BACKGROUND -/- The need for detailed description and modeling of cells drives the continuous generation of large and diverse datasets. Unfortunately, there exists no systematic and comprehensive way to organize these datasets and their information. CELDA (Cell: Expression, Localization, Development, Anatomy) is a novel ontology for the association of primary experimental data and derived knowledge to various types of cells of organisms. -/- RESULTS -/- CELDA is a structure that can help to categorize cell types based on species, anatomical localization, (...) subcellular structures, developmental stages and origin. It targets cells in vitro as well as in vivo. Instead of developing a novel ontology from scratch, we carefully designed CELDA in such a way that existing ontologies were integrated as much as possible, and only minimal extensions were performed to cover those classes and areas not present in any existing model. Currently, ten existing ontologies and models are linked to CELDA through the top-level ontology BioTop. Together with 15.439 newly created classes, CELDA contains more than 196.000 classes and 233.670 relationship axioms. CELDA is primarily used as a representational framework for modeling, analyzing and comparing cells within and across species in CellFinder, a web based data repository on cells (http://cellfinder.org). -/- CONCLUSIONS -/- CELDA can semantically link diverse types of information about cell types. It has been integrated within the research platform CellFinder, where it exemplarily relates cell types from liver and kidney during development on the one hand and anatomical locations in humans on the other, integrating information on all spatial and temporal stages. CELDA is available from the CellFinder website: http://cellfinder.org/about/ontology. (shrink)

This is a book about the philosophy of Henri Bergson which shows how relevant Bergson is to much contemporary philosophy. The book takes as its point of departure Bergson's insistence on precision in philosophy. It then discusses a variety of topics including laughter, the nature of time as experienced, how intelligence and language should be construed as a pragmatic product of evolution, and the antinomies of reason represented by magic and religion. This is not just another exposition of Bergson's work. (...) It offers an account of why Bergson commanded such a massive reading public in his own day and why he deserves to be read now. Written in a terse and clear style, this book will prove appealing to teachers and students of philosophy, cognitive science, psychology, religious studies and literature. (shrink)

What I eat is your business -- The pesticide controversy -- The chemical fertilizer controversy -- The carbon footprint controversy -- The GMO controversy -- The farm subsidy controversy -- The local food controversy -- Controversies about livestock -- Parting thoughts.

La «question de l'Inconditionné» est développée par Paul Tillich dans une Religionsphilosophie pensée comme Logique de la raison religieuse et comme Théorie du sens, dans une perspective théonome. La présente étude analyse le projet du premier Tillich, après l'avoir situé en relation au paradigme de la Modernité. Tillich mène un double combat, face à l'«hybris religieuse» de l'hétéronomie et à l'«hybris culturelle» de la pure autonomie. Partant de la tension fondamentale entre identité mystique et différence éthique, le projet de Tillich (...) souligne l'aspect paradoxal et dialectique de la religion, son vouloir d'atteindre le contenu inconditionné à travers des formes conditionnées, sa résistance à être pur objet et concept d'une science. Dépassant le paradigme de la Modernité, Tillich construit une Philosophie de la Religion située dans le système des sciences, mais non fondée sur le conditionné, mais au contraire sur l'Inconditionné. Les éléments et catégories du religieux sont soumis à l'analyse à travers un processus méthodologique complexe, critique et dialectique, intuitif et vital; est ainsi formulée l'unité de sens entre le fondé, le fondant et le fondement ultime qui soutient tout. La dialectique du sacré et du profane, du divin et du démoniaque, de la foi et de l'incrédulité, de Dieu et du monde, est éclairée dans la perspective théonome; d'où est surpassée la pure autonomie, en lutte avec l'hétéronomie religieus. (shrink)

The growth characteristics of the recently derived Trans-Gompertz function are compared to those of the Generalized Logistic function. Both functions are defined by one shaping parameter and one rate parameter. The functions are matched at a specified point on the growth curve by equating both the first and second derivatives. Analysis shows that the matched Trans-Gompertz function will have grown at a faster rate with a larger inflection point ratio.

"Growth," a term borrowed from biology, is often used to describe change in human history. The use of such terms, however, tends to obscure the fundamental differences between historical and natural causality. Vico and Herder were among the first to make a radical distinction between our understanding of events in nature and of those in human affairs. They argued that man can make conscious decisions which make his actions different from events in the nonhuman world. Yet, they also believed that (...) human history has a purpose of its own, which man cannot alter. However, if human choice is to be truly free, then the outcome of human history cannot be entirely predetermined. Though Vico and Herder, like many other writers, attempted to merge these two notions, they failed to provide a satisfactory theory. (shrink)