We consider connections between number sense—the ability to judge number—and the interpretation of natural language quantifiers. In particular, we present empirical evidence concerning the neuroanatomical underpinnings of number sense and quantifier interpretation. We show, further, that impairment of number sense in patients can result in the impairment of the ability to interpret sentences containing quantifiers. This result demonstrates that number sense supports some aspects of the language faculty.

Indirect speech acts—responding “I forgot to wear my watch today” to someone who asked for the time—are ubiquitous in daily conversation, but are understudied in current neurobiological models of language. To comprehend an indirect speech act like this one, listeners must not only decode the lexical-semantic content of the utterance, but also make a pragmatic, bridging inference. This inference allows listeners to derive the speaker’s true, intended meaning—in the above dialog, for example, that the speaker cannot provide the time. In (...) the present work, we address this major gap by asking non-aphasic patients with behavioral variant frontotemporal dementia and brain-damaged controls with amnestic mild cognitive impairment to judge simple question-answer dialogs of the form: “Do you want some cake for dessert?” “I’m on a very strict diet right now,” and relate the results to structural and diffusion MRI. Accuracy and reaction time results demonstrate that subjects with bvFTD, but not MCI, are selectively impaired in indirect relative to direct speech act comprehension, due in part to their social and executive limitations, and performance is related to caregivers’ judgment of communication efficacy. MRI imaging associates the observed impairment in bvFTD to cortical thinning not only in traditional language-associated regions, but also in fronto-parietal regions implicated in social and executive cerebral networks. Finally, diffusion tensor imaging analyses implicate white matter tracts in both dorsal and ventral projection streams, including superior longitudinal fasciculus, frontal aslant, and uncinate fasciculus. These results have strong implications for updated neurobiological models of language, and emphasize a core, language-mediated social disorder in patients with bvFTD. (shrink)

Beginning with a focus on the ethical foundations of caregiving in health and expanding towards problems of ethics and justice implicated in a range of issues, this book develops and expands the notion of care itself and its connection to practice. Organised around the themes of culture as a restraint on caregiving in different social contexts and situations, innovative methods in healthcare, and the way in which culture works to position care as part of a rhetorical approach to dependency, responsibility, (...) and justice, The Ethics of Carepresents case studies examining institutional responses to end-of-life issues, the notion of informed consent, biomedicine, indigenous rights and postcolonialism in care and theoretical approaches to the concept of care. Offering discussions from a variety of disciplinary approaches, including sociology, communication, and social theory, as well as hermeneutics, phenomenology, and deconstruction, this book will appeal to scholars across the social sciences with interests in healthcare, medicine, justice and the question of how we think about care as a notion and social form, and how this is related to practice. (shrink)

This is a commentary on selected texts of Plato concerned with poetry: the Ion and relevant sections of the Republic. It is the first commentary to present these texts together in one volume, and the first in English on Republic 2 and 3 and Ion for nearly 100 years. The introduction sets Plato's views in their Greek context and outlines their influence on later aesthetic thought. An important feature of the commentary is its exploration of the ambivalence of Plato's pronouncements (...) through an analysis of his own skill as a writer. (shrink)

George Berkeley's two major works, A Treatise Concerning the Principles of Human Knowledge and Three Dialogues Between Hylas and Philonous, are presented here, together with perhaps the most searching examination his ideas received during his lifetime, that of the American Samuel Johnson, who corresponded with Berkeley during his stay in the country.

"Presents an account of the ways scientists and others have perceived life and living processes from the times of the early Greek philosophers to the twentieth century ... The book follows out several major themes in the history of biological thought. How is it possible to harmonise atomism and organism? What has happened to the concept of the soul which played so important a part in early biologies? To what extent does our technology influence our understanding of the living process? (...) These and other questions are seen as instances of a major movement in the history of biological thought: a movement from an Aristotelian to a Cartesian vision of the nature of life"--From publisher description. (shrink)

