When positionally cloned in late 1989, it was anticipated that mutations within the Wilms' tumour suppressor gene (WT1) would prove responsible for this common solid kidney cancer of childhood. Characterisation of the WT1 expression pattern and of the structure of the encoded protein isoforms and their mode of action has now spanned almost a decade. WT1 proteins act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and repression. These activities are facilitated and constrained by interactions with other (...) proteins. Expression analyses and knockout mice indicate that WT1 protein plays a critical role in normal kidney and gonad development. Specific constitutional WT1 mutations results in several urogenital anomaly syndromes. While only 10% of sporadic Wilms' tumours do display WT1 mutation, WT1 is mutated in other cancers, including acute myeloid leukaemia. Much is still to be determined in WT1 biology. The next decade will see at least three streams of attention. The first two, elucidation of the role of WT1 in RNA metabolism and the characterisation of further protein partners, may together explain the distinct tissue-specific functions of WT1. Finally, further research into the role of WT1 in haematopoiesis will improve our understanding of WT1 in leukaemia. BioEssays 21:191-202, 1999. (C) 1999 John Wiley & Sons, Inc. (shrink)

An important ingredient in understanding such sentences is resolving the question of: level in/of what? protection from what? what sort of documents? danger from what? Each of these is an example coming from novels, television commercials, and news reports. In the first instance, it is from a commercial for a brand of computers. In the commercial, which is pushing the most recent version of that computer, the voice-over announces (1a) just as a teenager exults after having apparently accomplished something worthy (...) of jubilation in a computer game. The message is intentionally interpretable in multiple ways: You are taken to a new level in the game, you are taken to a new level in computing power/speed, and, being a commercial, one also reads that it takes you to a new level in life. The second example is a story caption in a local newspaper. The article is about the shortage of flu shot vaccine in the U.S., and the people are going to Canada for flu shots, seeking protection from contracting the flu. The third example, also from a newspaper report2, requires not just that the FBI agent sold some documents or other, but rather that they were sensitive confidential documents, likely purloined from the FBI itself. The final instance is from a novel. In the novel the protagonist, in seeking to solve a crime, has overlooked something which in retrospect appears terribly obvious. The character’s self-deprecation thus reads: Sherlock Holmes’ reputation as a master sleuth was in no danger of being diminished. Each example, in context, reads seamlessly and poses little challenge to attentive or even inattentive readers and listeners. (shrink)

This introduction to biological conservation assesses the value judgments at the heart of conservation. The author elaborates on such questions as: how much habitat does an endangered species require?; does this particular species deserve to be saved?; who will pay for its upkeep?; and much more.

Neither ecologists nor economists can teach us what we most need to know about nature: how to value it. The Hebrew prophets claimed that there can be no intelligent human ecology except as people learn to use land justly and charitably. Lands do not flow with milk and honey for all unless and until justice rolls down like waters. What kind of planet ought we humans wish to have? One we resourcefully manage for our benefits? Or one we hold in (...) loving care? Science and economics can't teach us that; perhaps religion and ethics can. (shrink)

Different natural deduction proof systems for intuitionistic and classical logic —and related logical systems—differ in fundamental properties while sharing significant family resemblances. These differences become quite stark when it comes to the structural rules of contraction and weakening. In this paper, I show how Gentzen and Jaśkowski’s natural deduction systems differ in fine structure. I also motivate directed proof nets as another natural deduction system which shares some of the design features of Genzen and Jaśkowski’s systems, but which differs again (...) in its treatment of the structural rules, and has a range of virtues absent from traditional natural deduction systems. (shrink)

In this paper I urge friends of truth-value gaps and truth-value gluts – proponents of paracomplete and paraconsistent logics – to consider theories not merely as sets of sentences, but as pairs of sets of sentences, or what I call ‘bitheories,’ which keep track not only of what holds according to the theory, but also what fails to hold according to the theory. I explain the connection between bitheories, sequents, and the speech acts of assertion and denial. I illustrate the (...) usefulness of bitheories by showing how they make available a technique for characterising different theories while abstracting away from logical vocabulary such as connectives or quanti- fiers, thereby making theoretical commitments independent of the choice of this or that particular non-classical logic. (shrink)

