Pleckstrin homology (PH) domains are a family of compact protein modules defined by sequences of roughly 100 amino acids. These domains are common in vertebrate, Drosophila, C. elegans and yeast proteins, suggesting an early origin and fundamental importance to eukaryotic biology. Many enzymes which have important regulatory functions contain PH domains, and mutant forms of several such proteins are implicated in oncogenesis and developmental disorders. Numerous recent studies show that PH domains bind various proteins and inositolphosphates. Here I discuss PH (...) domains in detail and conclude that they form a versatile family of membrane binding and protein localization modules. (shrink)

Neurofilaments are by far the most obvious elements of the neuronal cytoskeleton. Their subunits are biochemically among the most abundant neuron specific components, particularly in axons. Clearly they must be important to the neuron or they would not be so numerous But what do they do?.

Background Structured training in research integrity, research ethics and responsible conduct of research is one strategy to reduce research misconduct and strengthen reliability of and trust in scientific evidence. However, how researchers develop their sense of integrity is not fully understood. We examined the factors and circumstances that shape researchers’ understanding of research integrity. Methods This study draws insights from in-depth, semi-structured interviews with 33 researchers in the life sciences and medicine, representing three seniority levels across five research universities in (...) Switzerland. Results The results of this study indicate that early education, moral values inculcated by the family and participation in team sports were the earliest influences on notions of honesty, integrity and fairness among researchers. Researchers’ personality traits, including degree of ambition and internal moral compass, were perceived as critical in determining the importance they attributed to conducting research with high ethical standards. Positive and negative experiences in early research life also had a significant impact on their views regarding research integrity. Two thirds of the study participants had not received any formal training in research integrity. Their awareness of training opportunities at their institutions was also limited. Conclusion Age-appropriate development of honesty and integrity starts as early as primary education. Research integrity training should be offered from the bachelors level and continue throughout the entire professional life of researchers. Although these courses may not imbue researchers with integrity itself, they are essential to improving the research culture, reinforcing integrity norms, and discouraging researchers who lack personal integrity from engaging in research misconduct. (shrink)

The aim of this paper is to analyze the attitudes and reactions of researchers towards an authorship claim made by a researcher in a position of authority who has not made any scientific contribution to a manuscript or helped to write it. This paper draws on semi-structured interviews conducted with 33 researchers at three seniority levels working in biomedicine and the life sciences in Switzerland. This manuscript focuses on the analysis of participants’ responses when presented with a vignette describing an (...) authorship assignment dilemma within a research group. The analysis indicates that researchers use a variety of explanations and arguments to justify inclusion of what guidelines would describe as honorary or guest authorship. Fuzzy parameters such as “substantial contribution” lead to varied interpretation and consequently convenient application of authorship guidelines in practice. Factors such as the culture of the research group, the values and practice shaped by the research leaders, the hierarchy and relative positions of power within research institutions, and the importance given to publications as the currency for academic success and growth tend to have a strong influence on authorship practice. Unjustified authorship assignment practices can be reduced to some extent by creating empowering research cultures where each researcher irrespective of his/her career stage feels empowered to confidently raise concerns without fearing adverse impact on their professional lives. However, individual researchers and research institutions currently have limited influence on established methods for evaluating academic success, which is primarily based on the number of high impact publications. (shrink)

The goal of this book is to develop a new approach to reading the rule-following sections guided by a simple idea. The simple idea is that Wittgenstein's remarks on rule-following are split between two distinct but complementary projects. The projects are marked not only by different guiding questions, but different presuppositions and methodologies. There is of course precedent for reading the rule-following remarks as comprising two parts. For example, there is the reading of (S. Kripke 1982) on which Wittgenstein first (...) presents a skeptical challenge before turning to its skeptical solution. And there are readings like (Minar 2011) and (Goldfarb 2012) that likewise treat the sections as roughly divided into two components or "chapters." But even these commentators do not explicitly associate their components with different questions and associated methodologies, and so fall short of attributing to Wittgenstein's text anything quite like the thoroughgoing bipartite structure I will be proposing here. (shrink)

