The lantibiotics are a rapidly expanding group of biologically active peptides produced by a variety of Gram‐positive bacteria, and are so‐called because of their content of the thioether amino acids lanthionine and β‐methyllanthionine. These amino acids, and indeed a number of other unusual amino acids found in the lantibiotics, arise following post‐translational modification of a ribosomally synthesised precursor peptide. A number of genes involved in the biosynthesis of these highly modified peptides have been identified, including genes encoding the precursor peptide, (...) enzymes responsible for specific amino acid modifications, proteases able to remove the leader peptide, ABC‐superfamily transport proteins involved in lantibiotic translocation, regulatory proteins controlling lantibiotic biosynthesis and proteins that protect the producing strain from the action of its own lantibiotic. Analysis of these genes and their products is allowing greater understanding of the complex mechanism(s) of the biosynthesis of these unique peptides. (shrink)

This discussion of pride, shame, and guilt centers on the beliefs involved in the experience of any of these emotions. Through a detailed study, the author demonstrates how these beliefs are alike--in that they are all directed towards the self--and how they differ. The experience of these three emotions are illustrated by examples taken from English literature. These concrete cases supply a context for study and indicate the complexity of the situations in which these emotions usually occur.

Kant’s account of practical justification for belief has attracted much attention in the literature, especially in recent years. In this context, scholars have generally emphasized the originality of Kant’s thought about belief (Glaube), and Kant indeed offers a definition of belief that is very different from views that were prevalent in eighteenth-century Germany. In this article, however, I argue that it is very likely that Christian August Crusius exerted influence on Kant’s definition of belief and his account of practical justification. (...) In turn, acknowledging this influence has relevant consequences for how we understand the phenomenology of Kantian belief. (shrink)

Both in his pre-critical writings and in his critical works, Kant criticizes the Wolffian tradition for its use of the mathematical method in philosophy. The chapter argues that the apparent unambiguousness of this opposition between Kant and Wolff notwithstanding, the problem of ascertaining the relationship between Kant’s and Wolff’s methods in philosophy cannot be dismissed so quickly. Only a close consideration of Kant’s different remarks on Wolff’s approach and a comparison of the methods that Wolff and Kant actually used in (...) philosophy can allow us to determine when Kant’s criticisms are justified and where the differences in their methodological proposals for philosophy actually lie. We see that Kant’s account of philosophical method in fact has some elements in common with the Wolffian paradigm, even though there are also relevant differences. (shrink)

In this paper, I develop Mauricio Suárez’s distinction between denotation, epistemic representation, and faithful epistemic representation. I then outline an interpretational account of epistemic representation, according to which a vehicle represents a target for a certain user if and only if the user adopts an interpretation of the vehicle in terms of the target, which would allow them to perform valid (but not necessarily sound) surrogative inferences from the model to the system. The main difference between the interpretational conception I (...) defend here and Suárez’s inferential conception is that the interpretational account is a substantial account—interpretation is not just a “symptom” of representation; it is what makes something an epistemic representation of a something else. (shrink)

In this paper, I distinguish three general approaches to public trust in science, which I call the individual approach, the semi-social approach, and the social approach, and critically examine their proposed solutions to what I call the problem of harmful distrust. I argue that, despite their differences, the individual and the semi-social approaches see the solution to the problem of harmful distrust as consisting primarily in trying to persuade individual citizens to trust science and that both approaches face two general (...) problems, which I call the problem of overidealizing science and the problem of overburdening citizens. I then argue that in order to avoid these problems we need to embrace a (thoroughly) social approach to public trust in science, which emphasizes the social dimensions of the reception, transmission, and uptake of scientific knowledge in society and the ways in which social forces influence both positively and negatively the trustworthiness of science. (shrink)

