The issue of benefits in international clinical research is highly controversial. Against the background of wide recognition of the need to share benefits of research, the nature of benefits remains strongly contested. Little is known about the perspectives of research populations on this issue and the extent to which research ethics discourses and guidelines are salient to the expectations and aspirations existing on the ground. This exploratory study contributes to filling this void by examining perspectives of people in low-income South (...) African communities on benefits in international clinical research. Twenty-four individuals with and without experience of being involved in clinical research participated in in-depth interviews. Respondents felt that ancillary care should be provided to clinical research participants, while a clinical study conducted in particular community should bring better health to its members through post-trial benefits. Respondents' perspectives were grounded in the perception that the ultimate goal of international clinical research is to improve local health. We argue that perspectives and understandings of the respondents are shaped by local moral traditions rather than clinical research specificities and require attention as valid moral claims. It is necessary to acknowledge such claims and cultural worlds from which they emerge, thus building the foundation for equal and embracing dialogue to bridge different perspectives and handle contradicting expectations. (shrink)

Italian philosopher Giorgio Agamben—whose work has influenced intellectuals in political theory, political philosophy, legal theory, literature, and art—stands among the foremost intellectual figures of the modern era. Engaging with a range of thinkers from Carl Schmitt and Martin Heidegger to Jacques Rancière and Alain Badiou, Agamben considers some of the most pressing issues in recent history and politics. His work explores the relationship between the sovereign state and the politically marginalized _Homo Sacer_—exiles, refugees, prisoners of war, and others whom the (...) state actively excludes from political participation and full humanity. Further, his critique of the increasing deployment of a “state of exception”—the declaration of a state of emergency that legitimizes the sovereign state’s suspension of law for the public good—as a dominant paradigm for governing has particular power in today’s global political climate. Infused with the spirit of Agamben’s critical self-reflection, this special issue of _SAQ_ examines his seminal works _Homo Sacer_, _The Open_, and _State of Exception_. Some contributors use Agamben’s work to examine the history of abortion law in the West, the history of slavery, and women’s rights. Others analyze the connections between Agamben’s work and that of his contemporaries, including Jacques Derrida, Slavoj Žižek, and Jean-Luc Nancy. Still other essays identify new points of interdisciplinary communication between some of Agamben’s most provocative ideas and popular twentieth-century writing. _Contributors_. Andrew Benjamin, Claire Colebrook, Jean-Philippe Deranty, Penelope Deutscher, Eleanor Kaufman, Adrian Mackenzie, Catherine Mills, Alison Ross, Lee Spinks, Ewa Płonowska Ziarek, Krzysztof Ziarek. (shrink)

Jacques Rancière relies on references to theatre and literature to articulate the modes in which meanings are communicated. It is because they are displaceable from bodies and dis-incorporable from things that these patterns of meaning are available to being picked up. But this also means that meaning occurs as a pattern of communication that is not entirely rational. Meaning, we might say, moulds as it communicates. Such references to theatre and literature are more than allegorical. The general orientation of Rancière’s (...) thought pivots on the claim that politics is aesthetic; and that theatrical and literary fields of displacement and disincorporation are modes in which politics occurs as an alteration of ordered patterns of meaning, what he describes as ‘ways of being, doing and saying’. Although it would be possible to pursue cases of such alteration in film, in general Rancière’s writing on film does not do so. Rather, his critique of modernism is the framework he uses to examine the aesthetic settings and technical possibilities of film. From this perspective, he argues that the cinematic apparatus is indifferent to its material and that its technical arsenal does not determine cinematic forms. Further, because the ‘critical’ profile of cinema is in fact indistinguishable from the role it plays in the poetic depiction of the minutaie of life, claims regarding the political significance of film need radical qualification. The implications of this position on cinema are double: first, it may be argued that there is no reason that the prospects for dis-incorporation of meaning and the political significance he attaches to such modes of aesthetic communication in the cases of theatre and literature cannot be extended to cinema; a second set of implications bring into question the aesthetic settings he gives to politics. There is a clear fissure in Rancière’s thinking between the topic of film as an aesthetic form and its critical force for remoulding the conditions of communicability of meaning. It is because of the way this fissure occurs in the case of film that we can distinguish the strands that Rancière, on account of his position on aesthetic politics, would elsewhere like to consider fused. For this reason, I argue that Rancière’s discussion of cinema tends to undermine the general perspective he defends in which meaning-forming processes in the arts are taken to be political. (shrink)

Many philosophers and psychologists have thought that people untutored in philosophy are moral realists. On this view, when people make moral judgments, they interpret their judgments as tracking universal, objective moral facts. But studies of folk metaethics have demonstrated that people have a mix of metaethical attitudes. Sometimes people think of their moral judgments as purely expressive, or as tracking subjective or relative moral facts, or perhaps no facts at all. This paper surveys the evidence for folk metaethical pluralism and (...) argues for an explanation of this mix of folk metaethical attitudes: without philosophical education, these attitudes are typically caused by factors that are insensitive to their truth. Moreover, unless they can be justified by other means, metaethical attitudes with this etiology are, as a result, irrational, and ought not be used as evidence for or against moral realism. (shrink)

