The cilium/flagellum is a sensory-motile organelle ancestrally present in eukaryotic cells. For assembly cilia universally rely on intraflagellar transport (IFT), a specialised bidirectional transport process mediated by the ancestral and conserved IFT complex. Based on the homology of IFT complex proteins to components of coat protein I (COPI) and clathrin-coated vesicles, we propose that the non- vesicular, membrane-bound IFT evolved as a specialised form of coated vesicle transport from a protocoatomer complex. IFT thus shares common ancestry with all protocoatomer derivatives, (...) including all vesicle coats and the nuclear pore complex (NPC). This has major implications for the evolutionary origin of the cilium. First, it reinforces the tenet that duplication and divergence of pre-existing structures, rather than symbiosis, were the major themes during cilium evolution. Second, it suggests that the initial step in the autogenous origin of the cilium was the establishment of a membrane patch with transmembrane proteins transported by the ancestral vesicle-coating IFT complex. We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient. BioEssays 28: 191–198, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Con un'impostazione che coniuga la fedeltà testuale e l'approfondimento critico, il percorso di questo libro mira a ricondurre l'edificazione kierkegaardina - spesso considerata mera esortazione spirituale - allo spessore autenticamente filosofico d'una via soggettiva alla verità. Un modello antioggettivistico di filosofare senza perdere di vista né l'esercizio del dubbio né la dimensione della fede. Attraverso l' interpretazione kierkegaardiane di C. Fabro si è giunti all'esposizione e ai lineamenti descrittivi fondamentali della nozione del singolo. Il singolo viene presentato dallo stesso Kierkegaard (...) come la mia categoria. Sta di fatto che si può intendere l'intera produzione kierkegaardiana come un pensare soggettivamente il singolo. Pensiero etico carico di conseguenze pratiche, giacchè il danese non pretendeva fondare una scuola filosofica ma soltanto rendere attenti, svegliare le coscienze. (shrink)

L'opera è uno studio sugli aspetti teologici,metafisici, etici e politici della dottrina di Tommaso D'Aquino. Partendo dall'aspetto metafisico i principi della natura e l'ente e l'essenza scritti tra il 1252 e il 1256. L'opera verte sul rapporto tra l'ordine metafisico e quello logico. Affronta una serie di questioni centrali nel pensiero tomista: il principio di individuazione, il problema degli universali, il rifiuto dell'ilemorfismo universale, l'indefinibilità formale di Dio.

In 2007. Terence Tao wrote on his blog an essay about soft analysis, hard analysis and the finitization of soft analysis statements into hard analysis statements. One of his main examples was a quasi-finitization of the infinite pigeonhole principle IPP, arriving at the "finitary" infinite pigeonhole principle FIPP₁. That turned out to not be the proper formulation and so we proposed an alternative version FIPP₂. Tao himself formulated yet another version FIPP₃ in a revised version of his essay. We give (...) a counterexample to FIPP₁ and discuss for both of the versions FIPP₂ and FIPP₃ the faithfulness of their respective finitization of IPP by studying the equivalences IPP ↔ FIPP₂ and IPP ↔ FIPP₃ in the context of reverse mathematics ([9]). In the process of doing this we also introduce a continuous uniform boundedness principle CUB as a formalization of Tao's notion of a correspondence principle and study the strength of this principle and various restrictions thereof in terms of reverse mathematics, i.e., in terms of the "big five" subsystems of second order arithmetic. (shrink)

We adapt Streicher and Kohlenbach's proof of the factorization S = KD of the Shoenfield translation S in terms of Krivine's negative translation K and the Gödel functional interpretation D, obtaining a proof of the factorization U = KB of Ferreira's Shoenfield-like bounded functional interpretation U in terms of K and Ferreira and Oliva's bounded functional interpretation B.

