Phosphatidylinositol 5‐phosphate (PtdIns5P), the least characterized among the three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in the control of several cellular functions. Similar to PtdIns3P, it is present in low amounts in mammalian cells, and can be detected at the plasma membrane and endomembranes as well as in the nucleus. Changes in PtdIns5P levels are observed in mammalian cells following specific stimuli or stresses, and in human diseases. Recently, the contribution of several enzymes such as PIKfyve, myotubularins, (...) and type II PtdInsP‐kinases to PtdIns5P metabolism has gained a strong experimental support. Here, we provide a picture emerging from recent studies showing how this lipid can be generated and act as a regulator of membrane and cytoskeleton dynamics, and as a modulator of gene expression. We briefly summarize the current methods and tools for studying PtdIns5P, and discuss how PtdIns5P can integrate and coordinate different functions in a spatiotemporal manner. (shrink)

The maze and the masses -- Democracy as the rule of the dumb many? -- A selective genealogy of the epistemic argument for democracy -- First mechanism of democratic reason: inclusive deliberation -- Epistemic failures of deliberation -- Second mechanism of democratic reason: majority rule.

The purpose of this paper is to draw attention to a similarity between an ancient and a modern theory of living nature. There is no need to present the Aristotelian doctrine in full detail. I must rather apologize for repeating much that is well known. My endeavour is to offer it for comparison, and, incidentally, to clear it from misrepresentation. Uexküll's theory, on the other hand, is little known, and what is given here is an insufficient outline of it. I (...) do not maintain that either doctrine is right. I am fully aware that the problem of the essence of living nature by no means admits of an éasy solution. In offering for consideration the comparison contained in this paper I would go no farther than owning my belief that the two authors here discussed, both thinkers who combine an intensely philosophical outlook with a wide biological experience, are worth the attention not only of the historian of science and philosophy, but also of the student of philosophical biology. (shrink)

This paper takes stock of a recent but growing movement within the field of deliberative democracy, which normatively argues for the epistemic dimension of democratic authority and positively defends the truth-tracking properties of democratic procedures. Authors within that movement call themselves epistemic democrats, hence the recognition by many of an ‘epistemic turn’ in democratic theory. The paper argues that this turn is a desirable direction in which the field ought to evolve, taking it beyond the ‘fact of disagreement’ that had (...) previously blocked the conceptual road to acknowledging more than intrinsic properties to democratic decision procedures. The paper shows how two authors in particular – Joshua Cohen and David Estlund – have successfully lifted the Rawlsian requirement of epistemic abstinence and defends epistemic democrats and the implications of the epistemic turn in democratic theory against various misconceptions. (shrink)

ABSTRACTThe idea that the crowd could ever be intelligent is a counterintuitive one. Our modern, Western faith in experts and bureaucracies is rooted in the notion that political competence is the purview of the select few. Here, as in my book Democratic Reason, I defend the opposite view: that the diverse many are often smarter than a group of select elites because of the different cognitive tools, perspectives, heuristics, and knowledge they bring to political problem solving and prediction. In this (...) essay I defend my epistemic argument against proceduralist democrats; the value of model thinking against empiricists; the bracketing of fundamental value diversity against critics who see such diversity as an essential feature of politics; the intelligence of the masses in the face of voter ignorance and systematic biases; and the normative priority of democracy over market mechanisms. I also consider challenges to my use of Hong and Page's formal results, the epistemically proper selection method for representatives, and the role of deliberation in problem solving. I finally chart three avenues for further research. (shrink)

In Insister, Hlne Cixous brings a unique mixture of theoretical speculation, breath-taking textual explication and scholarly erudition to an extremely close reading of Derrida's work, always attentive to the details of his thinking. At the same time, Insister is an extraordinarily poetic meditation, a work of literature and of mourning for Jacques Derrida the person, who was a close friend and accomplice of Cixous's from the beginning of their careers.