ABSTRACT:Are face-to-face perception and picture perception different perceptual phenomena? The question is controversial. On the one hand, philosophers have offered several solid arguments showing that, despite some resemblances, they are quite different perceptual phenomena and that pictures are special objects of perception. On the other hand, neuroscientists routinely use pictures in experimental settings as substitutes for normal objects, and this practice is successful in explaining how the human visual system works. But this seems to imply that face-to-face perception and picture (...) perception are very similar, if not actually the same. How can we decide between these two opposite intuitions? Here I offer a regimentation of the notion of picture perception that can reconcile these two apparently conflicting ideas about pictures. It follows that philosophers and neuroscientists can maintain their respective stances without any theoretical conflict. (shrink)

In two often neglected passages of the Critique of Pure Reason, Kant submits that the Critique is a 'treatise' or a 'doctrine of method'. These passages are puzzling because the Critique is only cursorily concerned with identifying adequate procedures of argument for philosophy. In this book, Gabriele Gava argues that these passages point out that the Critique is the doctrine of method of metaphysics. Doctrines of method have the task of showing that a given science is indeed a science (...) because it possesses 'architectonic unity' – which happens when it realizes the 'idea' of a science. According to Gava's novel approach, the Critique establishes that metaphysics is capable of this unity, and his reading of the Critique from this perspective not only illuminates the central role of the Transcendental Doctrine of Method within it, but also clarifies the relationship between the different parts of the work. (shrink)

In this Paper I interpret Charles S. Peirce’s method of prescision as a transcendental method. In order to do so, I argue that Peirce’s pragmatism can be interpreted in a transcendental light only if we use a non‐justificatory understanding of transcendental philosophy. I show how Peirce’s prescision is similar to some abstracting procedure that Immanuel Kant used in his Critique of Pure Reason. Prescision abstracts from experience and thought in general those elements without which such experience and thought would be (...) unaccountable. Similarly, in the Aesthetics, Kant isolated the a priori forms of intuition by showing how they could be abstracted from experience in general, while experience in general cannot be thought without them. However, if Peirce’s and Kant’s methods are similar in this respect, they reached very different conclusions. (shrink)

This volume contains a selection of contributions to the workshop 'Linguistic realization of evidentiality in European languages', held at the 30th Annual ...

In this paper, I distinguish between two varieties of actualism—hardcore actualism and softcore actualism—and I critically discuss Ross Cameron’s recent arguments for preferring a softcore actualist account of the truthmakers for modal truths over hardcore actualist ones. In the process, I offer some arguments for preferring the hardcore actualist account of modal truthmakers over the softcore actualist one.

This paper introduces a possible alternative model of gravity based on the theory of fractional-dimension spaces and its applications to Newtonian gravity. In particular, Gauss’s law for gravity as well as other fundamental classical laws are extended to a D-dimensional metric space, where D can be a non-integer dimension. We show a possible connection between this Newtonian Fractional-Dimension Gravity (NFDG) and Modified Newtonian Dynamics (MOND), a leading alternative gravity model which accounts for the observed properties of galaxies and other astrophysical (...) structures without requiring the dark matter hypothesis. The MOND acceleration constant $${a_{0}} \simeq 1.2 \times 10^{-10} \text {m}\, \text{s}^{-2}$$ can be related to a natural scale length $$l_{0}$$ in NFDG, i.e., $$a_{0} \approx GM/l_{0}^{2}$$, for astrophysical structures of mass M, and the deep-MOND regime is present in regions of space where the dimension is reduced to $$D \approx 2$$. For several fundamental spherically-symmetric structures, we compare MOND results, such as the empirical Radial Acceleration Relation (RAR), circular speed plots, and logarithmic plots of the observed radial acceleration $$g_{obs}$$ vs. the baryonic radial acceleration $$g_{bar}$$, with NFDG results. We show that our model is capable of reproducing these results using a variable local dimension $$D\left( w\right)$$, where $$w =r/l_{0}$$ is a dimensionless radial coordinate. At the moment, we are unable to derive explicitly this dimension function $$D\left( w\right)$$ from first principles, but it can be obtained empirically in each case from the general RAR. Additional work on the subject, including studies of axially-symmetric structures, detailed galactic rotation curves fitting, and a possible relativistic extension, will be needed to establish NFDG as a viable alternative model of gravity. (shrink)