BackgroundResearch on prevalence of cognitive frailty phenotypes in community-dwelling older adults in different countries is important to estimate their prevalence and to determine the influence of cognitive reserve and mental health in order to prevent frailty. The aims of this study were to estimate the prevalence of reversible and potentially reversible cognitive frailty in a Portuguese sample of old adults and explore the associations between these phenotypes and demographic, comorbidity, social support, cognitive reserve and mental health factors.MethodsWe assessed frailty in (...) 250 community-dwelling older adults aged 60 years or over without dementia, neurological or psychiatric disorders. Subjective cognitive decline and Mild cognitive impairment were diagnosed according to standard criteria. The questionnaires Charlson Index, Medical Outcomes Study Social Support, Cognitive Reserve Index and General Health were used for assessing comorbidity, social support, cognitive reserve and mental health, respectively.ResultsPrevalence of R-CF was 14%, and that of PR-CF, 15.2%. Cognitive frailty profiles differed significantly in relation to education, comorbidity, mental health, and cognitive reserve, but not in age or sex. Multivariate logistic regression showed that age, sex, comorbidity, social support, mental health, and cognitive reserve together predicted R-CF and PR-CF with significant OR for mental health and cognitive reserve.DiscussionCognitive reserve and mental health are important factors predicting R-CF and PR-CF. We recommend assessing these factors for early detection of cognitive frailty and promoting psychological well-being and lifestyles that increase cognitive reserve in adults. (shrink)

The notion that nature is subject to laws is exciting from many different viewpoints. This paper is based on the context of modern cosmology. It will list the significant interdisciplinary implications generated by various aspects of the contemporary scientific discussion about the status of laws of nature, especially their dynamic nature. Recent work highlights how multiple aspects of the observed universe still lack explanation and that several problems of standard cosmology still form the object of debate. Considering these issues, several (...) proposals have been made that entail a revision of the concept of the law of nature, according to which the nature of time and of the relation between causality and natural laws ought to be reconsidered using approaches or viewpoints which point to philosophical issues. We argue that Tim Maudlin’s concept of Fundamental Law of Temporal Evolution (FLOTE) and Nancy Cartwright’s notion of the nomological machine provide new insights and valuable tools that can be used in the analysis of the status of laws in the context of cosmology and of complex systems theory. The limits of the traditional approach to laws of nature and their mathematical formulation are highlighted in this context, as well as the fact that many of the ultimate properties of nature may turn out to be formally unpredictable or uncomputable. (shrink)

Članak je pisan sa svrhom upoznavanja čitatelja s temeljnim sadržajem nove knjige R. Gibellinija, Teološke perspektive za XXI. stoljeće. Ta se knjiga tematski nadovezuje na njegovu prethodnu knjigu, Teologija dvadesetog stoljeća. Nakon panorame teološke misli XX. stoljeća, R. Gibellini se pita o zadaćama i perspektivama teološke misli u neposrednoj budućnosti. Budući da je knjigu koju predstavljamo njezin autor R. Gibellini zamislio kao bilancu u perspektivi budućnosti, bilancu koja se oslanja na teologiju XX. stoljeća, u prvom dijelu članka daje se prikaz (...) četiri teološka pravca XX. stoljeća. Ostala tri dijela članka prikazuju teološke perspektive XXI. stoljeća: perspektive teologije korelacije, perspektive teologije u doba mondijalizacije i perspektive teologije ekumenizma i međureligijskog dijaloga. Priloge su napisali međunarodno poznati teolozi. Oni se u razmišljanjima kreću uzduž bitnih linija promišljanja koja su izronila tijekom XX. stoljeća, napose pak u njegovim posljednjim desetljećima, i koje su otvorene daljnjem razvijanju na početku XXI. stoljeća.This article aims to introduce the readership to the basic content of R. Gibellini’s latest book en­titled Theological Perspectives for the 21st Century, which is, thematically speaking, an extensi­on of his previous book, bearing the title Theology of the 20th Century. Following the panoramaof theological thought in the 20th century, R. Gibellini turns to the tasks and perspectives oftheology and its reflections in the near future.Considering that Gibellini conceived the book here presented as a balance from the perspectiveof the future, a balance that draws on the theology of the 20th century, the first section of thearticle brings an overview of the four theological currents of the 20th century. The other threesections centre on the theological prospects of the 21st century: the prospects of the theology ofcorrelation, the prospects of theology in the era of globalisation, and the prospects of the theo­logy of ecumenism and interreligious dialogue. The book was contributed to by internationallyrenowned theologians. Their reflections follow the significant lines of thought that emergedduring the 20th century in general and its last decades in particular, and that are open to furtherdevelopment at the beginning of the 21st century. (shrink)