This article provides a systematic analysis of the proposal to use Covid‐19 vaccination status as a criterion for admission of patients with Covid‐19 to intensive care units (ICUs) under conditions of resource scarcity. The general consensus is that it is inappropriate to use vaccination status as a criterion because doing so would be unjust; many health systems, including the UK National Health Service, are based on the principle of equality of access to care. However, the analysis reveals that there are (...) several unique features of Covid vaccination status in the context of a pandemic that make this issue disanalogous to cases (such as lung cancer caused by smoking) discussed previously. First, there is equality in access to care at the point of vaccination; the unvaccinated refuse the offer of preventive care when they decline vaccination, weakening their claim to ongoing care if they become ill (this is qualitatively different from ‘poor lifestyle choices’ such as smoking). Second, the decision of one person to refuse vaccination substantially increases the risk that they will become seriously ill and need ICU care; the person who chooses not to get vaccinated thus potentially increases the pressure on intensive care bed provision, as well as increasing the risk that he or she will infect others who in turn might end up needing ICU care. Third, justice cuts both ways, and giving unvaccinated patients equal priority may itself be unjust when other patients have reduced their risk of ending up on the ICU by getting vaccinated. (shrink)

There has been a great deal of skepticism towards the value of the realism/anti-realism debate. More specifically, many have argued that plausible formulations of realism and anti-realism do not differ substantially in any way. In this paper, I argue against this trend by demonstrating how a hypothetical resolution of the debate, through deeper engagement with the historical record, has important implications for our criterion of theory pursuit and science policy. I do this by revisiting Arthur Fine’s ‘small handful’ argument for (...) realism and show how the debate centers on whether continuity should be an indicator for the future fruitfulness of a theory. I then demonstrate how these debates work in practice by considering the case of the Human Brain Project. I close by considering some potential practical considerations of formulating meta-inductions. By doing this, I contribute three insights to the current debate: 1) demonstrate how the realism/anti-realism debate is a substantive debate, 2) connect debates about realism/anti-realism to debates about theory choice and pursuit, and 3) show the practical significance of meta-inductions. (shrink)

The social trackways theory is centered on the remarkable 3.66 mya Laetoli Fossilized Trackways, for they incontrovertibly reveal our ancestors were already obligate bipeds with very human-like feet, and were intentionally stepping in other band members’ footprints to maintain safe footing. Trackways are unique among natural sign systems in possessing a depictive narratively generative structure, somewhat like the symbolic sign systems of gestural languages. Therefore, due to daily embodied reiteration of their own and other band member’s old footprints, both for (...) bipedal safety and as recognizable wayfinding markers for socio-ecological navigation, incrementally our Mid-Pliocene ancestors began to acquire a cognitive capacity for episodic personal memories and episodic future simulations. They began mentally representing themselves as intentional agents continuously travelling from the past into the future. This spatially and temporally self-projecting awareness manifested itself as extra theory of mind and mental space-and-time-travel capacities, which increasingly enabled intentional or conscious, top-down executive adjustment of past behaviors for the sake of achieving better ways of doing things in the future. Future-directed behavioral and cultural adaptations began to increase fitness in all domains, thus creating powerful selective feedback for further entrenchment. Here we focus on overtly or consciously intentional exploratory wayfinding and transmission of elsewhere-and-when information, using pragmatic, discursive modes of communication, which enabled far more cooperative and efficient foraging practices. Selection for better communication thus led to intentional trail marking and the earliest emergence of more conventional/symbolic depictive and gestural “protolanguages.”. (shrink)

ABSTRACT In this article, the first author provides a summary and translation from the Latin of an important early medical lecture on vampires by Nils Retzius. The lecture was delivered in Sweden, at Lund University, in 1737, and was published almost immediately thereafter. This important text has been overlooked by modern scholars of vampires. This article will bring the lecture back into circulation in its first English translation. The second author then offers an analysis of the intellectual background to this (...) rational debunking of vampires. He demonstrates how Retzius’s attempt at a comprehensive rational explanation for vampires, typical of much Enlightenment thinking, nevertheless employs a fusion of Galenic medical thinking with more modern medical and psychosomatic notions of medicine, as well as certain Lutheran notions concerning the devil and the spirit world. His argument scotches the belief in the idea of sympathetic magic affecting the dreams of the living, while emphasising the psychosomatic effects of the imagination on the physical body. (shrink)

