Cilia are unique eukaryotic organelles and exhibit remarkable conservation across evolution. Nevertheless, very different types of configurations are encountered, raising the question of their evolution. Cilia are constructed by intraflagellar transport (IFT), the movement of large protein complexes or trains that deliver cilia components to the distal tip for assembly. Recent data revealed that IFT trains are restricted to some but not all nine doublet microtubules in the protist Trypanosoma brucei. Here, we propose that restricted positioning of IFT trains could (...) offer potent options for cilia to evolve towards more complex (addition of new structural elements like in spermatozoa) or simpler configuration (loss of some elements like in primary cilia), and therefore be a driver of cilia diversification. We present two hypotheses to explain how IFT trains could be restricted to some doublets, either by a triage process taking place at the basal body level or by the development of molecular differences between ciliary microtubules. (shrink)

Could there have been nothing? is the first book-length study of metaphysical nihilism - the claim that there could have been no concrete objects. It critically analyses the debate around nihilism and related questions about the metaphysics of possible worlds, concrete objects and ontological dependence.

In a departure from the tradition of the Neoplatonic commentators of the Organon, the sequence of summaries in the insert two treatises between the Prior Analytics and the Posterior Analytics, namely the Resolution and the Sophistical Refutations. And even though the Tal30), while it. The contents of kitl and the different titles that the fahiktist), lead one to realize that it is an addition to the Prior Analytics offering a theory concerning the generation of the premisses of the syllogism, something (...) that may have appeared to Alfarabi as missing from Kits. (shrink)

This book is an account of the important influence on the development of mathematical logic of Charles S. Peirce and his student O.H. Mitchell, through the work of Ernst Schroder, Leopold Lowenheim, and Thoralf Skolem. As far as we know, this book is the first work delineating this line of influence on modern mathematical logic.

Does a concurrent cognitive task affect the dynamics of bimanual rhythmic coordination? In‐phase coordination was performed under manipulations of phase detuning and movement frequency and either singly or in combination with an arithmetic task. Predicted direction‐specific shifts in stable relative phase from 0° due to detuning and movement frequency were amplified by the cognitive task. Nonlinear cross‐recurrence analysis suggested that this cognitive influence on the locations of the stable points or attractors of coordination entailed a magnification of attractor noise without (...) a reduction in attractor strength. An approximation to these findings was achieved through parameter changes in a motion equation in relative phase. Results are discussed in terms of dual‐task performance as limited resources, dynamics rather than chronometrics, and reparameterization rather than degradation. (shrink)

Working Feminism looks at key concepts and debates within feminist theory and puts them to work concretely in relation to the real problems faced by Filipina ...

In the theoretical description of prospect theory, distinct sets of parameters can control the curvature of the value function and the shape of the probability weighting function. There is one for the gain domain and one for the loss domain. However, in most estimations, behaviour over losses is assumed to perfectly reflect behaviour over gains, through a unique set of parameters. We examine the consequences of relaxing this simplifying assumption in the context of Tanaka et al.’s (Am Econ Rev 100(1):557–571, (...) 2010) risk-elicitation procedure based on multiple price lists. We show that subjects’ behaviour for gains is mostly reflected for losses at the aggregate and individual levels, and is consistent with the distinctive prospect theory fourfold pattern. Reflection is only partial as the mean curvature of the value function is slightly less convex for losses than it is concave for gains. These results are robust to a high-stake context. However, we demonstrate that assuming reflection can have huge consequences on loss-aversion measures. Incidentally, we also highlight the existence of a strong, negative and persistent pure loss-frame effect on elicited loss aversion. We recommend that future practitioners and modellers are particularly cautious about the loss-aversion values they obtain or use because these are especially sensitive to parametric assumptions and framing. (shrink)

A printed record of the symposium held in 1971 that was sponsored by the University of California's medical campus in San Francisco and the City and County of San Francisco to examine man's destiny and moral development.

