An astonishing volume and diversity of evidence is available for many hypotheses in the biomedical and social sciences. Some of this evidence—usually from randomized controlled trials (RCTs)—is amalgamated by meta-analysis. Despite the ongoing debate regarding whether or not RCTs are the ‘gold-standard’ of evidence, it is usually meta-analysis which is considered the best source of evidence: meta-analysis is thought by many to be the platinum standard of evidence. However, I argue that meta-analysis falls far short of that standard. Different meta-analyses (...) of the same evidence can reach contradictory conclusions. Meta-analysis fails to provide objective grounds for intersubjective assessments of hypotheses because numerous decisions must be made when performing a meta-analysis which allow wide latitude for subjective idiosyncrasies to influence its outcome. I end by suggesting that an older tradition of evidence in medicine—the plurality of reasoning strategies appealed to by the epidemiologist Sir Bradford Hill—is a superior strategy for assessing a large volume and diversity of evidence. (shrink)

Measuring the effectiveness of medical interventions faces three epistemological challenges: the choice of good measuring instruments, the use of appropriate analytic measures, and the use of a reliable method of extrapolating measures from an experimental context to a more general context. In practice each of these challenges contributes to overestimating the effectiveness of medical interventions. These challenges suggest the need for corrective normative principles. The instruments employed in clinical research should measure patient-relevant and disease-specific parameters, and should not be sensitive (...) to parameters that are only indirectly relevant. Effectiveness always should be measured and reported in absolute terms (using measures such as 'absolute risk reduction'), and only sometimes should effectiveness also be measured and reported in relative terms (using measures such as 'relative risk reduction')-employment of relative measures promotes an informal fallacy akin to the base-rate fallacy, which can be exploited to exaggerate claims of effectiveness. Finally, extrapolating from research settings to clinical settings should more rigorously take into account possible ways in which the intervention in question can fail to be effective in a target population. (shrink)

I defend a radical interpretation of biological populations—what I call population pluralism—which holds that there are many ways that a particular grouping of individuals can be related such that the grouping satisfies the conditions necessary for those individuals to evolve together. More constraining accounts of biological populations face empirical counter-examples and conceptual difficulties. One of the most intuitive and frequently employed conditions, causal connectivity—itself beset with numerous difficulties—is best construed by considering the relevant causal relations as ‘thick’ causal concepts. I (...) argue that the fine-grained causal relations that could constitute membership in a biological population are huge in number and many are manifested by degree, and thus we can construe population membership as being defined by massively multidimensional constructs, the differences between which are largely arbitrary. I end by showing that positions in two recent debates in theoretical biology depend on a view of biological populations at odds with the pluralism defended here. (shrink)

Harms of medical interventions are systematically underestimated in clinical research. Numerous factors—conceptual, methodological, and social—contribute to this underestimation. I articulate the depth of such underestimation by describing these factors at the various stages of clinical research. Before any evidence is gathered, the ways harms are operationalized in clinical research contributes to their underestimation. Medical interventions are first tested in phase 1 ‘first in human’ trials, but evidence from these trials is rarely published, despite the fact that such trials provide the (...) foundation for assessing the harm profile of medical interventions. If a medical intervention is deemed safe in a phase 1 trial, it is tested in larger phase 2 and 3 clinical trials. One way to think about the problem of underestimating harms is in terms of the statistical ‘power’ of a clinical trial—the ability of a trial to detect a difference of a certain effect size between the experimental group and the control group. Power is normally thought to be pertinent to detecting benefits of medical interventions. It is important, though, to distinguish between the ability of a trial to detect benefits and the ability of a trial to detect harms. I refer to the former as power-B and the latter as power-H. I identify several factors that maximize power-B by sacrificing powerH in phase 3 clinical trials. If a medical intervention is approved for general use, it is evaluated by phase 4 post-market surveillance. Phase 4 surveillance of harms further contributes to underestimating the harm profile of medical interventions. At every stage of clinical research the hunt for harms is shrouded in secrecy, which further contributes to the underestimation of the harm profiles of medical interventions. (shrink)

Millstein argues against conceptual pluralism with respect to the definition of “population,” and proposes her own definition of the term. I challenge both Millstein’s negative arguments against conceptual pluralism and her positive proposal for a singular definition of population. The concept of population, I argue, does not refer to a natural kind; popula tions are constructs of biologists variably defined by contexts of inquiry.