Beall and Restall’s Logical Pluralism (2006) characterises pluralism about logical consequence in terms of the different ways cases can be selected in the analysis of logical consequence as preservation of truth over a class of cases. This is not the only way to understand or to motivate pluralism about logical consequence. Here, I will examine pluralism about logical consequence in terms of different standards of proof. We will focus on sequent derivations for classical logic, imposing two different restrictions on classical (...) derivations to produce derivations for intuitionistic logic and for dual intuitionistic logic. The result is another way to understand the manner in which we can have different consequence relations in the same language. Furthermore, the proof-theoretic perspective gives us a different explanation of how the one concept of negation can have three different truth conditions, those in classical, intuitionistic and dual-intuitionistic models. (shrink)

This essay examines whether or not absurdity is intrinsic to human life. It takes Camus’ interpretation of ‘The Absurd’ as its conceptual starting point. It traces such thought back to Schopenhauer, whose work is then critically analysed. This analysis focuses primarily on happiness and meaning. This essay accepts some of Schopenhauer’s premises, but rejects his conclusions. Instead, it considers Nietzsche’s alternatives and the role of suffering in life. It posits that suffering may help people acquire meaning and escape absurdity. It (...) then analyses the role of compassion in absurdity, in reference to Nietzsche’s work and Buddhist teachings. Lastly, it examines absurdity in relation to death, rejecting the notion that death exacerbates absurdity. This paper understands absurdity to be a natural part of the human condition, as characterised by suffering, death and an absence of meaning. It concludes that although human life is absurd by nature, it need not remain so. (shrink)

This paper concerns a key point of decision in Donald Davidson's early work in philosophy of language — a fateful decision that set him and the discourse in the area on the path of truth-theoretic semantics. The decision of moment is the one Davidson makes when, in the face of a certain barrier, he gives up on the idea of constructing an explicit meaning theory that would parallel Tarski's recursive way with truth theory. For Davidson there was little choice: he (...) tells us he does not see how to deal with the difficulty except in the radical way he proposes. But there is a way to give such a meaning theory — a meaning theory proper which, using classical logic only, meets a meaning-theoretic analogue of Convention T, satisfies Davidson’s three key desiderata for a theory of meaning, reflects linguistic competence, and avoids quantifying over meanings. The meaning theory sketched here uses Tarskian strategies, as Davidson proposed, but differs from Davidson's approach in not going by way of a truth theory for the target language. (shrink)

I present a new proof of the likelihood principle that avoids two responses to a well-known proof due to Birnbaum ([1962]). I also respond to arguments that Birnbaum’s proof is fallacious, which if correct could be adapted to this new proof. On the other hand, I urge caution in interpreting proofs of the likelihood principle as arguments against the use of frequentist statistical methods. 1 Introduction2 The New Proof3 How the New Proof Addresses Proposals to Restrict Birnbaum’s Premises4 A Response (...) to Arguments that the Proofs Are Fallacious5 Conclusion. (shrink)

In a rare discussion of Gadamer's work, Davidson takes issue with Gadamer's claim that successful communication requires that interlocutors share a common language. While he is right to see a difference between his own views and Gadamer's on this point, Davidson appears to have misunderstood what motivates Gadamer's position, conflating it with that of his more familiar conventionalist interlocutors. This paper articulates Gadamer's view of the role of language in communicative understanding as an alternative to both Davidson's and that of (...) the conventionalist writers Davidson critiques. It is argued, first, that Gadamer employs a conception of what individuates a language, and thus of what it means for two speakers to “share” a language, that Davidson never considers. By emphasizing the role of “application” in the historical development of languages, Gadamer develops a view in which languages are distinguished not by their particular semantic or syntactic rules, but by subtle differences between the concepts they express. Second, it is argued that the instances of “asymmetrical” communication—communication between interlocutors who have different sets of concepts at their disposal—that motivate Gadamer's position pose a challenge to Davidson's account of interpretative charity. (shrink)

Russell probes Morgenthau's realist ethics and the underpinnings of the nuclear threat in a technologically evolving modern world with increasingly obsolescent national boundaries.

