This paper analyzes recent attempts to reject reproduction with lineage formation as a necessary condition for evolution by means of natural selection :560–570, 2008; Stud Hist Philos Sci Part C Stud Hist Philos Biol Biomed Sci 42:106–114, 2011; Bourrat in Biol Philos 29:517–538, 2014; Br J Philos Sci 66:883–903, 2015; Charbonneau in Philos Sci 81:727–740, 2014; Doolittle and Inkpen in Proc Natl Acad Sci 115:4006–4014, 2018). Building on the strengths of these attempts and avoiding their pitfalls, it is argued that (...) a robust formulation of evolution by natural selection without reproduction can be established. The main contribution of this paper is a reformulation of Lewontin’s three principles stating that minimal evolution by natural selection occurs when two conditions are met in a population: fitness-related variation and memory. Paradigmatic evolution by natural selection, which can generate adaptations, takes place when an additional condition is present, namely regeneration. (shrink)

Recent years have seen a growing interest among psychologists for debates in moral philosophy. Moral psychologists have investigated the causal origins of the opposition between utilitarian and deontological judgments and the psychological underpinnings of people’s beliefs about the moral status of animals. One issue that remains underexplored in this research area is the relationship between people’s disposition to engage in utilitarian thinking and their attitudes towards animals. This gap is unfortunate considering the tight philosophical connection between utilitarianism and the claim (...) that animals have the same moral status as humans. Indeed, the principle of utility leads naturally enough to the view that animals count every bit as much as human beings. In this paper, we report two empirical studies dedicated to bridging this gap. In Study 1, we looked at the relationship between attitudes towards animals and utilitarian judgments in the context of sacrificial dilemmas. In Study 2, we bypassed the problems raised by the use of such dilemmas as a measure of utilitarianism by relying on other types of thought experiments. Overall, our results suggest no strong correlation between utilitarianism and attitudes towards animals. Rather, the existence of a correlation between utilitarianism and attitudes towards animals very much depends on how both are measured. (shrink)

Exploring responsibility in the works of Nietzsche, Sartre, Levinas, Heidegger, and Derrida, Raffoul identifies decisive moments in the development of the concept, retrieves its origins, and explores new reflections on it.

Dans les Premiers principes métaphysiques de la science de la nature, le principe d’articulation entre métaphysique et physique apparaît obscurci par le registre amphibolique du texte de la préface. L’étude successive de trois motifs amphiboliques permet d’introduire une nouvelle interprétation de cette articulation chez Kant : le problème de la spécification catégoriale qui anime le système des principes de la première Critique surdéterminerait le rapport entre ce système des principes et les Premiers principes métaphysiques de la science de la nature. (...) Ainsi, ce rapport ne doit s’entendre ni comme une application mécanique des principes et catégories de la philosophie transcendantale, ni comme une tentative arbitraire pour accommoder la physique newtonienne à la table des catégories, mais comme une spécification dont la modalité (modélisante) est héritée des particularités systémiques du registre critique. L’apparente instabilité de cette articulation est enfin référée à la situation inédite de la modélisation (mathématique) qui triomphe définitivement en sciences naturelles avec l’émergence du paradigme newtonien. Les Premiers principes se donnent alors à lire comme l’envers métaphysique de la modélisation mathématique en physique et révèlent la métaphysique implicite corrélative à une telle modélisation physique. (shrink)

This paper describes Alfred Clebsch’s 1871 article that gave a geometrical interpretation of elements of the theory of the general algebraic equation of degree 5. Clebsch’s approach is used here to illuminate the relations between geometry, intuition, figures, and visualization at the time. In this paper, we try to delineate clearly what he perceived as geometric in his approach, and to show that Clebsch’s use of geometrical objects and techniques is not intended to aid visualization matters, but rather is a (...) way of directing algebraic calculations. We also discuss the possible reasons why the article of Clebsch has been eventually completely forgotten by the historiography. (shrink)

