In a poem setting forth the way things are in nature, it is fitting for Lucretius to address, among many other phenomena, human conception and embryonic determination. With an eye toward ethics, Lucretius demonstrates how sexual reproduction at the seminal level can be explained by Epicurean atomism. In this paper, I am concerned with the biological ‘how’ of conception as explained inDe Rerum Natura(=DRN) but also with the ethical ‘therefore’ for Lucretius’ readership and (over)estimations of male autonomy. For modern audiences (...) with a basic grasp of procreation that includes sperm supplied by a male and egg supplied by a female, encountering Lucretius’ verses on women contributing semen (semina) to the process of conception can be surprising (4.1209–62). The idea of female semen may give us pause as we calibrate it with our understanding of eggs and ovulation, but Lucretius, in his time, was not advancing some novel theory. Wading into established debates on male-only or joint male-female semen production and gendered insemination (that is, who produces semen and whose semen is active at conception), Lucretius sides with those promulgating mutuality for both questions (for example Democritus [DK 24 A13]) and rejects Aristotle's representative exclusivist claim of male activity vs female passivity (τὸ ἄρρεν ἐστὶν ὡς κινοῦν καὶ ποιοῦν, τὸ δὲ θῆλυ ὡς παθητικόν,Gen. an.729a28–30; cf. 726a30–6). That is to say, a sexually mature female, like her male counterpart, emits semen that has determining potency in the formation of a human embryo (Lucr. 4.1209–62). Although the discharge and activity of female semen is the focus of this paper, my investigation is not aQuellenforschungor historical survey of Greco-Roman ideas about women's contributions to insemination and fertility, since others have treated these matters extensively. I concentrate rather on how Lucretius employs the concept of female semen in terms of his poetics in Book 4 and what I see as an ethical argument against the domineering nature of Roman masculinity. The problem of female semen, from the point of view of Lucretius’ Roman male audience, is that it is potentially costly to men because it rivals and threatens their status from the physiological to the discursive level. Iain Lonie broaches the same issue from Greek perspectives. (shrink)

Iain Atack identifies the contribution of nonviolence to political theory through connecting central characteristics of nonviolent action to fundamental debates about the role of power and violence in politics. This in turn provides a platform for going beyond historical and strategic accounts of nonviolence to a deeper understanding of its transformative potential. From Mahatma Gandhi and Martin Luther King to toppled communist regimes in Eastern Europe and pro-democracy movements in Serbia, Georgia and Ukraine, nonviolent action has played a significant (...) role in achieving social and political change in the last century. The Arab Spring revolutions, particularly those in Tunisia and Egypt, and the Occupy movement in the US and UK demonstrate that nonviolence continues to be a vital feature of many campaigns for democracy, human rights and social justice. (shrink)

Nuclear bodies contribute to non‐random organization of the human genome and nuclear function. Using a major prototypical nuclear body, the Cajal body, as an example, we suggest that these structures assemble at specific gene loci located across the genome as a result of high transcriptional activity. Subsequently, target genes are physically clustered in close proximity in Cajal body‐containing cells. However, Cajal bodies are observed in only a limited number of human cell types, including neuronal and cancer cells. Ultimately, Cajal body (...) depletion perturbs splicing kinetics by reducing target small nuclear RNA (snRNA) transcription and limiting the levels of spliceosomal snRNPs, including their modification and turnover following each round of RNA splicing. As such, Cajal bodies are capable of shaping the chromatin interaction landscape and the transcriptome by influencing spliceosome kinetics. Future studies should concentrate on characterizing the direct influence of Cajal bodies upon snRNA gene transcriptional dynamics.Also see the video abstract here. (shrink)

