Recent developments in 3D cultures exploiting the self‐organization ability of pluripotent stem cells have enabled the generation of powerful in vitro systems termed brain organoids. These 3D tissues recapitulate many aspects of human brain development and disorders occurring in vivo. When combined with improved differentiation methods, these in vitro systems allow the generation of more complex “assembloids,” which are able to reveal cell diversities, microcircuits, and cell–cell interactions within their 3D organization. Here, the ways in which human brain organoids have (...) contributed to demystifying the complexities of brain development and modeling of developmental disorders is reviewed and discussed. Furthermore, challenging questions that are yet to be addressed by emerging brain organoid research are discussed. (shrink)

For nearly two thousand years Buddhism has mystified and captivated both lay people and scholars alike. Seen alternately as a path to spiritual enlightenment, an system of ethical and moral rubrics, a cultural tradition, or simply a graceful philosophy of life, Buddhism has produced impassioned followers the world over. The Buddhist saint Nagarjuna, who lived in South India in approximately the first century CE, is undoubtedly the most important, influential, and widely studied Mahayana Buddhist philosopher. His many works include texts (...) addressed to lay audiences, letters of advice to kings, and a set of penetrating metaphysical and epistemological treatises. His greatest philosophical work, the Mulamadhyamikakarika--read and studied by philosophers in all major Buddhist schools of Tibet, China, Japan, and Korea--is one of the most influential works in the history of Indian philosophy. Now, in The Foundations of the Philosophy of the Middle Way, Jay L. Garfield provides a clear and and eminently readable translation of Nagarjuna's seminal work, offering those with little of no prior knowledge of Buddhist philosophy a view into the profound logic of the Mulamadhyamikakarika. Translated from the Tibetan, the tradition through which Nagarjuna's philosophical influence has largely been transmitted, Garfield presents a superb translation of Mulamadhyamikakarika in its entirety. Illuminating the systematic character of Nagarjuna's reasoning, as well as the works profundity, Garfield shows how Nagarjuna develops his doctrine that all phenomena are empty of inherent existence and essenceless. But, he argues, phenomena nonetheless exist conventionaly, and that indeed conventional existence and ultimate emptiness are in fact the same thing. This represents the radical understanding of the Buddhist doctrine of the two truths, or two levels of reality. Nagarjuna reinterprets all of Buddhist metaphysics and epistemology through this analytical framework--"a systematic and beautifully elegant philosophical dissection of reality." In turn, Garfield goes on to offer the only verse-by-verse commentary based upon the Indo-Tibetan Prasangika-Madhyamika reading of Nagarjuna, the school most influential in the development of Mahayana philosophy in Tibet, China, Korea, and Japan. Written specifically for the Western reader, the commentary explains Nagarjuna's positions and arguments in the language of Western metaphysics and epistemology, and connects Nagarjuna's concerns tho those of Western philosophers such as Sextus, Hume, and Wittgenstein. A fascinating and accessible translation of the foundational text for all Mahayana Buddhism text, The Fundamental Wisdom of the Middle Way will enlighten all those in search of the essence of reality. (shrink)

Belief in Psychology tackles the knotty problem of how to treat the propositional attitudes states such as beliefs, desires, hopes and fears within cognitive science. Jay Garfield asserts that the propositional attitudes can and must play useful theoretical roles in the science of the mind and stresses the importance of their social context in this sophisticated and original argument.Garfield proposes his own alternative to the apparent dilemma of either scrapping the propositional attitudes or of making room for them within a (...) dimly foreseen, futuristic cognitive science. He provides a characterization of the nature of propositional attitudes conceived as psychological states, and of their role in cognitive science. They must, he argues, be understood as relations between their bearers and their environments, including, in the case of persons, their social and linguistic environments. Understanding them in this way is consonant with current practice in empirical cognitive science and provides a philosophically useful analysis of mental representation.Along the way, Garfield discusses the relationship between the enterprise of science and our commonsense conception of ourselves and the world, and the ways in which this relation constrains our understanding of the propositional attitudes, and illuminates a realistic interpretation of a psychology of representational states and processes. Belief in Psychology is the only book that adopts such a view, and it is unique in providing a sustained critique of eliminativism, instrumentalism, and computational individualism - the main competing proposals within philosophy of cognitive science for eliminating or reconciling propositional attitudes.Jay Garfield is Associate Professor of Philosophy in the School of Communications and Cognitive Science at Hampshire College and a co-director of the University of Massachusetts Cognitive Science Institute. He is a co-author of Cognitive Science: An Introduction and editor of Modularity in Knowledge Representation and Natural Language Understanding, both Bradford books. A Bradford Book. (shrink)

