Activation of resting T lymphocytes through the T cell antigen receptor complex is initiated by critical phosphorylation and dephosphorylation events that regulate the function and interaction of a number of signaling molecules. Key elements in these reactions are members of the Src, Syk and Csk families of protein tyrosine kinases (PTKs) and the phosphotyrosine phosphatases (PTPases) that regulate and/or counteract them, such as CD45. The PTKs can autophosphorylate and phosphorylate each other at multiple sites and, as the result of these (...) interactions, they are induced to phosphorylate other cellular proteins. These phosphorylation events lead to modulation of enzymatic activities and/or serve as binding sites for other signaling molecules having phosphotyrosine‐binding Src homology 2 (SH2) domains. As a result, these proteins translocate to the receptor complexes and are juxtaposed to the kinases that phosphorylate them. Some of the SH2‐domain‐containing polypeptides lack enzymatic activities and, instead, serve as adapter molecules that couple the signal to downstream effectors, such as regulators of the Ras proteins, and further into serine/threonine‐specific protein kinase cascades. Through largely unknown steps these reactions lead to the transcription of previously silent genes, activation of lymphocyte effector functions, progression through the cell cycle and cell proliferation. (shrink)

Anne Conway produced only one short treatise – The Principles of the Most Ancient and Modern Philosophy – but addressed key problems in the philosophy of religion which are still much discussed today. The most significant of these are the problem of religious diversity and the problem of evil. Although the sources of her ideas may be found in the Kabbalah of Isaac Luria and the work of the Cambridge Platonists and the Quaker George Keith, among others, she offers (...) her own unorthodox solutions to these problems. The idea of Christ as an indwelling mediator of the divine who assists us in our moral endeavours is designed to appeal to those of all religions and none, while her claim that God created creatures knowing that they would eventually be redeemed, and that suffering promotes moral development which leads to redemption offers a novel response to the problem of evil. Conway's work is also important for its influence on the work of Gottfried Wilhelm Leibniz, and some have argued that it prefigures, at least in outline, the field theory of modern physics. (shrink)

