Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)

Hank Greely’s target article, “Human Brain Surrogates Research: The Onrushing Ethical Dilemma” reviews the manifold scientific and ethical questions surrounding models of human brains used i...

In October 2022, I had the privilege of joining Hank Greely on the opening panel of the annual International Neuroethics Society (INS) meeting in Montréal, Tiohtiá:ke, situated on the traditional t...

Peter Hanks defends a new theory about the nature of propositional content, according to which the basic bearers of representational properties are particular mental or spoken actions. He explains the unity of propositions and provides new solutions to a long list of puzzles and problems in philosophy of language.

Direct-to-Consumer genomics has been a controversial topic for over a decade. Much work has been done on the legal issues it raises. This article asks a different question: What will DTC genomics and its legal issues look like in ten to twenty years? After discussing the five current uses of DTC genomics, it describes three current legal issues: medical uses, privacy of genomic information, and privacy in collection and analysis of human DNA. It then suggests that changes in human genomics (...) and how it is used will make the first of those DTC genomics legal issues less important in the future, but that the third will be increasingly significant. (shrink)

In this paper I defend an account of the nature of propositional content according to which the proposition expressed by a declarative sentence is a certain type of action a speaker performs in uttering that sentence. On this view, the semantic contents of proper names turn out to be types of reference acts. By carefully individuating these types, it is possible to provide new solutions to Frege’s puzzles about names in identity- and belief-sentences.

The authors examine the scientific possibility and the legal and ethical implications of using DNA forensic technology, through partial matches to DNA from crime scenes, to turn into suspects the relatives of people whose DNA profiles are in forensic databases.

Human brain research is moving into a dilemma. The best way to understand how the human brain works is to study living human brains in living human beings, but ethical and legal standards make it d...

Propositions, the abstract, truth-bearing contents of sentences and beliefs, continue to be the focus of healthy debates in philosophy of language and metaphysics. This article is a critical survey of work on propositions since the mid-90s, with an emphasis on newer work from the past decade. Topics to be covered include a substitution puzzle about propositional designators, two recent arguments against propositions, and two new theories about the nature of propositions.

I have been involved with the current interest in de‐extinction since early 2012, nearly its beginning. I have given a lot of thought to the potential risks and benefits of de‐extinction. But only recently, after deep immersion in discussions around CRISPR‐Cas9, the hottest new tool in bioscience since polymerase chain reaction, have I thought about a more fundamental question: how, if at all, is de‐extinction special? Are “revived species” just another kind of genetically modified organism, raising essentially the same general (...) concerns? I answer, for the most part, yes. De‐extinction is not (very) special. New biotechnologies are giving humans even more power to change the biosphere but more directly, more quickly, and more utterly than ever before. De‐extinction is just one possible, and probably small, use of those technologies. Our attention, for the most part, should be on the bigger issues of regulating this power, rather than focusing specifically on their application to de‐extinction. (shrink)

In the 1330s Roger Swyneshed formulated a solution to semantic paradoxes based on the distinction between correspondence with reality and self-falsification as truth-making factors. Since Swyneshed states that some valid inferences are not truth-preserving, his view implies the question of the general definition of validity which he does not address explicitly. Logical works attributed to Paul of Venice contain developments of Swyneshed's contextualist semantics substantially modified by the assumption that sentential meanings are objective propositional entities. The main goals of this (...) paper are to show the correlations between the ontological and logical developments of Swyneshed's semantics in the works of Paul of Venice and to outline a context-sensitive formal semantics that could serve as a model of this family of semantic theories. (shrink)

The conference where this article was originally presented solicited recommendations for the “right questions” to ask regarding education and technology. The author of this article suggests that we already know what the right questions are for illuminating technology and its social meaning. What the author wants to know is why those questions in fact are not being asked more widely—why is widespread disinclination to enter explicit deliberation on the proper place of technology so resilient? Langdon Winner uses the term “technological (...) somnambulism” to describe the predominant stance toward technology in our culture, that “we so willingly sleepwalk through the process of reconstituting the conditions of human existence” via the adoption of new technologies. The basic institutional and ideological forces shaping the development and use of technology are not mysterious. But, scrutiny of those forces remains limited to a relative handful of academics and activists. How can technological somnambulism be countered? (shrink)

Geary suggests that implicit mathematical principles exist across human cultures and transcend sex differences. Is such knowledge present in animals as well, and is it sufficient to account for performance in all species, including our own? I attempt to trace the implications of Gearys target article for comparative psychology, questioning the exclusion of “subitizing” in describing human mathematical performance, and asking whether human researchers function as cultural agents with animals, elevating their implicit knowledge to secondary domains of numerical performance.

