Period homeostasis is the defining characteristic of a biological clock. Strict period homeostasis is found for the ultradian clocks of eukaryotic microbes. In addition to being temperature-compensated, the period of these rhythms is unaffected by differences in nutrient composition or changes in other environmental variables. The best-studied examples of ultradian clocks are those of the ciliates Paramecium tetraurelia and Tetrahymena sp. and of the fission yeast, Schizosaccharomyces pombe. In these single cell eukaryotes, up to seven different parameters display ultradian rhythmicity (...) with the same, species- and strain-specific period. In fission yeast, the molecular genetic analysis of ultradian clock mechanisms has begun with the systematic analysis of mutants in identified candidate genes. More than 40 “clock mutants” have already been identified, most of them affected in components of major regulatory and signalling pathways. These results indicate a high degree of complexity for a eukaryotic clock mechanism. BioEssays 22:16–22, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

Everyone agrees that justice is a profoundly important value. People march and protest to demand it; more than a few have died in its pursuit. Yet when we stop to reflect on what makes for justice, or try to state in a clear way what we mean when we speak of justice, we may be perplexed. But if you are going to die in defense of some value, it is important for you to have a fairly clear conception of what (...) that value is. This book is an attempt to explain and defend, in clear and precise terms, a novel and controversial view about what makes for distributive justice in a country. The theory is a form of desertism, according to which justice reigns in a country when the government ensures that citizens receive the benefits and burdens they deserve. (shrink)

A theory of information is developed in which the informational content of a signal (structure, event) can be specified. This content is expressed by a sentence describing the condition at a source on which the properties of a signal depend in some lawful way. Information, as so defined, though perfectly objective, has the kind of semantic property (intentionality) that seems to be needed for an analysis of cognition. Perceptual knowledge is an information-dependent internal state with a content corresponding to the (...) information producing it. This picture of knowledge captures most of what makes knowledge an important cpistcmological notion. It also avoids many of the problems infecting traditional justificational accounts of knowledge (knowledge as [justified, true belief those (unlike knowledge) having a content that can be either true or false (e.g., belief) – are described in terms of the way internal (presumably neural) structures acquire during learning a certain information-carrying role. The content of these structures (whether true or false) is identified with the kind of information they were developed to carry. (shrink)

Fred Feldman is an important philosopher, who has made a substantial contribution to utilitarian moral philosophy. This collection of ten previously published essays plus a new introductory essay reveal the striking originality and unity of his views. Feldman's version of utilitarianism differs from traditional forms in that it evaluates behaviour by appeal to the values of accessible worlds. These worlds are in turn evaluated in terms of the amounts of pleasure they contain, but the conception of pleasure involved is (...) a novel one and the formulation of hedonism improved. In Feldman's view pleasure is not a feeling but a propositional attitude. He also deals with problems of justice that affect standard forms of utilitarianism. The collection is ideally suited for courses on contemporary utilitarian theory. (shrink)

Godfrey-Smith’s environmental complexity thesis is most often applied to multicellular animals and the complexity of their macroscopic environments to explain how cognition evolved. We think that the ECT may be less suited to explain the origins of the animal bodily organization, including this organization’s potentiality for dealing with complex macroscopic environments. We argue that acquiring the fundamental sensorimotor features of the animal body may be better explained as a consequence of dealing with internal bodily—rather than environmental complexity. To press and (...) elucidate this option, we develop the notion of an animal sensorimotor organization that derives from an internal coordination account for the evolution of early nervous systems. The ASMO notion is a reply to the question how a collection of single cells can become integrated such that the resulting multicellular organization becomes sensitive to and can manipulate macroscopic features of both the animal body and its environment. In this account, epithelial contractile tissues play the central role in the organization behind complex animal bodies. In this paper, we relate the ASMO concept to recent work on epithelia, which provides empirical evidence that supports central assumptions behind the ASMO notion. Second, we discuss to what extent the notion applies to basic animal architectures, exemplified by sponges and jellyfish. We conclude that the features exhibited by the ASMO are plausibly explained by internal constraints acting on and within this multicellular organization, providing a challenge for the role the ECT plays in this context. (shrink)

Our concerns fall into three areas: (1) Barsalou fails to make clear what simulators are (vs. what they do); (2) activation of perceptual areas of the brain during thought does not distinguish between the activation's being constitutive of concepts or a mere causal consequence (Barsalou needs the former); and (3) Barsalou's attempt to explain how modal symbols handle abstraction fails.