ABSTRACTJohn Harris suggests that participation in or support for research, particularly medical research, is a moral duty. One kind of defence of this position rests on an appeal to the past, and produces two arguments. The first of these arguments is that it is unfair to accept the benefits of research without contributing something back in the form of support for, or participation in, research. A second argument is that we have a social duty to maintain those practices and institutions (...) that sustain us, such as those which contribute to medical knowledge. This argument is related to the first, but it does not rely so heavily on fairness. Another kind of defence of the duty to research rests on an appeal to the future benefits of research: research is an effective way to discharge a duty to rescue others from serious illness or death, therefore we have a duty to research. I suggest that all three of Harris' lines fail to provide a compelling duty to research and spell out why. Moreover, not only do the lines of argument fail in their own terms: in combination, they turn out to be antagonistic to the very position that Harris wants to defend. While it is not my intention here to deny that there might be a duty to research, I claim that Harris' argument for the existence of such a duty is not the best way to establish it. (shrink)

In Questioning Technology, Feenberg accuses Heidegger of an untenable 'technological essentialism'. Feenberg's criticisms are addressed not to technological essentialism as such, but rather to three particular kinds of technological essentialism: ahistoricism, substantivism, and one-dimensionalism. After these three forms of technological essentialism are explicated and Feenberg's reasons for finding them objectionable explained, the question whether Heidegger in fact subscribes to any of them is investigated. The conclusions are, first, that Heidegger's technological essentialism is not at all ahistoricist, but the opposite, an (...) historical conception of the essence of technology which serves as the model for Feenberg's own view. Second, that while Heidegger does indeed advocate a substantivist technological essentialism, he offers a plausible, indirect response to Feenberg's voluntaristic, Marcusean objection. Third, that Heidegger's one-dimensional technological essentialism is of a non-objectionable variety, since it does not force Heidegger to reject technological devices in toto. These conclusions help vindicate Heidegger's ground-breaking ontological approach to the philosophy of technology. (shrink)

In Kant and the Role of Pleasure in Moral Action, Iain Morrisson offers a new view on Kant’s theory of moral action.

Galen in a celebrated passage remarks that there were three ‘choirs’, in early Greek medicine: the choirs of Cos, of Cnidus, and of Sicily. The word is vague and suggestive, and we do well to keep it so. If we look in the Hippocratic Corpus for schools of medical theory, with distinct sets of doctrine marked off clearly from the doctrines of rival schools, we shall be lucky indeed if we can find them, and, having found them, succeed in convincing (...) others of their existence. But we shall find, now and again, an individual voice proclaiming itself from among its impersonal surroundings with clarity and vigour: some treatises in the collection have their author's personality stamped on them as distinctly as on a work of art. (shrink)

Cultural historian Iain McCalman tells the stories of Charles Darwin and his most vocal supporters and colleagues: Joseph Hooker, Thomas Huxley, and Alfred Wallace. Beginning with the somber morning of April 26, 1882--the day of Darwin's funeral--Darwin's Armada steps back in time and recounts the lives and scientific discoveries of each of these explorers. The four amateur naturalists voyaged separately from Britain to the southern hemisphere in search of adventure and scientific fame. From Darwin's inaugural trip on the Beagle (...) in 1835 through Wallace's exploits in the Amazon and Malaysia in the 1840s and 1850s, each man independently made discoveries that led him to embrace Darwin's groundbreaking theory of evolution. This book reveals the untold story of Darwin's greatest supporters who, during his life, campaigned passionately in the war of ideas over evolution and who lived on to extend and advance the scope of his work.--From publisher description. (shrink)

Science is continually faced with describing that which is beyond. This book, through contributions from nine prominent scholars, tackles that challenge.

