Since the turn of the millennium, the major development agencies have been promoting “knowledge for development,” “ICT for development,” or the “knowledge economy” as new paradigms to prompt development in less-developed countries. These paradigms display an unconditional trust in the power of Western technology and scientific knowledge to trigger development—they taste of epistemic and technological determinism. This article probes, by means of a genealogy, how and when development cooperation began adhering to epistemic and technological determinism, and which forms this adhesion (...) has taken over time. The genealogy shows, first, that knowledge and technology have always been integrally part of the very “development” idea since this idea was shaped during enlightenment. Second, while the genealogy reveals that epistemic and technological determinism were embedded in the development idea from the very beginning, it also illustrates that the determinism has always been challenged by critical voices. (shrink)

Research from the social and behavioral sciences shows that the drivers and impacts of climate change, as well as society’s responsiveness to it, are all profoundly governed by social and behavioral dynamics. Nevertheless, scientometric and research funding data from the United States and the European Union suggest that the social and behavioral sciences are noticeably underrepresented in mainstream climate research. We argue that a better understanding of social and behavioral dynamics, especially those that temper society’s response to the scientific evidence, (...) is fundamental for climate policies to be successfully adopted. (shrink)

Mathematical models are an important tool in the development ofsoftware technology, including programming languages and algorithms.During the last few years, a new class of such models has beendeveloped based on the notion of a mathematical game that isespecially well-suited to address the interactions between thecomponents of a system. This paper gives an introduction to thesegame-semantical models of programming languages, concentrating onmotivating the basic intuitions and putting them into context.

Cancers often express hundreds of genes otherwise specific to germ cells, the germline/cancer (GC) genes. Here, we present and discuss the hypothesis that activation of a “germline program” promotes cancer cell malignancy. We do so by proposing four hallmark processes of the germline: meiosis, epigenetic plasticity, migration, and metabolic plasticity. Together, these hallmarks enable replicative immortality of germ cells as well as cancer cells. Especially meiotic genes are frequently expressed in cancer, implying that genes unique to meiosis may play a (...) role in oncogenesis. Because GC genes are not expressed in healthy somatic tissues, they form an appealing source of specific treatment targets with limited side effects besides infertility. Although it is still unclear why germ cell specific genes are so abundantly expressed in cancer, from our hypothesis it follows that the germline's reproductive program is intrinsic to cancer development. (shrink)

After 1945, Czech philosophy and culture were first introduced to existentialism. First it was the original works of French existentialists (Sartre, Camus, Marcel), later by means of the journal Letters (1947) and Václav Černý (The first book on existentialism, 1948). The acceptance of existentialism in Czech context was not univocal. Besides factual analyses (J. Patočka, V. Navrátil, V. T. Miškovská), existentialism met with criticism and rejection mainly from Marxists and Catholic scholars for its rational weakness, pessimism, helplessness and intellectual decline.

Werner Hamacher, one of the most important and original theorists working in literary criticism and continental philosophy, explores topics at the intersection of philosophy, literary studies and politics.

Since rules - legal, ethical or otherwise - cannot determine their own application, they require persons of flesh and blood to interpret and apply them in concrete cases. Presidents and prime ministers, judges, prosecutors, mediators, leaders of international organizations, and even religious leaders and public intellectuals make decisions on how best to understand rules and how best to apply them. It stands to reason that their character traits influence the sort of decisions they take. This book provides the first systematic (...) framework for discussing global governance in terms of the virtues, and illustrates it with a number of detailed examples of concrete decision-making in specific situations. Virtue in Global Governance combines insights from law, ethics, and global governance studies in developing a unique approach to global governance and international law. (shrink)