Given that natural selection is so powerful at optimizing complex adaptations, why does it seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful, heritable mental disorders, such as schizophrenia or bipolar disorder? We assess three leading explanations for this apparent paradox from evolutionary genetic theory: (1) ancestral neutrality (susceptibility alleles were not harmful among ancestors), (2) balancing selection (susceptibility alleles sometimes increased fitness), and (3) polygenic mutation-selection balance (mental disorders reflect the inevitable mutational load on the thousands (...) of genes underlying human behavior). The first two explanations are commonly assumed in psychiatric genetics and Darwinian psychiatry, while mutation-selection has often been discounted. All three models can explain persistent genetic variance in some traits under some conditions, but the first two have serious problems in explaining human mental disorders. Ancestral neutrality fails to explain low mental disorder frequencies and requires implausibly small selection coefficients against mental disorders given the data on the reproductive costs and impairment of mental disorders. Balancing selection (including spatio-temporal variation in selection, heterozygote advantage, antagonistic pleiotropy, and frequency-dependent selection) tends to favor environmentally contingent adaptations (which would show no heritability) or high-frequency alleles (which psychiatric genetics would have already found). Only polygenic mutation-selection balance seems consistent with the data on mental disorder prevalence rates, fitness costs, the likely rarity of susceptibility alleles, and the increased risks of mental disorders with brain trauma, inbreeding, and paternal age. This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, psychiatry, behavior genetics, molecular genetics, and evolutionary approaches to studying human behavior. (Published Online November 9 2006) Key Words: adaptation; behavior genetics; Darwinian psychiatry; evolution; evolutionary genetics; evolutionary psychology; mental disorders; mutation-selection balance; psychiatric genetics; quantitative trait loci (QTL). (shrink)

Possibilities haunt history. The force of our explanations of events turns on the alternative possibilities these explanations suggest. It is these possible worlds which give us our understanding; and in human affairs we decide them by practical rather than theoretical judgement. In his widely acclaimed account of the role of counterfactuals in explanation, Geoffrey Hawthorn deploys extended examples from history and modern times to defend his argument. His conclusions cast doubt on existing assumptions about the nature and place of (...) theory, and indeed of the possibility of knowledge itself, in the human sciences. (shrink)

'Nobody reads Mill today,' wrote a reviewer in Time magazine a few years ago.! One could scarcely praise Mr Melvin Maddocks, who penned that remark, for his awareness of the present state of Mill studies, for of all nineteenth century philosophers who wrote in English, it is 1. S. Mill who remains the most read today. Yet it would not be so far from the truth to say that very few people pay much serious attention nowadays to Mill's writings about (...) logic and metaphysics (as distinct from those on ethical and social issues), despite the fact that Mill put enormous effort into their composition and through them exerted a considerable influen ce on the course of European philosophy for the rest of his century. But the only sections of A System of Logic (1843) and An Examination of Sir William Hamilton's Philosophy (1865) to which much reference is now made comprise only a small proportion of those very large books, and the prevailing assumption is that Mill's theories about logical and meta physical questions are, with few exceptions, of merely antiquarian in terest. Bertrand Russell once said that Mill's misfortune was to be born at the wrong time (Russell (1951), p. 2). It can certainly appear that Mill chose an inauspicious time to attempt a major work on logic. (shrink)

Bernard Williams is remembered as one of the most brilliant and original philosophers of the past fifty years. Widely respected as a moral philosopher, Williams began to write about politics in a sustained way in the early 1980s. There followed a stream of articles, lectures, and other major contributions to issues of public concern--all complemented by his many works on ethics, which have important implications for political theory.This new collection of essays, most of them previously unpublished, addresses many of the (...) core subjects of political philosophy: justice, liberty, and equality; the nature and meaning of liberalism; toleration; power and the fear of power; democracy; and the nature of political philosophy itself. A central theme throughout is that political philosophers need to engage more directly with the realities of political life, not simply with the theories of other philosophers. Williams makes this argument in part through a searching examination of where political thinking should originate, to whom it might be addressed, and what it should deliver.Williams had intended to weave these essays into a connected narrative on political philosophy with reflections on his own experience of postwar politics. Sadly he did not live to complete it, but this book brings together many of its components. Geoffrey Hawthorn has arranged the material to resemble as closely as possible Williams's original design and vision. He has provided both an introduction to Williams's political philosophy and a bibliography of his formal and informal writings on politics.Those who know the work of Bernard Williams will find here the familiar hallmarks of his writing--originality, clarity, erudition, and wit. Those who are unfamiliar with, or unconvinced by, a philosophical approach to politics, will find this an engaging introduction. Both will encounter a thoroughly original voice in modern political theory and a searching approach to the shape and direction of liberal political thought in the past thirty-five years. (shrink)

