Background Transplant coordinators face ethical conflicts in various situations, such as deciding who should receive organ donations and how to consider patient costs and such conflicts are expected to be more frequent in Korea, as organ transplant coordinators in the country perform both organ acquisition and transplantation. Research Aim This study aims to develop an ethics education program to enhance organ transplant coordinators’ ethical competence and address the ethical conflicts faced by them during clinical practice. Research design A descriptive study. (...) Participants and research context An online survey was conducted from March 22 to May 28, 2021. The study was conducted among 160 registered members of the Korea Organ Transplant Coordinators Association. Ultimately, 87 participants agreed to participate in the study. Ethical considerations Permission to conduct the study was obtained from the Institutional Review Board. Results The study revealed variations in the degree of ethical conflict based on the participants' general characteristics. Furthermore, organ transplant coordinators exhibited high levels of ethical competence and expressed a need for ethics education. The findings also indicated a positive correlation between higher ethical competence and greater demand for ethics education. Conclusions Based on the findings, developing standardized ethics education programs tailored to organ transplant coordinators is recommended. These programs should focus on improving ethical decision-making skills and establishing professional ethics. The education provided should be practical, applicable in the clinical setting, and responsive to the participants’ awareness and concerns regarding ethics education. (shrink)

Many innate immune response proteins recognize foreign nucleic acids from invading pathogens to initiate antiviral signaling. These proteins mostly rely on structural characteristics of the nucleic acids rather than their specific sequences to distinguish self and nonself. One feature utilized by RNA sensors is the extended stretch of double‐stranded RNA (dsRNA) base pairs. However, the criteria for recognizing nonself dsRNAs are rather lenient, and hairpin structure of self‐RNAs can also trigger an immune response. Consequently, aberrant activation of RNA sensors has (...) been reported in numerous human diseases. Yet, in most cases, the activating antigens remain unknown. Recent studies have developed sequencing techniques tailored to specifically capture dsRNAs and identified that various noncoding elements in the nuclear and the mitochondrial genome can generate dsRNAs. Here, the identity of endogenous dsRNAs, their recognition by dsRNA sensors, and their implications in the pathogenesis of human diseases ranging from inflammatory to degenerative are presented. (shrink)

In this paper, I argue that the adaptive fit between human cultures and their environment is persuasive evidence that some form of evolutionary mechanism has been important in driving human cultural change. I distinguish three mechanisms of cultural evolution: niche construction leading to cultural group selection; the vertical flow of cultural information from parents to their children, and the replication and spread of memes. I further argue that both cultural group selection and the vertical flow of cultural information have been (...) important. More conjecturally, I identify a potential role for meme-based cultural evolution in the explanation of the ‘human revolution’ of the last 100 000 or so years, and defuse an important objection to that explanation. Introduction Cultural groups The cultural invention of adaptive complexes Niche construction models Dual inheritance Memes Memes or minds? Conclusion. (shrink)

In the last few years, nativist, modular views of moral cognition have been influential. This paper shares the view that normative cognition develops robustly, and is probably an adaptation. But it develops an alternative view of the developmental basis of moral cognition, based on the idea that adults scaffold moral development by organising the learning environment of the next generation. In addition, I argue that the modular nativist picture has no plausible account of the role of explicit moral judgement, and (...) that no persuasive version of the ‘poverty of the stimulus' applies to moral cognition. (shrink)

A preference method probed infants` perception of object motion on an inclined plane. Infants viewed videotaped events in which a ball rolled downward (or upward) while speeding up (or slowing down). Then infants were tested with events in which the ball moved in the opposite direction with appropriate or inappropriate acceleration. Infants aged 7 months, but not 5 months, looked longer at the test event with inappropriate acceleration, suggesting emerging sensitivity to gravity. A further study tested whether infants appreciate that (...) a stationary object released on an incline moves downward rather than upward; findings again were positive at 7 months and negative at 5 months. A final study provided evidence, nevertheless, that 5-monthold infants discriminate downward from upward motion and relate downward motion in videotaped events to downward motion in live events. Sensitivity to certain effects of gravity appears to develop in infancy. (shrink)

There is nothing like an overwhelming consensus of opinion to encourage a less than rigourous approach to analyzing complex ethical issues. Unfortunately, this is nowhere more apparent than in the discussion of human reproductive cloning contained in the federal House of Representatives Standing Committee on Legal and Constitutional Affairs’ report on human cloning, released last August The report may well fulfil the first half of its project, namely the empirical task of adequately summarizing and categorizing the various submissions made to (...) the Committee. However, it is clearly inadequate as a discussion of the ethical and legal permissibility of human reproductive cloning. (shrink)

