In his new book on Pascal's Wager, Jeff Jordan argues that only the ‘Jamesian’ version of the wager argument, as he sees it presented in William James' essay The Will to Believe , constitutes a sound pragmatic argument in favour of theism, whereas Pascal's original wager argument is doomed to fail on various grounds. This article argues that Jordan's theory is untenable. The many-gods objection is used as an example: it is demonstrated that the Jamesian (...) Wager argument too is powerless to rebut this objection. (shrink)

Pascal's wager is an argument in support of religious belief taking its name from the seventeenth century polymath Blaise Pascal. Unlike more traditional arguments for the existence of God, Pascal's wager is a pragmatic argument, concluding not that God exists but that one should wager for God; that is, one should live as if God exists. After an introduction to the elements of decision theory needed to understand the wager, I discuss the interpretation of Pascal's reasoning (...) in the Infini rien fragment of the Pensees, in which he presents several versions of a wager-style argument. Recent discussions of the role of the wager within Pascal's overall project of Christian apologetics are also examined. I then review contemporary formulations of, attacks on, and objections to Pascal's wager. Recent authors have pressed moral objections, epistemological objections, objections relating to infinite utilities, the many Gods objection, and objections to the expectation rule, among others. After an examination of this literature, I conclude with a brief discussion of noncanonical versions of the wager, including Jeff Jordan's Jamesian wager. (shrink)

Pragmatic arguments seek to justify the performance of an action by appealing to the benefits that may follow from that action. Pascal’s wager, for instance, argues that one should inculcate belief in God because there is everything to gain and little to lose by doing do. In this chapter I critically examine Pascal’s wager and William James’s famous “Will-to-Believe” argument by first explaining the logic of each argument and then by surveying the objections commonly arrayed against them. Finally, (...) I suggest that among the various versions of the wager found in Pascal’s Pensées is a neglected version that anticipates the Jamesian argument and that avoids the many-gods objection. (shrink)

This article explores “pragmatic arguments” for theistic belief – that is, arguments for believing in God that appeal, not to evidence in favor of God’s existence, but rather to alleged practical benefits that come from belief in God. Central to this exploration is a consideration of Jeff Jordan’s recent defense of “the Jamesian wager,” which portrays itself as building on the case for belief presented in William James’s essay “The Will to Believe.” According to Jordan, religious belief creates (...) significant gains in this‐worldly happiness , and provided the individual does not have decisive evidence against God’s existence, these gains give the individual sufficient reason to strive to believe in God. In its exploration of this argument, the article presents an overview of recent social scientific work on the this‐worldly effects of religious belief. It canvases several challenges to pragmatic arguments, namely, a challenge according to which happiness rooted in false belief is worth less than that rooted in truth, a perfectionistic challenge alleging that one should strive for personal excellence rather than happiness, and a challenge alleging that any happiness gains of religious belief are outweighed by the potential harms brought about by religious belief. (shrink)

Pragmatist responses to radical skepticism do not receive much attention in contemporary analytic epistemology. This observation is my motivation for undertaking a search for a coherent pragmatist reply to radical doubt, one that can compete, in terms of clarity and sophistication, with the currently most popular approaches, such as contextualism and relevant alternatives theory. As my point of departure I take the texts of C. S. Peirce and William James. The Jamesian response is seen to consist in the application (...) of a wager argument to the skeptical issue in analogy with Pascal's wager. The Peircean strategy, on the other hand, is to attempt a direct rejection of one of the skeptic's main premises: that we do not know we are not deceived. I argue that while the Jamesian attempt is ultimately incoherent, Peirce's argument contains the core of a detailed and characteristically "pragmatic" rebuttal of skepticism, one that deserves to be taken seriously in the contemporary debate. (shrink)