Heidegger, Art, and Postmodernity offers a radical new interpretation of Heidegger's later philosophy, developing his argument that art can help lead humanity beyond the nihilistic ontotheology of the modern age. Providing pathbreaking readings of Heidegger's 'The Origin of the Work of Art' and his notoriously difficult Contributions to Philosophy, this book explains precisely what postmodernity meant for Heidegger, the greatest philosophical critic of modernity, and what it could still mean for us today. Exploring these issues, Iain D. Thomson examines (...) several postmodern works of art, including music, literature, painting and even comic books, from a post-Heideggerian perspective. Clearly written and accessible, this book will help readers gain a deeper understanding of Heidegger and his relation to postmodern theory, popular culture and art. (shrink)

ABSTRACT:This article addresses the fundamental question of what is ethical leadership by rearticulating relations between leaders and followers in terms of “affective leadership.” The article develops a Spinozian conception of ethics which is underpinned by a deep suspicion of ethical systems that hold obedience as a primary virtue. We argue that the existing research into ethical leadership tends to underplay the ethical capacities of followers by presuming that they are in need of direction or care by morally superior leaders. In (...) contrast, affective leadership advocates a profoundly political version of ethics, which involves people in the pursuit of joyful encounters that augment our capacity to affect and be affected by others. Instead of being led by people in leadership positions, we are led by active affections that enhance our capacity for moral action. (shrink)

This article develops Thomson’s post-Heideggerian view that ontological education is centrally concerned with disclosing being creatively and responsibly. To disclose being creatively and responsibly is to realize the meaning of being, developing our historical understanding of what being means along with our consequent understanding of what it means for us to be, both communally and in the many facets of our own individual lives. As ontological educators, we disclose our own being by becoming who we are, which we do best (...) by learning-in-public, that is, by ‘teaching learning’. In the teaching and learning that belong together in ontological education, we come into our own by helping others to come into their own as well. Thomson explains and develops the crucially meaningful difference between creatively and responsibly disclosing inchoate meanings, on the one hand, and technologically imposing pre-existing plans and ideas, on the other. Responding to five recent essays on Heidegger allows Thomson to elaborate a non-nihilistic way of understanding education, teaching, learning, and being in our late-modern age of increasing technology. This article thereby articulates and embodies some of the important educational possibilities opened up by a more genuinely meaningful postmodern understanding of being. (shrink)

The digitisation of academic journals has created the technical possibility that research can be made available to any interested party free of charge. This possibility has been undermined by the proprietary control that commercial publishers exercise over the majority of this material. The control of commercial publishers over publicly-funded research has been criticised by charitable bodies, politicians and academics themselves. While the existing critical literature on academic publishers has considerable value, it fails to link questions of control within the journal-industry (...) to the wider restructuring of economic and social relations that has taken place over the last three decades. This article seeks to complement this literature by highlighting how broader profitability pressures and the subsequent attempts by state-managers to expand the social space for capitalist accumulation have structured the development of the journal-industry. (shrink)

This article examines the development of Heidegger's philosophical views on university education, situates these views within their broader historical and philosophical context, and shows them to be largely responsible for Heidegger's decision to become the first Nazi Rector of Freiburg University in 1933. Did Heidegger learn from this appalling political misadventure and so transform the underlying philosophical views that helped motivate it? It is argued, against the interpretations of Pöggeler and Derrida, that the later Heidegger continued to develop and refine (...) the core of these philosophical views rather than abandoning them after 1933. (shrink)

In this article I address some questions concerning the emerging conjunction of musical research on improvisation and work in the ‘posthumanities’, in particular the theoretical results of the ‘ontological turn’ in the humanities. Engaging with the work of the composer John Cage, and George E. Lewis’s framing of Cage’s performative indeterminacy as a ‘Eurological’ practice that excludes ‘Afrological’ jazz improvisation, I examine how critical discourse on Cage and his conception of sound is relevant to the improvisation-posthumanities conjunction. After discussing some (...) criticisms of ontological and materialist approaches to sound, I consider the Actor-Network Theory (ANT) of Bruno Latour, posed as offering an alternative to these approaches. Following an examination of some limitations to ANT based around the themes of critique and abstraction, I draw from the work of Gilles Deleuze and Georgina Born to suggest that work on improvisation and the posthumanities may be fruitful, but must be part of a pluralistic mode of inquiry that does not reject critique and abstraction, as some work in the posthumanities has done. (shrink)

