ObjectivesTo describe reporting of informed consent in pragmatic trials, justifications for waivers of consent and reporting of alternative approaches to standard written consent. To identify factors associated with (1) not reporting and (2) not obtaining consent.MethodsSurvey of primary trial reports, published 2014–2019, identified using an electronic search filter for pragmatic trials implemented in MEDLINE, and registered in ClinicalTrials.gov.ResultsAmong 1988 trials, 132 (6.6%) did not include a statement about participant consent, 1691 (85.0%) reported consent had been obtained, 139 (7.0%) reported a (...) waiver and 26 (1.3%) reported consent for one aspect (eg, data collection) but a waiver for another (eg, intervention). Of the 165 trials reporting a waiver, 76 (46.1%) provided a justification. Few (53, 2.9%) explicitly reported use of alternative approaches to consent. In multivariable logistic regression analyses, lower journal impact factor (p=0.001) and cluster randomisation (p<0.0001) were significantly associated with not reporting on consent, while trial recency, cluster randomisation, higher-income country settings, health services research and explicit labelling as pragmatic were significantly associated with not obtaining consent (all p<0.0001).DiscussionNot obtaining consent seems to be increasing and is associated with the use of cluster randomisation and pragmatic aims, but neither cluster randomisation nor pragmatism are currently accepted justifications for waivers of consent. Rather than considering either standard written informed consent or waivers of consent, researchers and research ethics committees could consider alternative consent approaches that may facilitate the conduct of pragmatic trials while preserving patient autonomy and the public’s trust in research. (shrink)

Hermann Weyl succeeded in presenting a consistent overarching analysis that accounts for symmetry in material artifacts, natural phenomena, and physical theories. Weyl showed that group theory is the underlying mathematical structure for symmetry in all three domains. But in this study Weyl did not include appeals to symmetry arguments which, for example, Einstein expressed as “for reasons of symmetry”. An argument typically takes the form of a set of premises and rules of inference that lead to a conclusion. Symmetry may (...) enter an argument both in the premises and the rules of inference, and the resulting conclusion may also exhibit symmetrical properties. Taking our cue from Pierre Curie, we distinguish two categories of symmetry arguments, axiomatic and heuristic; they will be defined and then illustrated by historical cases. (shrink)

Randomized controlled trial trial designs exist on an explanatory-pragmatic spectrum, depending on the degree to which a study aims to address a question of efficacy or effectiveness. As conceptualized by Schwartz and Lellouch in 1967, an explanatory approach to trial design emphasizes hypothesis testing about the mechanisms of action of treatments under ideal conditions, whereas a pragmatic approach emphasizes testing effectiveness of two or more available treatments in real-world conditions. Interest in, and the number of, pragmatic trials has grown substantially (...) in recent years, with increased recognition by funders and stakeholders worldwide of the need for credible evidence to inform clinical decision-making. This increase has been accompanied by the onset of learning healthcare systems, as well as an increasing focus on patient-oriented research. However, pragmatic trials have ethical challenges that have not yet been identified or adequately characterized. The present study aims to explore the views of key stakeholders with respect to ethical issues raised by the design and conduct of pragmatic trials. It is embedded within a large, four-year project that seeks to develop guidance for the ethical design and conduct of pragmatic trials. As a first step, this study will address important gaps in the current empirical literature with respect to identifying a comprehensive range of ethical issues arising from the design and conduct of pragmatic trials. By opening up a broad range of topics for consideration within our parallel ethical analysis, we will extend the current debate, which has largely emphasized issues of consent, to the range of ethical considerations that may flow from specific design choices. Semi-structured interviews with key stakeholders, across multiple jurisdictions, identified based on their known experience and/or expertise with pragmatic trials. We expect that the study outputs will be of interest to a wide range of knowledge users including trialists, ethicists, research ethics committees, journal editors, regulators, healthcare policymakers, research funders and patient groups. All publications will adhere to the Tri-Agency Open Access Policy on Publications. (shrink)