A major new history of how the Enlightenment transformed people’s everyday lives The Secular Enlightenment is a panoramic account of the radical ways that life began to change for ordinary people in the age of Locke, Voltaire, and Rousseau. In this landmark book, familiar Enlightenment figures share places with voices that have remained largely unheard until now, from freethinkers and freemasons to French materialists, anticlerical Catholics, pantheists, pornographers, readers, and travelers. Margaret Jacob, one of our most esteemed historians of (...) the Enlightenment, reveals how this newly secular outlook was not a wholesale rejection of Christianity but rather a new mental space in which to encounter the world on its own terms. She takes readers from London and Amsterdam to Berlin, Vienna, Turin, and Naples, drawing on rare archival materials to show how ideas central to the emergence of secular democracy touched all facets of daily life. Human frailties once attributed to sin were now viewed through the lens of the newly conceived social sciences. People entered churches not to pray but to admire the architecture, and spent their Sunday mornings reading a newspaper or even a risqué book. The secular-minded pursued their own temporal and commercial well-being without concern for the life hereafter, regarding their successes as the rewards for their actions, their failures as the result of blind economic forces. A majestic work of intellectual and cultural history, The Secular Enlightenment demonstrates how secular values and pursuits took hold of eighteenth-century Europe, spilled into the American colonies, and left their lasting imprint on the Western world for generations to come. (shrink)

Over de vraag hoe geloof en verstand zich onderling verhouden, bestaat geen communis opinio; ook in het verleden is die er nooit geweest. Integendeel, de filosofiehistorie vertoont een complexe verscheidenheid van opvattingen. In dit artikel heb ik deze geordend in een beperkt aantal grondschema’s of grondmodellen. Ik breng zeven van die grondmodellen ter sprake, en duid ze kortweg aan met de termen identificatie, conflict, subordinatie, complementariteit, fundering, authenticiteit en transformatie. Mijn analyse laat zien hoe deze modellen, eenmaal present op het (...) publieke forum, zich blijvend doen gelden, tot op de dag van vandaag. Hun sterke en zwakke kanten dagen ons uit tot een eigen standpuntbepaling in het debat over religie en rede. (shrink)

This article begins with a review of studies in perception and depth psychology concerning the experience of exposure to sacred artworks in Roman Catholic and Eastern Orthodox contexts. This follows with the results of a qualitative inquiry involving 45 Roman Catholic, Eastern and Coptic Orthodox, and Protestant Christians in Canada. First, participants composed narratives detailing memories of spiritual experiences involving iconography. Then, in the context of a darkened room evocative of a sacred space, they viewed artworks depicting Biblical themes and (...) interpreted their meanings. Stimuli included “Western” paintings from the Roman tradition—a selection from the Gothic, Northern Renaissance, and Renaissance canon—and matched “Eastern” icons in the Byzantine style. Spiritual experience narratives were analyzed in terms of word frequencies, and interpretations of sacred artworks were analyzed thematically. Catholics tended to utilize emotional language when recalling their spiritual experiences, while religious activity was most often the concern of Protestants, and Orthodox Christians wrote most about spiritual figures and their signifiers. A taxonomy of response styles was developed to account for participants’ interpretations of Western and Eastern artworks, with content ranging from detached descriptions to projective engagement with the art-objects. Our approach allows for representation of diverse Christians’ interpretations of sacred art, taking into consideration personal, collective, and cultural-religious sources of meaning. Our paradigm also offers to enrich our understanding of the numinous or emotional dimension of mystical contact. (shrink)

This edition of Houston Stewart Chamberlain's Politische Ideale reveals the historical significance of Chamberlain in German conservative political philosophy. Contrasting the vital nationalistic state with the sterile commercialism of liberal democracies, moral freedom with the unruly selfishness of democratic parties, and the decaying culture of the Anglo-Saxon peoples with the relatively pure Teutonic, Chamberlain evokes in this work the principal elements of a genuinely conservative state.