Heidegger is now widely recognized as one of the most influential and controversial philosophers of the twentieth century, yet much of his later philosophy remains shrouded in confusion and controversy. Restoring Heidegger's understanding of metaphysics as 'ontotheology' to its rightful place at the center of his later thought, this book demonstrates the depth and significance of his controversial critique of technology, his appalling misadventure with Nazism, his prescient critique of the university, and his important philosophical suggestions for the future of (...) higher education. It will be required reading for those seeking to understand the relationship between Heidegger's philosophy and National Socialism, as well as the continuing relevance of his work. (shrink)

The Commission on Assisted Dying was an unofficial body set up to investigate the legal position on assisted dying in the UK in the autumn of 2010. Its report was published to some degree of media attention in the first week of January 2012; its most headline-grabbing suggestion provided a framework setting out how British law might be reformed to allow assisted dying for the terminally ill. In this paper, I analyse some of the key points of the report and (...) argue that it adds little that could settle – or even add to – the assisted dying debate. (shrink)

Chemokines (chemotactic cytokines) drive and direct leukocyte traffic. New evidence suggests that the unusual CCR6/CCL20 chemokine receptor/ligand axis provides key homing signals for recently identified cells of the adaptive immune system, recruiting both pro‐inflammatory and suppressive T cell subsets. Thus CCR6 and CCL20 have been recently implicated in various human pathologies, particularly in autoimmune disease. These studies have revealed that targeting CCR6/CCL20 can enhance or inhibit autoimmune disease depending on the cellular basis of pathogenesis and the cell subtype most affected (...) through different CCR6/CCL20 manipulations. Here, we discuss the significance of this chemokine receptor/ligand axis in immune and inflammatory functions, consider the potential for targeting CCR6/CCL20 in human autoimmunity and propose that the shared evolutionary origins of pro‐inflammatory and regulatory T cells may contribute to the reason why both immune activation and regulation might be controlled through the same chemokine pathway. (shrink)

`I would encourage undergraduates students to read it, for it does summarise well a classical Marxist analysis of social policy and welfare' - Social Policy The anti-capitalist movement is increasingly challenging the global hegemony of neo-liberalism. The arguments against the neo-liberal agenda are clearly articulated in Rethinking Welfare. The authors highlight the growing inequalities and decimation of state welfare, and use Marxist approaches to contemporary social policy to provide a defence of the welfare state. Divided into three main sections, the (...) first part of this volume looks at the growth of inequality, and social and environmental degradation. Part Two centres on the authors' argument for the relevance of core Marxists concepts in aiding our understanding of social policy. This section includes Marxist approaches to a range of welfare issues, and their implications for studying welfare regimes and practices. Issues covered include: · Class and class struggle · Opression · Alienation and the family The last part of the book explores the question of globalization and the consequences of international neo-liberalism on indebted countries as well as the neo-liberal agenda of the Conservative and New Labour governments in Britain. The authors conclude with the prospect of an alternative welfare future which may form part of the challenge against global neo-liberalism. (shrink)

Elizabeth A. Kaye specializes in communications as part of her coaching and consulting practice. She has edited Requirements for Certification since the 2000-01 edition.

Martin Heidegger (1889-1976) is widely considered one of the most original and important philosophers of the 20th century, and, thanks to his (failed) attempt to assume philosophical leadership of the century’s most execrable political movement (Nazism) and his later critique of the history of metaphysics from Anaximander to Nietzsche as inherently nihilistic, he is also certainly the most controversial.

Preface to paperback edition -- Why Schelling? why naturephilosophy? -- The powers due to becoming: the reemergence of platonic physics in the genetic philosophy -- Antiphysics and neo-Fichteanism -- The natural history of the unthinged -- "What thinks in me is what is outside me". phenomenality, physics and the idea -- Dynamic philosophy, transcendental physics -- Conclusion: transcendental geology.