The notion of modularity, introduced by Noam Chomsky and developed with special emphasis on perceptual and linguistic processes by Jerry Fodor in his important book The Modularity of Mind, has provided a significant stimulus to research in cognitive science. This book presents essays in which a diverse group of philosophers, linguists, psycholinguists, and neuroscientists - including both proponents and critics of the modularity hypothesis - address general questions and specific problems related to modularity. Jay L. Garfield is Associate Professor of (...) Philosophy in the School of Communications and Cognitive Science at Hampshire College. (shrink)

Why you don’t have a self—and why that’s a good thing In Losing Ourselves, Jay Garfield, a leading expert on Buddhist philosophy, offers a brief and radically clear account of an idea that at first might seem frightening but that promises to liberate us and improve our lives, our relationships, and the world. Drawing on Indian and East Asian Buddhism, Daoism, Western philosophy, and cognitive neuroscience, Garfield shows why it is perfectly natural to think you have a self—and why it (...) actually makes no sense at all and is even dangerous. Most importantly, he explains why shedding the illusion that you have a self can make you a better person. Examining a wide range of arguments for and against the existence of the self, Losing Ourselves makes the case that there are not only good philosophical and scientific reasons to deny the reality of the self, but that we can lead healthier social and moral lives if we understand that we are selfless persons. The book describes why the Buddhist idea of no-self is so powerful and why it has immense practical benefits, helping us to abandon egoism, act more morally and ethically, be more spontaneous, perform more expertly, and navigate ordinary life more skillfully. Getting over the self-illusion also means escaping the isolation of self-identity and becoming a person who participates with others in the shared enterprise of life. The result is a transformative book about why we have nothing to lose—and everything to gain—by losing our selves. (shrink)

Ecologist Richard Levins argues population biologists must trade‐off the generality, realism, and precision of their models since biological systems are complex and our limitations are severe. Steven Orzack and Elliott Sober argue that there are cases where these model properties cannot be varied independently of one another. If this is correct, then Levins's thesis that there is a necessary trade‐off between generality, precision, and realism in mathematical models in biology is false. I argue that Orzack and Sober's arguments fail since (...) Levins's thesis concerns the pragmatic features of model building not just the formal properties of models. (shrink)

In this essay, I argue for four related claims. First, Richard Levins’ classic “The Strategy of Model Building in Population Biology” was a statement and defense of theoretical population biology growing out of collaborations between Robert MacArthur, Richard Lewontin, E. O. Wilson, and others. Second, I argue that the essay served as a response to the rise of systems ecology especially as pioneered by Kenneth Watt. Third, the arguments offered by Levins against systems ecology and in favor of his own (...) methodological program are best construed as “pragmatic”. Fourth, I consider limitations of Levins’ arguments given contemporary population biology. (shrink)

India has been independent for 70 years now, and it is a good time to reflect on the political philosophy that underwrote the movement that gained that independence. When we do so, we discover the origins of a political vocabulary that is still in use today, although sadly not used with the same rigor and precision with which it was used then. We also find that those who recur to Indian political thought from the pre-independence period tend to return to (...) a single strand of that thought—the theorization of ahimsa by Mohandas K. Gandhi, as for instance in the recent essay on Indian political thought in The New York Times by Gopalkrishna Gandhi (Gandhi won’t leave India 2017). In this discussion, we hope to draw attention to some of the less well-known resources offered by pre-independence Indian philosophy and in particular the political thought of the Arya samaji Congressman, philosopher and political activist, Lajpat Rai. His political philosophy is important for understanding the theorization of and debates within the Indian independence movement; we think that it also suggests ways to think about contemporary political and revolutionary movements and merits consideration in current debates in political philosophy. (shrink)