Accumulating evidence suggests that different magnitudes (e.g., number, size, and duration) are spatialized in the mind according to a common left–right metric, consistent with a generalized system for representing magnitude. A previous study conducted by two of us (Holmes & Lourenco, ) provided evidence that this metric extends to the processing of emotional magnitude, or the intensity of emotion expressed in faces. Recently, however, Pitt and Casasanto () showed that the earlier effects may have been driven by a left–right (...) mapping of mouth size rather than emotional magnitude, and they found no evidence for an emotional magnitude mapping when using words as stimuli. Here, we report two new experiments that further examine these conclusions. In Experiment 1, using face stimuli with mouths occluded, we replicate the original finding: Less emotional faces were associated with the left and more emotional faces with the right. However, we also find that people can reliably infer the sizes of the occluded mouths, and that these inferred mouth sizes can explain the observed left–right mapping. In Experiment 2, we show that comparative judgments of emotional words yield a left–right mapping of emotional magnitude not attributable to stimulus confounds. Based on these findings, we concur with Pitt and Casasanto that faces pose challenges for isolating the forces driving spatialization, but we suggest that emotional magnitude, when assessed using unconfounded stimuli in a sufficiently sensitive task, may indeed be spatialized as originally proposed. Suggestions for further research on the spatialization of emotional magnitude are discussed. (shrink)

I offer myself as a nature guide, exploring for values. Many before us have got lost and we must look the world over. The unexamined life is not worth living; life in an unexamined world is not worthy living either. We miss too much of value.

We consider Borel equivalence relations E induced by actions of the infinite symmetric group, or equivalently the isomorphism relation on classes of countable models of bounded Scott rank. We relate the descriptive complexity of the equivalence relation to the nature of its complete invariants. A typical theorem is that E is potentially Π03 iff the invariants are countable sets of reals, it is potentially Π04 iff the invariants are countable sets of countable sets of reals, and so on. The proofs (...) use various techniques, including Vaught transforms, changing topologies, and the Scott analysis of countable models. (shrink)

For decades, nursing as a discipline has tried to establish itself within the socio‐professional and the socio‐political arenas. To date, several theorists have attempted to thoroughly define the essence (ontology) of nursing while others have proposed means (syntax) to achieve this ‘collective’ objective. Considering that this preoccupation, rooted in essentialism, is pervasive in the nursing literature, our claim is that these quests should be criticized because they impede innovative and transdisciplinary approaches to nursing theory. Our criticism includes the perspective supported (...) by the so‐called ‘postmodern nursing theorists’. We argue that the oeuvre of some nursing postmodern scholars is as prescriptive and linear as the ones they critique. Like it was done before, the discourse of these thinkers perpetuates the status quo by excluding alternative forms of knowledge that cross the boundaries of the discipline of nursing. Using the work of Deleuze and Guattari, this paper proposes an alternative way to conceive the development of nursing knowledge, which, we think, could represent an alternative way to explore the discipline of nursing. (shrink)

Nature is examined as a carrier of values. Despite problems of subjectivity and objectivity in value assignments, values are actualized in human relationships with nature, sometimes by constructive activity depending on a natural support, sometimes by a sensitive, if an interpretive, appreciation of the characteristics of natural objects. Ten areas of values associated with nature are recognized: economic value, life support value, recreational value, scientific value, aesthetic value, life value, diversity and unity values, stability and spontaneity values, dialectical value, and (...) sacramental value. Bach is analyzed and illustrated with particular reference to the objective precursors of value as these are described by natural science. (shrink)