Book reviewed in this article: The Philosophical Assessment of Theology: Essays in Honour of Frederick C. Copleston. Edited by Gerard J. Hughes. Language, Meaning and God: Essays in Honour of Herbert McCabe OP. Edited by Brian Davies. God Matters. By Herbert McCabe. Philosophies of History: A Critical Essay. By Rolf Gruner. The ‘Phaedo’: A Platonic Labyrinth. By Ronna Burger. Lessing's ‘Ugly Ditch’: A Study of Theology and History. By Gordon E. Michalson, Jr. Peirce. By Christopher Hookway. Frege: Tradition and Influence. (...) Edited by Crispin Wright. The Private World. Selections from the Diario Íntimo and Selected Letters 1890–1936. By Miguel de Unamuno, translated by Anthony Kerrigan, Allen Lacy, Martin Nozick. A Third Collection: Papers by Bernard J.F. Lonergan, S.J. Edited by Frederick E. Crowe. Philosophical Papers. By Charles Taylor. 2 vols. Principles of Language and the Mind. By T.P. Waldron. The Principle of Double Effect: A Critical Appraisal of its Traditional Understanding and its Modern Reinterpretation. By L.I. Ugorji. Human Rights: Fact or Fancy By Henry B. Veatch. Enlightenment and Alienation: An Essay towards a Trinitarian Theology. By Colin Gunton. Only Human. By Don Cupitt. The Roots of the Modern Christian Tradition. Edited by E. Rpzanne Elder. ‘Africanische Theologie’: Darstellung und Dialog.. By Heribert Rücker. African Religions in Western Conceptual Schemes. By Emefie Ikenga Metuh. The Destiny of Man: Dagaare Beliefs in Dialogue with Christian Eschatology. By Edward Kuukure. The World in Between: Christian Healing and the Struggle for Spiritual Survival. By E. Milingo. Theology in Africa. By Kwesi A. Dickson. The Future of Anglican Theology. Edited by M. Darrol Bryant. Reconciling. By John Coventry. The Genesis of Faith: The Depth Theology of Abraham Joshua Heschel. By John C. Merkle. Anthropology in Theological Perspective. By Wolfhart Pannenberg. Contemporary Approaches to the Study of Religion. Volume II: The Social Sciences. Edited by Frank Whaling. American Sociology: Worldly Rejections of Religion and Their Directions. By Arthur J. Vidich and Stanford M. Lyman. A Critical Theory of Religion: The Frankfurt School. By Rudolf J. Siebert. The Anthropology of Evil. Edited by David Parkin. The Wealth of Christians. By Redmond Mullin. Biblical Interpretation in Ancient Israel. By Michael Fishbane. Reading the Old Testament: An Introduction. By Lawrence Boadt. Old Testament Theology: Its History and Development. By John H. Hayes and Frederick C. Prussner. God's Conflict with the Dragon and the Sea: Echoes of a Canaanite Myth in the Old Testament. By John Day. Law and Wisdom from Ben Sira to Paul. By Eckhard J. Schnabel. The Order of the Synoptics: Why Three Synoptic Gospels? By Bernard Orchard and Harold Riley. The Making of Mark. By J. Duncan M. Derrett. Argumentation bei Paulus. By Folker Siegert. Christians and the Military: The Early Experience. Edited by Robert J. Daly. Origienes' Eucharistielehre im Streit der Konfessionen; Die Auslegungsgeschichte seit der Reformation. By Lothar Lies. L'église de Cappadoce au IVe siècle d'après la correspondance de Basile de Césarée. By Benpit Gain Cave Monasteries of Byzantine Cappadocia. By Lyn Rodley. Augustine of Hippo, Selected Writings. Translated with an Introduction by Mary T. Clark. Wisdom from St Augustine. By Vernon J. Bourke. A History of Religious Ideas, Vol. 3: From Muhammad to the Age of Reforms. By Mircea Eliade. Les Lectionnaires Copies Annuels: Basse‐Egypte. By Ugo Zanetti. Humanism and Scholasticism in Late Medieval Germany. By James H. Overfield. Wyclif. By Anthony Kenny. The Lady and the Virgin: Image, Attitude and Experience in Twelfth Century France. By Penny Shine Gold. Unquiet Souls: Fourteenth‐Century Saints and Their Religious Milieu. By Richard Kieckhefer. Luther: Theologian for Catholics and Protestants. Edited by George Yule. La Réforme Catholique: Le Combat de Maldonat. By Paul Schmitt. Roman Catholicism in England: From the Elizabethan Settlement to the Second Vatican Council. By Edward Norman. The Life of David Brainerd. Edited by Norman Pettit. Nineteenth Century Religious Thought in the West. Edited by Ninian Smart, John Clayton, Patrick Sherry and Steven T. Katz The Significance of Jesus Christ in Asia. By Hans Staffner. Is the Virgin Mary Appearing at Medjugorje? By René Laurentin and Ljudevit Rupčić. Mary Queen of Peace: Is the Mother of God Appearing in Medjugorje? By Lucy Rooney and Robert Fancy. (shrink)

A major and timely re-examination of key areas in the social and political thought of Hegel and Marx. The editors' extensive introduction surveys the development of the connection from the Young Hegelians through the main Marxist thinkers to contemporary debates. Leading scholars including Terrell Carver, Chris Arthur, and Gary Browning debate themes such as: the nature of the connection itself scientific method political economy the Hegelian basis to Marxs' "Doctoral Dissertation" human needs history and international relations.