Cosmopolitanism seeks a political ethics of world togetherness and a political aesthetics that can contribute to this task critically and imaginatively. Regarding political ethics, I explore the world as a “cosmopolitan mind” composed of “dialogic voices” and threatened by neoliberalism, neofascism, and other nihilistic “oracles.” I also construct a criterion for determining which public artworks (1) resist oracles and (2) help us imagine a “cosmopolitan democracy” and its political ethics. The latter includes the concordance of three ethico-political virtues—solidarity, heterogeneity, and (...) fecundity (creating new voices through the interplay among other voices)—and must appeal to different peoples worldwide. I also examine how this political ethics and aesthetics can be applied to nonhuman life and non-sentient formations in a non-anthropocentric manner; indeed, how the cosmos in its entirety and plurality can also be thought of as voices and participants in the cosmopolitan mind and its artistic expression. Moreover, I contend that my ontology of dialogic voices and proposed public art criterion, like the cosmopolitan mind itself, are “events” or “becomings.” This means that there can never be an articulation of the ontology that is final nor a public art criterion that could curtail the imaginative reach of art. (shrink)

This paper critically examines a particular strategy for resolving the central ethical dilemma associated with randomized clinical trials — the “community equipoise” strategy . The dilemma is that RCTs appear to violate a physician's duty to choose that therapy which there is most reason to believe is in the patient's best interest, randomizing patients even once evidence begins to favor one treatment. The community equipoise strategy involves the suggestion that our judgment that neither treatment is to be preferred is to (...) be assessed according to a community rather than an individual standard. Thus, though a physician may personally believe that there is some reason to prefer one treatment, patients can legitimately be randomized if there remains disagreement in the community of medical professionals. Rationales in favor of this conception include the following: medical knowledge is best understood as residing in the community, the judgments of others count as evidence, and so should change one's own opinion, subjects would not be better off outside the trial, and the point of any trial is the resolution of dispute in the medical community. I critically examine these rationales and argue that they are insufficient. Amongst the problems are tensions between various of these underlying rationales, and important ambiguities in just what the CE criterion is to amount to. Finally, I argue that even if use of CE was justified, it would not justify carrying out RCTs anywhere near long enough to discharge our duty to gain reliable knowledge on which to base safe and effective medical practice. Hence, we need some different justification for carrying out RCTs. (shrink)

If consciousness is good for something, conscious things must differ in some causally relevant way from unconscious things. If they do not, then, as Davies and Humphreys conclude, too bad for consciousness: ‘psychological theory need not be concerned with this topic.’Davies and Humphreys are applying a respectable metaphysical idea — the idea, namely, that if an object's having a property does not make a difference to what that object does, if the object's causal powers are in no way enhanced by (...) its possession of this property, then nothing the object does can be explained by its having that property. A science dedicated to explaining the behavior of such objects would not have to concern itself with that property. That is why being an uncle is of no concern to the psychology of uncles. I am an uncle, yes, but my being so does not enable me to do anything I would not otherwise be able to do. (shrink)

The neuropsychology of religious activity in normal and selected clinical populations is reviewed. Religious activity includes beliefs, experiences, and practice. Neuropsychological and functional imaging findings, many of which have derived from studies of experienced meditators, point to a ventral cortical axis for religious behavior, involving primarily the ventromedial temporal and frontal regions. Neuropharmacological studies generally point to dopaminergic activation as the leading neurochemical feature associated with religious activity. The ventral dopaminergic pathways involved in religious behavior most closely align with the (...) action-extrapersonal system in the model of 3-D perceptual–motor interactions proposed by Previc . These pathways are biased toward distant space and also mediate related extrapersonally dominated brain functions such as dreaming and hallucinations. Hyperreligiosity is a major feature of mania, obsessive-compulsive disorder, schizophrenia, temporal-lobe epilepsy and related disorders, in which the ventromedial dopaminergic systems are highly activated and exaggerated attentional or goal-directed behavior toward extrapersonal space occurs. The evolution of religion is linked to an expansion of dopaminergic systems in humans, brought about by changes in diet and other physiological influences. (shrink)

Popper's critique of the philosophical doctrines underlying totalitarian ideology is powerful. Yet, having the regimes of Hitler and Stalin in full view before him, he did not give full and balanced consideration to the range of effects these doctrines can have within actually existing ideologies and regimes. The ideas he correlates with totalitarianism can and do exist in benign forms or tempered by other ideas and by institutions. Moreover, the struggle with totalitarianism is only partly a struggle of philosophical ideas. (...) Political argument and rhetoric appeal to feeling as well as intellect. This tends to be a blindspot of liberalism that often weakens it in the competition with its adversaries. (shrink)

