Phototoxicity frequently occurs during live fluorescence microscopy, and its consequences are often underestimated. Damage to cellular macromolecules upon excitation light illumination can impair sample physiology, and even lead to sample death. In this review, we explain how phototoxicity influences live samples, and we highlight that, besides the obvious effects of phototoxicity, there are often subtler consequences of illumination that are imperceptible when only the morphology of samples is examined. Such less apparent manifestations of phototoxicity are equally problematic, and can change (...) the conclusions drawn from an experiment. Thus, limiting phototoxicity is a prerequisite for obtaining reproducible quantitative data on biological processes. We present strategies to reduce phototoxicity, e.g. limiting the illumination to the focal plane and suggest controls for phototoxicity effects. Overall, we argue that phototoxicity needs increased attention from researchers when designing experiments, and when evaluating research findings. (shrink)

The paper presents an argument against a "metaphysical'* conception of logic according to which logic spells out a specific kind of mathematical structure that is somehow inherently related to our factual reasoning. In contrast, it is argued that it is always an empirical question as to whether a given mathematical structure really does captures a principle of reasoning. lMore generally, it is argued that it is not meaningful to replace an empirical investigation of a thing by an investigation of its (...) a priori analyzable structure without paying due attention to the question of whether it really is the structure of the thing in question.) It is proposed to elucidate the situation by distinguishing two essentially different realms with which our reason must deal: "the realm of the natural'*, constituted by the things of our empirical world, and "the realm of the formal'*, constituted by the structures that we use as "prisms'* to view, to make sense of, and to reconstruct the world. It is suggested that this vantage point may throw light on many foundational problems of logic. (shrink)

Doing Worlds with Words throws light on the problem of meaning as the meeting point of linguistics, logic and philosophy, and critically assesses the possibilities and limitations of elucidating the nature of meaning by means of formal logic, model theory and model-theoretical semantics. The main thrust of the book is to show that it is misguided to understand model theory metaphysically and so to try to base formal semantics on something like formal metaphysics; rather, the book states that model theory (...) and similar tools of the analysis of language should be understood as capturing the semantically relevant, especially inferential, structure of language. From this vantage point, the reader gains a new light on many of the traditional concepts and problems of logic and philosophy of language, such as meaning, reference, truth and the nature of formal logic. (shrink)

This book addresses the hasty development of modern logic, especially its introducing and embracing various kinds of artificial languages and moving from the study of natural languages to that of artificial ones. This shift seemed extremely helpful and managed to elevate logic to a new level of rigor and clarity. However, the change that logic underwent in this way was in no way insignificant, and it is also far from an insignificant matter to determine to what extent the "new logic" (...) only engaged new and more powerful instruments to answer the questions posed by the "old" one, and to what extent it replaced these questions with new ones. Hence, this movement has generated brand new kinds of philosophical problems that have still not been dealt with systematically. Philosophy of Logical Systems addresses these new kinds of philosophical problems that are intertwined with the development of modern logic. Jaroslav Peregrin analyzes the rationale behind the introduction of the artificial languages of logic; classifies the various tools which were adopted to build such languages; gives an overview of the various kinds of languages introduced in the course of modern logic and the motifs of their employment; discusses what can actually be achieved by relocating the problems of logic from natural language into them; and reaches certain conclusions with respect to the possibilities and limitations of this "formal turn" of logic. This book is both an important scholarly contribution to the philosophy of logic and a systematic survey of the standard logical systems that were established during the short history of modern logic. (shrink)

Variations on the argument “Inferences are moves from meaningful statements to meaningful statements; hence the meanings cannot be inferential roles” are often used as knock-down argument against inferentialism. In this short paper I indicate that the argument is simply a non sequitur.