Due to the COVID-19 pandemic, most employees face increasing career-related stress, particularly those who work in multinational corporations, because the international travel constraints prevent them from going back to their families. Hence, it is imperative to investigate the critical impact of employees’ occupational burnout on career-related outcomes. In response, this research explores the moderating effect of OB on the relationships between career competencies and career sustainability. To achieve a more comprehensive understanding of relevant issues, we adopted a mixed-method research design (...) that includes both qualitative and quantitative analyses. Findings indicate that all the three dimensions of CCs were positively related to CS; moreover, OB negatively moderated the individual relationships of CC and BC with CS. The main contribution of this study is to enrich the existing career literature by addressing the critical moderating role of OB in the links of CC and BC individually with CS. Practical implications are also discussed in this study. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Persecution of Writing: Revisiting Strauss and CensorshipGeorges Van Den Abbeele (bio)In the 1542 edition of Pantagruel, Rabelais’s narrator terminates a long tirade extolling the Gargantuan Chronicles’ extraordinary virtues (curing toothaches, relieving the pain of treatments for syphilis, and so on) with the proviso that he will maintain the absurd truth of these claims “jusques au feu exclusive (to any point short of the stake)” [215]. This clause, absent (...) from earlier editions, while implicating the comic cowardice of the narrator also adumbrates a tragic sense of prudence. In the early years of the sixteenth century, not just Rabelais but the rest of his Renaissance world had come increasingly to know the heavy hand of censorship and persecution. Bookburning, of course, had lost its traditional source of terror with the invention of the printing press: no longer could a single bonfire extinguish all versions of a single manuscript. Instead, Church and State authorities had in the course of the Renaissance to invent new practices for controlling and regulating the circulation of dangerous words: bans on publication, excision of offensive passages prior to printing, indices of prohibited books, and so on. When left with no other alternative, however, one could still burn not just sample copies of the book but the offending author too, such as in the case of Giordano Bruno, whose auto-da-fé menacingly lit up the skies in the very first year of the seventeenth century. 1Today, with the advent of electronic media and the virtual extirpation of texts from the materiality of print and paper, it is even more difficult to abolish or even regulate the spread of refractory discourses. In the last decade, though, we have seen renewed attempts at censorship, not just of modern visual, aural, and electronic modes of representation (as is commonly recognized and debated), but also of that reputed cornerstone of liberal democratic rights, the printed text. And while in the contemporary American context it may seem that the debate over censorship has “become an argument almost exclusively about pornography and obscenity” [McGrail 51], there is also a critical need for reflection on the renewed onslaught today in virtually every part of the planet against the freedom of writers and that of the press per se. The gravity of the situation best emblematized by the case of Salman Rushdie should not blind us to the parallel stories of Taslima Nasrin, Wole Soyinka, Farag Fuda, Nawal el Saadawi, and others sadly too numerous to list. 2 [End Page 3]In this context, Leo Strauss’s 1941 essay “Persecution and the Art of Writing” retains a remarkable currency on the subject and remains a crucial point of departure from which to reflect on the contemporary crisis of censorship and the writer. Written at a time, over half a century ago, when another wave of explicit attacks on writers shocked the intellectual world, Strauss’s essay, on the one hand, struck a hopeful chord by evoking the kinds of techniques available to writers in their efforts to evade or foil censorship, that is, by demonstrating that no censorship can fully succeed in terroristically bringing about an end to heterodox forms of expression. On the other hand, he posits at least the possibility for every text that it has an inexorable core that is esoteric. No censorship can be total, but there is also no such thing as a pristine state of letters prior to censorship. As Michael Holquist has written in a more recent venue, “censorship is” [16], and all discussion must begin from that understanding if we are ever to approach the magnitude of the contemporary debacle.It is perhaps no small irony, too, that a certain Straussianism begs the question of censorship, complaining about the strictures of “political correctness” while seeking to restore a canon that not only would deny many forms of alternative discourse but also the very historicity of such constructs as canons and approved reading lists as well as indices of “forbidden books.” A useful approach might be to consider whether more recent forms of censorship have historically exceeded the terms of Strauss’s argument or whether the Straussian version of history is not itself an... (shrink)

The Marquis de Sade has been labeled everything from a sadomasochistic pornographer to the fiction writer responsible for the ideas that led to the Nazi death camps. Must We Burn Sade? peels away the negative legacy that has shrouded Sade for too long. Deepak Narang Sawhney points out that "Sade's legacy has been neglected, recreated, fictionalized, and venerated by medical guilds, literary hacks, religious detractors, and intellectual movements. In the past two centuries, Sade has come to represent many things for (...) many people.... It is unclear whether we know Sade the writer or the apparatus which has been set up to either condemn or to sanctify his life and work." By contrast, this intriguing collection of essays seeks to examine Sade for what he was—a writer of novels and letters, a creator of plays and stories, and an author of essays and political manifestos. The contributors examine the literary, theatrical, political, social, and philosophical aspects of Sade's work, acquitting him of the false accusations and trials that have plagued his name by revealing his influences and motivations, and by providing an understanding of society's fear of Sade. What is so alarming about Sade's books that civilized society has felt compelled to disassociate itself from his works? This volume forces us to rethink Sade. Included are essays by Kathy Acker, David Allison, Georges Bataille, Catherine Cusset, Lucienne Frappier-Mazur, Annie Le Brun, Alphonso Lingis, Stephen Pfohl, Deepak Narang Sawhney, Philippe Sollers, and Alistair Welchman. (shrink)