Alfred Fouillée écrit à une époque marquée par l'affrontement de la France et de l'Allemagne et par la crainte d'une déchirure de la société face à l'emprise croissante des idées révolutionnaires et au déclin irréversible des formes traditionnelles d'autorité. Ses ouvrages consacrés à la "question sociale" ont assuré sa notoriété jusqu'à en faire le "parrain intellectuel" de la Troisième République, ce qui peut aussi expliquer le relatif oubli dont il est l'objet.Pourtant la signification et la portée de l'œuvre d'Alfred Fouillée (...) ne se réduisent pas à cette dimension. Il est aussi l'auteur d'une philosophie évolutionniste de la vie dont l'idée-force est le concept central. La vie est la synthèse de la force et de l'idée, et l'évolution est le processus par lequel l'accent passe de la force à l'idée. Du vivant au social, l'idée-force devient idéal et l'évolution, initialement involontaire, devient réforme volontaire. Si elle commence avec l'égoïsme et la lutte pour la vie, l'évolution ne prend son sens que par sa fin, l'altruisme et la fraternité. C'est pourquoi la démocratie est l'idée-force en politique, même si, du fait que l'évolution requiert maintenant la volonté et la liberté, la crise est le régime normal de la démocratie, si l'ont sait voir en elle l'aiguillon qui l'incite à s'approcher de son idéal. Pages de début Introduction. Philosopher et servir son pays I. Refonder la société II. Une philosophie de l'évolution III. Unesociologie réformiste Conclusion Bibliographie complémentaire Pages de fin. (shrink)

Ces remarques sont suscitées par la lecture de l’article de Philippe Perrot. Comme lui nous récusons la dévaluation dont l’écrit, par rapport à la parole, est souvent l’objet. Mais nous pensons qu’il n’est pas nécessaire pour cela de penser « contre Platon ». Il convient toutefois de cesser de confondre « dialogue socratique » et « dialogue platonicien ». L’écriture, en ce qu’elle appelle la lecture, rend possible une forme nouvelle de dialogue : le dialogue de l’âme avec elle-même.

Pierre des Noyers, secretary of Queen of Poland Louise-Marie Gonzaga, is known for his role as a messenger, envoy, court journalist and sometimes propagandist. His work as an unofficial diplomat for the Queen and ambassador for France is less famous though no less interesting. Even though he was already quite involved in these time-consuming tasks, Pierre des Noyers also acted as a scientific intermediary for the quite curious Queen Louise-Marie of Poland. He maintained contacts with many scholars from France and (...) Italy. He could nurture this network thanks to his position as an informal diplomat at the court of the Queen and his dedication to science in general. Even by discarding his most official and political letters, his known correspondence amounts to several hundred letters written in a period of around 50 years to various friends and scholars. Roberval, Gassendi, Boulliau, Hevelius or Pascal are among these contacts and he plays for most of them the role of a scientific intermediary sharing with them observations, books and anecdotes. His letters are filled with astronomical observations, prodigies and prophecies. Des Noyers was also a practitioner of science. Having possessed a rather large collection of scientific instruments he always sought the improved ones and his daily life was marked by scientific studies. He wrote meteorological bulletins for Academia del Cimento in Florence, studied the measurement of time, observed the sun and showed interest in the inner workings of the human body. This article will delve further into more scientific aspects of Pierre des Noyers’s life, both at the court of Louise-Marie and outside. The first part presents a rough overview of the secretary’s contacts in the scientific environment of 17th Century France and how they were used to connect scholars from Poland with this environment. The second part of this work presents Pierre des Noyers’s practice of science as a tool to understand the world and for which utmost diligence in measurement and practice is required. The last part focuses on des Noyers’s application of this scientific method in two, now pseudo-scientific fields: astrology and divination. (shrink)

Historians and philosophers of science agree that Darwin had an understanding of species which led to a workable theory of their origins. To Darwin species did not differ essentially from ‘varieties’ within species, but were distinguishable in that they had developed gaps in formerly continuous morphological variation. Similar ideas can be defended today after updating them with modern population genetics. Why then, in the 1930s and 1940s, did Dobzhansky, Mayr and others argue that Darwin failed to understand species and speciation? (...) Mayr and Dobzhansky argued that reproductively isolated species were more distinct and ‘real’ than Darwin had proposed. Believing species to be inherently cohesive, Mayr inferred that speciation normally required geographic isolation, an argument that he believed, incorrectly, Darwin had failed to appreciate. Also, before the sociobiology revolution of the 1960s and 1970s, biologists often argued that traits beneficial to whole populations would spread. Reproductive isolation was thus seen as an adaptive trait to prevent disintegration of species. Finally, molecular genetic markers did not exist, and so a presumed biological function of species, reproductive isolation, seemed to delimit cryptic species better than character-based criteria like Darwin’s. Today, abundant genetic markers are available and widely used to delimit species, for example using assignment tests: genetics has replaced a Darwinian reliance on morphology for detecting gaps between species. In the 150th anniversary of The Origin of Species , we appear to be returning to more Darwinian views on species, and to a fuller appreciation of what Darwin meant. (shrink)

The author divides this work into three parts entitled: analytical therapy; yoga; and a comparison.