Philosophical ethics comprises metaethics, normative ethics and applied ethics. These have characteristically received analytic treatment by twentieth-century Anglo-American philosophy. But there has been disagreement over their interrelationship to one another and the relationship of analytical ethics to substantive morality – the making of moral judgments. I contend that the expertise philosophers have in either theoretical or applied ethics does not equip them to make sounder moral judgments on the problems of bioethics than nonphilosophers. One cannot "apply" theories like Kantianism or (...) consequentialism to get solutions to practical moral problems unless one knows which theory is correct, and that is a metaethical question over which there is no consensus. On the other hand, to presume to be able to reach solutions through neutral analysis of problems is unavoidably to beg controversial theoretical issues in the process. Thus, while analytical ethics can play an important clarificatory role in bioethics, it can neither provide, nor substitute for, moral wisdom. Keywords: abortion, applied ethics, bioethics, metaethics, normative ethics CiteULike Connotea Del.icio.us What's this? (shrink)

According to the “knowability thesis,” every truth is knowable. Fitch’s paradox refutes the knowability thesis by showing that if we are not omniscient, then not only are some truths not known, but there are some truths that are not knowable. In this paper, I propose a weakening of the knowability thesis (which I call the “conjunctive knowability thesis”) to the e:ect that for every truth p there is a collection of truths such that (i) each of them is knowable and (...) (ii) their conjunction is equivalent to p. I show that the conjunctive knowability thesis avoids triviality arguments against it, and that it fares very di:erently depending on another thesis connecting knowledge and possibility. If there are two propositions, inconsistent with one another, but both knowable, then the conjunctive knowability thesis is trivially true. On the other hand, if knowability entails truth, the conjunctive knowability thesis is coherent, but only if the logic of possibility is weak. (shrink)

This paper focuses on the practical question of how the ideas of John Dewey can contribute to improved intercultural communication theory and practice, especially to training. The question is answered in four parts. The first part refers to the presumed superiority of sensitivity to difference as opposed to similarity in intercultural communication. The second part suggests that Dewey’s duality of potentiality and interaction can be carried over to the duality of competence and performance. The third part highlights the use of (...) the generic concepts of pattern and habit to better understand culture as a practical experience. The final part advocates a closer look at the idea and experience of rhythm as an epistemological alternative to subject vs object. The author relies on his experience as a trainer and a teacher of Intercultural Communication and proceeds down an interdisciplinary path, especially attempting to set up a dialogue with biology, systems and the arts. (shrink)

The ArgumentEtienn-François Geoffroy' Table des Rapports is generally regarded as a landmark in the evolution of chemistry during the eighteenth century. Issues have arisen among historians concerning the significance and originality of the Table that require fuller attention to the immediate context of chemical research in the Academie des sciences during the two decades that preceded its appearance. The present paper argues that, despite the transition from communal to individual research projects that marked the reorganization of the Academy in 1699, (...) chemists continued to pursue shared problems within a communal ethos. The interactions between Wilhelm Homberg, Etienne-François Geoffroy, and Louis Lemery were particularly prominent. The paper traces one example of this interaction, involving the sulfur principle and its influence on one entry in Geoffroy's Table. Further such studies are needed to elucidate the relation between the concepts of chemical composition and reactions implied in Geoffroy's table and the concepts embodied in the previous work of Geoffroy and his associates in the Academy. (shrink)

Book reviewed in this article: No Longer Patient: Feminist Ethics & Health Care. By Susan Sherwin Feminist Perspectives in Medical Ethics. Edited by Helen Bequaert Holmes and Laura M. Purdy.

Louis Charland has argued that the Cluster B personality disorders, including borderline personality disorder, are primarily moral rather than clinical conditions. Part of his argument stems from reflections on effective treatment of borderline personality disorder. In the argument from treatment, he claims that successful treatment of all Cluster B personality disorders requires a positive change in a patient’s moral character. Based on this claim, he concludes (1) that these disorders are, at root, deficits in moral character, and (2) that effective (...) treatment of these disorders requires a sort of moral education rather than clinical intervention. In this paper, I evaluate the argument from treatment through a critical analysis of two psychotherapeutic interventions that have shown recent effectiveness against borderline personality disorder. I suggest that both Dialectical Behaviour Therapy and Mentalization-Based Treatment indicate that borderline personality disorder is, at root, a deficit in non-moral cognitive and emotional capacities. I suggest that these non-moral deficits obscure the expression of an otherwise intact moral character. In light of this, I conclude that effective treatment of borderline personality disorder requires primarily clinical intervention rather than moral edification. (shrink)