Preface ix Acknowledgements xi 1 Introduction: towards an acceptable fideism 1 The metaquestion: what is the issue about the ‘justifiability’ of religious belief? 4 Faith-beliefs 6 Overview of the argument 8 Glossary of special terms 18 2 The ‘justifiability’ of faith-beliefs: an ultimately moral issue 26 A standard view: the concern is for epistemic justifiability 26 The problem of doxastic control 28 The impossibility of believing at will 29 Indirect control over beliefs 30 ‘Holding true’ and ‘taking to be true’ (...) 33 A second—direct—locus of doxastic control 35 Moral doxastic responsibilities 41 The moral significance of faith-beliefs 47 Linking moral to epistemic justifiability: reinstating the standard view? 48 3 The epistemic justifiability of faith-beliefs: an ambiguity thesis 53 Plausibility of requiring epistemic for moral justifiability under a realist interpretation of faith-beliefs 53 Interpreting the link principle: epistemic entitlement as requiring evidential justification 55 Evidentialist requirements specified by an implicit evidential practice 65 Rational empiricist evidential practice 66 Applying rational empiricist evidential practice to theistic faith-beliefs: an ambiguity thesis 68 vi contents 4 Responses to evidential ambiguity: isolationist and Reformed epistemologies 77 Two strategies for defending the moral probity of theistic faith-belief in the face of evidential ambiguity 78 Appealing to a special theistic evidential practice/improved epistemologies 79 An isolationist epistemology 79 Reformed epistemology 86 Conclusion: the need for a fideist response to ambiguity 99 5 Faith as doxastic venture 101 Agenda for a defence of doxastic venture 102 The nature of theistic faith 103 The doxastic venture model 106 The psychological possibility of doxastic venture 111 A Jamesian account 112 ‘Passionally’ caused beliefs 113 6 Believing by faith: a Jamesian position 122 An initial hypothesis for a Jamesian thesis on permissible doxastic venture 123 The notion of a ‘genuine option’ 125 A ‘degrees of belief ’ challenge 128 Evidentially undecidable forced options 129 Permissible doxastic venture: supra- not counter-evidential 135 How theistic religion could present essentially evidentially undecidable genuine options: the notion of a highest-order framing principle 137 Restricting thesis ( Ji) to faith-propositions: thesis ( J) 145 7 Integrationist values: limiting permissible doxastic venture 151 Can counter-evidential fideism be non-arbitrarily excluded? 151 A coherence requirement and integrationist values 155 Moral integration of faith-commitments 163 Implications for reflective faith-believers 167 Coda: A reflection on Abraham as forebear in faith 170 contents vii 8 Arguments for supra-evidential fideism 174 The importance of defending the epistemic permissibility of faith-ventures 176 Strategies for supporting fideism 178 An ‘assimilation to personal relations cases’ strategy: experimental ventures in interpersonal trust 180 The ‘assimilation to personal relations cases’ strategy: cases where ‘faith in a fact can help create a fact’ 182 A consequentialist strategy 185 A note on Pascal’s Wager 187 The tu quoque strategy 189 Is hard-line evidentialism self-undermining? 190 Attitudes to passional doxastic inclinations 194 Epistemological externalism again: a presumption in favour of fideism? 196 Scepticism about passional doxastic inclinations as guides to truth: how passions may be schooled 197 The significance of scientific theories of passional motivations for faith-commitment 204 An impasse? 206 9 A moral preference for modest fideism? 208 Implications of accepting ( J+) for orthodox and revisionary theistic faith-ventures 209 The apparent fideist/evidentialist impasse and its implications 211 Beyond impasse? Direct moral evaluation of the fideist/evidentialist debate 215 Self-acceptance and authenticity 216 Hard-line evidentialism as grounded in doctrinaire naturalism 220 Coherence amongst moral and religious passional commitments 225 Conclusion 227 Bibliography 230 Index 237. (shrink)

_This is a personal account based on many years experience as a medical writer. It considers aspects of medical writing with particular focus on the intellectual and ethical dilemmas it can raise. What makes medical writing both so interesting and so challenging is the fact that it often takes place at the border between different disciplines. For example, it straddles both science and art. Ethical issues also arise at the boundaries between academia and commerce. Until recently there have been few (...) guidelines to help navigate such potentially dangerous territory. I have been privileged to be involved in developing two such guidelines and I describe how I hope the Good Publication Practice guidelines for pharmaceutical companies and the European Medical Writers Association guidelines may improve the practice of this fascinating profession, Medical Writing._. (shrink)

Gray argues that my three earlier counterexamples fail to refute representational theories of phenomenal character. I maintain that, despite Gray's arguments, each example does in fact work against the particular representational theory at which it is targeted. Further, I question whether my internalism regarding phenomenal character and Gray's externalism regarding modularity are in genuine conflict with one another.

