COVID-19 often manifests with different outcomes in different patients, highlighting the complexity of the host-pathogen interactions involved in manifestations of the disease at the molecular and cellular levels. In this paper, we propose a set of postulates and a framework for systematically understanding complex molecular host-pathogen interaction networks. Specifically, we first propose four host-pathogen interaction (HPI) postulates as the basis for understanding molecular and cellular host-pathogen interactions and their relations to disease outcomes. These four postulates cover the evolutionary dispositions involved (...) in HPIs, the dynamic nature of HPI outcomes, roles that HPI components may occupy leading to such outcomes, and HPI checkpoints that are critical for specific disease outcomes. Based on these postulates, an HPI Postulate and Ontology (HPIPO) framework is proposed to apply interoperable ontologies to systematically model and represent various granular details and knowledge within the scope of the HPI postulates, in a way that will support AI-ready data standardization, sharing, integration, and analysis. As a demonstration, the HPI postulates and the HPIPO framework were applied to study COVID-19 with the Coronavirus Infectious Disease Ontology (CIDO), leading to a novel approach to rational design of drug/vaccine cocktails aimed at interrupting processes occurring at critical host-coronavirus interaction checkpoints. Furthermore, the host-coronavirus protein-protein interactions (PPIs) relevant to COVID-19 were predicted and evaluated based on prior knowledge of curated PPIs and domain-domain interactions, and how such studies can be further explored with the HPI postulates and the HPIPO framework is discussed. (shrink)

Studies of patient decision‐making use many different measures to evaluate the quality of decisions and the decision‐making process, partly to determine whether the ethical goals of informed consent, patient autonomy, and shared decision‐making have been achieved. We describe these measures, grouped under three main approaches, and review their limitations, leading to three conclusions. First, no measure or combination of measures can provide a complete assessment of decision quality. Second, the quality of a decision is best characterized vaguely, for instance as (...) “good,” “satisfactory,” or “poor,” and these categorizations depend on qualitative judgments that go beyond quantitative measures. Third, bioethicists should focus on identifying and addressing poor or problematic decisions, rather than trying to incrementally increase decision quality, quantified by a measure. Decision‐quality measures can be useful in research and in advancing important goals of bioethics, as long as the challenges of defining and measuring decision quality are recognized. (shrink)

Food Problems and Economic Problems in America, Africa, the Middle East and Asia : Struggles and Resignation What are the various dynamics of crisis, revolt, and resignation currently operating on the American and African continents, in the Middle East and in Asia. What effects do they have on the policies adopted to “get out of the crisis”? These are the issues which Greg Albo, Kako Nubukpo, Rhina Roux, Marie Noëlle Abiyaghi and Son Youg Woo address in this article. They (...) examine the consequences of neo-liberal capitalism and the succession of crises in food, oil, finance, and in the economy, before going on to explain how they emerge in their regional contexts where they take on their specific guises. (shrink)

The question of whether donors should be able to set conditions on who can receive their tissue has been discussed by bioethicists, but so far there has been little consideration of whether the answer to this question should be different depending on the type of tissue under discussion. In this article, we compare the donation of organs with the donation of reproductive material such as sperm, eggs, and embryos, exploring possible arguments for allowing donors to set conditions in one case (...) but not the other. After considering arguments from procreative liberty, special parental obligations, and donors meeting their genetic offspring, we find that there is no ethically defensible reason to have different policies between these two cases. As a consequence, we conclude that jurisdictions operating with this inconsistency should consider moving their policies into better alignment. We also make some recommendations for the standardisation of the terminology around conditional donation. (shrink)

Here is an account of the enlightenment experience and its consequences written by a trained philosopher and mathematician who is also a master of English prose.

C.S. Peirce, the founder of pragmatism, was an American philosopher and mathematician whose influence has been enormous on the field of semiotics. Merrell uses Pierce's theories to reply to the all-important question: "What and where is meaning?".

This book presents a philosophy that includes the enlightenment experience--a philosophy grounded on the authority of direct realization resulting from transformation in consciousness.