Sherwood Anderson's Winesburg, Ohio, published in 1919, is an episodic collection of character sketches based mostly around the perspective of George Willard, a small-town journalist who listens to the stories of various characters, often described in grotesque terms, whose passionate inner lives contrast with their limited outwardly lived existences. The initial critical response to these stories was to regard Anderson as a sort of cheap Freudian who was making an obvious criticism of American Puritanism and conformity. One reviewer, Regis (...) Michaud, wrote that Winesburg, Ohio was "entirely in keeping with the most recent contributions of American literature to psychoanalysis";1 another reviewer, H. W. Boynton. (shrink)

The “Burning Bush” was the name of a cultural circle in Bucharest in the 1940s, comprised of clergy and intellectuals who met periodically to discuss theology, philosophy, literature and to learn about prayer. Some of the most significant members of this group were arrested during the second repressive wave by the Romanian communist regime (1958); along with twelve elderly monks and intellectuals, four students who kept in touch with them were also arrested. Their names were George Văsâi, Șerban Mironescu, (...) Nicolae Rădulescu, and Emanoil Mihăilescu. Using memoirs, oral history interviews and documents from the Securitate archives, the paper will address the interactions between the young students and the elder members of the Burning Bush group of clergy and intellectuals. The narratives of the informative and criminal files of the Securitate regarding the content of their meetings will also be depicted, all inside a larger context of the regime’s repressive measures and relations with the Romanian Orthodox Church. (shrink)

We discuss how Burns' conception may be further extended to integrate research on eye movement abnormalities, but then point to a contradiction between Burns' conception of schizophrenia as the genetic price for human social life and the diffusion tensor imaging (DTI) data, which constitute his central piece of evidence.

RésuméCet article est une exégèse appréciative de l'article de Steven Burns intitulé « If a lion could talk ». Dans son essai, Burns clarifie la remarque énigmatique de Ludwig Wittgenstein, « Si un lion pouvait parler, on ne serait pas capables de le comprendre », en la situant dans le contexte plus large de l’œuvre de Wittgenstein en philosophie de la psychologie. Nous lisons l'interprétation de cette remarque par Burns comme ouvrant les questions wittgensteiniennes fondamentales au sujet (...) du sens et de la (mé)compréhension, et nous la situons dans le cadre du travail de l'enseignant de Burns, Peter Winch. Notre discussion est une exégèse étroite du contenu immédiat de la remarque sur le lion et elle met en lumière les liens avec les réflexions écrites de Wittgenstein sur The Golden Bough de James George Frazer. Nous montrons comment Burns et Winch utilisent les méthodes de Wittgenstein pour résoudre les énigmes philosophiques en attirant l'attention sur des cas familiers intermédiaires. Enfin, nous concluons par quelques remarques impressionnistes sur Socrate dans une brève discussion au sujet de la difficulté de la technique et de l'activité philosophiques que Burns déploie et recommande. (shrink)

While strike action has been common since the industrial revolution, it often invokes a passionate and polarising response, from the strikers themselves, from employers, governments and the general public. Support or lack thereof from health workers and the general public is an important consideration in the justification of strike action. This systematic review sought to examine the impact of strike action on patient and clinician attitudes, specifically to explore (1) patient and health worker support for strike action and (2) the (...) predictors for supporting strike action and the reasons given for engaging in strike action. A systematic scoping review was employed to identify all relevant literature, followed by a textual narrative synthesis. A total of 34 studies met inclusion criteria. Support for strike action was largely context‐dependent. A range of factors impact support for strike action; broader cultural and structural factors, such as unionisation and general acceptance of strike action; systemic factors, such as the nature of the healthcare system, including infrastructure and work conditions; the strike itself and a range of individual factors, the most notable of which was being a student or in an early career stage. There were also some surprising results, for example, during doctors strike, nurses were provided with the opportunity to expand their role, which led to greater professional autonomy and job satisfaction. (shrink)

