Before a general cognitive model for recurrent complex visual hallucinations (RCVH) is accepted, there must be more research into the neuropsychological and cognitive characteristics of the various disorders in which they occur. Currently available data are insufficient to distinguish whether the similar phenomenology of RCVH across different disorders is in fact produced by a single or by multiple cognitive mechanisms.

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

According to accuracy-first epistemology, accuracy is the fundamental epistemic good. Epistemic norms — Probabilism, Conditionalization, the Principal Principle, etc. — have their binding force in virtue of helping to secure this good. To make this idea precise, accuracy-firsters invoke Epistemic Decision Theory (EpDT) to determine which epistemic policies are the best means toward the end of accuracy. Hilary Greaves and others have recently challenged the tenability of this programme. Their arguments purport to show that EpDT encourages obviously epistemically irrational behavior. (...) We develop firmer conceptual foundations for EpDT. First, we detail a theory of praxic and epistemic good. Then we show that, in light of their very different good-making features, EpDT will evaluate epistemic states and epistemic acts according to different criteria. So, in general, rational preference over states and acts won’t agree. Finally, we argue that based on direction-of-fit considerations, it’s preferences over the former that matter for normative epistemology, and that EpDT, properly spelt out, arrives at the correct verdicts in a range of putative problem cases. (shrink)

The Cambridge Companion to Socrates is a collection of essays providing a comprehensive guide to Socrates, the most famous Greek philosopher. Because Socrates himself wrote nothing, our evidence comes from the writings of his friends (above all Plato), his enemies, and later writers. Socrates is thus a literary figure as well as a historical person. Both aspects of Socrates' legacy are covered in this volume. Socrates' character is full of paradox, and so are his philosophical views. These paradoxes have led (...) to deep differences in scholar's interpretation of Socrates and his thought. Mirroring this wide range of thought about Socrates, this volume's contributors are unusually diverse in their background and perspective. The essays in this volume were authored by classical philologists, philosophers, and historians from Germany, Francophone Canada, Britain, and the United States, and they represent a range of interpretive and philosophical traditions. (shrink)

In 2012, a new and promising gene manipulation technique, CRISPR-Cas9, was announced that seems likely to be a foundational technique in health care and agriculture. However, patents have been granted. As with other technological developments, there are concerns of social justice regarding inequalities in access. Given the technologies’ “foundational” nature and societal impact, it is vital for such concerns to be translated into workable recommendations for policymakers and legislators. Colin Farrelly has proposed a moral justification for the use of patents (...) to speed up the arrival of technology by encouraging innovation and investment. While sympathetic to his argument, this article highlights a number of problems. By examining the role of patents in CRISPR and in two previous foundational technologies, we make some recommendations for realistic and workable guidelines for patenting and licensing. (shrink)

Many of the arguments against reductionism and fundamental theory as a method for explaining physical phenomena focus on the role of models as the appropriate vehicle for this task. While models can certainly provide us with a good deal of explanatory detail, problems arise when attempting to derive exact results from approximations. In addition, models typically fail to explain much of the stability and universality associated with critical point phenomena and phase transitions, phenomena sometimes referred to as "emergent." The paper (...) examines the connection between theoretical principles like spontaneous symmetry breaking and emergent phenomena and argues that new ways of thinking about emergence and fundamentalism are required in order to account for the behavior of many phenomena in condensed matter and other areas of physics. (shrink)

Agent-causal libertarians maintain we are irreducible agents who, by acting, settle matters that aren’t already settled. This implies that the neural matters underlying the exercise of our agency don’t conform to deterministic laws, but it does not appear to exclude the possibility that they conform to statistical laws. However, Pereboom (Noûs 29:21–45, 1995; Living without free will, Cambridge University Press, Cambridge, 2001; in: Nadelhoffer (ed) The future of punishment, Oxford University Press, New York, 2013) has argued that, if these neural (...) matters conform to either statistical or deterministic physical laws, the complete conformity of an irreducible agent’s settling of matters with what should be expected given the applicable laws would involve coincidences too wild to be credible. Here, I show that Pereboom’s argument depends on the assumption that, at times, the antecedent probability certain behavior will occur applies in each of a number of occasions, and is incapable of changing as a result of what one does from one occasion to the next. There is, however, no evidence this assumption is true. The upshot is the wild coincidence objection is an empirical objection lacking empirical support. Thus, it isn’t a compelling argument against agent-causal libertarianism. (shrink)

Event-causal libertarians maintain that an agent’s settling of whether certain states-of-affairs obtain on a particular occasion can be reduced to the causing of events (e.g., bodily motions, coming to a resolution) by certain mental events or states, such as certain desires, beliefs and/or intentions. Agent-causal libertarians disagree. A common critique against event-causal libertarian accounts is that the agent’s role of settling matters is left unfilled and the agent “disappears” from such accounts—a problem known as the disappearing agent problem. Recently, Franklin (...) (Philos Stud 170:413–432, 2014) has argued that an “enriched” event-causal account can overcome this problem. Franklin, however, doesn’t consider whether, as Pereboom (J Philos 99:499–531, 2015) argues, the agent as decider of “torn decisions” disappears from even enriched accounts. As I show here, Franklin’s enriched account takes some modifying if it is to overcome Pereboom’s torn decision problem—a special case of the disappearing agent problem. However, as I also show, there is a more fundamental problem facing event-causal libertarian accounts. It is implausible that an agent qua event or state simultaneously settles whether and how she intervenes. The upshot is that events and/or states lack an ability essential to completely fulfilling an agent’s role qua settler. This isn’t a problem for agent-causal accounts like the one offered by Steward (A metaphysics for freedom. Oxford University Press, Oxford, 2012) because in as much as an agent qua substance settles whether her body moves in certain ways on certain occasions she simultaneously settles whether and how she intervenes. As a consequence, event-causal libertarians face a dilemma, or rather several, that agent-causal libertarians do not. This may ultimately be explained by the irreducibility of causation by agents to causation by events. (shrink)