In 2021, Canada revised its Medical Assistance in Dying (MAID) law, removing the "reasonably foreseeable death" requirement. Opponents of MAID voiced concerns about a "slippery slope" leading to broader access, with some arguing the line has already been crossed. I examine the arguments against expanded eligibility, particularly those presented by Tom Koch (2023). Koch's reasoning, I submit, is flawed, lacking nuance in its understanding of the slippery slope and relying on a problematic argument about healthcare access.

The most recent and, arguably, the most scientifically rigorous study of the healing power of intercessory prayer, the so-called “STEP” (“Study of the Therapeutic Effects of Prayer”) study involved over 1,800 subjects and roughly a decade of study. Though the results did little, if anything, to lend support to the idea that prayers really can heal the sick, religious believers might remain optimistic. Two main reasons for this optimism stem from, first, a crucial missing (though practically unavoidable) study control and, (...) second, the warning that studying the effectiveness of prayer amounts to an (improper) attempt at quantifying God’s effects in the world. And few serious religious believers will want to say that we could ever pin God down in that way and, hence, that God, in order to maintain the importance of faith in religion, would have good reason to manipulate the results of an experiment on the effectiveness of prayer (even if prayer was very effective when not formally studied). But, then, the only evidence to which prayer proponents can appeal is anecdotal. The problems associated with anecdotal evidence as support for hypotheses is discussed here (generally, as well as with respect to intercessory prayer) and, I submit, the empirical case for the healing powers of prayer is weak. (shrink)

The idea that fictions may educate us is an old one, as is the view that they distort the truth and mislead us. While there is a long tradition of passionate assertion in this debate, systematic arguments are a recent development, and the idea of empirically testing is particularly novel. Our aim in this chapter is to provide clarity about what is at stake in this debate, what the options are, and how empirical work does or might bear on its (...) resolution. We distinguish between merely influencing people’s opinions and providing genuine learning, where the latter requires that the source of the change in opinion should be reliable. Other important ideas here are the extent to which authors of fiction may be considered to provide testimony, or something like it, and the possibility of recognizing an unstated purpose in the project of the fictional work. We ask whether fictions can furnish us not merely with ideas but with reasons for believing them, perhaps by constituting thought experiments. We consider whether the focus should be on understanding rather than on knowledge, and whether fictions can inform us about the qualities of another’s experiences. We briefly describe some experimental work of recent decades and suggest that the evidence for learning from fiction is currently meagre. (shrink)

We propose capability as a universal or type intermediate between function and disposition. A capability is, broadly speaking, a disposition that is of a type whose instances can be evaluated on the basis of how well they are realized. A function, on the view we are proposing, is a capability the possession of which is the rationale for the existence of its bearer. To say for example that a water pump has the function to pump water is to say that (...) the pump exists because something was needed that would pump water. A water pump may have many capabilities, including: to be weatherproof, to run without lubricant, to be transportable, and so forth. But its function is to pump water. We focus here on capabilities possessed by humans – such as piano playing or language using – and we explore the relation between capabilities of these sorts and structures in the brain. (shrink)

This series builds on the fact that pictures are easier to memorize than words. Each topic is summarized on a single page using annotated diagrams and concise notes with a full index for easy reference. -/- Expert authors have taken the content of the AS and A Level specifications and presented them in a refreshingly clear and concise format.

In his "Materialism without Reductionism: What Materialism Does not Entail," Richard Boyd answers Kripke's challenge to materialists to come up with a way to explain away the apparent contingency of mind-brain identities. Boyd accuses Kripke of an imaginative myopia manifesting itself as a failure to realize that the more theoretical term in the identity is fixed by contingent descriptions - descriptions that might pick out otherworldly kinds of neural events where C-fibres are absent. If this is something we can confuse (...) in the imagination with actual C-fibre firings, then we have an explanation of the apparent contingency of the necessary identity 'Pain=C-fiber firings.' However, for this to succeed it must be the case that the reference of 'C-fiber firings'€™ is fixed by some contingent description, which is false. Boyd, I submit, has failed to answer Kripke'€™s challenge after all. (shrink)