This volume consists of papers originally presented at the international conference "Occasionalism: History and Problems," held in Venice in 2015; it contains twelve chapters, nine of which are in English, three in French. In their introduction, the editors describe occasionalism as a theory that was viewed by Medieval Christian philosophers as a "dangerous and treacherous" threat, only later to be "proudly asserted" in the post-Descartes era. This raises the question of to what degree this transition should be seen as a (...) result of interpretations of the commitments of Cartesian metaphysics, particularly with regard to questions concerning mind-body interaction. Many scholars have pointed out that to view... (shrink)

Here we have a new edition of Hume's Enquiry concerning Human Understanding, one that will become essential for scholars alongside the new Norton and Norton edition of Hume's Treatise. L. A. Selby-Bigge's nineteenth century edition provided a good text to nineteenth century standards—good enough for it to become the standard for many years. But times change, and we now, quite reasonably, ask for more. Beauchamp's new edition provides a text and apparatus that is a vast improvement; it will surely replace (...) Selby-Bigge's as the common reference text for scholars and students. To be sure, scholars at least will not for many years be able to do without the latter's edition: so many have come out over the years with the references to the pages of this edition, that we will still have to refer to the older edition. But students have a new and very useful edition. (shrink)

The management literature is replete with studies on business ethics. Unfortunately, most of these studies have dealt exclusively with ethics in large businesses. Although a handful of studies can be found on small business ethics, none has paid attention to the issue of ethics in small minority businesses. Similarly, several studies on ethics have utilized the Wood et al. (1988) 16-vignette ethics scale, although reliability and validity issues associated with the scale have never been fully addressed. In this study, a (...) purification (via content analysis) of the above mentioned scale was performed. Three reliable factors were extracted from the purified scale. They were used to investigate the ethics in small minority businesses. The study found an association between business ethics and demographic and company-related variables. In the case of age of respondents, findings ran counter the usual relationship of age being positively related to ethical attitudes. The implications of these findings are also discussed. (shrink)

Humans can learn complex functional relationships between variables from small amounts of data. In doing so, they draw on prior expectations about the form of these relationships. In three experiments, we show that people learn to adjust these expectations through experience, learning about the likely forms of the functions they will encounter. Previous work has used Gaussian processes—a statistical framework that extends Bayesian nonparametric approaches to regression—to model human function learning. We build on this work, modeling the process of learning (...) to learn functions as a form of hierarchical Bayesian inference about the Gaussian process hyperparameters. (shrink)

ABSTRACT Drawing inspiration from Fred Dretske, L. S. Carrier, John A. Barker, and Robert Nozick, we develop a tracking analysis of knowing according to which a true belief constitutes knowledge if and only if it is based on reasons that are sensitive to the fact that makes it true, that is, reasons that wouldn’t obtain if the belief weren’t true. We show that our sensitivity analysis handles numerous Gettier-type cases and lottery problems, blocks pathways leading to skepticism, and validates (...) the epistemic closure thesis that correct inferences from known premises yield knowledge of the conclusions. We discuss the plausible views of Ted Warfield and Branden Fitelson regarding cases of knowledge acquired via inference from false premises, and we show how our sensitivity analysis can account for such cases. We present arguments designed to discredit putative counterexamples to sensitivity analyses recently proffered by Tristan Haze, John Williams and Neil Sinhababu, which involve true statements made by untrustworthy informants and strange clocks that sometimes display the correct time while running backwards. Finally, we show that in virtue of employing the paradox-free subjunctive conditionals codified by Relevance Logic theorists instead of the paradox-laden subjunctive conditionals codified by Robert Stalnaker and David Lewis. (shrink)

Jerry Fodor's arguments for a language of thought are largely theoretical. Is there any empirical evidence that supports the existence of LOT? There is. Research on Global Aphasia supports the existence of LOT. In this paper, I discuss this evidence and why it supports Fodor's theory that there is a language of thought.