A common view is that relativism requires tolerance. We argue that there is no deductive relation between relativism and tolerance, but also that relativism is not incompatible with tolerance. Next we note that there is no standard inductive relation between relativism and tolerance—no inductive enumeration, argument to the best explanation, or causal argument links the two. Two inductive arguments of a different sort that link them are then exposed and criticized at length. The first considers relativism from the objective point (...) of view ‘of the universe’, the second from the subjective point of view of the relativist herself. Both arguments fail. There is similarly no deductive relation between absolutism and tolerance—neither entails the other—and no inductive connection of any sort links the two. We conclude that tolerance, whether unlimited or restricted, is independent of both relativism and absolutism. A metaethical theory that says only that there is one true or valid ethical code, or that there is a plurality of equally true or valid ethical codes, tells us nothing about whether we should be tolerant, much less how tolerant we should be. (shrink)

Background: Financial conflict of interest in clinical research is an area of active debate. While data exist on the perspectives and roles of academic institutions, investigators, industry sponsors, and scientific journals, little is known about the perspectives of potential research participants.Methods: The authors surveyed potential research participants over the internet, using the Harris Interactive Chronic Illness Database. A potential research participant was defined by: self report of diagnosis by a health care professional and willingness to participate in clinical trials. Email (...) invitations were sent to 20 205 persons with coronary artery disease, breast cancer, or depression; a total of 6363 persons were screened; of these, 86% or 5478 met inclusion criteria and completed the survey. The outcome measures were respondents’ ratings on: importance of knowing conflict of interest information, whether its disclosure ought to be required, and its effect on willingness to participate—across seven widely discussed scenarios of financial conflicts of interest .Results: Majority responded that knowing conflict of interest information was “extremely” or “very” important; a larger majority felt financial conflicts of interest should be disclosed as part of informed consent . In all seven scenarios, a majority was still willing to participate but in some scenarios a sizable minority would be wary of participation. Respondents were more wary of individual than institutional conflicts of interest. Illness group and sociodemographic factors had modest effects and did not affect the main trends.Conclusions: The prevailing practice of non-disclosure of financial conflicts of interest in clinical research appears contrary to the values of potential research participants. (shrink)

The wide range of conflicting interpretations that exist in regard to Locke's philosophy of mind and body (i.e. dualistic, materialist, idealistic) can be explained by the general failure of commentators to appreciate the full extent of his nominalism. Although his nominalism that focuses on specific natural kinds has been much discussed, his mind-body nominalism remains largely neglected. This neglect, I shall argue, has given rise to the current diversity of interpretations. This paper offers a solution to this interpretative puzzle, and (...) it attributes a view to Locke that I shall describe as nominal symmetry. (shrink)

Konu din çalışmaları olunca objektiflik her zaman ana kriter olsa da içeriden/dışarıdan bireylerin bir dini ne kadar objektif olarak ele alabilecekleri ve konu olan dinin, o dine mensup içeridekilerin mi yoksa dışarıdakilerin mi en iyi şekilde çalışabileceği meselesi din incelemesinin başından günümüze kadar tartışmalı bir konu olagelmiştir. Bu konu, emik/etik anlatım, yakın/ uzak tecrübe ve düşünümsellik gibi üzerine düşünülmesi gereken olguları da beraberinde getirmektedir. Kim Knott, bu makalesinde bu kavramlar çerçevesinde tam katılımcı, katılımcı olarak gözlemci, gözlemci olarak katılımcı ve tam (...) gözlemci rollerini benimsemiş farklı araştırmacıların anlatılarını ele alarak içeriden ve dışarıdan sorununu incelemiştir. (shrink)

An amalgamation base p in a simple theory is stably definable if its canonical base is interdefinable with the set of canonical parameters for the ϕ-definitions of p as ϕ ranges through all stable formulae. A necessary condition for stably definability is given and used to produce an example of a supersimple theory with stable forking having types that are not stably definable. This answers negatively a question posed in [8]. A criterion for and example of a stably definable amalgamation (...) base whose restriction to the canonical base is not axiomatised by stable formulae are also given. The examples involve generic relations over non CM-trivial stable theories. (shrink)

Measuring Chinese character recognition ability is essential in research on character learning among learners of Chinese as a second language. Three methods are typically used to evaluate character recognition competence by investigating the following properties of a given character: pronunciation, meaning, and pronunciation and meaning. However, no study has explored the similar or dissimilar outcomes that these three measurements might yield. The current study examined this issue by testing 162 CSL learners with various L1 backgrounds and Chinese proficiency levels. Participants' (...) performance in character recognition measured using a phonological method, a semantic method, and a PS method was compared, which led to two major findings. In terms of similarity, participants' performance in character recognition and the influence of L1 background and Chinese proficiency level on character recognition was similar across the three methods. As for differences, the semantic method could yield a character recognition test with better quality than the other two methods, and the three methods yielded different best fitting models and showed different predictions for Chinese proficiency across different L1 groups. Theoretical and practical implications of these findings are proposed. (shrink)

It is shown that the jet mechanism derivable from the Lorentz deformation picture leads to a nearly constant average jet transverse momentum. It is pointed out that this is consistent with the high-energy experimental data. It is pointed out further that this result strengthens the physical basis for the minimal time-energy uncertainty combined covariantly with Heisenberg's space-momentum uncertainty relation.