In his (1977) "Anomalous Monism and Kripke's Cartesian Intuitions," Colin McGinn argues that Donald Davidson's anomalous monism is untouched by Kripke's (1980) argument against the identity theory. The type-identity of the physical with the mental may very well fall at the feet of Kripke's powerful arguments, but a token identification, argues McGinn, is left standing due to the simple fact that token physicalism countenances a kind of imagined separation of token mental states with their corresponding token physical states. If McGinn (...) is correct, a full-blooded physicalism is consistent with Kripke's Cartesian intuitions regarding the non-identity of the mental and the physical. But I think McGinn is mistaken. In particular, McGinn misunderstands the nature of an "epistemic counterpart" of a token pain. So contrary to McGinn, token physicalism does not seem to be able to defend against Kripke after all. (shrink)

Gendlin's Philosophy of the Implicit offers root concepts, and a schema derived from them, for thinking about living and experiencing in very general terms, in ways that build bridges for thinking about human experience and animal experience together. He describes living as occurring into implying - what occurs is happening into implying something helpful - and when what occurs actually is helpful he describes this as living carrying forward. His term “the implicit” points towards the complexity involved in being helpful, (...) from the standpoint of a life appreciated as a whole. His concepts support disciplined thick description of animals’ lives. Looking, for example, at passages of kangaroo mothers' living, reveals their concurrent, crossed sensitivity to grass and other food, to their young's behavior, to predators, and to what other members of their group are doing. Standard methods for researching behavior hide this complexity. Looking at animal lives from the perspective of implying creates opportunities for describing animals’ lives holistically. This creates new research opportunities, and provides new tools for practical problems like designing conservation strategies so they work from animals' perspectives. (shrink)

Last century, Michael Dummett argued that the principles of intuitionistic logic are semantically neutral, and that classical logic involves a distinctive commitment to realism. The ensuing debate over realism and anti-realism and intuitionistic logic has now receded from view. The situation is reversed in mathematics: constructive reasoning has become more popular in the twenty-first century with the rise of proof assistants based on constructive type theory. In this paper, I revisit Dummett’s concerns in the light of these developments, arguing that (...) both constructive and classical reasoning are recognizable and coherent assertoric and inferential practices. (shrink)

In the near future developments in non-invasive prenatal testing may soon provide couples with the opportunity to test for and diagnose a much broader range of heritable and congenital conditions than has previously been possible. Inevitably, this has prompted much ethical debate on the possible implications of NIPT for providing couples with opportunities for reproductive choice by way of routine prenatal screening. In view of the possibility to test for a significantly broader range of genetic conditions with NIPT, the European (...) Society of Human Genetics and American Society of Human Genetics recommend that, pending further debate, prenatal screening for reproductive choice should only be offered where concerning serious congenital conditions and childhood disorders. In support of this recommendation, the ESHG and ASHG discuss a number of ethical issues on which they prompt further debate: the informational privacy of the future child, the trivialization of abortion, the risk of information overload, and issues of distributive justice. This paper responds to this call with further reflection on each ethical issue and how it relates to the moral justification of providing couples with opportunities for meaningful reproductive choice. The paper concludes that whilst there may be good reasons for qualifying the scope of any unsolicited prenatal screening offer to serious congenital conditions and childhood disorders, if prenatal screening is justified for providing couples with opportunities for meaningful reproductive choice, then health services may have obligations to empower couples with the same opportunity where concerning other conditions. (shrink)

Thomas Polger has argued in favor of the mind-brain type-identity theory, the view that mental states or processes are type-identical to states of the central nervous system. Acknowledging that the type-materialist must respond to Kripke's modal anti-materialist argument, Polger insists that Kripke's argument rests on dubious assumptions concerning the identity conditions of brain states. In brief, Polger claims that one knows that x and y are non-identical when one knows the identity conditions for both x and y. Replace x and (...) y with 'brain states' and 'sensations' and it follows that one can know that brain states and sensations are non-identical only if one knows the identity conditions for brain states. But, according to Polger, we do not know the identity conditions for brain states. Hence, we should not be so confident that brains states and sensations are non-identical after all. But Polger's account is terribly flawed. Ironically, if Polger's skepticism is warranted, then Polger himself has no good reasons to be a type-materialist. But more importantly, Polger's skepticism regarding the identity conditions of brain states is deeply defective. We do, I submit, understand the identity conditions of brain states. In the end, I submit, Kripke is safe from Polger. (shrink)