Prevailing accounts of natural values as the subjective response of the human mind are reviewed and contested. Discoveries in the physical sciences tempt us to strip the reality away from many native-range qualities, including values, but discoveries in the biological sciences counterbalance this by finding sophisticated structures and selective processes in earthen nature. On the one hand, all human knowing and valuing contain subjective components, being theory-Iaden. On the other hand, in ordinary natural affairs, in scientific knowing, and in valuing, (...) we achieve some objective knowing of the world, agreeably with and mediated by the subjective coefficient. An ecological model of valuing is proposed, which is set in an evolutionary context. Natural value in its relation to consciousness is, examined as an epiphenomenon, an echo, an emergent, an entrance, and an education, with emphasis on the latter categories. An account of intrinsic and instrumental natural value is related both to natural objects, life fonns and land forms, and to experiencing subjects, extending the ecological model. Ethical imperatives follow from this redescription of natural value and the valuing process. (shrink)

In this paper I argue that Bonjour’s claim that empirical beliefs can only be justified by other empirical beliefs and his use of non-normative “spontaneous empirical beliefs” and the “The Doxastic Preumption” fail to solve the problems of coherence theory. I propose a justification of empirical (and other beliefs) based on the work of B. Lonergan.

Philosophers love a priori knowledge: we delight in truths that can be known from the comfort of our armchairs, without the need to venture out in the world for confirmation. This is due not to laziness, but to two different considerations. First, it seems that many philosophical issues aren’t settled by our experience of the world — the nature of morality; the way concepts pick out objects; the structure of our experience of the world in which we find ourselves — (...) these issues seem to be decided not on the basis of our experience, but in some manner by things prior to (or independently of) that experience. Second, even when we are deeply interested in how our experience lends credence to our claims about the world, the matter remains of the remainder: we learn more about how experience contributes to knowledge when we see what knowledge is available independent of that experience. (shrink)

"A book that has been needed for several years. It certainly will be one of the most important evangelical books of the year. Its exploration of possible Christian answers to some of the basic problems of philosophy is thoughtful, well-written, and bears all the marks of having been written by a highly competent philosopher."--Ronald H. Nash, Western Kentucky University.

A deep investigation of proprioceptive processes is necessary to understand the relationship between sensory afferent inputs and motor outcomes. In this work, we investigate whether and how perception of wrist position is influenced by the direction along which the movement occurs. Most previous studies have tested Joint Position Sense through 1 degree of freedom wrist movements, such as flexion/extension or radial/ulnar deviation. However, the wrist joint has 3-DoF and many activities of daily living produce combined movements, requiring at least 2-DoF (...) wrist coordination. For this reason, in this study, target positions involved movement directions that combined wrist flexion or extension with radial or ulnar deviation. The chosen task was a robot-aided Joint Position Matching, in which blindfolded participants actively reproduced a previously passively assumed target joint configuration. The JPM performance of 20 healthy participants was quantified through measures of accuracy and precision, in terms of both perceived target direction and distance along each direction of movement. Twelve different directions of movement were selected and both hands tested. The left and right hand led to comparable results, both target extents and directions were differently perceived according to the target direction on the FE/RUD space. Moreover, during 2-DoF combined movements, subjects’ perception of directions was impaired when compared to 1-DoF target movements. In summary, our results showed that human perception of wrist position on the FE/RUD space is symmetric between hands but not isotropic among movement directions. (shrink)