Background Journal editors are responsible for what they publish and therefore have a duty to correct the record if published work is found to be unreliable. One method for such correction is retraction of an article. Anecdotal evidence suggested a lack of consistency in journal policies and practices regarding retraction. In order to develop guidelines, we reviewed retractions in Medline to discover how and why articles were retracted. Methods We retrieved all available Medline retractions from 2005 to 2008 and a (...) one-in-three random selection of those from 1988 to 2004. This yielded 312 retractions (from a total of 870). Details of the retraction including the reason for retraction were recorded by two investigators. Results Medline retractions have increased sharply since 1980 and currently represent 0.02% of included articles. Retractions were issued by authors (63%), editors (21%), journals (6%), publishers (2%) and institutions (1%). Reasons for retraction included honest error or non-replicable findings (40%), research misconduct (28%), redundant publication (17%) and unstated/unclear (5%). Some of the stated reasons might have been addressed by corrections. Conclusions Journals' retraction practices are not uniform. Some retractions fail to state the reason, and therefore fail to distinguish error from misconduct. We have used our findings to inform guidelines on retractions. (shrink)

Background: Breaches of publication ethics such as plagiarism, data fabrication and redundant publication are recognised as forms of research misconduct that can undermine the scientific literature. We surveyed journal editors to determine their views about a range of publication ethics issues. Methods: Questionnaire sent to 524 editors-in-chief of Wiley-Blackwell science journals asking about the severity and frequency of 16 ethical issues at their journals, their confidence in handling such issues, and their awareness and use of guidelines. Results: Responses were obtained (...) from 231 editors (44%), of whom 48% edited healthcare journals. The general level of concern about the 16 issues was low, with mean severity scores of <1 (on a scale of 0–3) for all but one. The issue of greatest concern (mean score 1.19) was redundant publication. Most editors felt confident in handling the issues, with <15% feeling “not at all confident” for all but one of the issues (gift authorship, 22% not confident). Most editors believed such problems occurred less than once a year and >20% of the editors stated that 12 of the 16 items never occurred at their journal. However, 13%–47% did not know the frequency of the problems. Awareness and use of guidelines was generally low. Most editors were unaware of all except other journals’ instructions. Conclusions: Most editors of science journals seem not very concerned about publication ethics and believe that misconduct occurs only rarely in their journals. Many editors are unfamiliar with available guidelines but would welcome more guidance or training. (shrink)