Recent decades are marked by the upswing of the use of the term “normativity“ not only in philosophical discussions, but increasingly also within reports of empirical scientists. This may invoke the question how far these developments overlap and in how far they go past each other. A significant overlap might lead to an interesting coalescence of the two approaches to norms, which may provide for a ”naturalization” of some philosophical speculations about normativity, putting them on a firmer foundation, while offering (...) the empirical scientists some new impulses for directing their research. In this paper I give an overview of some recent empirical results concerning human normativity and I point out a certain philosophical tradition, rooted especially in the works of Wittgenstein, Sellars and Brandom, which treats normativity so that it becomes more or less compatible with these results. (shrink)

We investigate several ideal versions of the pseudointersection number \(\mathfrak {p}\), ideal slalom numbers, and associated topological spaces with the focus on selection principles. However, it turns out that well-known pseudointersection invariant \(\mathtt {cov}^*({\mathcal I})\) has a crucial influence on the studied notions. For an invariant \(\mathfrak {p}_\mathrm {K}({\mathcal J})\) introduced by Borodulin-Nadzieja and Farkas (Arch. Math. Logic 51:187–202, 2012), and an invariant \(\mathfrak {p}_\mathrm {K}({\mathcal I},{\mathcal J})\) introduced by Repický (Real Anal. Exchange 46:367–394, 2021), we have $$\begin{aligned} \min \{\mathfrak (...) {p}_\mathrm {K}({\mathcal I}),\mathtt {cov}^*({\mathcal I})\}=\mathfrak {p},\qquad \min \{\mathfrak {p}_\mathrm {K}({\mathcal I},{\mathcal J}),\mathtt {cov}^*({\mathcal J})\}\le \mathtt {cov}^*({\mathcal I}), \end{aligned}$$ respectively. In addition to the first inequality, for a slalom invariant \(\mathfrak {sl_e}({\mathcal I},{\mathcal J})\) introduced in Šupina (J. Math. Anal. Appl. 434:477–491, 2016), we show that $$\begin{aligned} \min \{\mathfrak {p}_\mathrm {K}({\mathcal I}),\mathfrak {sl_e}({\mathcal I},{\mathcal J}),\mathtt {cov}^*({\mathcal J})\}=\mathfrak {p}. \end{aligned}$$ Finally, we obtain a consistency that ideal versions of the Fréchet–Urysohn property and the strictly Fréchet–Urysohn property are distinguished. (shrink)

Business ethics represents an important aspect that influences each country’s socio-economic system, and is important to society, environment, and economy. The present article aims to define significant attributes of business ethics in the sector of small and medium-sized enterprises (SMEs) and compares their attitudes within the three most significant business sectors in the Visegrad Group countries (V4 countries: Czech Republic, Slovak Republic, Poland, and Hungary). An empirical study, focusing on the attitudes of small and medium-sized firms, was conducted in June (...) 2022 in Visegrad Group countries through the reputable hired company MNFORCE, using the Computer Assisted Web Interviewing research method. The total number of respondents in the Visegrad Group countries was 1,398. Statistical hypotheses were tested using descriptive statistics, chi-square, and Z-score at a significance level of α = 5%. The most important conclusion of this research is that there are no significant differences in the approach of SMEs to business ethics based on the sector in which the companies operate. Some notable differences in attitudes among SMEs in Slovakia and the Czech Republic were identified, but these were marginal. Therefore, differences in the transformation process within selected economic sectors do not impact the formation of attitudes of small and medium-sized companies in business ethics. It is evident that business ethics is significantly determined primarily by the personal characteristics of the owner/manager of the company, and the specificities of individual sectors do not influence this field. (shrink)

Growth modelling is of interest to scientists in various disciplines. In our article, we will collect 17 models designed for growth modelling, appraise these models and contribute to the discussion of their applicability. The merit of the paper lies in studying the convergence properties of nonlinear regression in selected models. Our studies will be performed mainly concerning the quality of the obtained estimates, which are closely related to the intrinsic curvature of the model according to Bates and Watts. This curvature (...) determines the size of the linearization domains. Only if the initial solution is in this domain, then the convergence of the estimate in nonlinear regression is guaranteed. The primary goal is to design a methodology for selecting a growth model. We will demonstrate fruitfulness of our methodology on the weight measurements of 10 calves under 25 months of age from cowsheds in the village Záluží in the Czech Republic. Estimated parameters of growth curves, sizes of linearization domain, calculated residues and coefficients of determination indices will be the subject of discussion. (shrink)

Tomáš Marvan Otázka významu: Cesty analytické filosofie jazyka. 1. vyd. Praha: Togga, 2010, ISBN 978-80-87258-33-0, 150 stran.