This paper aims at giving an account of the philosophy of norms of Georges Canguilhem in the framework of his philosophical vitalism. According to Canguilhem, vitalism is not a metaphysical or ontological theory, but rather a general attitude or a perspective about life and living beings, both understood employing the axiological concept of ‘normativity’. This notion allows Canguilhem to enlarge the concept of life beyond the field of biological phenomena, encompassing also phenomena of the social world, included technique and scientific (...) knowledge and rationality. Canguilhem’s perspective relocates human activities within a vitalistic conception of life, which redefines the meaning of human reason by putting it in relation to values and norms. (shrink)

My two daughters would love to go tobogganing down the hill by themselves, but they are just toddlers and I am an apprehensive parent, so, before letting them do so, I want to ensure that the toboggan won’t go too fast. But how fast will it go? One way to try to answer this question would be to tackle the problem head on. Since my daughters and their toboggan are initially at rest, according to classical mechanics, their final velocity will (...) be determined by the forces they will be subjected to between the moment the toboggan will be released at the top of the hill and the moment it will reach its highest speed. The problem is that, throughout their downhill journey, my daughters and the toboggan will be subjected to an incredibly large number of forces—from the gravitational pull of any massive object in the universe to the weight of the snowflake that is sitting on the tip of one of my youngest daughter’s hairs—so that any attempt to apply the theory directly to the real-world system in all its complexity seems to be doomed to failure. (shrink)

In Schwichtenberg, Schwichtenberg fine-tuned Tait’s technique so as to provide a simplified version of Gentzen’s original cut-elimination procedure for first-order classical logic. In this note we show that, limited to the case of classical propositional logic, the Tait–Schwichtenberg algorithm allows for a further simplification. The procedure offered here is implemented on Kleene’s sequent system G4. The specific formulation of the logical rules for G4 allows us to provide bounds on the height of cut-free proofs just in terms of the logical (...) complexity of their end-sequent. (shrink)

Suppose we want to take seriously the neoverificationist idea that an intuitionistic theory of meaning can be generalized in such a way as to be applicable not only to mathematical but also to empirical sentences. The paper explores some consequences of this attitude and takes some steps towards the realization of this program. The general idea is to develop a meaning theory, and consequently a formal semantics, based on the idea that knowing the meaning of a sentence is tantamount to (...) having a criterion for establishing what is a justification for it. Section 1 motivates a requirement of epistemic transparency imposed onto justifications conceived as mental states. In Section 2, the formal notion of justification for an atomic formula is defined, in terms of the notion of cognitive state. In Section 3, the definition is extended to logically complex formulas. In Section 4, the notion of truth-ground is introduced and is used to give a definition of logical validity. (shrink)

Among the theses that for centuries have ensured Niccolò Machiavelli an ambiguous fame, a special place goes to his extremely positive opinion of social conflicts, and, more in particular, to the claim that in ancient Rome 'the disunion between the plebs and the Roman senate made that republic free and powerful'. Contrary to a long tradition that had always highly valued civic concord, Machiavelli thought that - at least under certain conditions - internecine discord could be a source of strength (...) and not of weakness, and built upon this daring proposition an original vision of political order. Machiavelli in Tumult is the first book-length study entirely devoted to analyzing this idea, its ancient roots, its enduring influence up until the American and the French Revolution, and its relevance for contemporary political theory. (shrink)