While the technical aspects of engineering are emphasized in education and industry, the ethical aspects are, in some ways, just as vital. Engineering instructors should teach undergraduates about their ethical responsibilities in the realm of engineering. Students would then be more likely to grasp their responsibilities as professionals. For many students, undergraduate study is a time of growth and change, with their ethical development just beginning to take shape. In this study, we aim to understand the progression of ethical development (...) for engineering undergraduate students and identify key factors that may contribute to their development. To help us assess ethical development, we deployed in Fall 2020 a survey to undergraduate engineering students at two universities; the survey entailed the Defining Issues Test-2 (DIT-2). The DIT-2 evaluates ethical development based on Kohlberg’s theory of moral development; the test recognizes three levels of morality—preconventional, conventional, and postconventional. This study evaluates the associations between students’ university and class year and their Personal Interest, Maintaining Norms, and N2 scores. We utilized the results of a multivariate analysis of variance (MANOVA) to address the following research question: _Is a student’s ethical development associated with their university and class year?_ The results of the analysis reveal that students’ ethical development appear to differ between universities and to lie along a continuum, changing from first-year students to seniors of engineering undergraduate study. (shrink)

Spinoza presents the “dictates of reason” as the foundation of “the right way of living”. An influential reading of his position assimilates it to that of Hobbes. The dictates of reason are normative principles that prescribe necessary means to a necessary end: self-preservation. Against this reading I argue that, for Spinoza, the term “dictates of reason” does not refer to a set of prescriptive principles but simply the necessary consequences, or effects, of the mind's determination by adequate ideas. I draw (...) on this conclusion in highlighting an abiding tension in Spinoza's notion of the preservation of one's being, which reinforces his divergence from Hobbes. (shrink)

An excellent critical analysis and scientific assessment of the nature and actual level of risk leading environmental health hazards pose to the public. Issues such as radiation from nuclear testing, radon in the home, and the connection between electromagnetic fields and cancer, environmental factors and asthma, pesticides and breast cancer and leukemia clusters around nuclear plants are discussed and how scientists assess these risks is illuminated.

At the center of many critiques of liberalism is liberal neutrality, which is attacked on two fronts. First, it is argued that neutrality yields a restrictive sphere of public reason. Contentious views—like those endorsed by citizens with marginalized comprehensive doctrines—are outlawed from public consideration. Second, state policies must have neutral effects, lest they differentially impact those with unpopular views. Contentious state actions—like those endorsed by citizens with marginalized moral views—are outlawed from implementation. It is this combination of demands for neutrality (...) at the individual and state levels that produces the concern: if marginalized comprehensive doctrines cannot be discussed in the realm of public reason, and if marginalized moral views cannot be acted upon by the state, how will we ever achieve the goals of feminism, itself a marginalized moral view? Does liberal neutrality prohibit progress toward gender equality? In this paper, I argue to the contrary. Many objections regarding liberalism’s supposed failure to secure gender justice rely on a conception of neutrality as neutrality of effect. But at both the individual and state levels, liberalism’s demand for neutrality is about justification. Liberalism, specifically political liberalism, requires neither neutral content of public reasons nor neutral effects of state policies. (shrink)

In [3] John S. Bell proposed how to associate particle trajectories with a lattice quantum field theory, yielding what can be regarded as a |Ψ|2-distributed Markov process on the appropriate configuration space. A similar process can be defined in the continuum, for more or less any regularized quantum field theory; such processes we call Bell-type quantum field theories. We describe methods for explicitly constructing these processes. These concern, in addition to the definition of the Markov processes, the efficient calculation of (...) jump rates, how to obtain the process from the processes corresponding to the free and interaction Hamiltonian alone, and how to obtain the free process from the free Hamiltonian or, alternatively, from the one-particle process by a construction analogous to “second quantization.” As an example, we consider the process for a second quantized Dirac field in an external electromagnetic field. (shrink)

Under what conditions would an artificially intelligent system have wellbeing? Despite its clear bearing on the ethics of human interactions with artificial systems, this question has received little direct attention. Because all major theories of wellbeing hold that an individual’s welfare level is partially determined by their mental life, we begin by considering whether artificial systems have mental states. We show that a wide range of theories of mental states, when combined with leading theories of wellbeing, predict that certain existing (...) artificial systems have wellbeing. Along the way, we argue that there are good reasons to believe that artificial systems can have wellbeing even if they are not phenomenally conscious. While we do not claim to demonstrate conclusively that AI systems have wellbeing, we argue that there is a significant probability that some AI systems have or will soon have wellbeing, and that this should lead us to reassess our relationship with the intelligent systems we create. (shrink)