Neste artigo, discutiremos os limites do modelo de estabilização empregado nas operações da Organização das Nações Unidas para construção da paz de longo prazo. Nosso argumento é que a estratégia política da estabilização, por ser baseada no uso robusto da força para combater grupos armados e apoiar governos no restabelecimento da autoridade estatal, acaba perdendo de vista os esforços de resolução dos conflitos, o que, no limite, contribui para o prolongamento da violência. Metodologicamente, o artigo se baseia no estudo do (...) caso do combate ao grupo armado M23 pela MONUSCO na RDC, por meio da análise de dados e documentos que nos permitam avaliar dois aspectos principais: (i) os níveis de violência armada; e (ii) a condução de um processo político de resolução do conflito. (shrink)

Many groups of closely related species have reticulate phylogenies. Recent genomic analyses are showing this in many insects and vertebrates, as well as in microbes and plants. In microbes, lateral gene transfer is the dominant process that spoils strictly tree‐like phylogenies, but in multicellular eukaryotes hybridization and introgression among related species is probably more important. Because many species, including the ancestors of ancient major lineages, seem to evolve rapidly in adaptive radiations, some sexual compatibility may exist among them. Introgression and (...) reticulation can thereby affect all parts of the tree of life, not just the recent species at the tips. Our understanding of adaptive evolution, speciation, phylogenetics, and comparative biology must adapt to these mostly recent findings. Introgression has important practical implications as well, not least for the management of genetically modified organisms in pest and disease control. (shrink)

Cet article a déjà paru dans Justice spatiale-Spatial Justice, n° 6, juin 2014. Nous remercions Sandra Mallet de nous avoir autorisé à le reproduire ici. Le processus de néolibéralisation joue un rôle prépondérant dans la restructuration des rythmes collectifs. Un temps linéaire s'impose, redéfinissant les rythmes et provoquant un effacement des temps « secondaires », traditionnellement hors du travail et de la production. Le modèle d'une ville en continu fonctionnant 24h/24, 7j/7, interroge, ce qui - Géographie – Nouvel article.

The study of metaphysical possibility involves two central questions: What are possible worlds? Is there an empty possible world? In looking at the first question we consider the different accounts of possible worlds—Lewisian realism, ersatzism, etc. In looking at the second question we consider the discussions of metaphysical nihilism, the modal ontological arguments, etc. In this paper I am drawing these two questions together in order to show how the position we hold on one of these issues affects the position (...) we should hold on the other. (shrink)

This paper aims to contribute to intercorporeal ethics studies by enlarging their political understanding. Intercorporeal ethics revolve around the idea that, within organizations, our embodied interaction with each other is a conduit to enact genuine ethical relations of autonomy, mutual recognition, respect, care and responsibility. However, how intercorporeality can also be a means for organizations to shape and control their members’ ethical relationships in pursuit of corporate interests remains to be examined. We explore this political perspective on intercorporeality by combining (...) insights from Merleau-Ponty and Nussbaum. We analyze how the deployment of a lean management program in a financial institution produces unethical relations of objectification between employees by influencing their embodied interactions. Our study thus enlarges the political understanding of intercorporeality by showing the processes through which the embodied experience of one another is conditioned not only by our corporeal sensibility but also by managerial prescriptions. This provides a more nuanced understanding of intercorporeality as a basis to counter control and domination in organizations. (shrink)