The provision of police services and the suppression of crime is one of the first functions of civil government. Article 3 of the Universal Declaration of Human Rights speaks of a right to “security of person.” “The term ‘police’ traditionally connoted social organization, civil authority, or formation of a political community—the control and regulation of affairs affecting the general order and welfare of society,” including the protection of public health. Civil dispute resolution is also an important part of a system (...) that moves people away from self-help and toward reliance on collectively constituted, peaceful channels for working out problems.A safe and secure environment is tied to health. Research in social epidemiology suggests that a shared sense of security from physical violence and interference with property can contribute to better community health. (shrink)

George Berkeley's two major works, A Treatise Concerning the Principles of Human Knowledge and Three Dialogues Between Hylas and Philonous, are presented here, together with perhaps the most searching examination his ideas received during his lifetime, that of the American Samuel Johnson, who corresponded with Berkeley during his stay in the country.

ABSTRACT The list of proposed addictions has recently grown to include television, videogames, shopping, day trading, kleptomania, and use of the Internet. These activities share with a more established entry, gambling, the property that they require no delivery of a biological stimulus that might be thought to unlock a hardwired brain process. I propose a framework for analyzing that class of incentives that do not depend on the prediction of physically privileged environmental events: people have a great capacity to coin (...) endogenous reward; we learn to cultivate it, and, where it is entrapping, to minimize it, by managing internally generated appetites for it. The basic method of cultivating endogenous reward is to learn cues that predict when best to harvest the reward that has been made possible by the growth of these appetites. This hedonic management occurs in the same motivational marketplace as the instrumental planning that seeks environmental goods in the conventional manner, and presumably obeys the same laws of temporal difference learning; but these laws are no longer limiting. Furthermore, instrumental contingencies often provide the most productive structure for hedonic management as well, for reasons that I discuss; but the needs of hedonic management create incentives both to pursue instrumental goals in a suboptimal manner and to avoid noticing how the hedonic incentive affects this pursuit. The result is the apparent irrationality that is often observed in process addictions. (shrink)

Deaths of Despair (DoD), or mortality resulting from suicide, drug overdose, and alcohol-related liver disease, have been rising steadily in the United States over the last several decades. In 2020, a record 186,763 annual despair-related deaths were documented, contributing to the longest sustained decline in US life expectancy since 1915–1918. This forum feature considers how health humanities disciplines might fruitfully engage with this era-defining public health catastrophe and help society better understand and respond to the crisis.

This book considers Karl Marx’s ideas in relation to the social and political context in which he lived and wrote. It emphasizes both the continuity of his commitment to the cause of full human emancipation, and the role of his critique of political economy in conceiving history to be the history of class struggles. The book follows his developing ideas from before he encountered political economy, through the politics of 1848 and the Bonapartist “farce,”, the maturation of the critique of (...) political economy in the Grundrisse and Capital, and his engagement with the politics of the First International and the legacy of the Paris Commune. Notwithstanding errors in historical judgment largely reflecting the influence of dominant liberal historiography, Marx laid the foundations for a new social theory premised upon the historical consequences of alienation and the potential for human freedom. (shrink)

George Dickie; Symposium: Monroe Beardsley's Legacy in Aesthetics EDITED BY MICHAEL WREEN AND DONALD CALLEN: The Origin of Beardsley's Aesthetics, The Journal o.

By delving into the history and development of logic from its beginnings to the modern era, George Englebretsen rehabilitates term logic and demonstrates that an enhanced traditional logic remains a viable possibility. Taking inspiration from Fred Sommers' work, he creates an updated and fascinating version of term logic; one he believes to be just as legitimate as, and in ways superior to, the currently predominant mathematical logic.