We draw on the behavioral agency model to explore the ethical consequences of CEO equity incentives. We argue that CEOs are more concerned with funding pension plans when they have more to gain from their stock options yet will increasingly underfund employee pension funds as their current option wealth increases. Our findings reveal that both effects hold when the CEO has greater power (also occupying board chair) over firm decision making. Our study suggests that there is an ethical dimension to (...) equity incentives, given they are intended to align CEO interests with shareholders, yet potentially incentivize CEO behaviors with adverse consequences for employees. Insights from our findings provide boards and regulators with behavioral levers to protect employee well-being in the context of pension funding. (shrink)

Descartes' account of the material world relies heavily on time. Most importantly, time is a component of speed, which figures in his fundamental conservation principle and laws. However, in his most systematic discussion of the concept, time is treated as some-how reducible both to thought and to motion. Such reductionistic views, while common among Descartes' late scholastic contemporaries, are very ill-suited to Cartesian physics. I show that, in spite of the apparent identifications with thought and motion, Cartesian time retains—in the (...) form of what I will call 'successive duration'—precisely the intrinsic structure necessary to serve as an independent parameter of quantitative physics. As is often the case with Descartes, he gives the impression of embracing traditional doctrines while in fact radically transforming the underlying concepts to serve his scientific agenda. His theory of time, though formulated in Aristotelian terms, anticipates Newton in important respects. (shrink)

This paper examines how communities of naturalists in mid-nineteenth-century Britain were formed and solidified around the shared practices of public meetings, the publication and reading of periodicals, and the making and printing of images. By focusing on communities of naturalists and the sites of their communication, this article undermines the distinction between amateur and professional scientific practice. Building on the notion of imagined communities, this paper also shows that in some cases the editors and illustrators utilized imagery to construct a (...) specifically British naturalist community. Following three ‘amateur’ natural-history periodicals (Science Gossip,Midland Naturalistand theJournal of the Quekett Microscopical Club) the article demonstrates how the production and reproduction of natural history in the nineteenth century was contingent on community debate – and that this debate both was highly visual and moved across printed and geographical boundaries. This paper investigates images both for their purported success and for their ascribed value to natural history. Additionally, it considers the debates over their limitations and alleged failures of printing. Altogether, the article argues that investigating the communal practices of observation, writing, drawing and engraving allows for a better understanding of the shared practices of nineteenth-century natural history. (shrink)

In this book an international and multidisciplinary team addresses significant ethical questions about the rights to access, manage and interpret the material remains of the past.

It is critically important for emerging professionals in education to be sensitised to the ethical and moral responsibilities of their practice throughout their training and beyond. There is a wide disparity in contemporary practice in this regard, which points to a need for greater clarity and consistency in our thinking about ethics within education. Ethics in Education attempts to meet this need, and will be a valuable resource for students, teachers and researchers in education, health and social sciences. Most significantly, (...) the increasing awareness of the importance of ethics, diversity and social pedagogy in the teacher education curriculum will ensure that this book becomes essential reading or recommended reading for initial teacher education and CPD courses in education. The Editors have gathered together an exciting and dynamic group of contributors across many fields of English education, and asked them to help rethink the role of ethics in education in the 21st century. The types of questions that we address include: Do we have a shared view of ethical practice? What are the values that underpin ethical practice? What are our ethical responsibilities as pedagogues? (shrink)

In this bold interdisciplinary work, Geoffrey Galt Harpham argues that asceticism has played a major role in shaping Western ideas of the body, writing, ethics, ...

The articles that comprise this special issue of Intellectual History Review are briefly described.

When Michael Hunter first publicized the idea of ‘Psychoanalysing Robert Boyle’ I understood that his main aim was to test three competing psychoanalytical theories against the historical evidence provided by the life and work of Robert Boyle. Although this would have been a valuable exercise, and one that the British Society for the History of Science meeting partly engaged, the papers by Brett Kahr, John Clay and Karl Figlio published here raise some far more compelling issues which I shall explore (...) in the ensuing discussion. Before turning to this discussion I offer a few introductory remarks. (shrink)

This paper sets out to examine the changes which took place in Thomas Young's concepts of the ether between 1799 and 1807. During the earlier part of this period he supposed the ether to consist of mutually repelling subtle particles which are attracted to particles of matter. Hence, he considered that the ether is denser within dense bodies than in rare ones. Furthermore, Young proposed that the ether density does not change abruptly at an interface; instead the denser ether extends (...) beyond the geometrical limit of a body to form an atmosphere around it. As this hypothesis of an atmosphere of dense ether surrounding material bodies will be the central subject of this paper, I shall in future refer to it as the ether distribution hypothesis. (shrink)