This paper explores the relationship between dynamic and truth conditional semantics for epistemic modals. It provides a generalization of a standard dynamic update semantics for modals. This new semantics derives a Kripke semantics for modals and a standard dynamic semantics for modals as special cases. The semantics allows for new characterizations of a variety of principles in modal logic, including the inconsistency of ‘p and might not p’. Finally, the semantics provides a construction procedure for transforming any truth conditional semantics (...) for modals into a dynamic semantics for modals with similar properties. (shrink)

Recent advances in natural language processing have given rise to a new kind of AI architecture: the language agent. By repeatedly calling an LLM to perform a variety of cognitive tasks, language agents are able to function autonomously to pursue goals specified in natural language and stored in a human-readable format. Because of their architecture, language agents exhibit behavior that is predictable according to the laws of folk psychology: they function as though they have desires and beliefs, and then make (...) and update plans to pursue their desires given their beliefs. We argue that the rise of language agents significantly reduces the probability of an existential catastrophe due to loss of control over an AGI. This is because the probability of such an existential catastrophe is proportional to the difficulty of aligning AGI systems, and language agents significantly reduce that difficulty. In particular, language agents help to resolve three important issues related to aligning AIs: reward misspecification, goal misgeneralization, and uninterpretability. (shrink)

This book examines and compares the two major traditions of institutionalist thinking in economics: the 'old' institutionalism of Veblen, Mitchell, Commons, and Ayres, and the 'new' institutionalism developed more recently from neoclassical and Austrian sources and including the writings of Coase, Williamson, North, Schotter, and many others. The discussion is organized around a set of key methodological, theoretical, and normative problems that necessarily confront any attempt to incorporate institutions into economics. These are identified in terms of the issues surrounding the (...) use of formal or non-formal analytical methods, individualist or holistic approaches, the respective roles of rational choice and rule-following behavior, the relative importance of the spontaneous evolution and deliberative design of institutions, and questions concerning the normative appraisal of institutions. The old and the new institutionalism have often been paired on opposite sides of these issues, and the issues themselves presented in a series of sharp dichotomies. Professor Rutherford argues, however, that matters are both more complex and more challenging. Although each tradition embodies fascinating insights into the study of economic institutions - their functioning, evolution, and impact on human welfare - neither has as yet provided fully satisfactory answers to the problems identified. (shrink)

Recent research has identified a tension between the Safety principle that knowledge is belief without risk of error, and the Closure principle that knowledge is preserved by competent deduction. Timothy Williamson reconciles Safety and Closure by proposing that when an agent deduces a conclusion from some premises, the agent’s method for believing the conclusion includes their method for believing each premise. We argue that this theory is untenable because it implies problematically easy epistemic access to one’s methods. Several possible solutions (...) are explored and rejected. (shrink)

In the last quarter of the nineteenth century, Ludwig Boltzmann explained how irreversible macroscopic laws, in particular the second law of thermodynamics, originate in the time-reversible laws of microscopic physics. Boltzmann’s analysis, the essence of which I shall review here, is basically correct. The most famous criticisms of Boltzmann’s later work on the subject have little merit. Most twentieth century innovations – such as the identification of the state of a physical system with a probability distribution on its phase space, (...) of its thermodynamic entropy with the Gibbs entropy of , and the invocation of the notions of ergodicity and mixing for the justification of the foundations of statistical mechanics – are thoroughly misguided. (shrink)

This paper examines the question of whether Large Language Models (LLMs) like ChatGPT possess minds, focusing specifically on whether they have a genuine folk psychology encompassing beliefs, desires, and intentions. We approach this question by investigating two key aspects: internal representations and dispositions to act. First, we survey various philosophical theories of representation, including informational, causal, structural, and teleosemantic accounts, arguing that LLMs satisfy key conditions proposed by each. We draw on recent interpretability research in machine learning to support these (...) claims. Second, we explore whether LLMs exhibit robust dispositions to perform actions, a necessary component of folk psychology. We consider two prominent philosophical traditions, interpretationism and representationalism, to assess LLM action dispositions. While we find evidence suggesting LLMs may satisfy some criteria for having a mind, particularly in game-theoretic environments, we conclude that the data remains inconclusive. Additionally, we reply to several skeptical challenges to LLM folk psychology, including issues of sensory grounding, the "stochastic parrots" argument, and concerns about memorization. Our paper has three main upshots. First, LLMs do have robust internal representations. Second, there is an open question to answer about whether LLMs have robust action dispositions. Third, existing skeptical challenges to LLM representation do not survive philosophical scrutiny. (shrink)

