A particular model of scientific achievement is embedded within the Nobel Prize, one that privileges the scientific `loner', whoachieves a distinct discovery at a particularmoment in time. A common criticism of this`individualistic' story of achievement is thatit obscures the social and cultural factors inscientific discovery. A collective story,highlighting the role of social relations andscientific milieux, may offer more explanatorypower in accounting for scientific discoveriesand inventions. This paper explores the processby which Henry Dale became recognized as thediscoverer of the (...) chemical transmission ofnerve impulses. It compares the explanatorypower of the story of individual creativitywith a story that highlights the interactionbetween a scientist and his environment. (shrink)

This collection gathers a set of central papers from the emerging area of ethics and climate change.

The role of the Nobel Laureate Henry Dale in the history of allergy and the association of anaphylactic conditions with the liberation of histamine is often overlooked. This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning. It also assesses the impact of his working environment, especially the unique conditions he enjoyed at the beginning of the twentieth century in the Wellcome Physiological Research (...) Laboratories . The WPRL belonged to the pharmaceutical manufacturer Henry Wellcome, and it was the juxtaposition of the routine commercial obligation of testing drugs for Burroughs, Wellcome & Co., with the opportunities of pursuing unfettered physiological research in well-equipped and supported laboratories, that resulted in what Dale referred to as ‘happy accidents’ when one set of results suggested experimental strategies and designs to another circumstance. In this way an observation of an unusual effect of an extract of ergot of rye led to collaborative chemical and physiological explorations which revealed the presence of histamine, previously known only as a synthetic product. Further work, accidentally facilitated by the fact that the WPRL produced serum anti-toxins commercially and surplus horse serum was used in experiments where other physiologists routinely used saline, hinted that histamine played a role in the symptom complex known as anaphylaxis. This paper explores some of these themes and elaborates their significance. (shrink)

The role of the Nobel Laureate Henry Dale (1875-1968) in the history of allergy and the association of anaphylactic conditions with the liberation of histamine is often overlooked. This paper examines his work in this field in the broader context of his researches into endogenous mediators of normal physiological and abnormal pathological functioning. It also assesses the impact of his working environment, especially the unique conditions he enjoyed at the beginning of the twentieth century in the Wellcome Physiological (...) Research Laboratories (WPRL). The WPRL belonged to the pharmaceutical manufacturer Henry Wellcome, and it was the juxtaposition of the routine commercial obligation of testing drugs for Burroughs, Wellcome & Co., with the opportunities of pursuing unfettered physiological research in well-equipped and supported laboratories, that resulted in what Dale referred to as 'happy accidents' when one set of results suggested experimental strategies and designs to another circumstance. In this way an observation of an unusual effect of an extract of ergot of rye led to collaborative chemical and physiological explorations which revealed the presence of histamine, previously known only as a synthetic product. Further work, accidentally facilitated by the fact that the WPRL produced serum anti-toxins commercially and surplus horse serum was used in experiments where other physiologists routinely used saline, hinted that histamine played a role in the symptom complex known as anaphylaxis. This paper explores some of these themes and elaborates their significance. (shrink)

A collection of seminal articles in climate ethics and climate justice.

English interpretations, appropriations, and transpositions of the figure of Don Quixote play a pivotal role in eighteenth-century constructions of so-called English national character. A corpus of quixotic narratives worked to reinforce the centrality of Don Quixote and the practice of quixotism in the national literary landscape. They stressed the man from La Mancha’s eccentricity and melancholy in ways inextricable from English self-constructions of these traits.2 This is why Stuart Tave is able to write that eighteenth-century Britons could “recast” Don Quixote (...) in a fashion that followed “national pride” in the “freedom” of their humors.1 However, Don Quixote’s integral place in patriotic self-constructions was troubled by gender. While national character was construed as masculine by default, quixotism’s association with masculinity was complicated by the potential passive penetrability of quixotism and the proliferation of narratives about female quixotic readers. This essay will analyze these tensions. Henry Fielding’s Joseph Andrews (1742) and Laurence Sterne’s Tristram Shandy (1759–67) are key examples of quixotic texts that respond to the figure of the female quixote by interrogating the relationship between Englishness, masculinity, and quixotism. (shrink)

Utilitarianism, the approach to ethics based on the maximization of overall well-being, continues to have great traction in moral philosophy and political thought. This Companion offers a systematic exploration of its history, themes, and applications. First, it traces the origins and development of utilitarianism via the work of Jeremy Bentham, John Stuart Mill, Henry Sidgwick, and others. The volume then explores issues in the formulation of utilitarianism, including act versus rule utilitarianism, actual versus expected consequences, and objective versus subjective (...) theories of well-being. Next, utilitarianism is positioned in relation to Kantianism and virtue ethics, and the possibility of conflict between utilitarianism and fairness is considered. Finally, the volume explores the modern relevance of utilitarianism by considering its practical implications for contemporary controversies such as military conflict and global warming. The volume will be an important resource for all those studying moral philosophy, political philosophy, political theory, and history of ideas. (shrink)