Are humans at their core seekers of their own pleasure or cooperative members of society? Paradoxically, they are both. Pleasure-seeking can take place only within the context of what works within a defined community, and central to any community are the evolved codes and principles guiding appropriate behavior, or morality. The complex interaction of morality and self-interest is at the heart of Geoffrey M. Hodgson’s approach to evolutionary economics, which is designed to bring about a better understanding of human (...) behavior. In From Pleasure Machines to Moral Communities, Hodgson casts a critical eye on neoclassical individualism, its foundations and flaws, and turns to recent insights from research on the evolutionary bases of human behavior. He focuses his attention on the evolution of morality, its meaning, why it came about, and how it influences human attitudes and behavior. This more nuanced understanding sets the stage for a fascinating investigation of its implications on a range of pressing issues drawn from diverse environments, including the business world and crucial policy realms like health care and ecology. This book provides a valuable complement to Hodgson’s earlier work with Thorbjørn Knudsen on evolutionary economics in Darwin’s Conjecture, extending the evolutionary outlook to include moral and policy-related issues. (shrink)

An essential guide to an essential book, this first anthology on Camera Lucida offers critical perspectives on Barthes's influential text. Roland Barthes's 1980 book Camera Lucida is perhaps the most influential book ever published on photography. The terms studium and punctum, coined by Barthes for two different ways of responding to photographs, are part of the standard lexicon for discussions of photography; Barthes's understanding of photographic time and the relationship he forges between photography and death have been invoked countless times (...) in photographic discourse; and the current interest in vernacular photographs and the ubiquity of subjective, even novelistic, ways of writing about photography both owe something to Barthes. Photography Degree Zero, the first anthology of writings on Camera Lucida, goes beyond the usual critical orthodoxies to offer a range of perspectives on Barthes's important book. Photography Degree Zero includes essays written soon after Barthes's book appeared as well as more recent rereadings of it, some previously unpublished. The contributors' approaches range from psychoanalytical to Buddhist ; they include a history of Barthes's writings on photography and an account of Camera Lucida and its reception; two views of the book through the lens of race; and a provocative essay by Michael Fried and two responses to it. The variety of perspectives included in Photography Degree Zero, and the focus on Camera Lucida in the context of photography rather than literature or philosophy, serve to reopen a vital conversation on Barthes's influential work. (shrink)

In a critical scene deeply troubled by questions of justice and responsibility, and beset by political and moral scandals, no issue in recent years has been more urgent or more unsettled than the question of ethics. Geoffrey Galt Harpham, whose previous book, The Ascetic Imperative in Culture and Criticism, was one of the first to announce the critical renewal of ethics, attempts in this new book to explain why ethical questions resist settlement. He urges a new account of ethics (...) not as a stable set of principles, values, or prescriptions, but as a variable factor of "imperativity" immanent in language, analysis, narrative, and creation. (shrink)

The privacy of the dead might be thought to be violated by, for instance, the disinterment for research purposes of human physical remains or the posthumous revelation of embarrassing facts about people's private lives. But are there any moral rights to privacy which extend beyond the grave? Although this notion can be challenged on the ground that death marks the end of the personal subject, with the consequent extinction of her interests, I argue that a right to privacy belongs to (...) deceased persons in virtue of their moral status while alive and reflects their interest in the preservation of their dignity. The paper investigates what prima-facie privacy rights and interests may plausibly be ascribed to the dead and why these need to be taken seriously by those, such as archaeologists or biographers, who have "dealings with the dead.". (shrink)

Philosophical discussion of forgiveness has mainly focused on cases in which victims and offenders are known to each other. But it commonly happens that a victim brings an offender under a definite description but does not know to which individual this applies. I explore some of the conceptual and moral issues raised by the phenomenon of forgiveness in circumstances in which identification is incomplete, tentative or even mistaken. Among the conclusions reached are that correct and precise identification of the offending (...) individual is not essential for forgiveness to take place; that an offender can, under certain strict conditions, be said to be forgiven by proxy where the victim has misidentified the offender and ‘forgiven’ the wrong person; and that proxy forgiveness of this sort is not subject to the objections commonly levelled against ‘proxy’ or ‘third-party forgiveness.’. (shrink)

This essay argues that the overuse of the idiom of forgiveness has distorted our understanding of the nature and requirements of political reconciliation, and proposes its supplementation by a notion of grace. This is a mode of response to wrongs that is less hedged around by conventions and conditions, and grace complements forgiveness in contexts in which the latter is inappropriate; it is also more serviceable for maintaining inter-community harmony in the long term. Following a detailed analysis of grace in (...) the political environment, the paper concludes by tracing a concept of grace in the Sermon on the Mount. (shrink)