The first sustained exploration of Simondon's work to be published in English. This collection of essays, including one by Simondon himself, outlines the central tenets of Simondon's thought, the implication of his thought for numerous disciplines and his relationship to other thinkers such as Heidegger, Deleuze and Canguilhem.Complete with a contextualising introduction and a glossary of technical terms, it offers an entry point to this important thinker and will appeal to people working in philosophy, philosophy of science, media studies, social (...) theory and political philosophy.Gilbert Simondon's work has recently come to prominence in America and around the Anglophone world, having been of great importance in France for many years. (shrink)

Genetic testing can be used to determine if unexplained fractures in children could have resulted from a predisposition to bone fractures, e.g., osteogenesis imperfecta. However, uncertainty is introduced if a variant of unknown significance is identified. Proper interpretation of VUS in these situations is critical because of its influence on clinical care and in court rulings. This study sought to understand how VUS are interpreted and used by practitioners when there is a differential diagnosis including both osteogenesis imperfecta and non-accidental (...) injury.A 15-question survey was emailed to physicians who requested analysis of two genes, COL1A1 and COL1A2, from the University of Washington from 2005-2013 for patient cases involving suspicion of child abuse.Among the 89 participants, responses differed about when genetic testing should be ordered for osteogenesis imperfecta, who should be consulted about utilization of VUS test results, follow-up procedures, and who should receive the VUS results.There are no clear guidelines for how to interpret and follow up on VUS. In the legal setting, misinterpreted VUS could lead to unintended consequences and deleterious ramifications for family members. The need for better practice guidelines to help promote more equitable handling of these sensitive legal cases is clear. (shrink)

Who has what and why in our societies is a pressing issue that has prompted explanation and exposition by philosophers, politicians and jurists for as long as societies and intellectuals have existed. It is a primary issue for a society to tackle this and these answers have been diverse. This collection of essays approaches some of these questions and answers to shed light on neglected approaches to issues of distribution and how these issues have been dealt with historically, socially, conceptually, (...) and practically. The volume moves away from the more dominating and traditionally cast understandings of distributive justice and shows novel and unique ways to approach distributive issues and how these can help enlighten our course of action and thought today by creating new pathways of understanding. The editors and contributors challenge readers by exploring the role and importance of restorative justice within distributive justice, exploring the long shadow of practices of trusteeship, and concepts of social and individual rights and obligations in welfare and economic systems, social protection/provision schemes, egalitarian practices and post-colonial African political thought. Distributive Justice Debates in Political and Social Thought empowers the reader to cast a more critical and historically complete light on the idea of a fair share and the implications it has on societies and the individuals who comprise them. (shrink)

Features essays on moral philosophy written in honor of Elizabeth Flower's retirement.

Résumé: Dans ce dialogue, deux personnages principaux, Philopolis et Éleuthérios, proposent la position communautarienne et la position contractualiste libérale comme fondements de la théorie politique. Le débat se déroule, comme tout bon débat devrait le faire, autour d’une bouteille de Chardonnay.

This thesis presents an alternative method for the detection of MIMIC models. Previous methods (such as factor analysis) suffer from a number of significant aws and limitations, which the new method (a causal search algorithm) doesn't suffer. A new algorithm is introduced, followed by a worked-through example of its application. Discussion focuses on some of the limiting assumptions the algorithm currently requires. Finally, recommendations for future work address improvements of the algorithm, as well as its applicability.

TWENTIETH CENTURY PHENOMENOLOGY articulates itself in terms of both an implicit and explicit interpretation of Greek philosophy. 'Phenomenology' is not only a Greek-based word, it signifies a Greek way of thinking. Yet within this Hellenic economy two affiliated currents appear that lead, at first, to a small difference and, then, finally, to a dramatic difference in the way phenomenology relates to the Greeks. The first current is represented by Husserl whose relation I shall call the constructing one, the second by (...) Heidegger which I shall call the deconstructing one. I want to explore and contrast these relations from that perspective. To a remarkable degree, they bear a resemblance to those which open and close the nineteenth century, which is to say the first great phenomenologist, Hegel, and the first great deconstructionist, Nietzsche. According to the constructive program, the purpose of phenomenology is to carry forward philosophical thought, while revising and shifting it, in order to build and complete the edifice of Greek philosophical science. It supposes a certain archë, follows a course even as it insists on past diversions and errance [[sic]] in its pursuit, and orients itself toward a future telos. (shrink)