This book offers a comprehensive account of logic that addresses fundamental issues concerning the nature and foundations of the discipline. The authors claim that these foundations can not only be established without the need for strong metaphysical assumptions, but also without hypostasizing logical forms as specific entities. They present a systematic argument that the primary subject matter of logic is our linguistic interaction rather than our private reasoning and it is thus misleading to see logic as revealing "the laws of (...) thought". In this sense, fundamental logical laws are implicit to our "language games" and are thus more similar to social norms than to the laws of nature. Peregrin and Svoboda also show that logical theories, despite the fact that they rely on rules implicit to our actual linguistic practice, firm up these rules and make them explicit. By carefully scrutinizing the project of logical analysis, the authors demonstrate that logical rules can be best seen as products of the so called reflective equilibrium. They suggest that we can profit from viewing languages as "inferential landscapes" and logicians as "geographers" who map them and try to pave safe routes through them. This book is an essential resource for scholars and researchers engaged with the foundations of logical theories and the philosophy of language. (shrink)

The heyday of discussions initiated by Searle's claim that computers have syntax, but no semantics has now past, yet philosophers and scientists still tend to frame their views on artificial intelligence in terms of syntax and semantics. In this paper I do not intend to take part in these discussions; my aim is more fundamental, viz. to ask what claims about syntax and semantics in this context can mean in the first place. And I argue that their sense is so (...) unclear that that their ability to act as markers within any disputes on artificial intelligence is severely compromised; and hence that their employment brings us nothing more than an illusion of explanation. (shrink)

Brandom’s inferentialism explains meaning in terms of inferential rules. As he insists that “the normative” is not reducible to “the natural,” inferentialism would seem an unlikely ally of naturalism. However, in this paper I suggest that Brandom’s theory of language harbors insights which can promote a naturalistic theory of meaning and language, and that a naturalistic version of Brandom’s inferentialism might have great potential. Also I sketch the lines along which such a theory could be built.

Logic is usually presented as a tool of rational inquiry; however, many logicians in fact treat logic so that it does not serve us, but rather governs us – as rational beings we are subordinated to the logical laws we aspire to disclose. We denote the view that logic primarily serves us as logica serviens, while denoting the thesis that it primarily governs our reasoning as logica dominans. We argue that treating logic as logica dominans is misguided, for it leads (...) to the idea of a “genuine” logic within a “genuine” language. Instead of this, we offer a naturalistic picture, according to which the only languages that exist are the natural languages and the artificial languages logicians have built. There is, we argue, no language beyond these, especially none that would be a wholesome vehicle of reasoning like the natural languages and yet be transparently rigorous like the artificial ones. Logic is a matter of using the artificial languages as idealized models of the natural ones, whereby we pinpoint the laws of logic by means of zooming in on a reflective equilibrium. (shrink)

There may be various reasons for claiming that meaning is normative, and additionally, very different senses attached to the claim. However, all such claims have faced fierce resistance from those philosophers who insist that meaning is not normative in any nontrivial sense of the word. In this paper I sketch one particular approach to meaning claiming its normativity and defend it against the anti-normativist critique: namely the approach of Brandomian inferentialism. However, my defense is not restricted to inferentialism in any (...) narrow sense for it encompasses a much broader spectrum of approaches to meaning, connected with the Wittgensteinian and especially Sellarsian view of language as an essentially rule-governed enterprise; and indeed I refrain from claiming that the version of inferentialism I present here is in every detail the version developed by Brandom. (shrink)

Following an historical survey of ethical perspectives, the author focuses on an emerging "market ethics" dictating economic, cultural and legal principles and practices. He is especially concerned with the subsequent loss of human and social capital, and suggests the need for reviving those vital ethical considerations, especially during this time of transition for The Czech Republic and other Eastern European nations.

In this study two strands of inferentialism are brought together: the philosophical doctrine of Brandom, according to which meanings are generally inferential roles, and the logical doctrine prioritizing proof-theory over model theory and approaching meaning in logical, especially proof-theoretical terms.