Definitions of death are often referred to as legal fictions since brain death was conceived in the mid-twentieth century. Reference to legal fiction is generally paired with bioethicists’ concern that it facilitates post-mortem tissue donation and the health system generally, by determining death earlier on the continuum of dying and availing more viable tissue and therapeutic resources for others. The author argues that spatio-legal theory, drawing from legal geography, can account for the heterogeneity of effects that the fiction has in (...) spatially managing bodies (e.g., physicians, patient, family) at the bedside. The legal fiction is produced in physicians’ socio-legal practices, coordinating decision-making according to geographies of scarcity and severable, self-contained live- and dead-bodies. The determination liminally exists between private and public, enacting a sterile, affectless ordering of bodies but administered in the spectacle of sovereign death-making, conveying authority whilst managing patient’s and family’s consents. Spatialising traces of anatamo-politics and biopolitics thereby congeal and are enacted heterogeneously in and through the legal form of the fiction, securing preferred constructions of the body in the management of mortality. These spatio-legal features of the legal fiction are described from their collision with case law and literature that document competing nomoi produced from or secreted by antinomian bodies. (shrink)

In conjunction with the growing feminist literature on pregnancy and visualization, this paper uses Foucault’s The Birth of the Clinic to demonstrate how the effort to make the interior of the pregnant body visible in medical discourse was a crucial part of the development of the modern medical gaze. In doing so I develop two concurrent arguments. First, I argue that the pathological corpse of the Clinic can conceptually serve as a double for the pregnant body as it emerged in (...) modern medicine in the 20th century. At the same time I use the insights of the Clinic to illustrate changes in pregnancy from early modernity to the 20th century. In early modernity, the pregnant body was understood in terms of generation, as a tree that bears fruit; by the 19th century, the pregnant body was a machine that reproduced the species. This transition can be seen in the overlap of pathology and pregnancy in early modernity, an overlap that continued throughout the 19 century and is inadvertently reinforced through the practice of ultrasound. (shrink)

In this article I argue that vagueness concerning consent to post‐mortem organ donation causes considerable harm in several ways. First, the information provided to most people registering as organ donors is very vague in terms of what is actually involved in donation. Second, the vagueness regarding consent to donation increases the distress of families of patients who are potential organ donors, both during and following the discussion about donation. Third, vagueness also increases the chances that the patient's intention to donate (...) will not be fulfilled due to the family's distress. Fourth, the consequent reduction in the number of donated organs leads to avoidable deaths and increased suffering among potential recipients, and distresses them and their families. There are three strategies which could be used to reduce the harmful effects of this vagueness. First, recategorizing the reasons (commonly referred to as ‘overrules’ under the current system) given by families who refuse donation from registered donors would bring greater clarity to donation discussions. Second, people who wish to donate their organs should be encouraged to discuss their wishes in detail with their families, and to consider recording their wishes in other ways. Finally, the consent system for organ donation could be made more detailed, ensuring both that more information is provided to potential donors and that they have more flexibility in how their intentions are indicated; this last strategy, however, could have the disadvantage of discouraging some potential donors from registering. (shrink)

Blair's account, like the intelligence field in general, treats many distinct constructs as if they were practically interchangeable – this is not self-evident. Paradigm integration and rationalization of redundant nomenclature are important for the continued development of understanding. The prior task is to demonstrate where synonymity of constructs across paradigms occurs, and where it fails. We present arguments why this is the case. (Published Online April 5 2006).

If you are kind to me, I am likely to reciprocate and doing so feels fair. Many theories of social exchange assume that such reciprocity and fairness are well aligned with one another. We argue that this correspondence between reciprocity and fairness is restricted to interpersonal dyads and does not govern more complex multilateral interactions. When multiple people are involved, reciprocity leads to partiality, which may be seen as unfair by outsiders. We report seven studies, conducted with people from the (...) United States, in which participants were asked to evaluate situations involving resource distribution in contexts such as economic games, government, and the workplace. Specifically, we find that equal resource distribution in multilateral interactions is seen as more fair than engaging in reciprocity. We also find that negative reciprocity is seen as more fair than positive reciprocity in these multilateral situations because positive reciprocity is perceived as based in favoritism. We rule out alternative explanations and demonstrate that there are contexts where favoritism is not viewed as unfair. These findings are important for theories of fairness and reciprocity as they demonstrate the central role of perceived partiality in the evaluation of multi‐party resource allocation. (shrink)