Self-confidence is associated with many positive outcomes, and training programs routinely seek to build participants’ self-efficacy. In this article, however, we consider whether self-confidence increases unethical behavior. In a series of studies, we explore the relationship between negotiator self-efficacy—an individual’s confidence in his or her negotiation ability—and the use of deception. We find that individuals high in negotiator self-efficacy are more likely to use deception than individuals low in negotiator self-efficacy. We also find that perceptions of the risk of deception (...) mediate this relationship. By identifying negotiator self-efficacy as an antecedent to unethical behavior, our findings offer important theoretical and empirical insights into the use of deception, the role of individual differences in ethical decision making, and the broader consequences of self-confidence in business and society. (shrink)

The origin of eukaryotes is one of the major challenges of evolutionary cell biology. Other than the endosymbiotic origin of mitochondria and chloroplasts, the steps leading to eukaryotic endomembranes and endoskeleton are poorly understood. Ras‐family small GTPases are key regulators of cytoskeleton dynamics, vesicular trafficking and nuclear function. They are specific for eukaryotes and their expansion probably traces the evolution of core eukaryote features. The phylogeny of small GTPases suggests that the first endomembranes to evolve during eukaryote evolution had secretory, (...) and not phagocytic, function. Based on the reconstruction of putative roles for ancestral small GTPases, a hypothetical scenario on the origins of the first endomembranes, the nucleus, and phagocytosis is presented. BioEssays 25:1129–1138, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

This thesis inquiries into the Giacomo Leopardi's anthropologic and moral reflections, ruling as from the twenty Operette written in the 1824, along an itinerary that leads from the utopia, exemplified in the myth of the Californians, to the disenchantment, remarkable in some Operette and above all in the Scommessa di Prometeo. The origin of that negative anthropological conception in the Leopardi's philosophy happens through a process of lectures and thoughts that is reconstructed in the thesis, divided into three chapters. The (...) research work marks the limit a quo of the anthropologic utopia of the "happy" peoples in the fifty strophe of the Inno ai Patriarchi (July 1822), considered the last significant place of the "mith" of the Californians, and looks at the lectures of the first stay in Roma (17 november 1822 - 3 may 1823), to find out the constitutive elements of the negative anthropology exposed in the Operette. In the first chapter j examine the net of the lectures and the thoughts that flows into the Abbozzo dell'Inno ai Patriarchi and the fifty strophe of the Inno. The second chapter follows the complex way of the lecture of the Barthélemy's Voyage du jeune Anacharsis en Grece and of the Plutarco's Opuscoli morali - particularly of the Discorso di consolazione ad Apollonio -, in the context of the reflections on the human natural condition. The new leopardian vision of the ancient Greece, that recognizes the roots of the tragic Greek thought and consolidates a negative conception of the human condition, synthesized in the sentence "it's better not to be born". The third chapter dwells upon the interpretation of the Prometheus's myth produced by Leopardi, connected with the lecture of the myth present in the Luciano di Samosata's works. La Scommessa di Prometeo is submitted to a complete analysis, both in the direction of the fonts and on the plane of the statement of the contents, that reveals an original torsion of the Promethean tradition and develops in a dynamic of the full anthropologic disenchantment. (shrink)