Linkage of population-based administrative data is a valuable tool for combining detailed individual-level information from different sources for research. While not a substitute for classical studies based on primary data collection, analyses of linked administrative data can answer questions that require large sample sizes or detailed data on hard-to-reach populations, and generate evidence with a high level of external validity and applicability for policy making. There are unique challenges in the appropriate research use of linked administrative data, for example with (...) respect to bias from linkage errors where records cannot be linked or are linked together incorrectly. For confidentiality and other reasons, the separation of data linkage processes and analysis of linked data is generally regarded as best practice. However, the ‘black box’ of data linkage can make it difficult for researchers to judge the reliability of the resulting linked data for their required purposes. This article aims to provide an overview of challenges in linking administrative data for research. We aim to increase understanding of the implications of the data linkage environment and privacy preservation; the linkage process itself and linkage quality and potential bias in linked data. We draw on examples from a number of countries to illustrate a range of approaches for data linkage in different contexts. (shrink)

It is generally assumed that existing artificial systems are not phenomenally conscious, and that the construction of phenomenally conscious artificial systems would require significant technological progress if it is possible at all. We challenge this assumption by arguing that if Global Workspace Theory (GWT) — a leading scientific theory of phenomenal consciousness — is correct, then instances of one widely implemented AI architecture, the artificial language agent, might easily be made phenomenally conscious if they are not already. Along the way, (...) we articulate an explicit methodology for thinking about how to apply scientific theories of consciousness to artificial systems and employ this methodology to arrive at a set of necessary and sufficient conditions for phenomenal consciousness according to GWT. (shrink)

This paper develops an information-sensitive theory of the semantics and probability of conditionals and statements involving epistemic modals. The theory validates a number of principles linking probability and modality, including the principle that the probability of a conditional If A, then C equals the probability of C, updated with A. The theory avoids so-called triviality results, which are standardly taken to show that principles of this sort cannot be validated. To achieve this, we deny that rational agents update their credences (...) via conditionalization. We offer a new rule of update, Hyperconditionalization, which agrees with Conditionalization whenever nonmodal statements are at stake but differs for modal and conditional sentences. (shrink)

In this paper I argue that there is a preface paradox for intention. The preface paradox for intention shows that intentions do not obey an agglomeration norm, requiring one to intend conjunctions of whatever else one intends. But what norms do intentions obey? I will argue that intentions come in degrees. These partial intentions are governed by the norms of the probability calculus. First, I will give a dispositional theory of partial intention, on which degrees of intention are the degrees (...) to which one possesses the dispositions characteristic of full intention. I will use this dispositional theory to defend probabilism about intention. Next, I will offer a more general argument for probabilism about intention. To do so, I will generalize recent decision theoretic arguments for probabilism from the case of belief to the case of intention. (shrink)

This paper develops a semantic solution to the puzzle of Free Choice permission. The paper begins with a battery of impossibility results showing that Free Choice is in tension with a variety of classical principles, including Disjunction Introduction and the Law of Excluded Middle. Most interestingly, Free Choice appears incompatible with a principle concerning the behavior of Free Choice under negation, Double Prohibition, which says that Mary can’t have soup or salad implies Mary can’t have soup and Mary can’t have (...) salad. Alonso-Ovalle 2006 and others have appealed to Double Prohibition to motivate pragmatic accounts of Free Choice. Aher 2012, Aloni 2018, and others have developed semantic accounts of Free Choice that also explain Double Prohibition. -/- This paper offers a new semantic analysis of Free Choice designed to handle the full range of impossibility results involved in Free Choice. The paper develops the hypothesis that Free Choice is a homogeneity effect. The claim possibly A or B is defined only when A and B are homogenous with respect to their modal status, either both possible or both impossible. Paired with a notion of entailment that is sensitive to definedness conditions, this theory validates Free Choice while retaining a wide variety of classical principles except for the transitivity of entailment. The homogeneity hypothesis is implemented in two different ways, homogeneous alternative semantics and homogeneous dynamic semantics, with interestingly different consequences. (shrink)