Who can say "I am Jewish?" What does "Jew" mean? What especially does it mean for Jacques Derrida, founder of deconstruction, scoffer at boundaries and fixed identities, explorer of the indeterminate and undecidable? In _Portrait of Jacques Derrida as a Young Jewish Saint_, French feminist philosopher Hélène Cixous follows the intertwined threads of Jewishness and non-Jewishness that play through the life and works of one of the greatest living philosophers. Cixous is a lifelong friend of Derrida. They both grew (...) up as French Jews in Algeria and share a "belonging constituted of exclusion and nonbelonging"--not Algerian, rejected by France, their Jewishness concealed or acculturated. In Derrida's family "one never said 'circumcision'but 'baptism,'not 'Bar Mitzvah'but 'communion.'" Judaism cloaked in Catholicism is one example of the undecidability of identity that influenced the thinker whom Cixous calls a "Jewish Saint." An intellectual contemporary of Derrida, Cixous's ideas on writing have an affinity with his philosophy of deconstruction, which sought to overturn binary oppositions--such as man/woman, or Jew/non-Jew--and blur boundaries of exclusion inherent in Western thought. In portraying Derrida, Cixous uses metonymy, alliteration, rhyme, neologisms, and puns to keep the text in constant motion, freeing language from any rigidity of meaning. In this way she writes a portrait of "Derrida in flight," slipping from one appearance to the next, unable to be fixed in one spot, yet encompassing each point he passes. From the circumcision act to family relationships, through Derrida's works to those of Celan, Rousseau, and Beaumarchais, Cixous effortlessly merges biography and textual commentary in this playful portrait of the man, his works, and being (or not being) Jewish. (shrink)

This book combines loosely "autobiographical" texts by two of the most influential French intellectuals of our time. "Savoir," by Hélène Cixous is an account of her experience of recovered sight after a lifetime of severe myopia; Jacques Derrida's "A Silkworm of One's Own" muses on a host of motifs, including his varied responses to "Savoir.".

Le volume 46 de la série des EAD se présente comme le premier tome de la publication de l’Artémision principal de Délos, qui en comprendra au moins un autre. Il est le résultat d’une collaboration de longue date entre Christian Llinas, disparu en 2011, Philippe Fraisse et Jean-Charles Moretti à qui revient le choix de l’organisation de la publication. Elle commence par une première partie qui forme une introduction générale à l’étude de l’architecture de l’Artémision, qui sert à l’étude du (...) te... (shrink)

This article is another unapologetic contribution to ‘the gentle art of rational choice bashing’. The debate over rational choice theory (RCT) may appear to have tired out; yet RCT is as dominant in political sciences as ever. The reason is that critics typically take aim at the symptoms of RCT’s failings, rather than their root cause: RCT’s very ambition of being the ‘science of choice’. In this article I argue that RCT fails twice, first as a science of choice and (...) then as a science of choice. Both failures suggest that political sciences need an epistemologic (re)conversion away from the Platonic ideal of a deductive and universal science of choice toward a more inductive and pluralist paradigm. While advocates of RCT rightly insist that ‘you can’t beat something with nothing’, I take their advice, with a grain of salt: in order for alternatives to appear, the frame of references needs to be modified. I draw a few perspectives for the political sciences. (shrink)

Consensus plays an ambiguous role in deliberative democracy. While it formed the horizon of early deliberative theories, many now denounce it as an empirically unachievable outcome, a logically impossible stopping rule, and a normatively undesirable ideal. Deliberative disagreement, by contrast, is celebrated not just as an empirically unavoidable outcome but also as a democratically sound and normatively desirable goal of deliberation. Majority rule has generally displaced unanimity as the ideal way of bringing deliberation to a close. This article offers an (...) epistemic perspective on this question of consensus versus disagreement. For ensuring the production of better decisions, we argue, the normative appeal of consensus varies depending on the deliberative task – whether it entails problem solving or prediction. We argue that in pure problem-solving contexts, consensus retains a strong normative appeal and forms the ideal deliberative outcome of deliberation. In contrast, on predictive tasks, consensus should generally not be used as a stopping rule noris it likely to be epistemically desirable as an outcome. Instead deliberators may be better served by ending the deliberation with a form of deliberative disagreement we call ‘positive dissensus’, which paves the way for more accurate aggregate predictions. (shrink)