In order to explain Cavell's account of what makes movies so magical, this article will offer a chronological survey of his major writings on film, beginning with the first edition of The World Viewed (1971), where he poses an intriguing theoretical hypothesis about what distinguishes the movies from the other major art forms. The survey will continue by considering the expanded edition of The World Viewed (1979), Pursuits of Happiness: The Hollywood Comedy of Remarriage (1984), and Contesting Tears: The Hollywood (...) Melodrama of the Unknown Woman (1997), and will conclude with an analysis of Cavell's discussion of Emersonian perfectionism in Cities of Words (2005). Throughout, I show how the specific film interpretations he proposes serve as archetypal examples of crucial features of his philosophy. Cavell's general thesis, I take it, is that films can pose particularly satisfying responses to the skepticism we all harbour about our most deeply held values. In a nutshell, the movies are magical because they tell us myths that allow us to see our lives as worth living, helping to restore our faith in the wellsprings of human value: romantic love, individual autonomy, nonconformity, and the search for self-improvement. (shrink)

Joint attention (JA) is hypothesized to have a close relationship with developing theory of mind (ToM) capabilities. We tested the co-occurrence of ToM and JA in social interactions between adults with no reported history of psychiatric illness or neurodevelopmental disorders. Participants engaged in an experimental task that encouraged nonverbal communication, including JA, and also ToM activity. We adapted an in-lab variant of experience sampling methods (Bryant, Coffey, Povinelli, & Pruett, 2013) to measure ToM during JA based on participants’ subjective reports (...) of their thoughts while performing the task. This experiment successfully elicited instances of JA in 17/20 dyads. We compared participants’ thought contents during episodes of JA and non-JA. Our results suggest that, in adults, JA and ToM may occur independently. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Young Finley:Observations on Naiden, Perry, and TompkinsBrent D. ShawIn this cursory response, I reflect on the hard work done by the three colleagues on whose articles I am commenting. Their investigations have contributed to a better understanding of the complex academic and professional background of a man who was surely one of the more influential historians of Greek and Roman antiquity writing in the latter half of the (...) twentieth century. So it is to these colleagues that the reader should pay most attention. My comments are in part directed to some specifics in their papers, and in part they are thoughts provoked by first listening to two of the papers at the 2012 Association of Ancient Historians meeting, and then reading all three (now including Jonathan Perry’s) in written form the following year.My first observation made in reflecting on the detailed recountings of one individual’s past—ordered details that produce an apparently sensible and logical narrative—is to see less conscious and perhaps seemingly trivial factors in the making of the professional historian. These are easily ignored, but their long-term and situational impact was sometimes great. The first of them is boredom.1 After all, in accordance with his father’s wishes, in 1929 Finley began work in the legal department of General Motors after securing a Master’s degree in American constitutional law. Like his older brother Murray, he could have continued to serve usefully and profitably in this capacity, and might have entered the governing echelons of one of the great capitalist corporations of his time: what a concept! Why did he not stay with GM? By his own account in the interview with Keith Hopkins, glacial boredom drove him back to his avocation of history. Like the rest of us who have this fascination, he was intrigued by the past, and this compelling interest overrode other possible ways forward.2 Sometimes details like these just jump out of the [End Page 267] piles of facts, and sometimes they are important in defining the person. I remember standing in front of the large portrait of Finley at Darwin College, Cambridge, and saying to a friend of mine, standing beside me, "There’s something missing here." "The burning cigarette," he replied. He was right. And this, too, locates our man in a certain mode of past behavior.3A vivid scenario from the 1940s evoked in Fred Naiden’s paper (p. 250) features the divisions between the downtown and uptown communities in New York city that Finley somehow had to negotiate as part of his management of Russian War Relief. In one of the missives quoted about navigating his way between the shoals of these conflicts, I spotted the use of the adverb "flatly," and I immediately recognized our man: "I have flatly told the Landsmanschaft groups that..." he states in a 1943 memorandum warning that these groups should not deal with the Jewish Defense Committee (JDC), but rather with the Russian War Relief organization, in supporting Jewish communities that had been under Nazi occupation in eastern lands. As tiny a thing as it is, it is no surprise that this same absolute refusal is expressed with the same adverb in a much later 1975 letter to Pierre Vidal-Naquet, quoted by Naiden (above, p. 257): "It gives me no pleasure, as you can imagine, to turn you down flatly...," once again precisely in internal disagreement over strategy and Jewish identity, and in affirmation of Finley’s standoffish attitude to the new state of Israel. The two instances were linked. As the JDC people oriented themselves more and more towards Washington, lobbying the center, and away from New York, they became more pro-Israel. Meanwhile, the downtown left drifted away from such involvements. There are always these instances of movement. Like boredom, they signal changes and continuities.One is struck by the world of continuities, even as the Thirties were hurled violently into the Forties by the colossal forces of a global conflict. As seems increasingly clear from these three insightful and detailed pieces of research, however, the big discontinuity occurs immediately after the war, between 1946 and the end... (shrink)