Prisoners sometimes die in prison, either due to natural illness, violence, suicide, or a result of imprisonment. The purpose of this study is to understand deaths in custody using qualitative methodology and to argue for a comprehensive definition of death in custody that acknowledges deaths related to the prison environment. Interviews were conducted with 33 experts, who primarily work as lawyers or forensic doctors with national and/or international organisations. Responses were coded and analysed qualitatively. Defining deaths in custody according to (...) the place of death was deemed problematic. Experts favoured a dynamic approach emphasising the link between the detention environment and occurrence of death rather than the actual place of death. Causes of deaths and different patterns of deaths were discussed, indicating that many of these deaths are preventable. Lack of an internationally recognised standard definition of death in custody is a major concern. Key aspects such as place, time, and causes of death as well as relation to the prison environment should be debated and incorporated into the definition. Systematic identification of violence within prison institutions is critical and efforts are needed to prevent unnecessary deaths in prison and to protect vulnerable prisoners. (shrink)

Cet article se propose de réinterroger les relations entre le régime d’historicité « présentiste » et le régime de patrimonialité contemporain à partir de l’étude du conflit patrimonial en cours autour de l’ancien couvent Reille, situé dans le 14 e arrondissement de Paris, en attente d’un réemploi et/ou d’un projet immobilier. Cette friche est étudiée comme révélatrice de la fragilité et des apories temporelles de « l’omnipatrimonialisation », qui se caractérise par une dissociation inédite de la reconnaissance et de la (...) protection patrimoniales, par une diversification des processus de patrimonialisation et même par une nécessaire patrimonialisation par réemploi. La brèche du temps ouverte par la défonctionnalisation du couvent se trouve prolongée et élargie par un processus de patrimonialisation multiforme, mené notamment par les riverains mobilisés, et instaure, à l’occasion de la révision du plan local d’urbanisme de la Ville de Paris, un temps d’attente fructueux, propice à l’éla... (shrink)

As part of a research conducted in the field of professional didactics for the design of video-based training for saddlers, we mobilize an iterative and collaborative analysis protocol with professionals. We compare the effects produced during a debate between experts mediated by the researcher, based sometimes on a confrontation with video traces of the activity, sometimes on the temporary diagrams of a conceptual structure of the situation. Using the argumentative trilogue analysis framework, we show how these methodologies are able to (...) foster the expression of a process of conceptualization depending on whether professionals are confronted with lived images or concep-tualizations produced by the researcher. (shrink)

À l’intérieur même de la mouvance cartésienne du second xviie siècle, la notion de santé est loin d’être univoque. À l’aide des œuvres des trois « médecins cartésiens », Regius, Louis de La Forge et Daniel Duncan, auxquelles nous conférons une valeur heuristique, nous souhaitons mettre en évidence que ce foisonnement s’enracine dans l’œuvre même de René Descartes et qu’il révèle une pluralité d’orientations métaphysiques.

This paper has been explicitly composed for oral presentation: written by ear to be (read as) heard. It stages an experiment/experience ( expérience ) with sound—and in the written text with the “sight” of sound—in order to solicit and engage the becoming sens (e) of sound in the space between resonance and response-ability it seeks to explicate and explore. The presentation begins with the sound of the first few bars of a popular song (whose identity I am withholding in this (...) submission in order to preserve the integrity of the expérience upon which its success depends), which is eventually heard in its entirety and which constitutes the point of departure, reference, and return—of resonance and response-ability—for the composition as a whole. (shrink)

This article reports on a series of 5 analyses of spontaneous production of verbal inflection (tense and person–number agreement) by 2‐year‐olds acquiring French as a native language. A formal analysis of the qualitative and quantitative results is developed using the unique resources of Optimality Theory (OT; Prince & Smolensky, 2004). It is argued that acquisition of morphosyntax proceeds via overlapping grammars (rather than through abrupt changes), which OT formalizes in terms of partial rather than total constraint rankings. Initially, economy of (...) structure constraints take priority over faithfulness constraints that demand faithful expression of a speaker's intent, resulting in child production of tense that is comparable in level to that of child‐directed speech. Using the independent Predominant Length of Utterance measure of syntactic development proposed in Vainikka, Legendre, and Todorova (1999), production of agreement is shown first to lag behind tense then to compete with tense at an intermediate stage of development. As the child's development progresses, faithfulness constraints become more dominant, and the overall production of tense and agreement becomes adult‐like. (shrink)