Neither ecologists nor economists can teach us what we most need to know about nature: how to value it. The Hebrew prophets claimed that there can be no intelligent human ecology except as people learn to use land justly and charitably. Lands do not flow with milk and honey for all unless and until justice rolls down like waters. What kind of planet ought we humans wish to have? One we resourcefully manage for our benefits? Or one we hold in (...) loving care? Science and economics can't teach us that; perhaps religion and ethics can. (shrink)

The paradoxes of self-reference are genuinely paradoxical. The liar paradox, Russell’s paradox and their cousins pose enormous difficulties to anyone who seeks to give a comprehensive theory of semantics, or of sets, or of any other domain which allows a modicum of self-reference and a modest number of logical principles. One approach to the paradoxes of self-reference takes these paradoxes as motivating a non-classical theory of logical consequence. Similar logical principles are used in each of the paradoxical inferences. If one (...) or other of these problematic inferences are rejected, we may arrive at a consistent (or at least, a coherent) theory. In this paper I will show that such approaches come at a serious cost. The general approach of using the paradoxes to restrict the class of allowable inferences places severe constraints on the domain of possible propositional logics, and on the kind of metatheory that is appropriate in the study of logic itself. Proof-theoretic and model-theoretic analyses of logical consequence make provide different ways for non-classical responses to the paradoxes to be defeated by revenge problems: the redefinition of logical connectives thought to be ruled out on logical grounds. Non-classical solutions are not the “easy way out” of the paradoxes. (shrink)

A B S T R AC T: In this paper I consider an interpretation of future contingents which motivates a unification of a Łukasiewicz-style logic with the more classical supervaluational semantics. This in turn motivates a new non-classical logic modelling what is “made true by history up until now. ” I give a simple Hilbert-style proof theory, and a soundness and completeness argument for the proof theory with respect to the intended models.

“Daddy, is God real or is he a part of people's imagination?” The brain constructs reality by bottom‐up, genetically programmed mechanisms. Nature selected the human holistic, symbolically thinking, aesthetic brain using a mechanism of brain‐language coevolution. Our religious nature and moral capabilities are rooted in this brain, and in the real images it constructs.

This article argues that the mid-1960s saw a dramatic shift in how ‘brainwashing’ was popularly imagined, reflecting Anglo-American developments in the sciences of mind as well as shifts in mass media culture. The 1965 British film The Ipcress File provides a rich case for exploring these interconnections between mind control, mind science and media, as it exemplifies the era’s innovations for depicting ‘brainwashing’ on screen: the film’s protagonist is subjected to flashing lights and electronic music, pulsating to the ‘rhythm of (...) brainwaves’. This article describes the making of The Ipcress File’s brainwashing sequence and shows how its quest for cinematic spectacle drew on developments in cybernetic science, multimedia design and modernist architecture. I argue that often interposed between the disparate endeavours of 1960s mind control, psychological science and media was a vision of the human mind as a ‘cybernetic spectator’: a subject who scrutinizes how media and other demands on her sensory perception can affect consciousness, and seeks to consciously participate in this mental conditioning and guide its effects. (shrink)

An Archaeology of Disability is a research station designed for the Venice Biennale, Architettura 2021 by David Gissen, Jennifer Stager, and Mantha Zarmakoupi and exhibited later at La Gipsoteca di Arte Antica of Pisa in 2022, at the Canellopoulos Museum of Athens in 2023, and at the Archaeological Museum of Thessaloniki in 2024. The research station works with languages and forms used by contemporary disabled people to reproduce elements—a ramp, a seat, an art gallery—from the ancient Acropolis in Athens that (...) vanished long ago and that have little or no extant material forms. Among the many people who contributed to the research station are two performers, Christopher Tester and Pia Hargrove, who performed, respectively, the ekphrastic film and audio description Sēmata (Signs) (2021). The following dialogic essay draws on conversations with the curators and performers led by Brooke Holmes and Pasquale Toscano. This dialogic form surfaces some of the collaborative aspects of the research station to highlight the ways in which such collaboration brings different lenses to antiquity. (shrink)

Adolescent populations have become increasingly accessible through online data collection methods. Online surveys are advantageous in recruiting adolescent participants and can be designed for adol...