English summary: »Selbstbestimmung« is a basic concept in the German ethical discourse, similar to »autonomy«, »liberty«, or »human dignity«. Even though this term is clearly in need of further definition, it has been barely addressed in the theological discourse. The contributions to this volume take a variety of approaches to the question of how we have to understand and interpret the concept of »self-determination« within the framework of theological ethics. In order to achieve this, the authors resort to the orientation (...) and perspectives of reality fostered by reformatory theology. Apart from a fundamental essay that in tracing the different facets of the term »self-determination« refers back to the theology of Martin Luther, the anthology contains a number of contributions from the field of applied ethics. German description: Der Begriff »Selbstbestimmung« gehort zu den Grundbegriffen der Ethik. Er begegnet in vielen aktuellen ethischen Diskursen Ahnlich haufig wie die Begriffe »Autonomie«, »Freiheit« oder »Menschenwuerde«. Trotz eines offensichtlichen Klarungsbedarfs hat sich die Theologie dieses Begriffs bisher noch kaum angenommen. Die Beitrage des vorliegenden Sammelbandes stellen sich in unterschiedlicher Perspektive der Frage, wie das Konzept »Selbstbestimmung« im Rahmen theologischer Ethik verstanden und inhaltlich gefuellt werden kann. Dafuer wird die Orientierungsleistung des von der reformatorischen Theologie gepragten Wirklichkeitsverstandnisses fruchtbar gemacht. Neben einem grundlegenden Aufsatz, der den Begriff »Selbstbestimmung« mit Hilfe von Impulsen aus der Theologie Martin Luthers entfaltet, stehen Aufsatze aus dem Bereich der angewandten Ethik. (shrink)

This essay proposes that Kant′s unjust enemy has a central place within his conception of international law. The first part rejects the assumption that the unjust enemy is part of Kant′s law of war and primarily a domestic problem. Instead, it is argued that this figure is best understood as a spoiler of the building process of international law. Several forms of the unjust enemy are distinguished in order to show that the theorem has also positive functions within Kant′s theory. (...) These positive features could be used within Kant′s evolutionary conception of international law to point to some internal deficiencies. (shrink)

The present article seeks to provide an overview of the general characteristics of the cultural and scientific climate in the Duchy of Urbino. Three of the Duchy’s milieus seem to have been particularly important for scholars who were engaged in the study of mathematics: the so-called “School of Urbino”, the environment of the court, and the world of the technicians and engineers. While the Urbino School has already been the object of previous studies, the other two milieus and their effect (...) on the mathematicians’ work have been rather neglected and are, consequently, addressed here. The paper’s final section presents some documents that attest the importance of Renaissance scholars’ interaction with these environments to their actual scientific activity, taking the case of Guidobaldo dal Monte as an example. (shrink)

Sport gehört zum Leben vieler Menschen weltweit. Sport wirft ethische Fragen und Probleme auf, die in den Massenmedien, an Stammtischen und auch in der Wissenschaft diskutiert werden. Wenn es um Doping, Sexismus, Umweltzerstörung, politische Ideologisierung und ähnliches geht, stehen im Hintergrund solcher Diskussionen auch Fragen nach einem dem gesellschaftlichen Zusammenleben und dem Sport angemessenen Menschenbild. In Auseinandersetzung mit leibphänomenologischen Konzepten der zeitgenössischen philosophischen Anthropologie und die Leiblichkeit des Menschen betreffenden Aussagen der theologischen Anthropologie wird in dieser Sportethik das christliche Menschenbild (...) beschrieben. Das Phänomen Sport wird vom Spielgedanken her in den Blick genommen. Als ethisches Leitbild dient die allen Menschen gleiche Würde. Sie wird in Auseinandersetzung mit zeitgenössischen philosophischen und theologischen Entwürfen von der Lehre der Gottebenbildlichkeit des Menschen her beschrieben und für ethische Fragen im Sport fruchtbar gemacht. Exemplarisch werden die Themen Doping, Geschlechterverhältnis, Tier- und Umweltschutz, Politisierung, Kommerzialisierung und die Möglichkeit ethischer Bildung im Sport erörtert. (shrink)

This volume views human existence from various perspectives and asks what its purpose is. The underlying thesis is that humans are creatures of relationships. Any anthropology that fails to take this fact seriously will of necessity remain abstract. Instead the authors are interested in how different academic disciplines describe the variety of relationships in human life, taking into account their ethical and theological dimensions.