Ve své polemice s mou recenzí jeho knihy Tomáš Marvan argumentuje, že debatu mezi realismem a relativismem (či konstruktivismem) lze rozřešit, a to prostřednictvím důkazů ve prospěch realismu. V tomto příspěvku vysvětluji, že podle mne realismus nemůže být prokázán, protože to není teze, kterou by bylo možné dokazovat, ale spíše něco jako kantovská „regulativní idea“. In his polemic reply to my review of his book Tomáš Marvan argues that the debate between realism and relativism (or constructivism) can be resolved, especially (...) by means of evidence in favor of realism. In this contribution I explain that according to me realism cannot be demonstrated, because it is not a thesis that could be supported by evidence, but rather something as a Kantian "regulative idea". (shrink)

Odborná práce z oboru hudební teorie. Navazuje na knihu téhož autora "Teoretické základy harmonie s hľadiska vedeckej filozofie", jež vyšla r. 1954. Soustřeďuje pozornost k oněm názorům a teoriím, které jsou z hlediska filosofického ovlivněny idealistickým postojem. V první části sleduje a hodnotí vlivy idealismu na nauku o harmonii v 19. a 20. století, v druhé se obírá předpoklady dialektického materialismu v hudební teorii.

A review of deVries' and O'Shea's books, both titled "Wilfrid Sellars". By Jaroslav Peregrin.

I propose that logic may be seen as a science of patterns—however, not in the sense in which mathematics is a science of patterns, but rather in the sense in which physics is. The proposal is that logic identifies, explores, and fixes the inferential patterns which de facto govern our argumentative practices. It can be seen, I argue, as picking up the patterns and working from them toward the state of reflective equilibrium, where the laws it aims at are explicitly (...) articulated. Due to the normativity of logic, this process is not quite the same as that in which a natural science works its way from data to its laws; however, there is no reason why it should be seen as proceeding via a mysterious "a priori analysis.” Instead, it should proceed in the intersubjective space in which the sciences are practiced. (shrink)

In this paper I put forward a thesis regarding the anatomy of “cultural evolution”, in particular the way the “cultural” transmission of behavioral patterns came to piggyback, through us humans, on the transmission effected by genetic evolution. I claim that what grounds and supports this new kind of transmission is a complex behavioral “meta-pattern” that makes it possible to grasp a pattern as something that “ought to be”, i.e. that transforms the pattern into what we can call a rule. (Here (...) I draw especially on the philosophical insights of Wilfrid Sellars.) In this way I interlink empirical research done in evolution theory with some more speculative philosophical theories, thus shedding new light on the former and adding an empirical footing to the latter. (shrink)

V knize konfrontuji běžné pojetí jazyka, podle kterého je význam záležitostí vztahu slovo-věc, se strukturalistickým pohledem, podle kterého význam nemůže existovat bez toho, aby byly výrazy určitým způsobem provázány mezi sebou. Ukazuji, že takový strukturalismus není jen věcí Ferdinanda de Saussura, ale že se vyskytuje (pod jménem holismus) i v základech (post)analytické filosofie Quina, Davidsona, Sellarse a Brandoma. Ukazuji také, že není neslučitelný s formálně-logickým přístupem k významu, jaký byl rozpracován Carnapem, Montaguem a dalšími.

Někteří filosofové napřeli své úsilí do sektoru služeb.

The perennial question – What is meaning? – receives many answers. In this paper I present and discuss inferentialism – a recent approach to semantics based on the thesis that to have ( such and such ) a meaning is to be governed by ( such and such ) a cluster of inferential rules . I point out that this thesis presupposes that looking for meaning requires seeing language as a social institution (rather than, say, a psychological reality). I also (...) indicate that this approach may be seen as a new embodiment of the old ideas of structuralism. (shrink)

In a remarkable early paper, Wilfrid Sellars warned us that if we cease to recognize rules, we may well find ourselves walking on four feet; and it is obvious that within human communities, the phenomenon of rules is ubiquitous. Yet from the viewpoint of the sciences, rules cannot be easily accounted for. Sellars himself, during his later years, managed to put a lot of flesh on the normative bones from which he assembled the remarkable skeleton of the early paper; and (...) his followers too. However, what they say is somewhat divergent; and therefore my aim in this paper is to concentrate on the very concept of rule and analyse it in the context of the question what it is about us humans that makes us special. (shrink)