Brief consideration of (1) Peirce’s ‘logic of vagueness’, (2) his categories, and (3) the concepts of overdetermination and underdetermination, vagueness and generality, and inconsistency and incompleteness, along with (4) the abrogation of classical Aristotelian principles of logic, bear out the complexity of all relatively rich sign systems. Given this complexity, there is semiotic indeterminacy, which suggests sign limitations, and at the same time it promises semiotic freedom, giving rise to sign proliferation the yield of which is pluralistic, inter-relational semiosis. This (...) proliferation of signs owes its perpetual flowing change in time to the inapplicability of classical logical principles, namely Non-Contradiction and Excluded-Middle, with respect to elements of vagueness and generality in all signs. Hempel’s ‘Inductivity Paradox’ and Goodman’s ‘New Riddle of Induction’ bear out the limitation and freedom of sign making and sign taking. A concrete cultural example, the Spaniards’ world including the Virgin of Guadalupe and the Aztecs world including their Goddess, Tonantzín, are given a Hempel-Goodman interpretation to reveal the ambiguous, vague, and complex nature of intercultural sign systems, further suggesting pluralism. In fact, when taking the ‘limitativetheorems’ of Gödel, Turing, and Chaitin into account, pluralism becomes undeniable, in view of the inconsistency-incompleteness of complex systems. A model for embracing and coping with pluralism suggests itself in the form of contextualized novelty seeking relativism. This form of pluralism takes overdetermination, largely characteristic of Peirce’s Firstness, and underdetermination largely characteristic of Peirce’s Thirdness, into its embrace to reveal a global context capable of elucidating local contexts the collection of which is considerably less than that global view. The entirety of this global context is impossible to encompass, given our inevitable finitude and fallibilism. Yet, we usually manage to cope with processual pluralism, within the play of semiosis. (shrink)

We gain new insight by returning to W. V. Quine’s first objection to quantified modal logic, a logic due to Ruth Marcus. After noting that much of Quine’s objection does not actually apply to that initial logic, I establish that, in any case, there was always an easy answer to Quine’s interpretive challenge that (i) was of the sort he called for and (ii) that he should probably have seen. The investigation yields a diagnosis of the underlying mistake Quine was (...) making in all his objections to modal logic and _de re_ modality generally—a mistake still being made today. (shrink)

This article delves into ecopedagogy, grounded in the work of the Brazilian pedagogue Paulo Freire on popular education and critical pedagogies, to teach students to critically deconstruct the subjectivity and transformability of our world (all humans, human populations) with the rest of Earth (i.e., rest of Nature). As Friere emphasized humans’ unique characteristic of ‘unfinishedness’ with abilities of self-reflexivity through our histories and goal-setting from our dreams, (environmental) pedagogues must teach toward deepened and widened understandings for praxis grounded in socio-environmental (...) justice and planetary sustainability, including disrupting anthropocentricism. This ‘unfinishedness’ has made humans agents of world-Earth unsustainably and dominance in constructing the Anthropocene, but also allows for possibilities of transformation to counter them. I argue that ecopedagogy is essential in disrupting the following falsely taught ideologies that justifies the Anthroposphere: (1) false commonsense that separates environmental and social violence (i.e., socio-environmental violence) and instills anthropocentrism that separates humans from the rest of Nature (i.e., world-Earth distancing); (2) fatalism that extinguishes hope of ending humans’ acts of unsustainable environmental violence; (3) ‘development’ for sustaining hegemony and planetary unsustainability (i.e., Development rather than development); and (4) epistemological dominance that legitimizes the first three ideologies given (e.g., epistemologies of the North). (shrink)