Greg Cooper’s The Science of the Struggle for Existence is a must read for those interested in the history and philosophy of ecology and in topics like laws of nature, scientific explanation, and mathematical modeling. If you want to explore some of the metaphysical and methodological challenges that face ecology, there is no better place to go. Thus, this book marks an important moment in the philosophy of ecology. Folks like myself will be responding to it for quite a while. (...) What I find most appealing about the book is just how much there is to argue with. On every page there are interesting ideas presented but which are excitingly controversial. Some will argue with Cooper’s interpretation of the history of ecology. There are parts of the book that empiricists will balk at. You will not be left unstirred. Having said this, Cooper can be longwinded and while you read you should remember patience is a virtue. (shrink)

Sellars’s views on the Myth of the Given and the ontological status of secondary qualities, one would have thought, are well-known, even if not always well-understood. One would not have expected his Carus Lectures, then, to offer anything radically new and exciting. The ground that they cover is, after all, familiar—from “Empiricism and the Philosophy of Mind”, from “Philosophy and the Scientific Image of Man”, from “The Identity Approach to the Mind-Body Problem”, and from the ensuing debates with Cornman and (...) with Firth. One would not really have anticipated many surprises. But one would have been wrong. (shrink)

As a philosophical scholar of phenomenology, literature, art, and philosophy of the social sciences and humanities, John O’Neill’s (1933–2022) writings are translated into Chinese. As a sociological translator of Maurice Merleau-Ponty (1908–1961), O’Neill’s five phenomenal bodies culminate in the communicative body as an intermingling of material and spiritual relations. I distill by own version of three phenomenal bodies that I call the East Asian communicative body. This essay traces the communicative body through horizontal and vertical phenomenology on the way to (...) Merleau-Ponty’s brief interaction with Chinese philosophy. (shrink)

I forgive the slight spin of sloganeering conveyed by the motto so frequently cited by proponents of a cosmos chock full of organisms: "Life will fed a way." Life is resilient and quite capable (especially in bacterial form) of living in the most damnably improbable places-from nearly boiling ponds in Yellowstone National Park to tiny pores in rocks as deep as two miles below the earth's surface. But even this degree of resilience must work within limits; if life ever evolved (...) on the Martian surface during its initial billion years with running water, the planet's later desiccation probably extinguished our solar system's second experiment in advanced carbon chemistry. (shrink)

Localism is a social movement often associated with “buy local” food initiatives or the prevention of big-box retail expansion. At its core, however, localism is also about fostering local independence by encouraging businesses to opt for local alternatives when making purchasing decisions. In this article, we develop and test hypotheses that organizations with stronger community-oriented identities are more likely to source locally and that this relationship is moderated by the importance of the focal firm’s purchasing decisions. Results support the strong (...) influence of identity but the conditional effect is unconfirmed. (shrink)

Wilfrid Sellars' conclusion in "Empiricism and the Philosophy of Mind" that "the Given" is a "Myth" quickly elicited philosophical opposition and remains contentious fifty years later. William Alston has challenged that conclusion on several occasions by attempting to devise an acceptable account of perception committed to the givenness of perceived objects. His most recent challenge advances a "Theory of Appearing" which posits irreducible non-conceptual relations, ostensibly overlooked by Sellars, e.g., of "looking red", between the subject and the object perceived, that (...) can playa justificatory role vis-à-vis the corresponding beliefs, e.g., that the object is red. I argue that Alston undermines his positive plausibility arguments by first blurring and then ignoring crucial differencesamong various looks-concepts, and that his own putative "phenomenal" looks-concept demonstrably cannot play the justificatory role that he envisions for it. Both his critique of Sellars' arguments and his own alternative proposal thus fail on all fronts. (shrink)