Francois Recanati presents the basic features of the *indexical model* of mental files, and defends it against several interrelated objections. According to this model, mental files refer to objects in a way that is analogous to that of indexicals in language: a file refers to an object in virtue of a contextual relation between them. For instance, perception and attention provide the basis for demonstrative files. Several objections, some of them from David Papineau, concern the possibility of files to preserve (...) and add information about objects across contexts. How is it possible to think about the same object when the subject no longer is in the original context? How is it possible to think of a perceived object as already known? Can this be done without an explicit identity judgment? Recanati answers these questions by invoking mental files of non-basic kinds and by describing the cognitive dynamics in which they take part. (shrink)

In this paper, I examine Adorno’s controversial claim that human rationality is inherently mimetic. To do so, I break this claim down into three puzzles (the natural historical puzzle, the metaphysical puzzle, and the epistemic puzzle) and consider each in turn. The first puzzle originates in Adorno’s assertion that in the course of human history the mimetic moment of human thought “is melted together with the rational moment”. So whereas, on his narrative, mimesis has become an intrinsic component of human (...) rationality, it appears that we are oblivious to this state of affair and unable to recognize the workings of mimesis in what we otherwise refer to as rationality. The second puzzle concerns the traditional metaphysical question regarding the possibility of knowledge. Adorno holds that the key to this question lies in the “mimetic moment of knowledge”, which he characterizes as the “moment of the elective affinity between the knower and the known.” The third puzzle concerns his views on how the mimetic moment of thought plays out in our epistemic practices. As he puts it, “consciousness knows of its other as much as it resembles that other,” which seems to entail that our very efforts to conceptualize objects somehow rely on imitative processes. I work out what I take to be the basics of Adorno’s understanding of mimesis and use them to make sense of each puzzle. I argue that Adorno’s insistence on the mimetic component of human rationality isn’t meant to promote more mimetic modes of comportment, but a reflexive awareness of the extent to which our rational activities already rely on imitative (or immersive) processes, even those we view as embodying the strongest claims to the contrary. (shrink)

Hundreds of clinical trials of potential treatments and vaccines for the “coronavirus 19 disease” (COVID-19) have been set up in record time. This is a remarkable reaction to the global pandemic, but the absence of a global coordination of clinical research efforts raises serious ethical concerns. Some COVID-19 patients might carry the burden of clinical trial involvement even though their trial cannot be completed as researchers are competing for patients. A shortage of medicines can occur when existing drugs are diverted (...) for clinical trials. Research ethics committees are overburdened with multiple applications. A multitude of trials can also overstretch medical staff and risk neglecting non-COVID-19 patients. And finally, conflicting conclusions from a multitude of heterogeneous trials might lead to delays in public health decisions about life-saving issues. These challenges are made worse by the unpredictable evolution of epidemics, the active involvement of political decision-makers in scientific issues and the pressure of social media globally. While freedom to conduct research must be safeguarded, global health emergency situations would greatly benefit from effective international coordination mechanisms for clinical research. (shrink)

The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular in the organic bone matrix) reflects a broad spectrum of biological functions within a unique tissue. PGs play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of collagen fibrillogenesis. PGs also display selective patterns of reactivity with several constituents including cytokines and growth factors, such as transforming growth factor‐β or osteoprotegerin thereby modulating their bio‐availability and biological activity (...) in the bone tissue. In this review, the complex PG composition in bone will be addressed together with the specific role played by PGs (or their GAGs chains) in bone biology, as regulatory molecules for bone resorption and their involvement in bone tumor development. These roles have been determined after modulation of PG expression or mutations in their corresponding genes, which revealed specific roles for these compounds in bone pathologies (e.g. perlecan or glypican‐3 mutations observed respectively in chondrodysplasia or dysmorphic syndrome). Finally, the potential therapeutic interest of PGs is discussed based on recent data, more particularly on bone tumor‐associated osteolysis as these molecules are involved both in bone resorption and tumor development. BioEssays 29:758–771, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

The aim of the paper is to develop the notion of partial probability distributions as being more realistic models of belief systems than the standard accounts. We formulate the theory of partial probability functions independently of any classical semantic notions. We use the partial probability distributions to develop a formal semantics for partial propositional calculi, with extensions to predicate logic and higher order languages. We give a proof theory for the partial logics and obtain soundness and completeness results.