This rich and varied collection of essays addresses some of the most fundamental human questions through the lenses of philosophy, literature, religion, politics, and theology. Peter Augustine Lawler and Dale McConkey have fashioned an interdisciplinary consideration of such perennial and enduring issues as the relationship between nature and history, nature and grace, reason and revelation, classical philosophy and Christianity, modernity and postmodernity, repentance and self-limitation, and philosophy and politics.

Henri Bergson se za svého života těšil velké popularitě. Přes jistý ústup ze slávy jeho filosofie i v druhé polovině dvacátého století inspirovala např. Gillese Deleuze. Nicméně analytická filosofie Bergsonovi dosud mnoho pozornosti nevěnovala. Ačkoli na první pohled skutečně s analytickou filosofií nemá mnoho společného, najdeme v jeho díle některé myšlenky, které by si zasloužily, aby je analytická filosofie zhodnotila. Zaměříme se na Bergsonovo pojetí špatně položených otázek, které je v mnohém podobné pojetí logických pozitivistů. Dále navrhneme, v čem může (...) spočívat jeho přínos pro teorii pravidel a normativistickou teorii významu. Obě témata jsou zde především programaticky nastíněna, jejich hlubší rozpracování je úkol pro další práci. (shrink)

By 1910 the Cambridge University physiology department had become the kernel of British physiology. Between 1909 and 1914 an astonishing number of young and talented scientists passed through the laboratory. The University College department was also a stimulating place of study under the dynamic leadership of Ernest Starling.I have argued that the reasons for this metropolitan axis within British physiology lie with the social structure of late-Victorian and Edwardian higher education. Cambridge, Oxford, and University College London were national institutions attracting (...) students from all over England and Wales. In contrast, the provincial colleges drew their clientele from relatively narrow geographic radii. Generally, also, these institutions were regarded as socially inferior to the longer-established universities.A brief survey of the biographies of some British physiologists demonstrates how physiology, as an occupation, became, over the later decades of the century, socially elite. The scientists who achieved full-time posts in the 1870s generally came from somewhat marginal backgrounds. Foster, like his mentors T. H. Huxley and William Sharpey, came from a non-conformist family. Edward Schäfer was also a dissenter and, like Foster, began his professional career as a general practitioner.Physiologists of the succeeding generation, however, came from wealthy families with established intellectual traditions. John Scott Haldane, nephew of John Burdon Sanderson, was the brother of the politician R. B. Haldane and uncle of the historian A. R. B. Haldane.71 Joseph Barcroft was one of the most affluent of all physiologists.72 His family's wealth derived from linen manufacturing. He attended the Ley's School Cambridge, where his schoolmates included Henry Dale, later Director of the National Institute for Medical Research; F. A. Bainbridge, who eventually became Professor of Physiology at St. Bartholomew's Hospital; and the Cambridge historian J. H. Clapham. A. V. Hill, Professor of Physiology at Manchester and, subsequently, London, married Margaret Keynes, sister of John Maynard Keynes and niece of Sir Walter Langdon Brown, Professor of Physic at Cambridge. Margaret Keynes's younger brother, the surgeon Sir Geoffrey Keynes, married a granddaughter of Charles Darwin; their son Richard Keynes also became a physiologist at Cambridge.These families were part of a new class emerging during the late Victorian period, descendants of the great reforming radicals of the 1830s, who had begun to achieve power through positions in the universities, the professions, and the civil service. Their social prestige rested upon their intellectual expertise. Physiology was an appealing research discipline to these groups because of its clear dissociation from industry and commerce. And because physiology's “practical” face was medicine, its acceptability was reinforced by professional ties.The nature of the Physiological Society confirms this image of physiology as an elite science. By the turn of the century the Society had taken on some of the characteristics of a dining club. The scientific meetings were generally followed by dinner: if the Society met at Oxford, they were entertained at Burdon Sanderson's college, Magdalen.73 Through a “black ball” system, unwanted candidates could be excluded. In 1912, when the question of admitting foreigners was discussed, E. H. Starling wrote to Edward Schäfer: “the Society has very much in it the nature of a club, and a certain amount of personal knowledge of the candidate is always desirable.”74.The developing institutional structure of physiology in late Victorian Britain indicates, therefore, that we must look beyond the achievements of individuals and departments to understand why physiology flourished. The discipline became part of a new social order in which the professional middle classes assumed increasing power. These groups valued intellectual skill, especially in the pure scienes, as forces both for self-advancement and for progress within society. (shrink)