Assertive community treatment (ACT) is a widely propagated team approach to community mental health care that ‘assertively’ engages a subgroup of individuals with severe mental illness who continuously disengage from mental health services. It involves a number of interested parties – including clients, carers, clinicians and managers. Each operates according to perceived ethical principles related to their values, mores and principles. ACT condenses a dilemma that is common in psychiatry. ACT proffers social control whilst simultaneously holding therapeutic aspiration. The clients’ (...) perspective of this dilemma was studied in interviews with 12 clients using the ‘grounded theory’ approach. Results suggest that clients’ disengagement is as much a historical and cultural phenomenon as a result of lack of insight. Many clients had experienced rejection of early help–seeking behaviour and all had been subject to coercive interventions. These coercive interventions were experienced as an attack on identity. All felt that their voice had not been listened to in previous interactions with psychiatric services. Consequentially the clients had an increased level of arousal around issues of power, which needs to be incorporated when examining the ethics of community psychiatry. Traditional notions of the difference between persuasion and coercion – for example – may need to be adapted for this client group. Results are compared with the provider perspective. We conclude that the perspectives differ on two key dimensions. Such an empirical approach to examining psychiatric ethics may ensure that we incorporate the subjectivities of various interested parties in the clinical decision–making process. (shrink)

Sahotra Sarkar’s Biodiversity and Environmental Philosophy is a welcome addition to the fields of environmental philosophy and the philosophy of science. First, his book has a rigorous and careful discussion of why we should preserve biodiversity. This is all the more important since much of environmental ethics has rested on normative claims which are unclear in meaning, appear unjustified at best and unjustifiable at worst, and are politically ineffective. Second, Sarkar is at home in the science of conservation biology and (...) offers important analyses of methodological issues in both ecology and conservation biology. Third, his book does not sustain what might be thought of as a “North American bias” but takes seriously environmental issues and perspectives from many different places like Australia and India. In this commentary, I raise worries and open questions that can be divided into four sections: (a) those concerning moral philosophy, (b) those concerning ecology and in particular whether we are in an extinction crisis, (c) how biodiversity is defined as a concept, and (d) what the aim and structure of conservation biology is. Ultimately, though my analysis is critical at some junctures, its purpose is to repay and hopefully improve on Sarkar’s rewarding analysis. Let me now turn from praise to criticism. (shrink)

he landscape of every career contains a few crevasses, and usually a more extensive valley or two—for every Ruth's bat a Buckner's legs; for every lopsided victory at Agincourt, a bloodbath at Antietam. Darwin's Origin of Species contains some wonderful insights and magnificent lines, but this masterpiece also includes a few notable clunkers. Darwin experienced most embarrassment from the following passage, curtailed and largely expunged from later editions of his book: In North America the black bear was seen by Hearne (...) swimming for hours with widely open mouth, thus catching, like a whale, insects in the water. Even in so extreme a case as this, if the supply of insects were constant, and if better adapted competitors did not already exist in the country, I can see no difficulty in a race of bears being rendered, by natural selection, more aquatic in their structure and habits, with larger and larger mouths, till a creature was produced as monstrous as a whale. Why did Darwin become so chagrined about this passage? His hypothetical tale may be pure speculation and conjecture, but the scenario is not entirely absurd. Darwin's discomfort arose, I think, from his failure to follow a scientific norm of a more sociocultural nature. Scientific conclusions supposedly rest upon facts and information. Speculation is not entirely taboo, and may sometimes be necessary faute de mieux. But when scientists propose truly novel and comprehensive theories—as Darwin tried to do in advancing natural selection as the primary mechanism of evolution—they need particularly good support, and invented hypothetical cases just don't supply sufficient confidence for crucial conclusions. (shrink)

ot long ago, Venus emerged from Jupiter, like Athena from the brow of Zeus—literally! It then assumed the form and orbit of a comet. In 1500 B.C., at the time of the Jewish exodus from Egypt, the earth passed twice through Venus's tail, bringing both blessing and chaos; manna from heaven (or rather from hydrocarbons of a cometary tail) and the bloody rivers of the Mosaic plagues (iron from the same tail). Continuing its erratic course, Venus collided with (or nearly (...) brushed) Mars, lost its tail, and hurtled to its present orbit. Mars then left its regular position and almost collided with the earth in about 700 B.C. So great were the terrors of these times, and so ardent our collective desire to forget them, that they have been erased from our conscious minds. Yet they lurk in our inherited and unconscious memory, causing fear, neurosis, aggression, and their social manifestations as war. (shrink)