Nation and liberty: two ideas that in spite of the innumerable works that have been devoted to them are still open to new approaches, indeed, to new definitions. They pose a problem whose essence is to remain without a definitive answer, to be always actual, because it concerns man of all times, all countries and all conditions. This apparently-simple remark raises a question: is it possible to put nation and liberty on the same level? It is permissible to consider liberty (...) and nation as a pair forming a new concept, or do we simply have a relationship located in a precise time at a given place? (shrink)

Introduction: We discuss Carol Gilligan's original concept of mature care in the light of the altruistic approach to caring and good clinical judgment. Discussion: In particular, we highlight how the concept of mature care can capture important challenges in today's nursing. Further, we illuminate how mature care might differ normatively from an altruistic approach to caring and the traditional prudential virtues in nursing. We also discuss similarities between mature care and virtue ethics. Conclusion: For nursing and nurses' identity, in today's (...) health care system that is increasingly pressured to ‘produce' health, we believe it is important to both developing further theories on mature care and having normative discussions about care. (shrink)

Cette étude introductive se constitue de deux parties. La première partie présente brièvement le contexte de recherche ainsi que les principaux enjeux du volume ; la seconde partie propose un bref résumé de chacun des articles.

Le tableau de Nicolas Poussin, Paysage avec un homme tué par un serpent (ou Les effets de la terreur), demeure énigmatique pour toute une critique qui oscille entre deux pôles : soit le tableau est mythologique, mais on ne sait pas à quelle histoire il renvoie (l’hypothèse de Cadmus n’étant guère soutenable) ; soit le tableau ne représente que les effets de la terreur, sans renvoyer à aucune histoire. La thèse défendue dans cet article est la suivante : tout en (...) représentant les effets de la terreur, le tableau renvoie à une histoire – non celle de Cadmus, mais celle de Narcisse, cet homme qui meurt près de la source qui le captive, prisonnier de l’amour vain qu’il se porte à lui-même. On se propose d’étayer cette thèse par la découverte de remarquables liens entre Narcisse et Python, non seulement à partir de l’œuvre poétique d’Ovide, mais encore à partir de l’œuvre picturale de Poussin. (shrink)

This book uncovers and explores the constant tension between the historical and the transcendental that lies at the heart of Michel Foucault's work. In the process, it also assesses the philosophical foundations of his thought by examining his theoretical borrowings from Kant, Nietzsche, and Heidegger, who each provided him with tools to critically rethink the status of the transcendental. Given Foucault's constant focus on the question of the possibility for knowledge, the author argues that his philosophical itinerary can be understood (...) as a series of attempts to historicize the transcendental. In so doing, he seeks to uncover a specific level that would identify these conditions without falling either into an excess of idealism or of materialism. The author concludes that, although this problem does unify Foucault's work and gives it its specifically philosophical dimension, none of the concepts successively provided manages to name these conditions without falling into the pitfalls that Foucault originally denounced as characteristic of the "anthropological sleep"--various forms of confusion between the historical and the transcendental. Although Foucault's work provides us with a highly illuminating analysis of the major problems of post-Kantian philosophies, ultimately it remains aporetic in that it also fails to overcome them. (shrink)

ArgumentThis paper studies the evolution of mathematics teaching in France and Germany from 1900 to about 1980. These two countries were leading in the processes of international modernization. We investigate the similarities and differences during the various periods, which showed to constitute significant time units and this in a remarkably parallel manner for the two countries. We argue that the processes of reform concerning the teaching of this major school subject are not understandable from within mathematics education or even within (...) the school system. Rather, the evolution of the processes of reform prove to be intimately tied to changing conceptions of modernity according to respective social and cultural values and to changing epistemological conceptions of mathematics. It is particularly novel that we show the key impact of the changing social status of primary schooling for these modernization processes. (shrink)

ML-HCAs have the potential to significantly change an entire healthcare system. It is not even necessary to presume that this will be disruptive but sufficient to assume that the mere adaptation of...