This collection of papers centres around a novel approach to the problem of phenomenal consciousness called cosmopsychism. A simple version of cosmopsychism says that the cosmos as a whole is conscious. In this collection, I focus on a comparison between arguably the most promising versions of cosmopsychism and panpsychism, called constitutive cosmopsychism and constitutive panpsychism, respectively. -/- The first paper, ‘A Blueprint for Cosmopsychism’ offers a blueprint for a cosmopsychist approach, comparing it to the panpsychist approach. It highlights how following (...) the blueprint allows one to sidestep the most serious of panpsychism’s problems, the combination problem, while also avoiding the problem of infinite decomposition. However, it notes that the approach must address a serious problem of its own in the derivation problem. -/- The second paper, ‘Beyond Panpsychism and Cosmopsychism? Focuses’ on two related views that reject subjects of experience at the fundamental level, thus avoiding the subject aspects of the combination and derivation problems. Albahari’s perennialism is touted as the natural successor to cosmopsychism; avoiding its subject derivation problem while maintaining a cosmic consciousness. Meanwhile, Coleman’s panqualityism is touted as a natural successor to panpsychism; avoiding its combination problem while maintaining that phenomenality is present at the level of microphysical ultimates. However, I show both views seem to face problems equal in measure to those they seek to avoid. -/- The third paper, ‘The Subject Problem for Panpsychism and Cosmopsychism’ targets the hardest problems for constitutive panpsychism and constitutive cosmopsychism; the subject combination problem and the subject derivation problem, respectively. I show that the two problems are almost identical, both hinging on the entailment of what I call synchronous perspectives scenarios. I formulate broad arguments from metaphysical impossibility and epistemic implausibility against both views, based on such scenarios. However, I provide a possible model of how to understand synchronous perspective scenarios unproblematically. I also provide several alternative responses. -/- The fourth, and final, paper in the collection provides an account of, and motivation for, a version of cosmopsychism I call CRP cosmopsychism. This version of cosmopsychism is created on the priority cosmopsychism blueprint and has three further key commitments: simple panpsychism, priority monism and Russellian monism. The paper motivates each of these commitments both in isolation and in partnership, before responding to each of the derivation problems; the subject derivation problem, the quality derivation problem and the structure derivation problem. Furthermore, I argue that cosmopsychism should be preferred over panpsychism owing to considerations concerning internal relations. (shrink)

This editorial explains why we are launching Research Integrity and Peer Review, a new open-access journal that will provide a home to research on ethics, reporting, and evaluation of research. We discuss how the idea to launch this journal came about and identify the gaps in knowledge where we would like to encourage more research and interdisciplinary discussion. We are particularly keen to receive submissions presenting actual research that will increase our understanding and suggest potential solutions to issues related to (...) peer review, study reporting, and research and publication ethics. (shrink)

This paper presents a pantheistic account of spiritual well-being drawn from the life and works of poet Robinson Jeffers. The account is based on a general conceptualisation of the spiritual life according to which it has three components: a conception of ultimate reality, a conception of the human condition (including a view of the actual position human beings find themselves in and a vision of their ideal position congruent with the view of ultimate reality), and a guide to the practical (...) structuring of a human life aimed at its transformation from its actual to its ideal position. Spiritual well-being, then, is conceived as the spiritual life that is going well for a person. A pantheistic account that includes each of the three components of the spiritual life is presented. Therefore, we arrive at a pantheistic account of spiritual well-being, and this undercuts common objections to pantheism. (shrink)

Representationism is the view that the phenomenal character of an experience supervenes on its representational content. Synaesthesia is a condition in which the phenomenal character of the experience produced in a subject by stimulation of one sensory modality contains elements characteristic of a second, unstimulated sensory modality. After reviewing some of the recent psychological literature on synaesthesia and one of the leading versions of representationism, I argue that cases of synaesthesia, as instances of what I call the extra qualia problem, (...) are counterexamples to externalist versions of representationism. (shrink)

Researchers have wondered how the brain creates emotions since the early days of psychological science. With a surge of studies in affective neuroscience in recent decades, scientists are poised to answer this question. In this target article, we present a meta-analytic summary of the neuroimaging literature on human emotion. We compare the locationist approach (i.e., the hypothesis that discrete emotion categories consistently and specifically correspond to distinct brain regions) with the psychological constructionist approach (i.e., the hypothesis that discrete emotion categories (...) are constructed of more general brain networks not specific to those categories) to better understand the brain basis of emotion. We review both locationist and psychological constructionist hypotheses of brain–emotion correspondence and report meta-analytic findings bearing on these hypotheses. Overall, we found little evidence that discrete emotion categories can be consistently and specifically localized to distinct brain regions. Instead, we found evidence that is consistent with a psychological constructionist approach to the mind: A set of interacting brain regions commonly involved in basic psychological operations of both an emotional and non-emotional nature are active during emotion experience and perception across a range of discrete emotion categories. (shrink)

Editors have a responsibility to retract seriously flawed articles from their journals. However, there appears to be little consistency in journals’ policies or procedures for this. In a qualitative study, we therefore interviewed editors of science journals using semi-structured interviews to investigate their experience of retracting articles. We identified potential barriers to retraction, difficulties in the process and also sources of support and encouragement. Our findings have been used as the basis for guidelines developed by the Committee on Publication Ethics.