This paper explores the socio-epistemic practice of shopping for experts. I argue that expert shopping is particularly likely to occur on what Thi Nguyen calls cognitive islands. To support my argument, I focus on macroeconomics. First, I make a prima-facie case for thinking that macroeconomics is a cognitive island. Then, I argue that ordinary people are particularly likely to engage in expert shopping when it comes to macroeconomic matters. In particular, I distinguish between two kinds of expert shopping, which I (...) call cynical and wishful, and introduce the notion of assisted expert shopping, which occurs when people or organizations shop for experts on behalf of other people. I argue that assisted expert shopping can sometime result in what I call a propagandistic use of expertise. Finally, I critically examine some possible reasons for optimism and find them wanting. I conclude by suggesting that that much of what I said about shopping for macroeconomic experts might also apply mutatis mutandis to other policy-relevant domains of expertise. (shrink)

In this paper, I distinguish scientific models in three kinds on the basis of their ontological status—material models, mathematical models and fictional models, and develop and defend an account of fictional models as fictional objects—i.e. abstract objects that stand for possible concrete objects.

The Simple Counterfactual Analysis (SCA) was once considered the most promising analysis of disposition ascriptions. According to SCA, disposition ascriptions are to be analyzed in terms of counterfactual conditionals. In the last few decades, however, SCA has become the target of a battery of counterexamples. In all counterexamples, something seems to be interfering with a certain object’s having or not having a certain disposition thus making the truth-values of the disposition ascription and of its associated counterfactual come apart. Intuitively, however, (...) it would seem that, if all interferences were absent, the disposition ascription and its associated conditional would have the same truth-value. Although this idea may seem obvious, it is far from obvious how to implement it. In fact, it has become widely assumed that the content of qualifying ceteris paribus clauses (such as ‘if all interferences were absent’) cannot be specified in a clear and non-circular manner. In this paper, I will argue that this assumption is wrong. I will develop an analysis of disposition ascriptions, the Interference-Free Counterfactual Analysis, which relies on a clear and non-circular definition of the notion of interference and avoids the standard counterexamples to SCA while vindicating the intuition that disposition ascriptions and counterfactual conditionals are intimately related. (Please note that an erratum has been issued for the published version of this paper. It is recommended to read the self-archived version of the paper.). (shrink)

This book presents a systematic interpretation of Charles S. Peirce’s work based on a Kantian understanding of his teleological account of thought and inquiry. Departing from readings that contrast Peirce’s treatment of purpose, end, and teleology with his early studies of Kant, Gabriele Gava instead argues that focusing on Peirce’s purposefulness as a necessary regulative condition for inquiry and semiotic processes allows for a transcendental interpretation of Peirce’s philosophical project. The author advances this interpretation through presenting original views on (...) aspects of Peirce’s thought, including: a detailed analysis of Peirce’s ‘methodeutic’ and ‘speculative rhetoric,’ as well as his ‘critical common-sensism’; a comparison between Peirce’s and James’ pragmatisms in view of the account of purposefulness Gava puts forth; and an examination of the logical relationships that order Peirce’s architectonic classification of the sciences. (shrink)

Mereological nihilism is the thesis that there are no composite objects—i.e. objects with proper material parts. One of the main advantages of mereological nihilism is that it allows its supporters to avoid a number of notorious philosophical puzzles. However, it seems to offer this advantage only at the expense of certain widespread and deeply entrenched beliefs. In particular, it is usually assumed that mereological nihilism entails eliminativism about ordinary objects—i.e. the counterintuitive thesis that there are no such things as tables, (...) apples, cats, and the like. In this paper, I argue that this assumption is false—mereological nihilists do not need to be eliminativists about tables, apples, or cats. Non-eliminativist nihilists claim that all it takes for there to be a cat is that there are simples arranged cat-wise. More specifically, non-eliminative nihilists argue that expressions such as ‘the cat’ in sentences such as ‘The cat is on the mat’ do not refer to composite objects but only to simples arranged cat-wise and compare this metaphysical discovery to the scientific discovery that ‘water’ refers to dihydrogen oxide. Non-eliminative nihilism, I argue, is not only a coherent position, but it is preferable to its more popular, eliminativist counterpart, as it enjoys the key benefits of nihilism without incurring the prohibitive costs of eliminativism. Moreover, unlike conciliatory strategies adopted by eliminative nihilists, non-eliminative nihilism allow its supporters to account not only for how we can assert something true by saying ‘The cat is on the mat’ but also for how we can believe something true by believing that the cat is on the mat. (shrink)