Pickering & Garrod's (P&G's) framework assumes an efference copy based on the interlocutor's intentions. Yet, elaborate attribution of intentions may not always be necessary for online prediction. Instead, contextual cues such as speaker gaze can provide similar information with a lower demand on processing resources.

This entry provides a presentation of grammar according to its early modern sense, as the art of speaking a particular language, as well as of the universal grammar of this period, whose scope is theoretical and which transcends any particular language.

Trade secret theft is a problem that almost all organizations face. The greatest threat is employee mobility and potential unethical post-employment behavior. This study investigates the role of individual personality traits in judgments about trade secret misappropriation. Our hypotheses were tested in three studies addressing three different situational contexts: current employees, employees about to be laid off, and students who had quit their job. Relationships were estimated with robust regression. The results show that some personality traits predict judgment about another (...) person's trade secret misappropriation, and that the situational context in which individuals formulate their ethical judgment moderates the impact of personality traits on ethical judgment. (shrink)

_Three Steps on the Ladder of Writing_ is a poetic, insightful, and ultimately moving exploration of 'the strange science of writing.' In a magnetic, irresistible narrative, Cixous reflects on the writing process and explores three distinct areas essential for 'great' writing: _The School of the Dead_--the notion that something or someone must die in order for good writing to be born; _The School of Dreams_--the crucial role dreams play in literary inspiration and output; and _The School of Roots_--the importance of (...) depth in the 'nether realms' in all aspects of writing. Cixous's love of language and passion for the written word is evident on every page. Her emotive style draws heavily on the writers she most admires: the Brazilian novelist Clarice Lispector, the Russian poet Marina Tsvetaeva, the Austrian novelists Ingeborg Bachmann and Thomas Bernhard, Dostoyevsky and, most of all, Kafka. (shrink)

Shepard's (1994) choice of kinematic geometry to support his theory is questioned by Todorovic, Schwartz, and Hecht. His theoretical framework, however, can be applied to another domain that may be less susceptible to some of their concerns. The domain is the representation of spatial layout. [Hecht; Schwartz; Shepard; Todorovic].

La scolastique tardive, au début du XVIIe siècle, est le théâtre d’un débat sur la définition du signe, qui se traduit par la division entre signum formale et signum instrumentale. Le premier est l’écho de la tendance médiévale à comprendre les concepts comme des signes. Le second correspond à une définition qui remonte à Augustin, selon laquelle le signe est une chose sensible qui doit être connue pour porter à la connaissance de quelque chose d’autre. Se démarquant de la voie (...) qui avait fait de la seule Logique de Port-Royal le paradigme de la pensée sémiotique de l’Âge classique, cet ouvrage montre, à partir de ce débat scolastique, que le XVIIe siècle se caractérise globalement par une translatio, visible notamment chez Bayle, Gassendi et Hobbes, d’un modèle linguistico-psychologique à une sémiotique emblématique d’une mutation de la logique désormais ordonnée vers l’épistémologie. (shrink)

This commentary implicates the neostriatum in the production of the EEG sleep spindle and in the processing of motor procedural learning in sleep. Whether the sleep spindle may implement not only the consolidation-based enhancement of procedural learning, but also its initial consolidation, is considered; as is the fit between (1) corticostriatal anatomy and physiology, and (2) the physical properties of the sleep spindle.

"I used to feel guilty at night. I live in, I always used to live in two countries, the diurnal one and the continuous very tempestuous nocturnal one.... What a delight to head off with high hopes to night's court, without any knowledge of what may happen! Where shall I be taken tonight! Into which country? Into which country of countries?"--Hélène Cixous, from _Dream I Tell You_ For years, Hélène Cixous has been writing down fragments of her dreams (...) immediately after awaking. In _Dream I Tell You_, she collects fifty from the past ten years. Cixous's accounts of her dreamscapes resist standard psychoanalytic interpretations and reflect her lyrical, affecting, and deeply personal style. The dreams, reproduced in what Cixous calls both their "brute and innocent state," are infused with Cixous's humor, wit, and sense of playfulness. Dreams have always been a crucial part of Cixous's writing. They are her archives and it is with them that she writes. Without dreaming, Cixous writes, "I would crumble to dust." As in many of her other texts, Cixous's mother, father, daughter, and friends populate this work, which offers artistic and provocative meditations on the themes of family, death, and resurrection. Scenes of a daily life-getting a haircut, caring for her child, preparing for work-become beautifully and evocatively skewed in Cixous's dreams. She also writes of dreams, both amusing and unsettling, in which she spends an evening with Martin Heidegger, has her lunch quietly interrupted by a young lion, flees the Nazis, and tours Auschwitz. The "you" of the title is fellow philosopher and friend Jacques Derrida, to whom these texts are addressed. The book reflects on many of the subjects the two grappled with in their work and in conversation: the deconstruction of psychoanalysis, literary production, subjectivity, sexual difference, and the question of friendship. (shrink)