Michel Serres developed a strong core of his philosophical practice around the logic of parasitism. To illustrate this, I propose a bipartite reflection that plays on the external-internal relationship. In the first part I follow Serres in his reflection on the dynamic and unstable relationship between parasitism and symbiosis. The biological and ecological dimension of parasitism occurs in the relationship between viruses, humans and reservoirs. Serres tries to make explicit a parasitic function, irreducible in a single language, which allows to (...) relate the anthropological and sociological characteristics of the parasite to the biological and ecological dynamics. According to Serres, love, humility and a sense of limitation are the global virtues that humanity willhave to rediscover to transform parasitism into symbiosis, rewriting, after Rousseau, a new Discours sur l'origine et les fondements de l'inégalité parmi les hommes. In the second part I put in perspective an extraordinarily global example of parasitism of our times: the spread of the Covid-19 virus in the context of the spillove. (shrink)

Desde la perspectiva de la metafísica tomasiana, el tema de la cultura se inscribe de lleno en la ontología de la causalidad intramundana, pero para emerger de ella trascendiéndola. La relevancia que aquí cobra el acontecer no es arbitraria. Le viene dada por el hecho de ser, en la esfera de lo generable y corruptible, la más eminente participación del acto creador, más íntimo a ella que ella misma.

La encarnación del Verbo de Dios, que culmina en el misterio pascual de la muerte y resurección de Jesucristo, es el hecho fundamental y la novedad radial del Cristianismo. En la encarnación del Verbo, el Dios infinito y creador se autocomunica amorosamente a lo otro creado, para redención y divinización del hombre, para recapitulación del cosmos.

Il saggio segue la metamorfosi dell’immagine edificante dello spettacolo della natura, metafora della pietade illuminata nell’opera dell’Abate Pluche e segno di un relativismo umanistico e prospettico negli Entretiens sur la pluralité des mondes del Fontanelle, fino a circoscrivere lo scenario del Dialogo di un Folletto e di uno Gnomo, che dà luogo a un originalissimo ribaltamento dell’immagine dello spettacolo. Le forme di tale torsione insieme poetica e di pensiero, che coinvolge l’orizzonte del sapere naturalistico leopardiano nella rappresentazione desolata e straniante (...) di una cruda verità cosmica, attestata dalla scienza e dalla filosofia naturale, sono descritte con l’adesione a puntuali riferimenti testuali, nella trama di letture giovanili richiamate da Leopardi nella produzione matura. (shrink)

In memoriam José Arrazola Ramírez The logic $\textbf{G}^{\prime}_3$ was introduced by Osorio et al. in 2008; it is a three-valued logic, closely related to the paraconsistent logic $\textbf{CG}^{\prime}_3$ introduced by Osorio et al. in 2014. The logic $\textbf{CG}^{\prime}_3$ is defined in terms of a multi-valued semantics and has the property that each theorem in $\textbf{G}^{\prime}_3$ is a theorem in $\textbf{CG}^{\prime}_3$. Kripke-type semantics has been given to $\textbf{CG}^{\prime}_3$ in two different ways by Borja et al. in 2016. In this work, we (...) continue the study of $\textbf{CG}^{\prime}_3$, obtaining a Hilbert-type axiomatic system and proving a soundness and completeness theorem for this logic. (shrink)

This article systematically investigates so-called “truth variants” of several functional interpretations. We start by showing a close relation between two variants of modified realizability, namely modified realizability with truth and q-modified realizability. Both variants are shown tobe derived from a single “functional interpretation with truth” of intuitionistic linear logic. This analysis suggests that several functional interpretations have truth and q-variants. These variants, however, require a more involved modification than the ones previously considered. Following this lead we present truth and q-variants (...) of the Diller-Nahm interpretation, the bounded modified realizability and the bounded functional interpretation. (shrink)