What is it to share the same concept? The question is an important one since sharing the same concept explains our ability to non-accidentally coordinate on the same topic over time and between individuals. Moreover, concept identity grounds key logical relations among thought contents such as samesaying, contradiction, validity, and entailment. Finally, an account of concept identity is crucial to explaining and justifying epistemic efforts to better understand the precise contents of our thoughts. The key question, then, is what psychological (...) and social facts could play these roles? Elsewhere, we have argued for a specific relational model of concept identity, the connectedness model (e.g. Schroeter 2012, Schroeter and Schroeter 2014, 2015). Our aim in this chapter is to further explain the motivations behind that account, to address worries about transitivity and vagueness, and to contrast our approach with closely related accounts of concept identity developed by François Recanati and Simon Prosser. -/- What’s distinctive of our approach is that we seek to vindicate the first-person epistemic perspective of concept users. Concepts, on our account, play a crucial normative role in setting regulative ideals for the representational practices in which individual subjects participate. This focus on the normative role of concepts – as opposed to a purely causal explanatory role – motivates our approach to concept identity and our toleration of vagueness and borderline cases. (shrink)

Résumé Le problème d’un « discours sur Dieu » aujourd’hui ne se pose plus dans le cadre aristotélico-thomiste où il se posait hier. Walter Kasper le rappelle fréquemment. Ce qui n’interdit pas la lecture de saint Thomas, mais la requiert au contraire. C’est donc en partant de Thomas d’Aquin que je voudrais proposer quelques réflexions sur le discours théologique, sur une certaine manière de « dire Dieu ». Je voudrais aussi montrer comment le « problème théologique » doit être posé (...) aujourd’hui par rapport à une certaine « pensée du langage ».The problem of a « discourse on God » today is no longer posed within the Aristotelian-Thomistic framework of yesterday. Walter Kasper brings this up frequently. Far from dismissing the study of Thomas Aquinas, this on the contrary makes recourse to his writings imperative. Hence it is by starting with Thomas Aquinas that I should like to propose some reflections on theological discourse, on a certain manner of « saying God ». I should like also to show how thinking on the « theological act » implies thinking about language. (shrink)

The author uses a sociological approach to review Council Vatican II’s interpretation throughout the time as a prophetic event. While taking Pierre Bourdieu’s analyses seriously, he questions his theory as well as our era wondering what is the importance now given to prophets. Are we not living at the time of sorcerers?

This is an experimental piece of writing by François Laruelle. Via its origins in both Greek and Judeo-Christian thought, philosophy has risen up from the abysses of the world and made its assault on human identity. Philosophy dominates man, and as long as he lives under the philosophical decision or ?Ontological Statute? he lives also within an impotence of thought and within an infinite culpability. Yet ultimately man is an inalienable reality, and nothing ? not even philosophy ? can (...) substitute itself for man and for his identity. There is no reversibility between man and philosophy. Man itself is the abolition of the Statute. (shrink)

Ce texte a déjà paru, sous une forme augmentée et corrigée, dans Le Social et le Sensible. Introduction à une anthropologie modale, Paris, Téraèdre, 2005, p. 101-118. Nous remercions François Laplantine de nous avoir autorisé à le reproduire ici sous sa forme originelle. Nous nous proposons dans cet article d'esquisser une confrontation entre une pensée de la vie et une pensée du social. Une telle confrontation s'avère problématique et délicate. Assez souvent soit elle risque de tourner court parce que (...) - Anthropologie. (shrink)

Healthy Volunteers (HVs) who participate in clinical trials are a vulnerable group that deserves specific protection. We assessed the number and types of studies that involve HVs around the world and outline the methodological barriers to their analysis. We found that tens of thousands of HVs are involved every year in clinical trials in a large variety of countries and that the overwhelming majority of studies are not “first-in-human” but pharmacokinetic studies. The two cornerstones for both ethical and safe participation (...) of HVs in clinical trials are properly obtained informed consent, and a minimization of exposure to risk, in particular by avoiding concealed participation in multiple trials. To minimize the risk of exploitation of HVs and their exposure to risk, we propose ways to ensure genuine informed consent, and advocate setting up national Healthy Volunteer volunteer registries as established in France and the U.K. (shrink)

Originally published in French as François Laruelle, "L’Appel et le Phénomène," Revue de Métaphysique et de Morale 1996 (1): 27–41. English translation by Kris Pender.