In this paper, it is argued that those who claim that the dispositionalist theory of color has even a prima facie advantage over color physicalism in accommodating the similarity relations that seem to hold among the colors are mistaken. The appearance that dispositionalists can handle the relevant similarity claims stems from the unexamined assumption that the similarity of two dispositions is simply a matter of the similarity of the manifestations of those dispositions. A more careful treatment of the ways in (...) which two dispositions can be similar to, or different from, one another must consider both the bases and the manifestation conditions of those dispositions in addition to their manifestations. After examining cases of dispositions from outside the domain of colors, it is argued that attention to conditions of manifestation provides a particularly strong reason for rejecting the assumption that similarity of manifestations entails similarity of dispositions. Without this assumption, dispositionalists about color are shown to be in the same position as non-dispositionalists regarding similarity relations among the colors. This way of responding to color dispositionalism is compared with two other responses [offered by Byrne :641–665, 2003) and McLaughlin ], and shown to be a candidate to strengthen, rather than replace, either one. (shrink)

A contemporary form of panpsychism says that phenomenality is prevalent because all physical ultimates instantiate phenomenal or protophenomenal properties. According to priority cosmopsychism, an alternative to panpsychism that we propose in this chapter, phenomenality is prevalent because the whole cosmos instantiates phenomenal or protophenomenal properties. It says, moreover, that the consciousness of the cosmos is ontologically prior to the consciousness of ordinary individuals like us. Since priority cosmopsychism is a highly speculative view our aim in this chapter remains modest and (...) limited. Instead of providing a full defense of priority cosmopsychism, we try to show only the theoretical advantage of the view over panpsychism. Tis, however, by no means entails that we develop the view in logical space merely for its own sake. We offer instead a blueprint for a new alternative to panpsychism and explain how such a view avoids some of the most persistent problems for panpsychism while maintaining several of its strengths. (shrink)

In our response, we clarify important theoretical differences between basic emotion and psychological construction approaches. We evaluate the empirical status of the basic emotion approach, addressing whether it requires brain localization, whether localization can be observed with better analytic tools, and whether evidence for basic emotions exists in other types of measures. We then revisit the issue of whether the key hypotheses of psychological construction are supported by our meta-analytic findings. We close by elaborating on commentator suggestions for future research.

We agree that conceptualisation is key in understanding the brain basis of emotion. We argue that by conflating facial emotion recognition with subjective emotion experience, Lindquist et al. understate the importance of biological predisposition in emotion. We use examples from the anxiety disorders to illustrate the distinction between these two phenomena, emphasising the importance of both emotional hardware and contextual learning.

van der Velde's & de Kamps's model encodes complex word-to-word relations in sentences but does not encode the hierarchical constituent structure of sentences, a fundamental property of most accounts of sentence structure. We summarize what is at stake and suggest two ways of incorporating constituency into the model.

In May 2016, we launched Research Integrity and Peer Review, an international, open access journal with fully open peer review (reviewers are identified on their reports and named reports are published alongside the article) to provide a home for research on research and publication ethics, research reporting, and research on peer review. As the journal enters its third year, we reflect on recent events and highlights for the journal and explore how the journal is faring in terms of gender and (...) diversity in peer review. We also share the particular interests of our Editors-in-Chief regarding models of peer review, reporting quality, common research integrity issues that arise during the publishing process, and how people interact with the published literature. We continue to encourage further research into peer review, research and publication ethics and research reporting, as we believe that all new initiatives should be evidence-based. We also remain open to constructive discussions of the developments in the field that offer new solutions. (shrink)