I offer Jimmy a dollar to wiggle his ears. He wiggles them because he wants the dollar and, as a result of my offer, thinks he will earn it by wiggling his ears. So I cause him to believe something that explains, or helps to explain, why he wiggles his ears. If I push a button, and a bell, wired to the button, rings because the button is depressed, I cause the bell to ring. I make it ring. Indeed, I (...) ring it. So why don’t I, by offering him a dollar, make Jimmy wiggle his ears? Why, indeed, don’t I wiggle them? If I ring a bell by pushing a button, why don’t I wiggle Jimmy’s ears by offering him a dollar?That is a question that has always vexed a compatibilist’s vision of human freedom. If an intentional act–say, wiggling one’s ears in order to earn a dollar–is caused by one’s beliefs and desires, then, by the transitivity of the causal relation, it appears to follow that it is caused by whatever causes one to have those beliefs and desires. But the causes of belief and desire are often factors over which one has no control. So intentional behavior is often something one is made to do by factors over which one has no control. This, however, robs intentional behaviorand, presumably, also voluntary action–of its autonomy. Deliberate acts–Jimmy wiggling his ears to earn a dollar–have the same causal structure as does a bell that rings because a button is pushed. The only difference is the switch. (shrink)

In earlier work I defended Intrinsic Attitudinal Hedonism—a view about what makes for individual personal welfare. On this view, a person’s level of welfare is entirely determined by the amounts of intrinsic attitudinal pleasure and pain he or she takes in things. The view seems to run into trouble in cases involving individuals who take their pleasure in disgusting, immoral things; and in cases involving individuals who take their pleasure in things that really don’t actually happen; and in cases involving (...) individuals who enjoy pleasures but who lead meaningless lives; and in cases involving individuals whose lives fail to manifest an attractive narrative structure. After sharpening up the objections, I introduce a distinction between Pure Welfare Narrowly Conceived and Enriched Welfare Broadly Conceived. I go on to claim that if this distinction is recognized, we will be able to say that each of the objections rests on the fallacy of equivocation. If, years ago, I had been more sensitive to the distinction between Pure Welfare and Enriched Welfare I would have been able to respond to the objections in a more coherent and effective way. I present that response here. In an appendix, I compare my current view with a related view defended by Shelly Kagan in ‘Me and My Life’. (shrink)

WHEN Aristotle takes up the task of establishing the foundations of ethics in the Nicomachean Ethics, he understands this task in a quite different way from many modern moral philosophers. For one thing, he explicitly distinguishes inquiries such as ethics and politics from more precise disciplines such as mathematics, and emphasizes that their end is action rather than knowledge. Moreover, he differs from many modern ethicists in the importance which he assigns to knowledge of what to do in a concrete (...) situation. Practical knowledge for Aristotle has two indispensable, interrelated components: apprehension of the ultimate end of human action, and practical rationality in virtue of which one knows how to pursue this end in concrete situations. As a moral epistemologist Aristotle is exceptional in the emphasis he places upon practical rationality. Even if one correctly apprehends the ultimate end, knowing how to attain it in action is no trivial matter of perfunctorily applying general precepts. Henry Veatch illustrates this important feature of Aristotle's thought by relating it to Sartre's anecdote of the young man who sought his advice during World War II as to whether he should stay with his mother or join the Free French forces. Veatch contends that Aristotle would agree with Sartre that a general apprehension of the end will not provide us with a priori recipes for answering "concrete moral questions," such as the dilemma posed in Sartre's anecdote. He would also agree that the young man must work out the answer for himself in the immediate context of action. But Veatch's Aristotle maintains, against Sartre, that moral agents can and should work out answers through "practical moral knowledge." Although this is an appealing construal of Aristotle's conception of rationality in action, it is not without opposition. John Cooper has challenged it in favor of the interpretation that deliberation may be completed with a decision on a type of action prior to the time of action. Cooper bases this interpretation on an extensive review of the texts. Nevertheless, as this essay attempts to show, the textual evidence clearly supports an interpretation along the lines suggested by Veatch. Section I considers the evidence concerning practical rationality and deliberation, and Section II that concerning practical insight and observation. (shrink)

There is a lively debate about the descriptive concept of happiness. What do we mean when we say (using the word to express this descriptive concept) that a person is “happy”? One prominent answer is subjective local desire satisfactionism. On this view, to be happy at a time is to believe, with respect to the things that you want to be true at that time, that they are true. Wayne Davis developed and defended an interesting and sophisticated version of this (...) view in a series of papers. I present, explain, and attempt to refute his version of the theory. I then sketch what I take to be a better theory of happiness -- a form of intrinsic attitudinal hedonism. (shrink)