L’examen de certains manuscrits inédits du Fonds Foucault déposé par Daniel Defert à la BnF, en 2013, montre que le Descartes de Foucault est une variante simplifiée de celui de Heidegger. Foucault reprend en effet à la lecture heideggérienne de Descartes la liaison que le philosophe allemand met en place entre la mathesis universalis et le cogito, qui ne se trouve assurément pas chez Descartes. C’est de cette manière que ces deux auteurs critiquent ce qu’ils mettent eux-mêmes au jour chez (...) Descartes – le sujet de la certitude – et qu’ils font de l’inquiétude l’affect historique propre à la pensée. La présente étude reconstruit le lien entre la mathesis et le cogito et la critique de la vérité comme certitude, tel qu’il est élaboré dans les cours de Heidegger sur Descartes, Augustin et Aristote, au début des années 20. La manière dont Heidegger établit ce lien suit l’évolution de la pensée de Heidegger, mais nous prenons le parti de mettre l’accent sur le cours sur Descartes de 1922-1923 (Introduction à la recherche phénoménologique), car dans les années 20, Heidegger fait de l’inquiétude la figure de l’ipséité. Nous reconstruisons en parallèle la manière dont Foucault intègre la lecture heideggérienne de Descartes à la sienne et comment il en déplace la signification, en évoquant certains textes connus de l’Histoire de la folie, mais aussi en analysant des manuscrits inédits de Foucault. Car le rapprochement que nous proposons entre les deux auteurs, tout comme la mise en relief de ce qui les distingue, se fait à la faveur de l’occasion historique que constitue la mise à disposition de textes qui étaient auparavant inédits. Et, en effet, les cours de Heidegger que nous analysons ont été publiés dans la Gesamtausgabe après la mort de Foucault, et leur traduction en français est toute récente. En procédant ainsi, nous voulons montrer comment la redéfinition contemporaine de la subjectivité s’est élaborée, au XXe siècle, à partir de la notion d’inquiétude, et plus spécifiquement de l’inquiétude historique. (shrink)

Being robustly committed to state neutrality which does not permit the promotion of liberal-perfectionist ideals and denying that there is anything normatively relevant or ‘special’ about religion leaves liberal-egalitarians embroiled in a paradox. If religion is not special, how and why do liberal states afford it differential treatment (in comparison with non-religious analogues like secular doctrines or deeply-held beliefs of individual conscience)? This paper explores liberal-egalitarian strategies for resolving this paradox with predominant reference to the disaggregation strategy advanced by Cécile (...) Laborde. After discussing the novelty and advantages of disaggregation relative to other liberal-egalitarian strategies, the paper distinguishes between the coverage and the basis in justification of differential treatment to argue that disaggregation does not ultimately succeed in solving the latter. Despite this, reflecting on the clarifications achieved through disaggregation and the deeper issues of justification and justice emerging therefrom, the paper concludes by proposing the need to consider a lateral solution to the paradox and speculating on what this might look like. (shrink)

This article addresses the exclusivism–inclusivism debate about religious reasons in law within a justificatory liberal framework. The question of whether religious reasons have justificatory capacity for attaining public justification has increasingly been seen as a matter of how public justification is understood between two rival models: the consensus model being aligned with exclusivism, the convergence model with inclusivism. More recently, however, that alignment has been challenged with attempts to show that consensus can reach an equivalent degree of inclusivism as convergence. (...) Against this, I contend that the purported equivalence is misplaced. First, I identify a crucial ambiguity about public justification and two corresponding domains. Upon demonstrating these to be mutually independent and severable, I conclude that the moves to equalize the models are confined within the more narrow domain while, in the more fundamental domain, the choice of model continues to prove determinative as to the exclusivist or inclusivist valence of justificatory liberalism. (shrink)

Name der Zeitschrift: Cognitive Linguistics Jahrgang: 27 Heft: 2 Seiten: 289-297.

ABSTRACTThis study assessed the knowledge and perception of human biological materials and biorepositories among three study groups in South Korea. The relationship between the knowledge and the perception among different groups was also examined by using factor and regression analyses. In a self‐reporting survey of 440 respondents, the expert group was found more likely to be knowledgeable and positively perceived than the others. Four factors emerged: Sale and Consent, Flexible Use, Self‐Confidence, and Korean Bioethics and Biosafety Action restriction perception. The (...) results indicate that those who are well aware of the existence of biobanks were more positively inclined to receive the Sale and Consent perception. As a result of the need for high quality HBMs and the use of appropriate sampling procedures for every aspect of the collection and use process, the biorepository community should pay attention to ethical, legal, and policy issues. (shrink)