Use of patient clinical photographs requires specific attention to confidentiality and privacy. Although there are policies and procedures for publishing clinical images, there is little systematic evidence about what patients and health professionals actually think about consent for publishing clinical images. We investigated the opinions of three stakeholder groups at 3 academic healthcare institutions and 37 private practices in Croatia. The questionnaire contained patient photographs with different levels of anonymization. All three respondent groups considered that more stringent forms of permission (...) for were needed identifiable photographs than for those with higher levels of anonymization. When the entire face was presented in a photo only 33% of patients considered that written permission was required, compared with 88% of the students and 89% of the doctors. Opinions about publishing patient photographs differed among the three respondent samples: almost half of the patients thought no permission was necessary compared with one-third of students and doctors. These results show poor awareness of Croatian patients regarding the importance of written informed consent as well as unsatisfactory knowledge of health professionals about policies on the publication of patients’ data in general. In conclusion, there is a need for increasing awareness of all stakeholders to achieve better protection of patient privacy rights in research and publication. (shrink)

Research that has been sponsored by pharmaceutical, medical device and biotechnology companies is often presented at scientific and medical conferences. However, practices vary between organizations and it can be difficult to follow both individual conference requirements and good publication practice guidelines. Until now, no specific guidelines or recommendations have been available to describe best practice for conference presentations.This document was developed by a working group of publication professionals and uploaded to PeerJ Preprints for consultation prior to publication; an additional 67 (...) medical societies, medical conference sites and conference companies were also asked to comment. The resulting recommendations aim to complement current good publication practice and authorship guidelines, outline the general principles of best practice for conference presentations and provide recommendations around authorship, contributorship, financial transparency, prior publication and copyright, to conference organizers, authors and industry professionals.While the authors of this document recognize that individual conference guidelines should be respected, they urge organizers to consider authorship criteria and data transparency when designing submission sites and setting parameters around word/character count and content for abstracts. It is also important to recognize that conference presentations have different limitations to full journal publications, for example, in the case of limited audiences that necessitate refocused abstracts, or where lead authors do not speak the local language, and these have been acknowledged accordingly. The authors also recognize the need for further clarity regarding copyright of previously published abstracts and have made recommendations to assist with best practice.By following Good Practice for Conference Abstracts and Presentations: GPCAP recommendations, industry professionals, authors and conference organizers will improve consistency, transparency and integrity of publications submitted to conferences worldwide. (shrink)

We analysed all journals from two Journal Citation Reports categories: ‘Dentistry, Oral Surgery and Medicine’ and ‘Otorhinolaryngology’ published in 2018 for their policies on publishing facial photographs and actual practices of publishing these photographs in articles. We extracted the following data for each journal: JCR category, impact factor, volume, issue, instructions for authors regarding ethical issues, instructions for photograph deidentification, journals’ references to standard research and publishing policies, presence and type of published clinical images, separate informed consent for the publication (...) of patient photograph and methods of deidentification. The sample included 103 journals, which published 568 articles with 1404 clinical images. Around a half of the journals had a policy on clinical images, however, the only predictor of having a journal policy on clinical images was reference in the policy to International Committee of Medical Journal Editors Recommendations. Identifiable patient photographs were found in 13% of the articles, constituting 9% of the total sample of images. Only 16% of articles publishing recognisable patient facial images included a statement about consent for publication of the image. From the total sample of articles, 34% contained deidentified but recognisable patient photographs and only 22% of them had a statement about patient consent for photograph publication. The patients’ consent was more likely stated in the article in cases of recognisable facial images. Journals publishing clinical research involving the face and neck region need to establish and enforce policies on publishing clinical images. (shrink)