Like the cracking of the genetic code and the creation of the atomic bomb, the discovery of how the brain's neurons work is one of the fundamental scientific developments of the twentieth century. The discovery of neurotransmitters revolutionized the way we think about the brain and what it means to be human yet few people know how they were discovered, the scientists involved, or the fierce controversy about whether they even existed. The War of the Soups and the Sparks tells (...) the saga of the dispute between the pharmacologists, who had uncovered the first evidence that nerves communicate by releasing chemicals, and the neurophysiologists, experts on the nervous system, who dismissed the evidence and remained committed to electrical explanations. The protagonists of this story are Otto Loewi and Henry Dale, who received Nobel Prizes for their work, and Walter Cannon, who would have shared the prize with them if he had not been persuaded to adopt a controversial theory (how that happened is an important part of this history). Valenstein sets his story of scientific discovery against the backdrop of two world wars and examines the fascinating lives of several scientists whose work was affected by the social and political events of their time. He recounts such stories as Loewi's arrest by Nazi storm troopers and Dale's efforts at helping key scientists escape Germany. The War of the Soups and the Sparks reveals how science and scientists work. Valenstein describes the observations and experiments that led to the discovery of neurotransmitters and sheds light on what determines whether a novel concept will gain acceptance among the scientific community. His work also explains the immense importance of Loewi, Dale, and Cannon's achievements in our understanding of the human brain and the way mental illnesses are conceptualized and treated. (shrink)

A feminist study of language and its rules argues that men have shaped it in order to instill their own prejudices and viewpoints on society, and shows how male-slanted language affects all women's lives.

The negative consequences of physicians' failure to establish and maintain personal relationships with patients are at the heart of the humanistic crisis in medicine. To resolve this crisis, a new model of doctor-patient interaction is proposed, based on the ideas of Martin Buber's philosophy of dialogue. This model shows how the physican may successfully combine the personal (I-Thou) and impersonal (I-It) aspects of medicine in three stages. These Three Stages of Medical Dialogue include:1. An Initial Personal Meeting stage, which initiates (...) the doctor-patient relationship and involves mutual confirmation; 2. An Examination stage, which requires a shift from a personal to an impersonal style of interaction; 3. An Integration Through Dialogue or Healing Through Meeting Stage, which involves the integration of the impersonal medical data into the ongoing dialogue between doctor and patient, as a basis for shared decision-making. The use of the model, as well as common failures of doctor-patient dialogue are discussed. (shrink)

It is often claimed that all acts of supererogation involve sacrifice. This claim is made because it is thought that it is the level of sacrifice involved that prevents these acts from being morally required. In this paper, I will argue against this claim. I will start by making a distinction between two ways of understanding the claim that all acts of supererogation involve sacrifice. I will then examine some purported counterexamples to the view that supererogation always involves sacrifice and (...) examine their limitations. Next, I will examine how this view might be defended, building on comments by Dale Dorsey and Henry Sidgwick. I will then argue that the view and the argument in favor of it should be rejected. I will finish by showing how an alternative explanation for the limits of moral obligation avoids the problems facing The Sacrifice View. (shrink)

Many diseases and disease symptoms still lack effective treatment. At the same time, certain controversial Schedule I drugs, such as heroin and cannabis, have been reputed to have considerable therapeutic potential for addressing significant medical problems. Yet, there is a paucity of U.S. clinical studies on the therapeutic uses of controlled drugs. For example, people living with HIV/aids experience a variety of disease- and medication-related symptoms. Their chronic pain is intense, frequent, and difficult to treat. Nevertheless, clinical trials of compassionate (...) management for their chronic symptoms, which should be a research priority, are stymied. Stakeholders’ Views on Barriers to Research on Controlled Substances Evelyn Rhodes, Michael Andreae, Tyler Bourgiose, Debbie Indyk, Rosamond Rhodes, and Henry Sacks We employed qualitative methods to develop an understanding of the barriers to research on potential therapeutic uses of Schedule I drugs so that they might be addressed. We elicited the perspectives of key stakeholder groups that would be involved in such studies: people living with HIV/aids, clinicians, and members of institutional review boards. As we identified obstacles to research, we found that all of the stakeholder groups arrived at the same conclusion, that clinical research on the therapeutic potential of these drugs is ethically required. (shrink)

