When positionally cloned in late 1989, it was anticipated that mutations within the Wilms' tumour suppressor gene (WT1) would prove responsible for this common solid kidney cancer of childhood. Characterisation of the WT1 expression pattern and of the structure of the encoded protein isoforms and their mode of action has now spanned almost a decade. WT1 proteins act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and repression. These activities are facilitated and constrained by interactions with other (...) proteins. Expression analyses and knockout mice indicate that WT1 protein plays a critical role in normal kidney and gonad development. Specific constitutional WT1 mutations results in several urogenital anomaly syndromes. While only 10% of sporadic Wilms' tumours do display WT1 mutation, WT1 is mutated in other cancers, including acute myeloid leukaemia. Much is still to be determined in WT1 biology. The next decade will see at least three streams of attention. The first two, elucidation of the role of WT1 in RNA metabolism and the characterisation of further protein partners, may together explain the distinct tissue-specific functions of WT1. Finally, further research into the role of WT1 in haematopoiesis will improve our understanding of WT1 in leukaemia. BioEssays 21:191-202, 1999. (C) 1999 John Wiley & Sons, Inc. (shrink)

An important ingredient in understanding such sentences is resolving the question of: level in/of what? protection from what? what sort of documents? danger from what? Each of these is an example coming from novels, television commercials, and news reports. In the first instance, it is from a commercial for a brand of computers. In the commercial, which is pushing the most recent version of that computer, the voice-over announces (1a) just as a teenager exults after having apparently accomplished something worthy (...) of jubilation in a computer game. The message is intentionally interpretable in multiple ways: You are taken to a new level in the game, you are taken to a new level in computing power/speed, and, being a commercial, one also reads that it takes you to a new level in life. The second example is a story caption in a local newspaper. The article is about the shortage of flu shot vaccine in the U.S., and the people are going to Canada for flu shots, seeking protection from contracting the flu. The third example, also from a newspaper report2, requires not just that the FBI agent sold some documents or other, but rather that they were sensitive confidential documents, likely purloined from the FBI itself. The final instance is from a novel. In the novel the protagonist, in seeking to solve a crime, has overlooked something which in retrospect appears terribly obvious. The character’s self-deprecation thus reads: Sherlock Holmes’ reputation as a master sleuth was in no danger of being diminished. Each example, in context, reads seamlessly and poses little challenge to attentive or even inattentive readers and listeners. (shrink)

Neither ecologists nor economists can teach us what we most need to know about nature: how to value it. The Hebrew prophets claimed that there can be no intelligent human ecology except as people learn to use land justly and charitably. Lands do not flow with milk and honey for all unless and until justice rolls down like waters. What kind of planet ought we humans wish to have? One we resourcefully manage for our benefits? Or one we hold in (...) loving care? Science and economics can't teach us that; perhaps religion and ethics can. (shrink)

Russell probes Morgenthau's realist ethics and the underpinnings of the nuclear threat in a technologically evolving modern world with increasingly obsolescent national boundaries.

This acclaimed book is back in print with a new introduction by its award-winning author.

According to the “knowability thesis,” every truth is knowable. Fitch’s paradox refutes the knowability thesis by showing that if we are not omniscient, then not only are some truths not known, but there are some truths that are not knowable. In this paper, I propose a weakening of the knowability thesis (which I call the “conjunctive knowability thesis”) to the e:ect that for every truth p there is a collection of truths such that (i) each of them is knowable and (...) (ii) their conjunction is equivalent to p. I show that the conjunctive knowability thesis avoids triviality arguments against it, and that it fares very di:erently depending on another thesis connecting knowledge and possibility. If there are two propositions, inconsistent with one another, but both knowable, then the conjunctive knowability thesis is trivially true. On the other hand, if knowability entails truth, the conjunctive knowability thesis is coherent, but only if the logic of possibility is weak. (shrink)

With a few notable exceptions disability studies has not taken account of intersexuality, and it is principally through the lenses of feminist and queer-theory oriented ethical discussions but not through ‘straight’ bioethics that modes valuing intersex difference have been proposed. Meanwhile, the medical presupposition that intersex characteristics are inherently disabling to social viability remains the taken-for-granted truth from which clinical practice proceeds. In this paper I argue against bioethical perspectives that justify extensive and invasive pre- and post-natal medical interference to (...) eradicate intersex. I argue instead that to constitute the necessary conditions for the recognition of the intersexed child as a person, a life valid in its own right, clinicians must refrain from aggressive interference. Clinical specialists presuppose that intersexed children will be socially disabled and unrecognizable as persons; frustrated by the general failure of traditional interventions to assign a sex, clinicians are now pursuing prenatal technologies, including selective termination, to erase intersex. (shrink)