BackgroundInaccurate, false or incomplete research publications may mislead readers including researchers and decision-makers. It is therefore important that such problems are identified and rectified promptly. This usually involves collaboration between the research institutions and academic journals involved, but these interactions can be problematic.MethodsThese recommendations were developed following discussions at World Conferences on Research Integrity in 2013 and 2017, and at a specially convened 3-day workshop in 2016 involving participants from 7 countries with expertise in publication ethics and research integrity. The (...) recommendations aim to address issues surrounding cooperation and liaison between institutions and journals about possible and actual problems with the integrity of reported research arising before and after publication.ResultsThe main recommendations are that research institutions should: develop mechanisms for assessing the integrity of reported research that are distinct from processes to determine whether individual researchers have committed misconduct;release relevant sections of reports of research integrity or misconduct investigations to all journals that have published research that was investigated;take responsibility for research performed under their auspices regardless of whether the researcher still works at that institution or how long ago the work was done;work with funders to ensure essential research data is retained for at least 10 years.Journals should: respond to institutions about research integrity cases in a timely manner;have criteria for determining whether, and what type of, information and evidence relating to the integrity of research reports should be passed on to institutions;pass on research integrity concerns to institutions, regardless of whether they intend to accept the work for publication;retain peer review records for at least 10 years to enable the investigation of peer review manipulation or other inappropriate behaviour by authors or reviewers.ConclusionsVarious difficulties can prevent effective cooperation between academic journals and research institutions about research integrity concerns and hinder the correction of the research record if problems are discovered. While the issues and their solutions may vary across different settings, we encourage research institutions, journals and funders to consider how they might improve future collaboration and cooperation on research integrity cases. (shrink)

BackgroundMany journals prohibit the use of declarative titles that state study findings, yet a few journals encourage or even require them. We compared the effects of a declarative versus a descriptive title on readers’ perceptions about the strength of evidence in a research abstract describing a randomized trial.MethodsStudy participants (medical or dental students or doctors attending lectures) read two abstracts describing studies of a fictitious treatment (Anticox) for a fictitious condition (Green’s syndrome). The first abstract (A1) described an uncontrolled, 10-patient, (...) case series, and the second (A2) described a randomized, placebo-controlled trial involving 48 patients. All participants rated identical A1 abstracts (with a descriptive title) to provide baseline ratings and thus reduce the effects of inter-individual variability. Participants were randomized so that half rated a version of A2 with a descriptive title and half with a declarative title. For each abstract, participants indicated their agreement with the statement “Anticox is an effective treatment for pain in Green’s syndrome” using 100 mm visual analogue scales (VAS) ranging from “disagree completely” to “agree completely.” VAS scores were measured by an investigator who was unaware of group allocation.ResultsOne hundred forty-four participants from four centres completed the study. There was no significant difference between the declarative and the descriptive title groups’ confidence in the study conclusions as expressed on VAS scales—in fact, the mean difference between A1 and A2 was smaller for the declarative title group than that for the descriptive title group (32.6 mm, SD 27.4 vs. 39.8 mm, SD 22.6, respectively, p = 0.09).ConclusionsWe found no evidence that the use of a declarative title affected readers’ perceptions about study conclusions. This suggests that editors’ fears that declarative titles might unduly influence readers’ judgements about study conclusions may be unfounded, at least in relation to reports of randomized trials. However, our study design had several limitations, and our findings may not be generalizable to other situations. (shrink)

Current theories suggest that the brain is the sole source of mental illness. However, affective disorders, and major depressive disorder (MDD) in particular, may be better conceptualized as brain-body disorders that involve peripheral systems as well. This perspective emphasizes the embodied, multifaceted physiology of well-being, and suggests that afferent signals from the body may contribute to cognitive and emotional states. In this review, we focus on evidence from preclinical and clinical studies suggesting that afferent thermosensory signals contribute to well-being and (...) depression. Although thermoregulatory systems have traditionally been conceptualized as serving primarily homeostatic functions, increasing evidence suggests neural pathways responsible for regulating body temperature may be linked more closely with emotional states than previously recognized, an affective warmth hypothesis. Human studies indicate that increasing physical warmth activates brain circuits associated with cognitive and affective functions, promotes interpersonal warmth and prosocial behavior, and has antidepressant effects. Consistent with these effects, preclinical studies in rodents demonstrate that physical warmth activates brain serotonergic neurons implicated in antidepressant-like effects. Together, these studies suggest that (1) thermosensory pathways interact with brain systems that control affective function, (2) these pathways are dysregulated in affective disorders, and (3) activating warm thermosensory pathways promotes a sense of well-being and has therapeutic potential in the treatment of affective disorders. (shrink)

Lindquist et al. convincingly argue that the brain implements psychological operations that are constitutive of emotion rather than modules subserving discrete emotions. However, thenatureof such psychological operations is open to debate. I argue that considering appraisal theories may provide alternative interpretations of the neuroimaging data with respect to the psychological operations involved.

