartre engaged Albert Camus in a bitter public confrontation over the ideas Camus articulated in his renowned work,. This volume contains English translations of the five texts constituting this famous philosophical quarrel. It also features a biographical and critical introduction plus two essays by contemporary scholars reflecting on the cultural and philosophical significance of this confrontation.

This new edition of "What is Literature?" also collects three other crucial essays of Sartre's for the first time in a volume of his.

The purposes of writing -- The itinerary of a thought -- Vietnam : imperialism and genocide -- Czechoslovakia : the socialism that came in from the cold -- France : masses, spontaneity, party -- Kierkegaard : the singular universal -- Mallarmé : the poetry of suicide -- Tintoretto : St. George and the dragon -- The man with the tape-recorder -- Psychoanalytic dialogue -- Reply to Sartre--Pontalis -- Reply to Sartre--Pingaud -- A plea for intellectuals -- A friend of the (...) people. (shrink)

Despite its internal divisions and the uncertainty surrounding many of its foundations, there is a growing consensus that the on‐going search for an alternative model of the mind finds a minimal theoretical identity in the pursuit of an anti‐Cartesian conception of mental phenomena. Nevertheless, this anti‐Cartesianism remains more or less explicitly committed to the neo‐Brentanian idea that intentionality is an essential feature of the mental—an idea that has prevailed since the advent of modern cognitive science in the 1950s. An issue (...) of compatibility is thereby raised, as neo‐Brentanism arguably sides with cognitive Cartesianism. The main goal of the paper is to put into full light one specific aspect of this largely unperceived problem of compatibility by arguing that the neo‐Brentanian property of intentionality is an essentially representational one that runs counter to the salient anti‐representationalism of anti‐Cartesianism. And, that this representational essence confronts the search for alternative models of the mind of an anti‐Cartesian kind with the following theoretical issue: To what extent is it possible to devise a non‐Brentanian property of intentionality, particularly one that is fully dissociated from the property of representation? This issue is shown to be much deeper and more difficult than it looks once the nature of representation is properly apprehended; it seems to be still waiting for an answer in the current search for an alternative model of the mind, if only because it has not yet be set in fully adequate terms. (shrink)

Grains de poussiere dans un rayon de soleil... poesie du discontinu que la lumiere de l'entendement met a jour, verite du mobile et du minuscule: l'atomisme de Democrite porte, assurement, a rever. A l'aide des nombreux temoignages et fragments reunis par Diels et Luria, J. Salem a souhaite retrouver l'unite d'inspiration qui dut presider a cette oeuvre encyclopedique. Il est tout a fait possible de distinguer l'immense silhouette de Democrite dans maints textes de l'Antiquite: aussi est-il fort tentant de reconstituer (...) le systeme de pensee de celui que Seneque a tenu pour le plus subtil de tous les Anciens. (shrink)

Cette note épistémologique porte sur le statut, en théorie de la décision, des concepts d’attitude par rapport au risque. A première vue, l’analyse axiomatique ne les exploite pas, ce qui reflète une certaine neutralité des modèles de décision au sujet de l’attitude par rapport au risque. Mais un examen plus poussé met en valeur la variation conditionnelle et le renforcement de l’attitude par rapport au risque, qui rattachent les concepts d’attitude par rapport au risque à l’analyse axiomatique.

Science and the institutions of science are far from democratic systems,and yet they are the most democratic of regimes. This essay examinesthe demand for transparency and public participation. One can distinguishseveral levels of public influence. Their function suggests thatdecision-makers, both scientists and technocrats, are being obligedto accept and work with rules which are no longer laid down by themselves.

Dans ce livre jubilatoire, Jean Salem développe une approche originale sur la question qui fait recette aujourd'hui dans les librairies, dans les gazettes, dans les sectes, chez les spirites et dans tous les endroits où l'on cause : pouvons-nous espérer le bonheur quand même? le bonheur est-il praticable, jusqu'en ces temps de catastrophe? avons-nous seulement le droit de prétendre à jouir d'un tel luxe quand l'horizon paraît bouché et que le sol semble s'enfoncer sous nos pieds? quand il n'y (...) a plus d'horizon. Ce livre rompt avec l'idéologie du bonheur individuel, du bonheur New Age, du bonheur " guimauve " et désengagé, induit par la société de consommation. On y entend parler non seulement du souverain bien des Anciens, mais aussi du bonheur d'agir, de résister, en un mot : du bonheur de lutter. Dans un style enlevé, drôle et polémique, Jean Salem mène son enquête au sujet du bonheur : " sur ce qui en a été dit par quelques bons esprits du passé, et sur les moyens de ne pas le manquer tout à fait en un temps d'inquiétude et de catastrophe. ". (shrink)

This view encouraged theorists to consider artistic geniuses the high-priests of humanity, creators of works that reveal the invisible essence of the world."--BOOK JACKET.