Public reason liberalism is defined by the idea that laws and policies should be justifiable to each person who is subject to them. But what does it mean for reasons to be public or, in other words, suitable for this process of justification? In response to this question, Kevin Vallier has recently developed the traditional distinction between consensus and convergence public reason into a classification distinguishing three main approaches: shareability, accessibility and intelligibility. The goal of this paper is to defend (...) the accessibility approach by demonstrating its ability to strike an appealing middle course in terms of inclusivity between shareability and intelligibility. We first argue against Vallier that accessibility can exclude religious reasons from public justification. Second, we use scientific reasons as a case study to show that accessibility excludes considerably fewer reasons than shareability. Throughout the paper, we connect our discussion of accessibility to John Rawls’s model of public reason, so as to give substance to the accessibility approach and to further our understanding of Rawls’s influential model. (shrink)

The most important question concerning picture perception is: what perceptual state are we in when we see an object in a picture? In order to answer this question, philosophers have used the results of the two visual systems model, according to which our visual system can be divided into two streams, a ventral stream for object recognition, allowing one to perceive from an allocentric frame of reference, and a dorsal stream for visually guided motor interaction, thus allowing one to perceive (...) from an egocentric frame of reference. Following this model, philosophers denied that we can be in a dorsal perceptual state when perceiving a depicted object. This is because a depicted object is not physically graspable or manipulable and, in turn, it cannot be egocentrically localized, as a normal object, by the dorsal stream. Thus, the impossibility of manipulating depicted objects and of localizing them from an egocentric frame of reference has led some people to be sceptical about the possibility of a representation of action properties in the perception of objects in pictures, which pertains to the dorsal visual system. The aim of the present paper is to show that it is possible for the depicted object to be represented by dorsal perception. That means that we can ascribe action properties to depicted objects as well, even if depicted objects cannot be egocentrically localized—at least, not as much as normal objects can. (shrink)

Philosophers have suggested that, in order to understand the particular visual state we are in during picture perception, we should focus on experimental results from vision neuroscience—in particular, on the most rigorous account of the functioning of the visual system that we have from vision neuroscience, namely, the ‘Two Visual Systems Model’. According to the initial version of this model, our visual system can be dissociated, from an anatomo-functional point of view, into two streams: a ventral stream subserving visual recognition, (...) and a dorsal stream subserving the visual guidance of action. Following this model, philosophers have suggested that, since the two streams have different functions, they represent different properties of a picture. However, the original view proposed by the ‘Two Visual Systems Model’ about the presence of a strong anatomo-functional dissociation between the two streams has recently been questioned on both philosophical and experimental grounds. Indeed, the analysis of several new pieces of evidence seems to suggest that many visual representations in our visual system, related to different tasks, are the result of a deep functional interaction between the streams. In the light of the renewed status of the ‘Two Visual Systems Model’, also our best philosophical model of picture perception should be renewed, in order to take into account a view of the process of picture perception informed by the new evidence about such interaction. Despite this, no account fulfilling this role has been offered yet. The aim of the present paper is precisely to offer such an account. It does this by suggesting that the peculiar visual state we are in during picture perception is subserved by interstream interaction. This proposal allows us to rely on a rigorous philosophical account of picture perception that is, however, also based on the most recent results from neuroscience. Unless the explanation offered in this paper is endorsed, all the recent evidence from vision neuroscience will remain unexplained under our best empirically informed philosophical theory of picture perception. (shrink)

The history of Pythagoreanism is littered with different and incompatible interpretations. This observation directs this book towards a fundamentally historiographical rather than philological approach, setting out to reconstruct the way in which the tradition established Pythagoreanism s image.".