This paper is an elaboration of Paul de Man’s critique, in “Heidegger’s Exegeses of Hölderlin,” of Martin Heidegger’s commentary on Friedrich Hölderlin’s poem, “As when on a holiday…” I show that de Man’s critique can be expanded into a critique of a type of testimony that Heidegger ascribes to Hölderlin’s poem. Heidegger ascribes to Hölderlin’s poem what I call “infinite testimony,” but, thereby, suppresses in the poem another type of testimony—what I call “finite testimony. This suppression is most in evidence (...) in Heidegger’s interpretation of Hölderlin’s reference to the myth of Semele, as well as in Heidegger’s excision, in the version of the poem that he printed in the commentary, of the concluding lines of the poem. Additionally, I discuss the political implications of Heidegger’s suppression of the finite testimony depicted in “As when on a holiday...”. (shrink)

Much of the ethical discourse concerning the coronavirus pandemic has focused on the allocation of scarce resources, be it potentially beneficial new treatments, ventilators, intensive care beds, or oxygen. Somewhat ironically, the more important ethical issues may lie elsewhere, just as the more important medical issues do not concern intensive care or treatment for COVID‐19 patients, but rather the diversion towards these modes of care at the expense of non‐Covid patients and treatment. In this article I explore how ethicists can (...) and should prioritize which ethical issues to deal with, and develop a method of triage for identification and prioritization of ethical issues both in the next public health emergency and in bioethics more widely. (shrink)

Poetry and informational text showcase the work of community animal shelters. Ten different fictional animals represent the millions of pets brought to shelters every day. Suggestions on animal adoption, including how to prepare and appropriate pet selection, are included, along with resources list.

The conceptual persona of the idiot recurs and evolves over the decades between Deleuze’s Difference and Repetition and his final book with Guattari, What is Philosophy?, shifting from a philosophical question to a nonphilosophical one that allies thought with literature and life. The great figure of this shock of literature is Antonin Artaud who, Deleuze argues, refinds thought’s creative capacity by putting it back in touch with its immanent outside – with a machinic and pre-personal ‘unthought’. This essay will argue (...) that by turning to works from later in Artaud’s œuvre, especially the 1946 poem-cycle Artaud le Mômo, the problem of idiocy meets a correlative problem concerning life and death. Artaud establishes a four-fold of thought-unthought-life-unlife which is problematically resolved in what he calls a ‘body’, a figure which I will argue requires that we rethink the relationship Artaud experiences between idiocy and suffering. (shrink)

Many ethical issues are posed by public health interventions. Although abstract theorizing about these issues can be useful, it is the application of ethical theory to real cases which will ultimately be of benefit in decision-making. To this end, this paper will analyse the ethical issues involved in Childsmile, a national oral health demonstration programme in Scotland that aims to improve the oral health of the nation's children and reduce dental inequalities through a combination of targeted and universal interventions. With (...) Scotland's level of dental caries among the worst in Europe, Childsmile represents one of the largest programmes of work aimed at combating oral health inequalities in the UK. The areas of ethical interest include several contrasting themes: reducing health inequalities and improving health; universal and targeted interventions; political values and evidence base; prevention and treatment; and underlying all of these, justice and utility. (shrink)

This book explores three worlds shared by the humans in their collective experiences. It identifies and explores the world of commonsense, the world of religion, and the world of science as three essential dimensions of human experience. The book helps understand that humans can gain comfort and pleasure in commonsense, achieve meaning and purpose from religion, and attain truth and rationality through science. It actively applies theories to and develops theoretical explanations from different domains or situations of human existence. This (...) book is of interest to theorists, researchers, instructors, and students across major academic disciplines in the humanities and social sciences. (shrink)

An important issue in the development of the American school of philosophy known as critical naturalism was whether the naturalistic vision implied a humanistic or a theistic interpretation of religion. Is the divine a creativity within nature but more than human effort, or is it the human vision of ideal possibilities and the effort to realize them? This issue is clarified through a study of the concept of the divine developed by the leading naturalist John Dewey in A Common Faith, (...) the misunderstanding of this book by Henry Nelson Wieman, and the discussion of this misunderstanding in the pages of Christian Century. The essay concludes that Wieman's misunderstanding of Dewey is instructive in that it reveals unintended possibilities in Dewey's thought. (shrink)