The followers of Wilfrid Sellars are often divided into “right” and “left” Sellarsians, according to whether they believe, in Mark Lance's words, that “linguistic roles constitutive of meaning and captured by dot quoted words are ‘normative all the way down.’” The present article anatomizes this division and argues that it is not easy to give it a nontrivial sense. In particular, the article argues that it is not really possible to construe it as a controversy related to ontology, and goes (...) on to argue that it is also not easy to construe it as one concerning the translatability of the normative idiom into the non-normative one. The conclusion is that the only coherent interpretation of this disagreement is as a disagreement about the possibility and desirability of assuming a standpoint “inside” our linguistic practices. (shrink)

The article addresses two closely related questions: What are the criteria of adequacy of logical formalization of natural language arguments, and what gives logic the authority to decide which arguments are good and which are bad? Our point of departure is the criticism of the conception of logical formalization put forth, in a recent paper, by M. Baumgartner and T. Lampert. We argue that their account of formalization as a kind of semantic analysis brings about more problems than it solves. (...) We also argue that the criteria of adequate formalization need not be based on truth conditions associated with logical formulas; in our view, they are better based on structural (inferential) grounds. We then put forward our own version of the criteria. The upshot of the discussion that follows is that the quest for an adequate formalization in a suitable logical language is best conceived of as the search for a Goodmanian reflective equilibrium. (shrink)

Tarskian model theory is almost universally understood as a formal counterpart of the preformal notion of semantics, of the “linkage between words and things”. The wide-spread opinion is that to account for the semantics of natural language is to furnish its settheoretic interpretation in a suitable model structure; as exemplified by Montague 1974.

Cieľom článku je nanovo reflektovať činnosť jednej z najslávnejších ženských filozofiek, Hip­parchie z Maróneie. Naším zámerom je ukázať, prečo sa stala v porovnaní s inými ženami antiky taká významná a v mnohom signifikantná pre ďalší vývoj procesu ženskej eman­cipácie. Hlavným svedectvom je pre nás fragment SSR V I 1 od Diogena Laertského, ktorý kladieme do súvislosti s ďalšími antickými správami o Antisthenovi a raných kynikoch. Dve hlavné témy Diogenovho svedectva sú Kratétova svadba s Hipparchiou a spor Hipparchie s Theodórom. Vo (...) výklade poukazujeme na momenty, v ktorých je filozofická osobnosť Hip­parchie nadčasová a inšpiratívna aj pre súčasnosť. (shrink)

There has been much controversy over the completeness and unity of Euripides᾽Heraclidaein the last two centuries. Hermann᾽s characterization of the play as a heavily mutilated piece, which was adopted by Kirchhoff, Wilamowitz, Nauck and Murray, prevailed for a long time. Wilamowitz's thesis that theHeraclidaewas revised by the ancient director found its adherents. It was Günther Zuntz who led the general offensive against this widely accepted opinion and whose critical scrutiny reversed the view of the play. According to Zuntz, the play (...) has come down to us substantially as it was written. The alleged mutilation, as well as the specific dramatic technique, shortness and swiftness of theHeraclidae, also influenced the general evaluation of the play as a minor or odd piece. It was Günter Zuntz again and also Franz Stoessl who reconstituted the reputation of theHeraclidae. Today Euripides᾽Heraclidaeis studied and recognized as a classicalHikesiedrama, a play deeply rooted in Athenian ideology and in the social and religious context of fifth-century Athens, and representing various aspects of communal life. Since the play has been interpreted and scrutinized from a very wide range of perspectives, I do not aim at a radically new general interpretation of theHeraclidae, but I would like to make a short remark on an aspect of it which has, as far as I know, been neglected or only briefly referred to: the term ἀμηχανία in crucial passages of the play, which signifies, or rather describes, a situation which is desperate, hopeless, and with no way out. I would like to show that for the characters in theHeraclidaewho follow the ideal of justice, in contrast to those who prefer profit, no situation is hopeless, even as it was not for Heracles, who managed to do things which could be evaluated as impossible. On the other hand, those who opt for the Heraclean ideal have to prepare to face the ultimate challenges. (shrink)