Libet-style experiments and volitions -- The need for an analysis of human agency -- An Aristotelian account of human agency -- Compatibilist concerns -- Choices and voluntary conduct -- Neuronal mechanisms and voluntary conduct -- A metaphysical framework : voluntary agency, emergence and downward causation.

These 14 essays bring Schelling in tune with such luminaries as Heidegger, Derrida, Bataille, Foucault, Deleuze, Levinas, and Irigaray and situate him squarely in the centre of current themes.

The chromodomain is a highly conserved sequence motif that has been identified in a variety of animal and plant species. In mammals, chromodomain proteins appear to be either structural components of large macromolecular chromatin complexes or proteins involved in remodelling chromatin structure. Recent work has suggested that apart from a role in regulating gene activity, chromodomain proteins may also play roles in genome organisation. This article reviews progress made in characterising mammalian chromodomain proteins and emphasises their emerging role in the (...) regulation of gene expression and genome organisation. BioEssays 22:124–137, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

Unlike Martin‐Löf randomness and Schnorr randomness, computable randomness has not been defined, except for a few ad hoc cases, outside of Cantor space. This paper offers such a definition (actually, several equivalent definitions), and further, provides a general method for abstracting “bit‐wise” definitions of randomness from Cantor space to arbitrary computable probability spaces. This same method is also applied to give machine characterizations of computable and Schnorr randomness for computable probability spaces, extending the previously known results. The paper contains a (...) new type of randomness—endomorphism randomness—which the author hopes will shed light on the open question of whether Kolmogorov‐Loveland randomness is equivalent to Martin‐Löf randomness. The last section contains ideas for future research. (shrink)

Education for Sustainable Development is a broad and varied field of study replete with compelling advocacies for a more humane world. Across a majority of its instances however, ESD might yet be seen to labour in stealth fidelity to a mode of political economy and model of human-nature relations complicit with planetary ecocide. This essay draws largely from the thinking of Jean Baudrillard in an effort to identify the implications of ESD’s mainstay commitments, particularly as expressed in the field’s lingering (...) fidelities to anthropocentric production and modes of protagonistic optimism. Such alliances are contrasted by the immanence of inhuman planetary difference as it might habilitate more eco-centric approaches and attitudes for thinking the very possibility of sustainable development in the present era of rapid ecological transformation. (shrink)

In this paper I explore some connections between two anti-essentialist approaches to democratic theory — Ernesto Laclau and Chantal Mouffe's hegemonic approach and Slavoj Zizek's psychoanalytic approach. I argue that a central virtue of Laclau and Mouffe's hegemonic approach to democracy is that it clearly emphasizes the ethos of democracy, not simply the institutions of democracy. This shift transforms democracy, now conceived as radical democratic ethos, into a site of further research about how to make our understanding of its conditions (...) more theoretically nuanced. In the main bulk of the paper, I explore how Slavoj Zizek's notion of an authentic political act seeks to develop this understanding. (shrink)

The morality of human beings, defined here as our ability to determine whether our actions are right or wrong, depends not just on following rules but also on understanding the impact of our actions on another person. How we understand the impact of our actions on another person depends on our state of consciousness, which is mediated by our brain and nervous system. We describe how we understand our morality to flow naturally from the biological state we are living in (...) and how we see our biology and our morality as mutually interactive. A change in one changes the other. Another way of saying this is that changing either our morality or our biology changes both—changes who we are and what we do. (shrink)

Mutations within the Steel and Dominant Spotting loci of mice have led to the recent identification of a growth factor/receptor system required for the normal development of germ cells, pigment cells and hematopoietic cells. Interactions between the products of these genes, Steel factor and c‐Kit respectively, have now been demonstrated to influence various developmental processes, including survival, proliferation, and/or differentiation of cells in a tissue specific manner. In addition, our current understanding of the molecular basis of various Steel and Dominant (...) Spotting alleles coupled with the emerging information on the expression pattern of steel factor and c‐kit transcripts during development, is now beginning to explain the pleiotropic affects of these mutations. (shrink)

This article examines the thought of two prominent political theorists: John Rawls and Jürgen Habermas. Both Rawls and Habermas take deliberation to be central to the theory of justice. In their view, deliberation provides a necessary alternative to paternalistic models of power and authority. The deliberative turn has been celebrated as one of the great frontiers of political theory. But what are its limitations? What are its blind spots? This article argues that the deliberative turn has reinforced the anthropocentrism of (...) modern political theory by categorically excluding the moral claims of animals from the sphere of justice. The article then proposes an evolutionary conception of justice as a way out of our anthropocentric social imaginary. (shrink)