The American Medical Association enacted its Code of Ethics in 1847, the first such national codification. In this volume, a distinguished group of experts from the fields of medicine, bioethics, and history of medicine reflect on the development of medical ethics in the United States, using historical analyses as a springboard for discussions of the problems of the present, including what the editors call "a sense of moral crisis precipitated by the shift from a system of fee-for-service medicine to a (...) system of fee-for-system medicine, better known as 'managed care.'" The authors begin with a look at how the medical profession began to consider ethical issues in the 1800s and subsequent developments in the 1900s. They then address the sociological, historical, ethical, and legal aspects of the practice of medicine. Later chapters discuss current and future challenges to medical ethics and professional values. Appendixes display various versions of the AMA's Code of Ethics as it has evolved over time. Contributors: George J. Annas, J.D., M.P.H., Arthur Isak Applbaum, Ph.D., Robert B. Baker, Ph.D., Chester R. Burns, M.D., Ph.D., Arthur L. Caplan, Ph.D., Alexander Morgan Capron, J.D., Christine K. Cassel, M.D., Linda L. Emanuel, M.D., Ph.D., Eliot L. Freidson, Ph.D., Albert R. Jonsen, Ph.D., Stephen R. Latham, J.D., Ph.D., Susan E. Lederer, Ph.D., Florencia Luna, Ph.D., Edmund D. Pellegrino, M.D., Charles E. Rosenberg, Ph.D., Mark Siegler, M.D., Rosemary A. Stevens, Ph.D., Robert M. Tenery, Jr., M.D., Robert M. Veatch, Ph.D., John Harley Warner, Ph.D., Paul Root Wolpe, Ph.D. (shrink)

Across the European Union, the receipt of agricultural subsidisation is increasingly being predicated on the delivery of public goods. In the English context, in particular, these changes can be seen in the redirection of money to the new Environmental Land Management scheme. Such shifts reflect the changed expectations that society is placing on agriculture—from something that provides one good (food) to something that supplies many (food, access to green spaces, healthy rural environment, flood resilience, reduced greenhouse gas emissions). Whilst the (...) reasons behind the changes are well documented, understanding how these shifts are being experienced by the managers expected to deliver on these new expectations is less well understood. Bourdieu’s social theory and the good farmer concept are used to attend to this blind spot, and to provide timely insight as the country progresses along its public goods subsidy transition. Evidence from 65 interviews with 40 different interviewees (25 of whom gave a repeat interview) show a general willingness towards the transition to a public goods model of subsidisation. The optimisation and efficiency that has historically characterised the productivist identity is colouring the way managers are approaching the delivery of public goods. Ideas of land sparing and land sharing (and the farming preference for the former over the latter) are used to help understand these new social and attitudinal realities. The policy implications of these findings are discussed, with reference to the new scheme’s ‘priority themes’. (shrink)

George Grant's magnificent four-part meditation sums up much that is central to his own thought, including a critique of modern liberalism, an analysis of John Rawls's Theory of Justice, and insights into the larger Western philosophical ...

This paper takes a less trodden path in its approach to Kant’s philosophy of religion. Rather than a detailed study of his mature works on the subject, some of his pre-Critical works are examined. These reveal what I hold to be four foundations which remain unchanged through Kant’s philosophical career and thus act to hold up his later work on the subject. The main body of the paper is presented in two parts. In the first, we see that Kant finds (...) that in addition to evil as limitation, there is now evil which is ontologically positive. The second part is devoted to Kant’s considerations of what was termed “physical evil”. He finds that this is neither an evil nor any form of divine punishment but rather those consequences of the laws of nature which are harmful to humans. Further, God does not intervene with the workings of these laws of nature which He has put in place but guarantees their continuity. However, it will be shown that such non-interference is problematic for Kant’s mature stance on miracles. (shrink)

The authors of this article are previous or current members of the Clinical Ethics Consultation Affairs (CECA) Committee, a standing committee of the American Society for Bioethics and Humanities (ASBH). The committee is composed of seasoned healthcare ethics consultants (HCECs), and it is charged with developing and disseminating education materials for HCECs and ethics committees. The purpose of this article is to describe the educational research and development processes behind our teaching materials, which culminated in a case studies book called (...) A Case-Based Study Guide for Addressing Patient-Centered Ethical Issues in Health Care (hereafter, the Study Guide). In this article, we also enumerate how the Study Guide could be used in teaching and learning, and we identify areas that are ripe for future work. (shrink)