Many bacteria that cause disease have the capacity to enter into and live within eukaryotic cells such as epithelial cells and macrophages. The mechanisms used by these organisms to achieve and maintain this intracellular lifestyle vary considerably, but most mechanisms involve subversion and exploitation of host cell functions. Entry into non‐phagocytic cells involves triggering host signal transduction mechanisms to induce rearrangement of the host cytoskeleton, thereby facilitating bacterial uptake. Once inside the host cell, intracellular pathogens either remain within membrane bound (...) inclusions or escape to the cytoplasm. Those living in the cytoplasm can further pirate the host actin system, using actin as a mechanism to facilitate movement within and between host cells. Organisms remaining within the vacuole have specialized mechanisms for intracellular survival and growth which involve additional communication with the host cell. Some of the processes involved in the various steps of facultative intracellular parasitism are discussed in the context of subverting the host cell cytoskeleton and signal transduction pathways for bacterial benefit. (shrink)

La meva intenció en les pàgines següents és analitzar la teoria del llenguatge que es troba en el Cràtil de Plató. D'una banda, s'analitza la concepció del significat de les paraules quePlató sembla defensar en aquest diàleg; de l'altra, s'ocupa del problema dels orígens delllenguatge. Aquestes qüestions s'estudien en relació amb la perspectiva ontològica i epistemològicade Plató: essencialisme, teoria de la reminiscència i les tesis dels sofistes sobre laimpossibilitat de parlar amb falsedat. La conclusió és que en el Cràtil podem (...) trobar ja la preparació de la teoria del llenguatge que Plató necessitarà per a la seva ulterior teoria de les idees. (shrink)

Ikhwān al-Ṣafāʼ ; Islamic philosophy ; Islam -- Doctrines.

Articles on the understanding of philosophy with special reference to Islamic teachings; includes theories of noted philosophers.

Tradit︠s︡ionnai︠a︡ ėpistemologii︠a︡ i eë problemy -- Ot tradit︠s︡ionnoĭ ėpistemologii k ėpistemologii snachala-znanii︠a︡ -- Kritika skeptit︠s︡izma i reli︠a︡tivizma -- Novye i gibridnye ėpistemologicheskie podkhody s tochki zrenii︠a︡ ėpistemologii snachala-znanii︠a︡ -- Ėpistemologicheskie problemy i kontekstualʹnyĭ realizm -- Gruppovai︠a︡ ėpistemologii︠a︡ -- Fenomenologii︠a︡, ėstetika i ėtika -- Perspektivnoe znanie -- Nauchnoe znanie v kontekste.

kn. 1. Chislo i forma v zhivoĭ prirode -- kn. 2. Iskusstvo arkhitektury.

On Islamic philosophy in the light of Koran.

The psychological side of Ukrainian spiritual music is one of its most important and defining factors, because it forms the essence through which the most important function of this music - the function of its psychological influence on the person - is carried out.

Speech comprehension across languages depends on encoding the pitch variations in frequency-modulated sweeps at different timescales and frequency ranges. While timescale and spectral contour of FM sweeps play important roles in differentiating acoustic speech units, relatively little work has been done to understand the interaction between the two acoustic dimensions at early cortical processing. An auditory oddball paradigm was employed to examine the interaction of timescale and pitch contour at pre-attentive processing of FM sweeps. Event-related potentials to frequency sweeps that (...) vary in linguistically relevant pitch contour and timescale in Mandarin Chinese were recorded. Mismatch negativities were elicited by all types of sweep deviants. For local timescale, FM sweeps with F0 contours yielded larger MMN amplitudes than F1 contours. A reversed MMN amplitude pattern was obtained with respect to F0/F1 contours for global timescale stimuli. An interhemispheric asymmetry of MMN topography was observed corresponding to local and global-timescale contours. Falling but not rising frequency difference waveforms sweep contours elicited right hemispheric dominance. Results showed that timescale and pitch contour interacts with each other in pre-attentive auditory processing of FM sweeps. Findings suggest that FM sweeps, a type of non-speech signal, is processed at an early stage with reference to its linguistic function. That the dynamic interaction between timescale and spectral pattern is processed during early cortical processing of non-speech frequency sweep signal may be critical to facilitate speech encoding at a later stage. (shrink)

Issledovanii︠a︡ Ekateriny Ilʹinichny Li︠a︡pushkinoĭ (1963-2018), literaturoveda, istorika russkoĭ literatury, dot︠s︡enta Sankt-Peterburgskogo gosudarstvennogo universiteta, obnaruzhivai︠u︡t nei︠a︡vnye smysly klassicheskikh tekstov. Prochtenie proizvedeniĭ Goncharova, Turgeneva, Dostoevskogo, Nabokova osnovyvaetsi︠a︡ na teorii literaturnoĭ germenevtiki. Teoreticheskie shtudii i praktika interpretat︠s︡ii realizui︠u︡t dialektiku ponimanii︠a︡ v obʺi︠a︡snenii︠a︡, to estʹ nalichie germenevticheskogo kruga, opredeli︠a︡i︠u︡shchee kompozit︠s︡ii︠u︡ predlagaemogo izdanii︠a︡.