This article responds to one of Thaddeus Metz's criticisms of the theory that the meaning of life is to fulfil a purpose assigned by God. In particular, it addresses the argument that only an atemporal God could ground meaning but that an atemporal God could not assign a purpose. In order to do this, the article first argues that Metz's criticisms misread the relevant sense of purpose. It then argues that on a more plausible reading of 'purpose', we can see (...) that it is in fact the kind of thing that an atemporal God could assign. (shrink)

I argue that comparisons of Stoic virtue to stochastic skills — now standard in the secondary literature on Stoicism — are based on a misreading of the sources and distort the Stoic position in two respects. In paradigmatic stochastic skills such as archery, medicine, or navigation the value of the skill’s external end justifies the existence and practice of the skill and constitutes an appropriate focus of rational motivation. Neither claim applies to virtue as the Stoics understand it. The stochastic (...) model of virtue almost certainly originated with Carneades and should be distinguished clearly from the Stoic account. Doing so clarifies the Stoic position and shows that it anticipates what Thomas Hurka calls a modern view of value. (shrink)

This collection of essays examines the wisdom of Dr. Seuss and the philosophical insights that his classic children's books hold for adults. Whether exploring morality, compassion, or conflict resolution, Dr. Seuss's works are a guide to living well, and being the best person you can be.

La conception fodorienne de la psychologie scientifique soulève les trois problèmes suivants qui peuvent, je crois, être résolus. La condition de formalité est-elle compatible avec l'existence de lois psychologiques intentionnelles ? L'atomisme sémantique est-il compatible avec le fonctionnalisme? L'atomisme sémantique est-il compatible avec la systématicité des pensées humaines? Dans les trois premières sections du présent article, j'essaie de résorber ces tensions. Dans la quatrième et dernière section, j'examine la conception des attributions de croyance développée par Fodor dans « Substitution Arguments (...) and the Individuation of Beliefs » selon laquelle la relation de croyance est une relation à quatre places entre une personne, un symbole , un rôle fonctionnel et un contenu propositionnel. Je fais valoir que Fodor est confronté à un dilemme : soit le rôle fonctionnel est un déterminant du contenu propositionnel, et Fodor doit rejeter l'atomisme sémantique; soit le rôle fonctionnel est un déterminant de l'efficacité causale d'un symbole, et il doit amender la condition de formalité.Fodor's views about scientific psychology raise three puzzles : Is the Formality Condition compatible with there being intentional psychological laws ? Is Content Atomism consistent with Fonctionalism? Can Content Atomism be reconciled with the claim that human thoughts are systematic? In the first three sections of this paper, I try and show how to solve the three puzzles. Finally, in the fourth section, I examine Fodor's recent view of belief-ascriptions in "Substitution Arguments and the Individuation of Beliefs" according to which the belief relation is a four place relation between a believer, a symbol token , a functional role and a propositional content. I argue that Fodor faces a dilemma : either the functional role is a determinant of content, in which case Fodor must reject Content Atomism; or it is a determinant of the causal efficacy of the vehicle, in which case he must amend his Formality Condition. (shrink)

ArgumentRecurring economic crises, like the one of 2007-2008, led to criticism of economic research and a demand to develop new strategies to avoid them. Standard economic theories use conventional approaches to deal with economic challenges, heterodox theories try to develop alternatives with which to face them. It remains unclear whether the 2007-2008 crisis led to a change in economic research as well as to a consideration of alternative approaches. We used co-word analysis to map the structure of economic research in (...) Germany between 2005 and 2014. Core topics within economic research, such as “market” or “production” hardly shift and can be linked to standard economic theories. Peripheral topics such as “inequality” or “unemployment” show greater dynamics. However, only a few of these topics can be linked to heterodox approaches. Certain changes have occurred in reaction to the 2007-2008 crisis. However, the unchanged importance of standard economic topics raises the question whether these changes are sufficient to face coming economic challenges. (shrink)