Police and pastoral power: governmentality and correctional forensic psychiatric nursing Since 1978, the federal inmates of Canada have had access to a full range of psychiatric care within the penitentiary system. Several psychiatric units are now integrated into the correctional services of Canada. This paper presents the results of a grounded theory doctoral study undertaken in a multilevel secured psychiatric ward within the Canadian federal penitentiary system. The author describes and discusses the results of qualitative data that emerged from his (...) fieldwork. The concept of governmentality, as defined by the late French philosopher Michel Foucault, constitutes one of the major theoretical tools that were helpful in analyzing these data. Police and pastoral power, two dimensions of the security apparatus of governmentality, were found to be useful in understanding and characterizing nursing practice caught between the penal and the psychiatric dispositifs. A Foucauldian perspective allows one to understand the manner in which forensic psychiatric nursing is involved in the governance of mentally ill inmates through three forms of power — sovereign, disciplinary and pastoral — which have posited nursing practice as a strategic tool of the correctional services. This research consists of a study of nursing practice in an extreme setting that deserves a radical analysis. (shrink)

Philosophers love a priori knowledge: we delight in truths that can be known from the comfort of our armchairs, without the need to venture out in the world for confirmation. This is due not to laziness, but to two different considerations. First, it seems that many philosophical issues aren’t settled by our experience of the world — the nature of morality; the way concepts pick out objects; the structure of our experience of the world in which we find ourselves — (...) these issues seem to be decided not on the basis of our experience, but in some manner by things prior to (or independently of) that experience. Second, even when we are deeply interested in how our experience lends credence to our claims about the world, the matter remains of the remainder: we learn more about how experience contributes to knowledge when we see what knowledge is available independent of that experience. (shrink)

The paradoxes of self-reference are genuinely paradoxical. The liar paradox, Russell’s paradox and their cousins pose enormous difficulties to anyone who seeks to give a comprehensive theory of semantics, or of sets, or of any other domain which allows a modicum of self-reference and a modest number of logical principles. One approach to the paradoxes of self-reference takes these paradoxes as motivating a non-classical theory of logical consequence. Similar logical principles are used in each of the paradoxical inferences. If one (...) or other of these problematic inferences are rejected, we may arrive at a consistent (or at least, a coherent) theory. In this paper I will show that such approaches come at a serious cost. The general approach of using the paradoxes to restrict the class of allowable inferences places severe constraints on the domain of possible propositional logics, and on the kind of metatheory that is appropriate in the study of logic itself. Proof-theoretic and model-theoretic analyses of logical consequence make provide different ways for non-classical responses to the paradoxes to be defeated by revenge problems: the redefinition of logical connectives thought to be ruled out on logical grounds. Non-classical solutions are not the “easy way out” of the paradoxes. (shrink)

This paper explores how, at the 1875 Royal Commission on Vivisection, the anaesthetised animal was construed as a boundary object around which “cooperation without consensus” Computer supported cooperative work: cooperation or conflict? Springer, London, 1993) could form, serving the interests of both scientists and animals. Advocates of anaesthesia presented it as benevolently intervening between the scientific agent and animal patient. Such articulations of ‘ethical’ vivisection through anaesthesia were then mandated in the 1876 Cruelty to Animals Act, and thus have had (...) significant downstream effects on the regulation of laboratory animals in Britain and beyond. Constructing this ‘consensus’ around the anaesthetised animal, however, required first excluding abolitionists and inhumane scientists, and secondly limiting the interests of experimental animals to the avoidance of pain through anaesthesia and euthanasia, thereby circumventing the issue of their possible interest in future life. This consensus also served to secure the interests of vivisecting scientists and to limit the influence of public opinion in the laboratory to administrative procedure and scheduled inspection. The focus on anaesthesia was connected with discussions of what supporting infrastructures were required to ensure proper ethical procedure was carried out by scientists. In contrast to the much studied polarisation in British society between pro- and antivivisectionists after 1876, we understand the 1875 Commission as a conflict amongst scientists themselves, while also being an intra-class conflict amongst the ruling class. (shrink)