Theists in general and Christians in particular have good grounds for affirming divine action in relation to twenty-first-century science. Although humans cannot perceive with their five senses the causation—both divine and creaturely—at work in our world, they have reasons to believe God acts as an efficient, but never sufficient, cause in creation. The essential kenosis option I offer overcomes liabilities in other kenosis proposals, while accounting for a God who acts personally, consistently, persuasively, and yet in diversely efficacious ways. We (...) can reasonably infer that the love, beauty, and truth expressed in creation derive from divine and creaturely causation. (shrink)

Grelling’s Paradox is the paradox which results from considering whether heterologicality, the word-property which a designator has when and only when the designator does not bear the word-property it designates, is had by ‘ ȁ8heterologicality’. Although there has been some philosophical debate over its solution, Grelling’s Paradox is nearly uniformly treated as a variant of either the Liar Paradox or Russell’s Paradox, a paradox which does not present any philosophical challenges not already presented by the two better known paradoxes. The (...) aims of this paper are, first, to offer a precise formulation of Grelling’s Paradox which is clearly distinguished from both the Liar Paradox and Russell’s Paradox; second, to offer a solution to Grelling’s Paradox which both resolves the paradoxical reasoning and accounts for unproblematic predications of heterologicality; and, third, to argue that there are two lessons to be drawn from Grelling’s Paradox which have not yet been drawn from the Liar or Russell’s Paradox. The first lesson is that it is possible for the semantic content of a predicate to be sensitive to the semantic context; i.e., it is possible for a predicate to be an indexical expression. The second lesson is that the semantic content of an indexical predicate, though unproblematic for many cases, can nevertheless be problematic in some cases. (shrink)

During his atomistic period, Russell felt compelled to include negative facts in his ontology. In this essay, I diagnose the grounds of that compulsion, Assess the cogency of an ontology which includes negative facts, And, Finding it inadequate, Consider finally alternative solutions within the atomistic framework to the root problems of negation.

Ecologists attempt to understand the diversity of life with mathematical models. Often, mathematical models contain simplifying idealizations designed to cope with the blooming, buzzing confusion of the natural world. This strategy frequently issues in models whose predictions are inaccurate. Critics of theoretical ecology argue that only predictively accurate models are successful and contribute to the applied work of conservation biologists. Hence, they think that much of the mathematical work of ecologists is poor science. Against this view, I argue that model (...) building is successful even when models are predictively inaccurate for at least three reasons: models allow scientists to explore the possible behaviors of ecological systems; models give scientists simplified means by which they can investigate more complex systems by determining how the more complex system deviates from the simpler model; and models give scientists conceptual frameworks through which they can conduct experiments and fieldwork. Critics often mistake the purposes of model building, and once we recognize this, we can see their complaints are unjustified. Even though models in ecology are not always accurate in their assumptions and predictions, they still contribute to successful science. (shrink)

Contemporary semantic theory rests upon lively theoretical disputes about the meaning of words, the proper form of semantic theory, and, ultimately, on the very possibility of semantic theory itself. Jay L. Garfield and Murray Kiteley have collected, in Meaning and Truth, the definitive articles on the history of semantics and the primary voices debating the interpretation of description, the theory of truth intensionality, the structure of meaning, natural language, and the relation of semantics to pragmatics. The details, complexities, and charming (...) eccentricities of language thus become visible against a background of abstract theory. Undergraduate and graduate students of semantics, linguistics, cognitive psychology, and philosophy of language will now be able to encounter all of the important theoretical debates of modern semantics in a single volume. Selections begin with the classic essay by Mill, "Of Names and Propositions," include such standards as "General Semantics" by Lewis and "Actualism" by Plantinga, and conclude with a chapter on "Linguistic Approaches to Semantics.". (shrink)