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)

Nursing is frequently described as practical or pragmatic and there are many parallels between nursing and pragmatism, the school of thought. Pragmatism is often glancingly referenced by nursing authors, but few have conducted in-depth discussions about its applicability to nursing; and few have identified it as a significant theoretical basis for nursing research. William James's pragmatism has not been discussed substantially in the nursing context, despite obvious complementarities. James's theme of pluralism fits with nursing's diversity and plurality; his emphasis on (...) social conscience in our actions matches nursing's fundamental purpose of improving the lives of others; his continuous testing of pluralistic truths in critically reflective practice pairs well with nursing's focus on developing best-available, holistic evidence; and his conceptualization of truth as being born in practice and becoming an instrument in practice is entirely compatible with nursing's theory–practice identity. The oft-discussed theory–practice gap is seen to hinder the development of nursing knowledge. If nursing is to find its identity in knowledge development and potentiate the knowledge developed, it is imperative to identify and address that which is impeding progress. By way of the pragmatic tenets of William James, I will argue that a significant part of the theory–practice gap lies in how nursing knowledge development is operationalized, creating a false dichotomy between practice and research. I will also argue that the research–practice schism has been widened by continued philosophical and methodological infighting in the research community. I will describe how Jamesian pragmatism can be 'what works' for rebuilding relationships and supporting an engaged plurality within nursing research and bring research and practice together into a collaborative and iterative process of developing nursing knowledge. (shrink)

Cryonics offers certain individuals the opportunity to preserve their bodies or brains with the potential for future revival. Proponents of this technology often invoke Pascal’s wager to argue that we all have a prudential reason to embrace cryonics: if future technology enables the revival of those who have been frozen, they stand to gain immense benefits; if not, undergoing cryonics is no worse than facing death directly. However, the cryonics wager carries hidden risks, not only in terms of (...) whether future generations will be able to revive us, but also in terms of how they will choose to treat us. Given that the potential returns of the cryonics wager are not necessarily positive, it is not a guaranteed investment but rather an uncertain venture. I demonstrate that the risks of cryonics vary from person to person, making it a safer option for those who are talented, kind, and hold a weak view of personal identity. This leads to a paradoxical conclusion: those most suited for cryonics might be those least keen on this technology. (shrink)

Pascal’s wager is unique among theistic arguments. It does not aim to establish that God exists but instead concludes that you ought to believe in, or wager on, God. In this chapter, I provide an overview of Pascal’s wager and discuss different approaches to the wager. Then, I consider how to motivate a wager for Christianity in particular. I also address common Christian objections to the wager. Finally, I cover the practical importance of Pascal’s (...) wager for both Christians and non-Christians. (shrink)

Cryonics offers certain individuals the opportunity to preserve their bodies or brains with the potential for future revival. Proponents of this technology often invoke Pascal’s wager to argue that we all have a prudential reason to embrace cryonics: if future technology enables the revival of those who have been frozen, they stand to gain immense benefits; if not, undergoing cryonics is no worse than facing death directly. However, the cryonics wager carries hidden risks, not only in terms of (...) whether future generations will be able to revive us, but also in terms of how they will choose to treat us. Given that the potential returns of the cryonics wager are not necessarily positive, it is not a guaranteed investment but rather an uncertain venture. I demonstrate that the risks of cryonics vary from person to person, making it a safer option for those who are talented, kind, and hold a weak view of personal identity. This leads to a paradoxical conclusion: those most suited for cryonics might be those least keen on this technology. (shrink)