True revolutions turn the entire world upside down, in ways expected and surprising, profound and mundane. The revolution spawned by advances in molecular biology is no exception. Most of the attention has gone, deservedly, to the possible effects of these advances on medicine, on society, and on our understanding of what it means to be human. But the revolution has already had effects—large and small, good and bad—in other areas. This paper analyzes one aspect of the industry created by that (...) revolution in molecular biology–biotechnology. Specifically, it surveys the various kinds of conflicting interests, both real and perceived, that develop among commercial enterprises, government, and institutions in biotechnology; and it examines the legal implications and public policy concerns of these conflicting interests.The paper focuses on three different kinds of conflicting interests that confront private and public enterprises competing or collaborating in the biotechnology industry: those among businesses involved within the industry; those in relationships between industry and government; and those in relationships between industry and universities. These types of conflicts raise very different issues, but each stems from circumstances unique to the young biotechnology industry. (shrink)

In 1913 Wittgenstein raised an objection to Russell’s multiple relation theory of judgment that eventually led Russell to abandon his theory. As he put it in the Tractatus, the objection was that “the correct explanation of the form of the proposition, ‘A makes the judgement p’, must show that it is impossible for a judgement to be a piece of nonsense. (Russell’s theory does not satisfy this requirement,” (5.5422). This objection has been widely interpreted to concern type restrictions on the (...) constituents of judgment. I argue that this interpretation is mistaken and that Wittgenstein’s objection is in fact a form of the problem of the unity of the proposition. (shrink)

Although the terms ‘poles’, ‘bipolar’, and ‘bipolarity’ do not appear in the Tractatus, it is widely held that Wittgenstein maintained his commitment to bipolarity in the Tractatus. As it is usually understood, the principle of bipolarity is that every proposition must be capable of being true and capable of being false, which rules out propositions that are necessarily true or necessarily false. Here I argue that Wittgenstein was committed to bipolarity in the Tractatus, but getting a clear view of this (...) commitment requires a different understanding of bipolarity. Properly understood, bipolarity is the view that every proposition represents two possible states of affairs, one positive and the other negative. Of course, in the case of elementary propositions, the sense of a proposition is only the positive state of affairs. There is thus an asymmetry between what a proposition represents, its true-false poles, and what it says, its sense. In this paper I show how Wittgenstein accounted for this asymmetry in Notes on Logic and I consider two ways he might have accounted for it in the Tractatus. (shrink)

This chapter explores the questions “What policy tools do we have to deal with human biological enhancements?” as well as “What policy tools do we need?.” After discussing the policy tools available in the United States, it examines their adequacy in coping with human biological enhancements in two respects – how easy they would be to adopt and how easy they would be to enforce. In each category, three major issues raised by human biological enhancement are considered: safety, coercion, and (...) fairness. It looks first at the adoption of, then at the enforcement of, policy tools available in the United States to cope with three real problems raised by such enhancements. It concludes that some policy tools needed to deal with enhancement already exist but need to be better focused. New legislation is the most direct way for the federal government to implement policy, but it is rarely easy. (shrink)

The problem of logical omniscience breaks down to the problems of the closure of knowledge under implication and of the distribution of knowledge over implication. In late medieval scholasticism these two related issues were engaged in various genres, in particular in general analysis of validity, games of obligationes, solution to self-referential antinomies and semantics of terms. The present study analyses the corpus of fourteenth-century texts with some overreaches to the subsequent two centuries, attempting to cover representatives of both the “British” (...) and the “Continental” tradition. With some degree of simplification, this results in a range of four basic positions: 1. knowledge is closed under “analytic entailment” (Buridan), 2. knowledge distributes over implication (Heytesbury), 3. knowledge distributes over implication provided that its consequent’s truth is being taken into consideration (Peter of Mantua), 4. knowledge does not distribute overimplication (Wyclif). (shrink)

_ Source: _Volume 55, Issue 4, pp 273 - 306 Jan Dullaert was a direct student of John Mair and a teacher of Gaspar Lax, Juan de Celaya, and Juan Luis Vives. His commentary on Aristotle’s _Peri Hermeneias_ addresses the foundations of propositional logic, including a detailed analysis of conditionals and the semantics of logical connectives. Dullaert’s propositional logic is limited to the immediate implications of the semantics of these connectives, i.e., their introduction and elimination rules. In the same context, (...) he discusses several alternative treatments of semantic paradoxes, paying most attention to the approaches derived from Martin Le Maistre and John Mair. (shrink)

Martin Le Maistre , also known as Martinus Magistri, was one of the nominalists at the university of Paris from the watershed between medieval and postmedieval scholasticism. This influential logician, moral philosopher and theologian wrote a repeatedly edited treatise on logical consequence Tractatus consequentiarum. The present paper focuses on this treatise where Le Maistre, influenced by late-medieval logicians, develops a theory of validity based upon postulating abstract compound entities as sentential meanings.

Higher-order theories of consciousness come in many varieties, but all adopt the 'transitivity principle' as a central, explanatory premise. The transitivity principle states that a mental state of a subject is conscious if and only if the subject is aware of it. This higher-order awareness is realized in different ways in different forms of higher-order theory. I argue that empirical studies of metacognition have falsified the transitivity principle by showing that there can be awareness of a mental state without that (...) state's becoming conscious. I present two such studies in detail and argue that the measures they employ cannot be interpreted in a way that would make the results compatible with higher-order theory. Since all versions of the theory rely on the transitivity principle, this entails that all forms of higher-order theory are false. (shrink)