NIMBY (Not In My Backyard) refers to an oppositional attitude from local residents against some risk generating facility that they have been chosen to host either by government or industry. The attitude is claimed to be characteristic of someone who is positive to a facility but who wants someone else to be its host. Since siting cannot be provided if everyone has this attitude, society ends up in a worse situation. The attitude is claimed to be egoistic and irrational. Here (...) it is argued that the NIMBY critique rests on questionable assumptions about the rightness of weighing total benefit against total cost. This weighing-principle will sometimes have to yield so that the rights of individuals can be acknowledged. (shrink)

Sur la céramique attique à figures rouges sont figurées de très nombreuses images d’athlètes se livrant à des activités variées, préparatifs avant le sport, nettoyage après le sport et actions diverses, course, saut, etc. Les athlètes sont des jeunes gens imberbes, le plus souvent, et nus. Face à cet abondant répertoire, il est difficile de trouver des images de femmes impliquées dans des activités sportives. À Athènes, le monde du sport n’est sûrement pas fermé aux jeunes filles, mais les i...

Background In bioethics, especially nursing ethics, systematic reviews are increasingly popular. The overall aim of a systematic review is to provide an overview of the published discussions on a specific topic. While a meta-review on systematic reviews on normative bioethical literature has already been performed, there is no equivalent for systematic reviews of empirical literature on ethical topics. Objective This meta-review aims to present the general trends and characteristics of systematic reviews of empirical bioethical literature and to evaluate their reporting (...) quality. Research design Literature search was performed on PubMed and Google Scholar. Qualitative content analysis and quantitative approaches were used to evaluate the systematic reviews. Characteristics of systematic reviews were extracted and quantitatively analyzed. The reporting quality was measured using an adapted PRISMA checklist. Findings Seventy-six reviews were selected for analysis. Most reviews came from the field of nursing (next to bioethics and medicine). Selected systematic reviews investigated issues related to clinical ethics (50%), followed by research ethics (36%) and public health ethics or organizational ethics (14%). In all, 72% of the systematic reviews included authors’ ethical reflections on the findings and 59% provided ethical recommendations. Despite the heterogeneous reporting of the reviews, reviews using PRISMA tended to score better regarding reporting quality. Discussion The heterogeneity currently observed is due both to the interdisciplinary nature of nursing ethics and bioethics, and to the emerging nature of systematic review methods in these fields. These results confirm the findings of our previous review of systematic reviews on normative literature, thereby highlighting a recurring methodological gap in systematic reviews of bioethical literature. This also indicates the need to develop more robust methodological standards. Conclusion Through its extensive overview of the characteristics of systematic reviews of empirical literature on ethical topics, this meta-review is expected to inform further discussions on minimal standards and reporting guidelines. (shrink)

Par leur engagement dans la Résistance, les femmes du Midi méditerranéen ont témoigné d'une conscience civique et politique qu'on aurait pu croire plus contrariée par les traditions culturelles locales. Mais à l'intérieur de cet ensemble géographique, ni la condition des femmes, ni les missions et les risques assumés par les résistantes n'apparaissent identiques : un parallèle entre des régions comme le Languedoc et la Corse montre que les motivations et les tâches y ont été sensiblement différentes ; et il donne (...) deux exemples de la hiérarchie entre les sexes dans les milieux résistants du Midi. (shrink)