This book introduces an important group of logics that have come to be known under the umbrella term 'susbstructural'. Substructural logics have independently led to significant developments in philosophy, computing and linguistics. _An Introduction to Substrucural Logics_ is the first book to systematically survey the new results and the significant impact that this class of logics has had on a wide range of fields.The following topics are covered: * Proof Theory * Propositional Structures * Frames * Decidability * Coda Both (...) students and professors of philosophy, computing, linguistics, and mathematics will find this to be an important addition to their reading. (shrink)

A key aspect of teaching ‘development’ is understanding the conundrums and tensions between balance and imbalance with constructs of global and...

The European Legacy, Volume 17, Issue 3, Page 399-400, June 2012.

Mind has played the starring role in the West's arts, humanities, and sciences, while an embodied notion of oneself, others, and the physical world has been customarily pushed under the rug. In view of radical new theories, methods and techniques that have emerged during the past century and a half, the notion of complementary, sympathetic co-participation, and its accompanying re-enchantment, merits attention. C. S. Peirce is at the crossroads between modernism, enchantment, and misplaced concreteness, on the one hand, and postmodernism (...) and its attendant poststructuralism, on the other. His categories of feeling, sensation, and thought, and his triadic, all-encompassing concept of the sign, can help bring all facets of human creativity, concrete living, and understanding into a proper balance. Three coined terms — homogeny, hierogeny, and heterogeny — serve to elucidate how Peirce's triadic vision can offer a middle path, a way of mediating between antagonistic modes of sensing, living, and thinking. This middle path follows traditional tenets of logic and reason — identity, non-contradiction, and excluded-middle — while at its fringes, it allows deviation — by way of process, inconsistency, and incompleteness — from the rigidity that lies therein. Studies of feminist postures and various cultural processes in Latin America bear out the premise that a dose of conformity accompanying a tendency toward resistance can synethnically help keep broad cultural processes on an even keel, balancing mind and body, conflicting theories and methods and modes of living, and styles of reason and unreason in equilibrium. (shrink)

This paper brings Lotman's semiotic space to bear on Peirce's categories of the universe's processes. Particular manifestations of cultural semiotic space within the semiosphere are qualified as inconsistent and/or incomplete, depending upon the cultural context. Inconsistency and incompleteness are of the nature of vagueness and generality respectively, that are themselves qualified in terms of overdetermination and underdetermination, the first being of the nature of the category of Firstness and the second of the nature Thirdness. The role of Secondness is unfolded (...) by acts of distinguishing the possibilities of Firstness into this and that, here and there, there and then, and all the distinctions that follow. Secondness, then, with respect to cultural semiotic space, gives rise to hegemony, to dominance and subervience, superordination and subordination. Commensurate with this interpretation of Secondness, the realms of overdetermination and underdetermination are labeled homogeny and heterogeny respectively. These theoretical assumptions will then be used as a modeling device providing an interpretation for various key aspects of Latin American cultures. (shrink)

Stanley and Williamson reject Ryle's knowing‐how/knowing‐that distinction charging that it obstructs our understanding of human action. Incorrectly interpreting the distinction to imply that knowledge‐how is non‐propositional, they object that Ryle's argument for it is unsound and linguistic theory contradicts it. I show that they (and their interlocutors) misconstrue the distinction and Ryle's argument. Consequently, their objections fail. On my reading, Ryle's distinction pertains to, not knowledge, but an explanatory gap between explicit and implicit content, and his argument for it is (...) sound. I defend the distinction's necessity in explaining human action and show that it propels a fruitful explanatory program. (shrink)