This paper discusses a sequence of extensions ofNFU, Jensen's improvement of Quine's set theory “New Foundations” (NF) of [16].The original theoryNFof Quine continues to present difficulties. After 60 years of intermittent investigation, it is still not known to be consistent relative to any set theory in which we have confidence. Specker showed in [20] thatNFdisproves Choice (and so proves Infinity). Even if one assumes the consistency ofNF, one is hampered by the lack of powerful methods for proofs of consistency and (...) independence such as are available for use withZFC; very clever work has been done with permutation methods, starting with [18] and [5], and exemplified more recently by [14], but permutation methods can only be applied to show the consistency or independence of unstratified sentences (see the definition ofNFUbelow for a definition of stratification). For example, there is no method available to determine whether the assertion “the continuum can be well-ordered” is consistent with or independent ofNF. There is one substantial independence result for an assertion with nontrivial stratified consequences, using metamathematical methods: this is Orey's proof of the independence of the Axiom of Counting fromNF(see below for a statement of this axiom).We mention these difficulties only to reassure the reader of their irrelevance to the present work. Jensen's modification of “New Foundations” (in [13]), which was to restrict extensionality to sets, allowing many non-sets (urelements) with no elements, has almost magical effects. (shrink)

Christopher Southgate recognizes that the natural world is both ambiguous, mixing goods and bads, and simultaneously dramatically creative, such creativity resulting from just this ambiguous challenge of environmental conductance and resistance. Life is lived in green pastures and in the valley of the shadow of death. Perhaps this is the only way God could have created the values found on Earth, by means of such disvalues, as a Darwinian natural selection account suggests. Generating Earth's biodiversity requires struggle, success, and failure—and (...) such an only way would constrain a powerful, loving God. But Southgate judges this too uncaring of suffering individuals, the products of evolution sacrificed to the systemic process. Perhaps God through Jesus redeems all the sacrificed individuals—pelicans in a pelican heaven—but redemption of all the bullfrogs and acorns becomes an incredible hope. Nature is a cruciform creation, where life persists in perpetual perishing. Life is forever conserved, regenerated, redeemed. (shrink)

Consider this situation: Here are two envelopes. You have one of them. Each envelope contains some quantity of money, which can be of any positive real magnitude. One contains twice the amount of money that the other contains, but you do not know which one. You can keep the money in your envelope, whose numerical value you do not know at this stage, or you can exchange envelopes and have the money in the other. You wish to maximise your money. (...) What should you do?1 Here are three forms of reasoning about this situation, which we shall call.. (shrink)

The usual construction of models of NFU (New Foundations with urelements, introduced by Jensen) is due to Maurice Boffa. A Boffa model is obtained from a model of (a fragment of) Zermelo–Fraenkel with Choice (ZFC) with an automorphism which moves a rank: the domain of the Boffa model is a rank that is moved. “Most” elements of the domain of the Boffa model are urelements in terms of the interpreted NFU. The main result of this paper is that the restriction (...) of the membership relation of the original model of set theory with automorphism to the domain of the Boffa model is first-order definable in the language of NFU. In particular, all information about the extensions in the original model of the urelements of the model of NFU is definable in terms of NFU. A corollary (answering a question of Thomas Forster) is that the urelements in a Boffa model are not homogeneous. (shrink)

We show in (the usual set theory without Choice) that for any set X, the collection of sets Y such that each element of the transitive closure of is strictly smaller in size than X (the collection of sets hereditarily smaller than X) is a set. This result has been shown by Jech in the case (where the collection under consideration is the set of hereditarily countable sets).

Journal Name: Apeiron Issue: Ahead of print.

Use of the imagination is a key aspect of successful psychotherapeutic treatments. Psychotherapy helps clients get in touch with, awaken, and learn to trust their creative inner life, while therapists use their imaginations to mentalise the suffering other and to trace the unconscious stirrings evoked by the intimacy of the consulting room. Working from this premise, in _The Therapeutic Imagination_ _Jeremy Holmes_ argues unashamedly that literate therapists make better therapists. Drawing on psychoanalytic and literary traditions both classical and contemporary, Part (...) I shows how poetry and novels help foster therapists’ understanding of their own imagination-in-action, anatomised into five phases: attachment, reverie, logos, action and reflection. Part II uses the contrast between secure and insecure narrative styles in attachment theory and relates these to literary storytelling and the transformational aspects of therapy. Part III uses literary accounts to illuminate the psychiatric conditions of narcissism, anxiety, splitting and bereavement. Based on Forster’s motto, ‘Only Connect’, Part IV argues, with the help of poetic examples, that a psychiatry shorn of psychodynamic creativity is impoverished and fails to serve its patients. Clearly and elegantly written, and drawing on the author’s deep knowledge of psychoanalysis and attachment theory and a lifetime of clinical experience, _Holmes _convincingly links the literary and psychoanalytic canon. _The Therapeutic Imagination _is a compelling and insightful work that will strike chords for therapists, counsellors, psychoanalysts, psychiatrists and psychologists. (shrink)