Over the past two decades there has been a rapid expansion in our understanding of how human genetic variability impacts susceptibility and severity of disease. Through applications of genome-wide association studies, genome and exome sequencing, researchers have made thousands of discoveries of genetic variants that impact risk of common and rare disorders affecting millions of people. Although these techniques have been primarily applied to highly prevalent chronic disorders such as diabetes1 and cardiovascular disease2, infectious diseases have proven to not be (...) immune to genome-wide association, with studies of Tuberculosis3, HIV4 and SARS-CoV25, to name but a few, identifying host susceptibility loci across the genome. Unlike non-communicable diseases, infectious diseases have the unique element of impacting not only the affected the host, but those who may be most vulnerable to acquiring the infection. Thus, genetic variants that impact one individual’s susceptibility to and severity of an infection may also have broader implications to public health, as was brought into keen focus during the COVID-19 pandemic. Therefore, as we begin to apply the knowledge gained from genomic studies in the clinic or into policy, there are unique ethical, legal, and social implications (ELSI) at the intersection of infectious diseases and human genomics. In this issue of the Journal of Law, Medicine and Ethics, Jose et al attempt to address this need by proposing a research agenda for ELSI studies at what they term the “blurred boundaries” of infectious and genetic diseases.6. (shrink)

Femmes intellectuelles, l’épithète, longtemps, parut incongrue : André Gide, quand s’ouvrirent en 1910 les Décades de Pontigny, rassemblement annuel d’intellectuels français et de toutes les nations, aurait en effet souhaité les bannir de cette sociabilité choisie. Cet ouvrage collectif entend précisément interroger les modalités (épouses suivant leurs maris ou le secondant, auditrices plus ou moins connues, conférencières, directrices de colloques) et surtout le sens de la présence féminine...

Qu'ont en commun Cioran, Simone Weil, Curzio Malaparte, Denis de Rougemont et les autres intellectuels et écrivains dont l'oeuvre et la vie sont évoquées dans ces pages? Il apparaît que, pour la plupart, ce sont des témoins d'une époque à bien des égards exceptionnelle, ne serait-ce que par la profondeur et l'intensité des malheurs qui y ont connu les hommes et les femmes. Mais alors pourquoi avoir choisi parmi tous les témoins possibles ceux qui, sans être inconnus dans les cercles (...) savants, ne le sont pas moins aujourd'hui du grand public? Peut-être s'agit-il de faire oeuvre d'éducation en permettant aux lecteurs d'accéder à la connaissance de ces témoins peu connus? Peut-être s'agit-il plutôt, à terme, de simplement rappeler ces existences marquées, au milieu de la tourmente, par la lucidité et le courage? Une telle entreprise peut paraître suspecte à une époque qui se targue d'avoir aboli toutes les idoles. Que vaut, en somme, ce type de célébration posthume dès lors que chaque existence, même la plus noble, porte en elle une part d'obscurité si déterminante? A cela s'ajoute que l'histoire, du moins celle que nourrit la recherche et que l'on enseigne dans les universités et les collèges, n'offre plus de modèles de vie, mais bien des faits, des explications et des interprétations que l'on souhaite les plus objectifs possible. Et pourtant, à cette époque que l'on dit de toutes les fins, de l'Art, de l'Histoire, de l'Homme, il a semblé nécessaire de renouer avec l'esprit de la tradition humaniste. Un jardin en soi, aurait pu écrire Montaigne, qu'on ne peut cultiver pour le mieux, car c'est là un art incertain, qu'en ayant à l'esprit un certain idéal. Or, renouer ainsi le fil rompu de la transmission de l'Idéal, tel était, et tel demeure encore aujourd'hui, notre volonté en publiant ces figures de pensée. (shrink)

Le trimètre ïambique gravé sur la base du Colosse fait simplement référence au fait, en soi remarquable, que cette base très lourde a été taillée dans le même marbre naxien que la statue : les dédicants tiennent à le rappeler parce que cette opération (travail en carrière et transport) représentait un supplément de dépense considérable, témoignage de leur piété envers le dieu. Un passage parallèle de Diodore de Sicile (I 47,3) vient à l'appui de cette interprétation.