The Ghirardi–Rimini–Weber (GRW) theory of spontaneous wave function collapse is known to provide a quantum theory without observers, in fact two different ones by using either the matter density ontology (GRWm) or the flash ontology (GRWf). Both theories are known to make predictions different from those of quantum mechanics, but the difference is so small that no decisive experiment can as yet be performed. While some testable deviations from quantum mechanics have long been known, we provide here something that has (...) until now been missing: a formalism that succinctly summarizes the empirical predictions of GRWm and GRWf. We call it the GRW formalism. Its structure is similar to that of the quantum formalism but involves different operators. In other words, we establish the validity of a general algorithm for directly computing the testable predictions of GRWm and GRWf. We further show that some well-defined quantities cannot be measured in a GRWm or GRWf world. (shrink)

From the acclaimed writer and thinker--whose award-winning books include both fiction and non-fiction--a dazzlingly original plunge into the drama of philosophy, revealing its hidden but essential role in today's debates on love, religion, politics, and science. Imagine that Plato came to life in the 21st century and set out on a multi-city speaking tour: How would he handle a host on Fox News who challenges him on religion and morality? How would he mediate a debate on the best way to (...) raise a child between a Freudian psychoanalyst and a Tiger Mom? How would he answer a neuroscientist who, about to scan Plato's brain, argues that all his philosophical problems can be solved by our new technologies? What would he make of Google, and the idea that knowledge can be crowdsourced rather than reasoned out by experts? With a philosopher's depth and a novelist's imagination, Rebecca Newberger Goldstein probes the deepest issues confronting us--from sexuality and child-rearing to morality and the meaning of life--by allowing us to eavesdrop on Plato as he encounters the modern world. By reviving the Platonic art of the dialogue for the 21st century, she demonstrates that the questions he first posed continue to confound and enlarge us. (shrink)

Triviality results threaten plausible principles governing our credence in epistemic modal claims. This paper develops a new account of modal credence which avoids triviality. On the resulting theory, probabilities are assigned not to sets of worlds, but rather to sets of information state-world pairs. The theory avoids triviality by giving up the principle that rational credence is closed under conditionalization. A rational agent can become irrational by conditionalizing on new evidence. In place of conditionalization, the paper develops a new account (...) of updating: conditionalization with normalization. (shrink)

Against Hume and Epicurus I argue that our selection of pleasure, pain and other objects as our ultimate ends is guided by reason. There are two parts to the explanation of our attraction to pleasure, our aversion to pain, and our consequent preference of pleasure to pain: 1. Pleasure presents us with reason to seek it, pain presents us reason to avoid it, and 2. Being intelligent, human beings (and to a degree, many animals) are disposed to be guided by (...) reason, and hence by what there is reason to choose, seek, and prefer, when they act. (shrink)

This is the most up-to-date and comprehensive interpretation of the philosophy of Gottfried Wilhelm Leibniz. Amongst its other virtues, it makes considerable use of unpublished manuscript sources. The book seeks to demonstrate the systematic unity of Leibniz's thought, in which theodicy, ethics, metaphysics and natural philosophy cohere. The key, underlying idea of the system is the conception of nature as an order designed by God to maximise the opportunities for the exercise of reason. From this idea emerges the view that (...) this world is the best of all possible worlds, and an ethical ideal in which the well-being of human beings is promoted through the gradual extension of intellectual enlightenment. (shrink)

This paper explores the principle that knowledge is fragile, in that whenever S knows that S doesn’t know that S knows that p, S thereby fails to know p. Fragility is motivated by the infelicity of dubious assertions, utterances which assert p while acknowledging higher-order ignorance whether p. Fragility is interestingly weaker than KK, the principle that if S knows p, then S knows that S knows p. Existing theories of knowledge which deny KK by accepting a Margin for Error (...) principle can be conservatively extended with Fragility. (shrink)