Dieser Essay möchte Kants Recht nach dem Krieg kritisch analysieren und untersuchen, welchen Beitrag es für die gegenwärtige Debatte um das ius post bellum leisten kann. Es wird dabei davon ausgegangen, dass Kants Konzeption des Naturzustands den Schlüssel zum Verständnis von Kants Kriegsrecht insgesamt darstellt. Zunächst wird die Struktur des ius post bellum durch seine systematische Stellung in Kants Völkerrecht rekonstruiert. Die einzelnen Bestimmungen des Rechts nach dem Krieg werden in zwei Gruppen geteilt und für sich erläutert. Dabei wird gelegentlich (...) auf Begrenzungen von Kants Perspektive hingewiesen. Die identifizierten Grundsätze von Kants Kriegsrecht werden schließlich dazu verwendet, weitere, nicht im Recht nach dem Krieg genannte Bestimmungen zu diskutieren, die die Nachkonfliktphase betreffen.This essay tries to critically analyze Kant’s right after war. It examines the contribution of Kant’s right after war to the contemporary debate about jus post bellum. It starts with the assumption that the key to the understanding of Kant’s law of war is his conception of the state of nature. The structure of the right after war will be reconstructed by analyzing the place of the right within Kant’s law of peoples. The features of the right after war will be divided into two groups and examined. Certain limitations of Kant’s perspective will be identified. The underlying principles of Kant’s law of war will be used to discuss other, not in the right after war included features, which are related to the post bellum phase. (shrink)

Durch genomweite Analysen werden vielfältige gesundheitsrelevante Informationen über eine Person gewonnen. Solche Informationen können die Behandlung von Krankheiten verbessern. Sie ermöglichen aber auch Vorhersagen, ob eine Person und deren Verwandte in Zukunft möglicherweise erkranken werden. Der neuartige Charakter des Informationseingriffs und sein prädiktive Potential bedürfen der ethischen, juristischen und ökonomischen Reflexion, damit diese Technologie zum Wohl der Patienten, der Familienangehörigen und der Solidargemeinschaft eingesetzt werden kann. Die vorliegende Schrift leistet mit ihren interdisziplinären, vom BMBF finanzierten Analysen dazu einen Beitrag. Grundlagen (...) für einen ethisch und juristisch verantwortbaren Einsatz der Genomsequenzierung zu medizinischen Zwecken werden erörtert und Eckpunkte für Kostenanalysen sowie Elemente einer “Guten klinischen Praxis” präsentiert. (shrink)

a la base de cet article a ´ et´ e pr´ esent´ ee ` a la cinqui` eme ‘Conference on Semantics and Linguistic Theory’ qui s’est tenue ` a Austin, Texas, en F´ evrier 1995, et va paraˆıtre dans les actes de celle-ci. Nous aimerions remercier les participants `.

Discussions often end before the issues that started them have been resolved. For example, in the late sixties and early seventies, a hot topic in philosophical logic was the development of an adequate semantics for the language of modal predicate logic. However, the result of this discussion was not one single system that met with general agreement, but a collection of alternative systems, each defended most ably by its proponents.

Of course, although this view on meaning was the prevailing one for almost a century, many of the people who initiated the enterprise of logical semantics, including people like Frege and Wittgenstein, had an open eye for all that it did not catch. However, the logical means which Frege, Wittgenstein, Russell, and the generation that succeeded them, had at their disposal were those of classical mathematical logic and set-theory, and these indeed are not very suited for an analysis of other (...) aspects of meaning than those which the slogan covers. A real change in view then had to await the emergence of other concepts, which in due course became available mainly under the influence of developments in computer science and cognate disciplines such as artificial intelligence. And this is one of the reasons why it took almost a century before any serious and successful challenge of the view that meaning equals truthconditions from within logical semantics could emerge. (shrink)

A common finding is that information order influences belief revision (e.g., Hogarth & Einhorn, 1992). We tested personal experience as a possible mitigator. In three experiments participants experienced the probabilistic relationship between pieces of information and object category through a series of trials where they assigned objects (planes) into one of two possible categories (hostile or commercial), given two sequentially presented pieces of probabilistic information (route and ID), and then they had to indicate their belief about the object category before (...) feedback. The results generally confirm the predictions from the Hogarth and Einhorn model. Participants showed a recency effect in their belief revision. Extending previous model evaluations the results indicate that the model predictions also hold for classification decisions, and for pieces of information that vary in their diagnostic values. Personal experience does not appear to prevent order effects in classification decisions based on sequentially presented pieces of information and in belief revision. (shrink)

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

The aim of this paper is to argue that update semantics is a natural framework for contextually restricted quantification, and to illustrate its use in the analysis of anaphoric definite descriptions and certain other anaphoric terms.