When beginning to think about the relation between experimental music and the thought of Gilles Deleuze, this quotation seems to be a natural starting point. In Deleuze and Guattari’s affirmation of this phrase from John Cage they suggest a resonance between music and philosophy: in both fields the experimental approach entails a dismantling of predetermining codes and hierarchies, and with this arises the opportunity for an open-endedness that accommodates singular events and encounters. This understanding of experimentation, however, is not as (...) transparent as it seems. In the context of the uptake and critique of Deleuzian ideas in the theorisation of music and sound, as well as recent re-evaluations of the milieu of “experimental music,” critics have argued that a range of normative demands, ideological assumptions, and metaphysical reductions undermine the purported freedoms of both Cagean and Deleuzian experimentalism. -/- Here I can only deal with a small aspect of the wide historical and theoretical problem this involves; but in short my aim is to begin to construct a means through which Deleuze and Guattari’s thought can be used to help us examine some strategies that composers and performers in post-Cagean musical experimentalism developed to navigate around the demands, assumptions, and reductions of Cage’s thought. (shrink)

This paper investigates the difficulties of creating economic, social, and environmental values when operating as a hybrid venture. Drawing on hybrid organizing and sustainable business model research, it explores the implications of alternative forms of business model experimented with by farmer owned, fairtrade social enterprise Cafédirect. Responding to changes and challenges in the market and societal environment, Cafédirect has tried multiple business model innovations to deliver on all three forms of value capture, with differing levels of success. This longitudinal case (...) study, therefore, provides a contribution to our understanding of how business models enact hybrid mission, providing a platform for triple-bottom-line value capture. In doing so, we are able to expand on the normative understandings of integrating hybrid objectives, and the complications of multiple types of value capture. (shrink)

In 2005, John Harris published a paper in the Journal of Medical Ethics in which he claimed that there was a duty to support scientific research. With Sarah Chan, he defended his claims against criticisms in this journal in 2008. In this paper I examine the defence, and claim that it is not powerful. Although he has established a slightly stronger position, it is not clear that the defence is sufficiently strong to show that there is a duty to support (...) scientific research. Important questions about fairness, about rescue, and about the relationship between reasons and obligations to act can still be raised; and these questions are important enough to destabilize the defence. (shrink)

Once the preserve of philosophy and theology, what Weber called `the problem of theodicy' - the problem of reconciling normative ideals with the reality in which we live - recurs in the social sciences in the secular form of `sociodicy'. Within a functionalist framework, sociodicies have offered legitimizing rationalizations of social adversities, inequalities and injustice, but seldom address the existential meaning and ethical implications of human affliction and suffering in social life. We suggest that an apparent indifference to these questions (...) in social theory reflects a deeper tension between modernity's millennial expectations of moral progress and the escalating history of violence, exploitation and suffering in the modern world. The task of sociodicy, we argue, should be reconstructed as a critique of the decivilizing implications of this tension, not just to document the consequences of suffering on people's lives, but in order to reassess the experience of modernity at the end of one of the most disturbed and violent centuries the world has known. (shrink)

At the intersection of metaphysics and social theory, this book presents and examines Adorno's unusual concept of possibility and aims to answer how we are to articulate the possibility of a redeemed life without lapsing into a vague and naïve utopianism.

Employee buy-in is a key factor in ensuring small- and medium-size enterprise (SME) engagement with corporate social responsibility (CSR). In this exploratory study, we use participant observation and semi-structured interviews to investigate the way in which three fair trade SMEs utilise human resource management (and selection and socialisation in particular) to create employee engagement in a strong triple bottomline philosophy, while simultaneously coping with resource and size constraints. The conclusions suggest that there is a strong desire for, but tradeoff within (...) these companies between selection of individuals who already identify with the triple bottomline philosophy and individuals with experience and capability to deal with mainstream brand management – two critical employee attributes that appear to be rarely found together. The more important the business experience to the organisation, the more effort the organisation must expend in formalising their socialisation programmes to ensure employee engagement. A key method in doing this is increasing employee knowledge of, and affection for, the target beneficiaries of the CSR programme (increased moral intensity). (shrink)