Transformative unlearning: safety, discernment and communities of learningThis paper aims to stimulate awareness about the intellectual and emotional work of ‘unlearning’ in knowledge workers in the emerging learning age. The importance of providing a safe space for dialogue to promote transformative learning, through building ‘communities of learning’, is highlighted. Unlearning is conceptualized within a transformative education paradigm, one whose primary orientation is discernment, a personal growth process involving the activities of receptivity, recognition and grieving. The author utilizes the metaphor of (...) an unfolding spiral path to explore her experience of needing to ‘unlearn’ a trusted nursing practice prior to ‘learning’ new best caring practices related to infant sleep positions. Macro and micro approaches to facilitating unlearning in organizations, in learners and in nurses are suggested. (shrink)

The author investigates the different readings of Ibn ufayPs epistle, ayy b. Yaqan. Following a suggestion by L. Gauthier, who simply asked that the epistle should be read as a whole, the author adds alAbd al- ab r's reading, which does justice only to what Asl. This impasse in the readings of ayy b. Yaqān reveals what is missing, namely an understanding of the tale which fundamentally conforms to several of Alfarabi's teachings, though not to L. Gauthier's interpretation.

Drawing on an ethnography among Quebecois and French female new Muslims, I consider how converts epitomize and embody the “encounter” between Muslim and western societies. By choosing Islam, converts position themselves on the margins, giving them a unique perspective on the “West.” My participants’ reflexive narratives hinge on continuity/disruption dialectics that dissolve the commonly held dichotomy between Sameness and Otherness. In analyzing these narratives, I view subjectivity as a rhetorical construction and elaborate upon converts’ daily intimate encounters and dialogues with (...) Otherness in social spaces. In light of Simmel’s figure of the Stranger based on distance and proximity, I show that converts’ experiences echo the “pacific coexistence” that Muslim and European populations have experienced historically. I argue that narratives are crucial to understanding how Islam—as a political and symbolic language of Otherness—can help frame and profile emergent western subjects and identities. (shrink)

Understandings of the relationship between space, culture and belief are formative in the experience of seeking healing. This paper examines the relationship between place, healing and spirituality in the context of interdisciplinary perspectives (particularly those of the medical humanities) on healing and well-being. The paper examines places of spiritual significance and their relationship to healing in the ‘uncertain’ quest for alleviation or cure, exploring these thematics in the context of the work on the geographies of ‘therapeutic landscapes.’ Through a discussion (...) of fieldwork at two sites in Perthshire, Scotland, a framework is proposed for the investigation of therapeutic sites of spiritual significance, detailing features such as connection, renewal, reproduction, participation, alleviation and expectation. A deeper examination of sites of healing with spiritual significance, it is proposed, has the potential to develop greater understandings of the ways in which people experience illness and well-being. (shrink)

Mental health is reaching a crisis point due to the ramifications of COVID-19. In an attempt to curb the spread of the virus and circumvent health systems from being overwhelmed, governments have imposed regulations such as lockdown restrictions and home confinement. These restrictions, while effective for infection control, have contributed to poorer lifestyle behaviors. Currently, Positive Psychology and Lifestyle Medicine are two distinct but complimentary disciplines that offer an array of evidence-based approaches for promoting mental health and well-being across a (...) universal population. However, these strategies for improving mental health are typically used in isolation. This perspective calls for a new paradigm shift to create and rollout well-designed interdisciplinary universal multicomponent mental health interventions that integrates the benefits of both disciplines, and uses innovative digital mental health solutions to achieve scalability and accessibility within the limitations and beyond the COVID-19 lockdown and restrictions. (shrink)

Gwénael Murphy est spécialiste de l’histoire des religieuses et des couvents pendant la Révolution française. Ayant rencontré de nombreuses épouses maltraitées réfugiées dans des couvents dans les sources consultées, il a décidé de consacrer ses recherches à l’histoire des rapports conflictuels entre hommes et femmes dans le cadre conjugal. L’ouvrage publié est le résultat de dix-huit années de recherches. L’auteur place sa réflexion dans le temps long, en analysant des sources issues des xvi...

Cet article a déjà paru dans Espacetemps.net en avril 2013. Nous remercions Sandra Mallet de nous avoir autorisé à le republier ici. Résumé : Qu'apportent les politiques temporelles et les Bureaux des Temps dans les façons de penser l'urbanisme? Apparus en France à la fin des années 1990, l'originalité et l'intérêt de leur démarche repose sur leur volonté d'intégrer la pluralité des rythmes urbains dans l'aménagement des territoires. La prise en compte de cette pluralité s'exprime dans les actions sous (...) - Géographie – Nouvel article. (shrink)