The identity of working-memory and long-term memory representations follows from many lines of evidence. However, the data provided by Ruchkin et al. are hardly compelling, as they make unproved assumptions about hypothetical generators. We cite studies from our lab in which congruent slow-wave topographies were found for short-term and long-term memory tasks, strongly suggesting that both activate identical cell assemblies.

Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. (...) We also discuss the rise and fall of somatic mutation rates during cancer progression. BioEssays 26:291–299, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This article presents results from a multidisciplinary research project on the integration and transfer of language knowledge into robots as an empirical paradigm for the study of language development in both humans and humanoid robots. Within the framework of human linguistic and cognitive development, we focus on how three central types of learning interact and co-develop: individual learning about one's own embodiment and the environment, social learning (learning from others), and learning of linguistic capability. Our primary concern is how these (...) capabilities can scaffold each other's development in a continuous feedback cycle as their interactions yield increasingly sophisticated competencies in the agent's capacity to interact with others and manipulate its world. Experimental results are summarized in relation to milestones in human linguistic and cognitive development and show that the mutual scaffolding of social learning, individual learning, and linguistic capabilities creates the context, conditions, and requisites for learning in each domain. Challenges and insights identified as a result of this research program are discussed with regard to possible and actual contributions to cognitive science and language ontogeny. In conclusion, directions for future work are suggested that continue to develop this approach toward an integrated framework for understanding these mutually scaffolding processes as a basis for language development in humans and robots. (shrink)

Evidence for the contribution of the neocortex to memory is overwhelming. However, the theory proposed by Ruchkin et al. does not only ignore subcortical contributions, but also introduces an unnecessary and empirically unsupported division between the posterior cortex, assumed to represent information, and the prefrontal cortex, assumed to control activation. We argue instead that the representational power of the neocortex is not restricted to its posterior part.

Conspiracy theories (CTs) are widespread ways by which people make sense of unsettling or disturbing cultural events. Belief in CTs is often connected to problematic consequences, such as decreased engagement with conventional political action or even political extremism, so understanding the psychological and social qualities of CTs belief is important. CTs have often been understood to be “monological”, displaying the tendency for belief in one conspiracy theory to be correlated with belief in (many) others. Explanations of monologicality invoke a nomothetical (...) or “closed” mindset whereby mutually supporting beliefs based on mistrust of official explanations are used to interpret public events as conspiracies, independent of the facts about those events (which they may ignore or deny). But research on monologicality offers little discussion of the content of monological beliefs and reasoning from the standpoint of the CT believers. This is due in part to the “access problem” (Wood & Douglas, 2015): CT believers are averse to being researched because they often distrust researchers and what they appear to represent. We used several strategies to address the access problem, and investigated the symbolic resources underlying CTs by reconstructing a conspiracy worldview - a set of beliefs held by CT believers about important dimensions of ontology, epistemology, and human agency. To do this, we analysed media documents, conducted field observation, and engaged in semi-structured interviews,. We describe six main dimensions of a conspiracy worldview: Views of the nature of reality, the self, the outgroup, the ingroup, action, and the future. We also describe a typology of five types of CT believers, which vary according to their positions on each of these dimensions. Our findings converge with prior explorations of CT beliefs but also revealed novel aspects: A sense of community among CT believers, a highly differentiated representation of the outgroup, a personal journey of conversion, variegated kinds of political action, and optimistic belief in future change. These findings are at odds with the typical image of monological CT believers as paranoid, cynical, anomic and irrational. For many, the CT worldview may rather constitute the ideological underpinning of a nascent pre-figurative social movement. (shrink)

The task of computing a function F with the help of an oracle X can be viewed as a search problem where the cost measure is the number of queries to X. We ask for the minimal number that can be achieved by a suitable choice of X and call this quantity the query complexity of F. This concept is suggested by earlier work of Beigel, Gasarch, Gill, and Owings on “Bounded query classes”. We introduce a fault tolerant version and (...) relate it with Ulam's game. For many natural classes of functions F we obtain tight upper and lower bounds on the query complexity of F. Previous results like the Nonspeedup Theorem and the Cardinality Theorem appear in a wider perspective. (shrink)