In Consecrating Science, Lisa Sideris argues that an anthropocentric and science‐based cosmology encourages human arrogance and diminishes a sense of wonder in human experience immersed in the natural world, as found in diverse cultural and religious traditions. I agree with her that science elevated to a commanding worldview, scientism, is a common and contemporary mistake, to be deplored, a lame science. But I further argue that science has introduced us to the marvels of deep nature and vastly increased our human (...) appreciation of nature as a wonderland at levels great and small. Sideris is right to fear consecrating science. She—and the humanists, sages, and saviors—need also to fear blindness to what science has to teach us about cosmogenesis and wonderland Earth. (shrink)

Gustav Bergmann was, arguably, the greatest ontologist of the twentieth century in pursuing the fundamental questions of first philosophy as deeply as any philosopher of any time. In 2006 and 2007, international conferences devoted solely to Bergmann's work were held at the University of Iowa in the USA, Université de Provence in France, and Università degli Studi Roma Tre in Italy. The papers in this volume were presented at the first of these conferences, in Iowa City, where Bergmann taught for (...) nearly four decades after escaping from Europe, following the dissolution of the Vienna Circle of which he had been the youngest member. There are nine philosophical papers, reminiscences of three of his students, and a complete bibliography of his published writings. (shrink)

In the first collection of his essays to be published, Jeremy Holmes discusses the wider application of psychotherapy within psychiatry and suggests that psychoanalysis needs to escape from its esotericism by taking into account contemporary advances in cognitive science, family therapy and the realities of psychiatric work in a public health setting. Illustrating his arguments with literary as well as clinical examples, he emphasizes the importance of creativity in psychotherapy and the connections between the artistic and psychotherapeutic impulse.

“Nature knows best” is reconsidered from an ecological perspective which suggests that we ought to follow nature. The phrase “follow nature” has many meanings. In an absolute law-of-nature sense, persons invariably and necessarily act in accordance with natural laws, and thus cannot but follow nature. In an artifactual sense, all deliberate human conduct is viewed as unnatural, and thus it is impossible to follow nature. As a result, the answer to the question, whether we can and ought to follow nature, (...) must be sought in a relative sense according to which human conduct is sometimes more and sometimes less natural. Four specific relative senses are examined: a homeostatic sense, an imitative ethical sense, an axiological sense, and a tutorial sense. Nature can be followed in a homeostatic sense in which human conduct utilizes naturallaws for our well-being in a stable environment, but this following is nonmoral since the moral elements can be separated from it. Nature cannot be followed in an imitative ethical sense because nature itself is either amoral or, by some accounts, immoral. Guidance for inter-human ethical conduct, therefore, must be sought not in nature, but in human culture. Nevertheless, in an axiological sense, persons can and ought to follow nature by viewing it as an object of orienting interest and value. In this connection, three environments are distinguished for human well-being in whichwe can and ought to participate-the urban, the rural, and the wild. Finally, in a tutorial sense, persons can and ought to follow nature by letting it teach us son1ething of our human role, our place, and our appropriate character in the natural system as a whole. In this last sense, "following nature" is commended to anyone who seeks in his human conduct to maintain a good fit with the natural environment-a sense of following nature involving both efficiency and wisdom. (shrink)

Three systems of double extension set theory have been proposed by Andrzej Kisielewicz in two papers. In this paper, it is shown that the two stronger systems are inconsistent, and that the third, weakest system does not admit extensionality for general sets or the use of general sets as parameters in its comprehension scheme. The parameter-free version of the comprehension principle of double extension set theory is also shown to be inconsistent with extensionality. The definitions of the systems and a (...) self-contained exposition of their properties is given, sufficient to develop the inconsistency proofs. (shrink)