Molyneux’s question famously asks about whether a newly sighted subject might immediately recognize, by sight alone, shapes that were already familiar to her from a tactile point of view. This paper addresses three crucial points concerning this puzzle. First, the presence of two different questions: the classic one concerning visual recognition and another one concerning vision-for-action. Second, the explicit distinction, reported in the literature, between ocular and cortical blindness. Third, the importance of making reference to our best neuroscientific account on (...) vision, ‘the two visual systems model’, in order to better address Molyneux’s problem. Then, by offering a new, deeper analysis of the relation between, and, this paper suggests that the subjects of Molyneux’s two different questions show the same visual impairment as brain-damaged subjects with different lesions of the visual cortex. In particular, the subject of the first question shows the same impairment in visual recognition as a visual agnosic subject, while the subject of the second question shows the same visual impairment in visuomotor processing as an optic ataxic subject. These impairments still hold even if ocular processing is restored. Therefore, I suggest the following. For the first classic question, the required experimental setting cannot be properly reached. By contrast, concerning the second question, based on the interpretation we select, either the answer is negative, or, as with the first question, the experimental setting cannot be properly reached. This proposal constitutes, with the other approaches offered in the literature, a further attempt to tackle the enormous complexity of Molyneux’s puzzle. (shrink)

According to the received view in the philosophical literature on pictorial perception, when perceiving an object in a picture, we perceive both the picture’s surface and the depicted object, but the surface is only unconsciously represented. Furthermore, it is suggested, such unconscious representation does not need attention. This poses a crucial problem, as empirical research on visual attention shows that there can hardly be any visual representation, conscious or unconscious, without attention. Secondly, according to such a received view, when looking (...) at a picture aesthetically, one both consciously represents and visually attends to both the depicted object and the picture’s surface simultaneously. Thus, contra the empirical research on attention, only conscious visual representations are coupled, by such current view, with attention. And this clearly poses a second problem, as this philosophical account is not in tune with what vision science tells us about the functioning of our visual system. Furthermore, this raises another crucial problem, namely, that of explaining why aesthetic experience of pictures does not feel odd or conflicting, since, as previously noted in the philosophical literature, and contra the received view, if we are simultaneously consciously perceiving both the picture’s surface and the depicted object, there seems to be two things, at the same time, in the foreground of one’s visual consciousness. But, if so, as suggested, this would lead to a conflicting spatial visual experience. This paper offers a new description of the role of visual attention in picture perception, which explains the difference between the usual and the aesthetic way of perceiving a depicted object, without facing the problems reported above. A crucial role in our new account is played by the notion of unconscious attention, the distinction between focal and distributed, as well as top-down and bottom-up visual attention and the relationship between visual attention and visual consciousness. The paper, thus, offers the first theory concerning the exercise of visual attention in pictorial perception that is both philosophically rigorous and empirically reliable. (shrink)

In this chapter, I investigate a problem for Kant’s claim that metaphysics can reach the status of science. The problem arises when one considers Kant’s account of the “architectonic unity” of metaphysics in the Architectonic of Pure Reason. Attaining architectonic unity is a condition for becoming a science for any body of cognitions that purports to be such. This is achieved when the cognitions belonging to a science are systematically organized according to the “idea of reason” which lies at the (...) basis of that science. However, Kant suggests that nobody can ever legitimately claim to have matched the idea of the philosopher, where this appears to imply that nobody can justifiably claim that she has fully grasped the idea of metaphysics. This generates a problem. I suggest that when Kant claims that the idea of the philosopher must remain an ideal or an archetype, he has a particular conception of philosophy in mind, that is, philosophy as a doctrine of wisdom. According to this understanding, philosophy must provide an example of how one can become virtuous. However, this is only a partial solution to our problem, for reasons that will be illustrated. (shrink)