This article will discuss Paulo Freire’s global influences on environmental pedagogies and argue that ecopedagogical reinventions are essential for ‘quality’ education, as touted in the United Nations Sustainable Development Goal (SDG) #4, for global, all-inclusive ‘development’ that is planetarily sustainable. The politics of how ‘development’ is taught or not taught to be critically read linguistically and dialogically will be problematized through Freire’s work, and reinventions of his work, on ecopedagogy. As Freire was a pedagogue of critical literacy, ecopedagogical literacy widens (...) ‘reading the word to read the world’ (all humans, human populations) to read Earth to read the world as part of Earth. Such reading is not anthropocentric. The article will first describe Freire’s influence on reinventing environmental pedagogies, including education for (un)sustainable development (ESD), with specific discussions on how language of ‘development’ and corresponding (un)sustainability is framed. These influences from Freire will then be discussed through his de/re/constructions of citizenship, utopia and education, and globalization. Throughout the article, I will argue the need for teaching ecopedagogical literacy with ecolinguistics is essential to better understand the politics of language and (non)hierarchical dialogue which influence how ‘development’ goals are constructed, including the SDGs. (shrink)

Watkins proposes a neo-Popperian solution to the pragmatic problem of induction. He asserts that evidence can be used non-inductively to prefer the principle that corroboration is more successful over all human history than that, say, counter-corroboration is more successful either over this same period or in the future. Watkins's argument for rejecting the first counter-corroborationist alternative is beside the point. However, as whatever is the best strategy over all human history is irrelevant to the pragmatic problem of induction since we (...) are not required to act in the past, and his argument for rejecting the second presupposes induction. (shrink)

We propose a definition of capability as a class intermediate between function and disposition as the latter are defined in Basic Formal Ontology (BFO). A disposition inheres in a material entity and is realized in a certain kind of process. An example is the disposition of a glass to break when struck, which is realized when it shatters. A function is a disposition which is (simply put) the rationale for the existence of its bearer. To say for example that a (...) water pump has the function to pump water is to say that the pump exists because something was needed that would pump water. Capabilities are a special sort of disposition in that that, like functions, they can be evaluated on the basis of how well they are realized. They differ from functions in that their realizations are not the rationale – not the primary reason – for the existence of their bearers. Thus, a water pump may have many capabilities, including to be weatherproof, to run without lubricant, and so forth, but only one function. All functions are capabilities on the view we defend, but not all capabilities are functions. We develop a series of axioms to distinguish capabilities formally from both dispositions and functions and provide examples of the use of ‘capability’ in a variety of domains. (shrink)

Something has been going wrong on many college campuses in the last few years. Speakers are shouted down. Students and professors say they are walking on eggshells and are afraid to speak honestly. Rates of anxiety, depression, and suicide are rising--on campus as well as nationally. How did this happen? First Amendment expert Greg Lukianoff and social psychologist Jonathan Haidt show how the new problems on campus have their origins in three terrible ideas that have become increasingly woven into (...) American childhood and education: What doesn't kill you makes you weaker; always trust your feelings; and life is a battle between good people and evil people. These three Great Untruths contradict basic psychological principles about well-being and ancient wisdom from many cultures. Embracing these untruths--and the resulting culture of safetyism--interferes with young people's social, emotional, and intellectual development. It makes it harder for them to become autonomous adults who are able to navigate the bumpy road of life. Lukianoff and Haidt investigate the many social trends that have intersected to promote the spread of these untruths. They explore changes in childhood such as the rise of fearful parenting, the decline of unsupervised, child-directed play, and the new world of social media that has engulfed teenagers in the last decade. They examine changes on campus, including the corporatization of universities and the emergence of new ideas about identity and justice. They situate the conflicts on campus within the context of America's rapidly rising political polarization and dysfunction. This is a book for anyone who is confused by what is happening on college campuses today, or has children, or is concerned about the growing inability of Americans to live, work, and cooperate across party lines. (shrink)

In “Toward an Ontology of Commercial Exchange” [11], we proposed human readable definitions for terms that are central to an ontology of commercial exchange. This paper furthers that project in two ways. First, the definitions have been modified to be compatible with the Common Core Ontologies (CCO). CCO is used in a wide variety of domains including the industrial and military domains. Having a commerce ontology compatible with CCO allows data about the exchange of goods relevant to those domains to (...) be tagged with compatible ontologies. Second, we propose preliminary formalizations of these definitions, with the aim of informing the creation of an ontology which can be used to assist in reasoning over businessrelated data. (shrink)