Henry Brooks Adams (February 16, 1838 - March 27, 1918) was an American historian and member of the Adams political family, being descended from two U.S. Presidents.As a young Harvard graduate, he was secretary to his father, Charles Francis Adams, Abraham Lincoln's ambassador in London, a posting that had much influence on the younger man, both through experience of wartime diplomacy and absorption in English culture, especially the works of John Stuart Mill. After the American Civil War, he became (...) a noted political journalist who entertained America's foremost intellectuals at his homes in Washington and Boston.In his lifetime, he was best known for his History of the United States During the Administrations of Thomas Jefferson and James Madison, a 9-volume work, praised for its literary style.His posthumously published memoirs, The Education of Henry Adams, won the Pulitzer Prize and went on to be named by the Modern Library as the top English-language nonfiction book of the 20th century.A LETTER TO AMERICAN TEACHERS OF HISTORY. It proposes a "theory of history" based on the second law of thermodynamics and the principle of entropy, which essentially states that all energy dissipates, order becomes disorder, and the earth will eventually become uninhabitable. He applied the physics of dynamical systems of Rudolf Clausius, Hermann von Helmholtz, and William Thomson to the modeling of human history. (shrink)

A collection of essays and lectures from Henry Steele Commager, one of America's eminent historians. The focus is on the age of enlightenment, with particular attention to Thomas Jefferson, and how enlightenment philosophy shaped the birth of the United States.

Rousseau preceded Sade: Rousseau (1712–1778) published most of his major works in two remarkably fecund years, 1761–17621; Sade (1740–1814) published most of his major texts between 1791 and 18012;...

AESTHETIC RELATIVITY Among the philosophical disciplines logic has the reputation of rigid and complete finality. It has been pronounced by no lesser..

Journal of Social Philosophy, EarlyView.

In this work Henry Kyburg presents his views on a wide range of philosophical problems associated with the study and practice of science and mathematics. The main structure of the book consists of a presentation of Kyburg's notions of epistemic probability and its use in the scientific enterprise i.e., the effort to modify previously adopted beliefs in the light of experience. Intended for cognitive scientists and people in artificial intelligence as well as for technically oriented philosophers, the book also (...) provides a general overview of the philosophy of science for the non-philosopher by one of the leading authorities in the field. (shrink)

Your Essential How-To Guide for Self-Healing The greatest medical breakthrough in recent years isn’t the creation of a new drug or treatment—it’s the discovery of how much your mind affects your health. With Your Power to Heal, Dr. Henry Grayson offers a treasury of techniques and insights to help you harness the mindbody connection. “When we can identify and change the inner voices that keep us feeling powerless,” writes Dr. Grayson, “we can go beyond treating just symptoms or relying (...) on doctors to fix us. We have far greater potential to heal than we realize.” In this practical guidebook, Dr. Grayson presents life-changing insights and effective tools anyone can use, including: • The new physics of healing—the ever-expanding body of research that reveals our untapped capacity for self-healing • Simple tips to nip many symptoms in the bud as they start • Self-assessment questionnaires to help you locate and change subconscious beliefs and disturbances • The Emotional Freedom Technique for resolving trauma and restoring your vitality • Thought Field Therapy to clear the blockages in your body’s energy system that are impeding health • Why therapy, diets, and exercise regimens often fail—and how to make them succeed You don’t need years of meditation practice to use your mind to improve your health. Your Power to Heal is an invaluable resource to help you harness the power of your own thoughts, transform illness at its source instead of just alleviating symptoms, and start taking charge of your health today. (shrink)

It is sometimes thought that the renowned essayist Isaiah Berlin was incapable of writing a big book. But in fact he developed some of his most important essays--including "Two Concepts of Liberty" and "Historical Inevitability"--from a book-length manuscript that he intended to publish but later set aside. Published here for the first time, Political Ideas in the Romantic Age is the only book in which Berlin lays out in one continuous account most of his key insights about the history of (...) ideas in the period that he made his own--the Romantic age. Distilling his formative early work in the history of ideas, the book also contains much that is not found elsewhere in his writings. The last of Berlin's posthumous books, it is of great interest both for his treatment of the subject and for what it reveals about his intellectual development. Written for a series of lectures at Bryn Mawr College in 1952, and heavily revised and expanded by Berlin afterward, the book argues that the political ideas of the Romantic age are still largely our own--down to the language and metaphors they are expressed in. Vividly expounding the central political ideas of leading European thinkers in the period 1760-1830, including Helvetius, Condorcet, Rousseau, Saint-Simon, Hegel, Schelling, and Fichte, the book is written in Berlin's characteristically accessible style. The book has been carefully prepared by Berlin's longtime editor Henry Hardy, and Joshua L. Cherniss provides an illuminating introduction that sets it in the context of Berlin's life and work. (shrink)