In this book, Canadian scholar David Geoffrey Smith reflects on over thirty years of research and teaching in the human sciences, including education. Written between 1986 and 2018, the essays are organized around three themes: Hermeneutics and the Human Sciences; The Poststructuralist Turn; Globalization and Its Discontents; East/West Encounters and the Search for Wisdom. As a historical guide through the defining discourses in the human sciences, this volume could well serve as an introductory text for graduate students in education (...) and other cognate disciplines like nursing, recreation and cultural studies. The writing can be described as a form of meditative praxis, while the emphasis on interculturality addresses issues in literacy, pedagogy, politics, critical thinking, teacher education, and cultural healing from a geopolitical perspective, drawing on insights from both Western and Eastern traditions and the author's personal experience of being born in China and raised in Central Africa (Northern Rhodesia/Zambia). (shrink)

At Cratylus 385b–c, Plato appears to argue that names have truth-value. Critics have almost universally condemned the argument as fallacious. Their case has proven so compelling that it has driven editors to recommend moving or removing the argument from its received position in the manuscripts. I argue that a close reading of the argument reveals it commits no fallacy, and its purpose in the dialogue justifies its original position. I wish to vindicate the manuscript tradition, showing that the argument establishes (...) that there is subject matter for investigation, and there is a correctness of names. (shrink)

From form to mechanism Content Type Journal Article DOI 10.1007/s11016-010-9455-7 Authors Geoffrey Gorham, Department of Philosophy, Macalester College, St. Paul, MN 55105, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.

Subtle-body practices are found particularly in Indian, Indo-Tibetan and East Asian societies, but have become increasingly familiar in Western societies, especially through the various healing and yogic techniques and exercises associated with them. This book explores subtle-body practices from a variety of perspectives, and includes both studies of these practices in Asian and Western contexts. The book discusses how subtle-body practices assume a quasi-material level of human existence that is intermediate between conventional concepts of body and mind. Often, this level (...) is conceived of in terms of an invisible structure of channels, associated with the human body, through which flows of quasi-material substance take place. Contributors look at how subtle-body concepts form the basic explanatory structure for a wide range of practices. These include forms of healing, modes of exercise and martial arts as well as religious practices aimed at the refinement and transformation of the human mindbody complex. By highlighting how subtle-body practices of many kinds have been introduced into Western societies in recent years, the book explores the possibilities for new models of understanding which these concepts open up. It is a useful contribution to studies on Asian Religion and Philosophy. (shrink)

Presidential addresses offer an opportunity to reflect on the history of our subject and where the history of science stands in our own day. Such reflections are particularly appropriate with the fiftieth anniversary of the founding of the British Society for the History of Science which is marked in 1997. Some may consider that looking back over our past is either an unacceptable luxury or an occasion for the kind of celebration that can all too easily degenerate into hagiography and (...) an excuse to rake over the past in a thoroughly uncritical manner. This address – and I trust the events of 1997 – will try to avoid such excesses and instead contribute to the historiography of our subject. (shrink)

Dramatic, profound and far-reaching changes are being visited on schools worldwide that have their genesis a long way from the classroom but which impact heavily on teachers and their work. Most of this reform has been achieved with little or no involvement of teachers themselves. This book sets out to survey the contemporary context of what is happening to the work of teaching, and focuses on Advanced Skills Teachers. It shows how teachers are 'speaking' the changes that are occuring to (...) their work in protracted economically rationalist times. Arguing against the discourses of economy as the major shaping force, the authors present a persuasive case for focusing on the discourses of teaching itself as the only feasible and adequate basis on which to make sense of teaching. And by presenting a range of voices of practising teachers - allowing them to speak for themselves about the difficulty of trying to translate policy-makers' intentions into words and actions - the book graphically illustrates the devastating long-term consequences for the future of schools of poorly-conceptualised reform policies. (shrink)

It has sometimes been claimed that the perceived badness of an act can in some circumstances, or for some agents, be a reason for performing it. The present paper challenges this claim, arguing that it is hard to make sense of the idea that a negative evaluation of an action can provide an intelligible reason for doing it. Apparent counter‐examples are discussed and dismissed and the paper concludes with some general reflections on the relationship between evaluation and motivation.

The argument I defend in this paper challenges whether Waldron’s explanation of the conditions required for a moral right to satisfy its autonomy-promoting function is the best one available. It questions the suitability of Waldron’s preferred taxonomy of moral action, where acts are divided into: (1) those that are morally required; (2) those that are morally prohibited; and (3) those that are morally indifferent, advocating instead for a binary classification consisting of: (a) actions that admit of reasonable moral disagreement; and (...) (b) actions that do not admit of reasonable moral disagreement. My claim is that the protective sphere moral rights set up in organizing the moral relations among persons is applicable only to the former category—namely, actions that admit of reasonable moral disagreement. Actions that do not admit of reasonable moral disagreement will either: (b’) not normally demand a right against interference in the first place (if the action is unquestionably permissible); or (b”) fail to admit of a right against interference at all (if the action is unquestionably impermissible). This competing explanation allows us to preserve the autonomy-promoting conception of moral rights Waldron endorses while avoiding a number of its suspect implications. (shrink)