During the past two decades, philosophers of biology have increasingly turned their attention to mechanisms of biological phenomena. Through analyses of mechanistic proposals advanced by biologists, the goal of these philosophers is to understand what a mechanism is and how mechanisms explain. These analyses have generally focused on mechanistic proposals for phenomenon that occur at the cellular or sub-cellular level, such as synapse firing, protein synthesis, or metabolic pathway operation. Little is said about the mechanisms of the macromolecular reactions that (...) underpin these phenomena. These reactions comprise a diverse family of reaction types, and include protein folding, macromolecular complex formation, receptor-ligand interactions, and enzyme catalysis. In this paper, I develop an account of mechanism that focuses exclusively on macromolecular reactions. I begin by reviewing how mechanism is understood in enzymology, and how mechanistic concepts of enzymology apply to macromolecular reactions in general. We will see that the mechanism of a macromolecular reaction is most accurately described as a progression of reaction intermediates, where the evolution of intermediates, from one to the next, is characterized by an energetic coupling between chemistry and protein dynamics. I then make the case that this description necessitates a grounding in a process ontology. To describe the mechanism by which a macromolecular reaction occurs is to describe a process. (shrink)

Abstract: The systemic role of corruption and its link to low human development is explored. The extractive resource industry is presented as an arena where conditions for corruption—monopoly and discretion without accountability—are especially intense. Corruption is maintained by a self-reinforcing cycle. Multiple stakeholders are involved in the maintenance of and/or opposition to the cycle: investing corporations, host country regimes and officials, inter-governmental bodies like the OECD, industry associations, non-governmental organization (NGO) watchdogs like Transparency International, and international agencies facilitating global investment (...) like the World Bank. Complementarity of interests between the demand and supply sides provides strong incentives for entrenched players to maintain corruptive relationships, to protect past gains and sustain current ones. Compulsory international regulation, maximum transparency, effective detection, and enforcement are recommended to enhance accountability, thereby reversing the cycle. It is also necessary to create a corporate culture built on integrity, if regulation itself is to succeed. (shrink)

ABSTRACT This article explores how literary study engages readers’ moral perception and imagination. Although some philosophers discuss reading as a largely solitary activity, this article explores social practices of reading common in English language arts classrooms in secondary schools. The article shows how reading with others can change the quality of moral perception and imagination in literary study. Reading with others, the article contends, can involve an ethic focused on the good of knowing one’s ways of seeing make a difference (...) to others. The article defends social practices of reading by arguing they can broaden and complicate students’ moral perception and imagination by making students accountable to texts, one another, and the wider world. (shrink)

Democracy surrounds us like the air we breath, and is normally taken very much for granted. Across the world democracy has become accepted as an unquestionably good thing. Yet upon further examination the merits of democracy are both paradoxical and problematic, and the treasured values of liberty and equality can be used to argue both for and against it. In the historical section of the book, Ross Harrison clearly traces the history of democracy by examining the works of, amongst (...) others, Plato and Aristotle, Hegel and Marx. Informed by facts and detailed knowledge of these famous thinkers, Harrison provides a clear and cogent justification of democracy. (shrink)

The human resources profession emphasizes the personal and interpersonal aspects of work, that make it conscious of complex ethical issues in relationships in the workplace, while finance specialists are conversant with routine compliance with regulations. Marketing professionals are under pressure to produce revenue results. Thus, this research hypothesized that human resources managers would be more disapproving of unethical conduct than both finance and marketing functional managers, and that finance managers would be more disapproving than marketing managers. When asked to evaluate (...) instances of unethical behavior in vignettes, human resources and finance managers were both significantly more disapproving than marketing managers. However, human resources managers were not significantly more disapproving than finance managers. Explanations for the results lie in the divergent antecedent conditions, objectives, perceptions of ethical problems and demands of the various functions. Alternative behavior patterns to resolve ethical dilemmas and expected consequences by the different functions also define their ethical orientations. Average responses on the disapproving side from all three functional groups are explained by two complementary trends that promote ethical awareness among all functional managers. One is the adoption of homogeneous conventions in ethical business practice. The other trend is the increase in ethical awareness specific to each of the functional professions. (shrink)

Carroll Izard’s theoretical and research contributions to the study of early socioemotional development are profiled. His studies of early emotional expression and the formulations of differential emotions theory have stimulated contemporary inquiry into the organization of early emotional life, the developmental processes by which distinct feelings and facial expressions become progressively concordant, and how the emotional expressions of others become imbued with emotion meaning. His work on emotion, attachment, and emotion–cognition relations has contributed to contemporary study of the emotional bases (...) of attachment organization and the development of the internal working models associated with attachment security. Because of Izard’s contributions, developmental emotions research is theoretically richer, and emotion has a more central place in our understanding of development and motivation. (shrink)

In this entry, we outline the ways in which evolutionary theory has implications for the objectivity of morality.

This article explores the philosopher Alice Crary’s ideas about ethics, literature, and nonhuman animals. Through studying certain works of literature, Crary writes, readers can see aspects of animals’ moral characteristics that are difficult to perceive outside of literary study. To illustrate and extend Crary’s argument, the article presents a reading of John Steinbeck’s (1937/1993) Of Mice and Men, a novella that is taught frequently in secondary schools and that has been re-evaluated by critics as offering insights into social inequality and (...) animal welfare. Drawing upon and adapting Crary’s work, which does not address questions of pedagogy, the article describes forms of instruction that enable students reading Of Mice and Men and other works of literature to explore the moral lives of animals. Thus, a key contribution of this project is its explanation of how educators can use philosophy to open pedagogy to new ways of seeing and assessing animals’ moral characteristics. (shrink)

General Equilibrium Theory: An Introduction treats the classic Arrow-Debreu general equilibrium model in a form accessible to graduate students and advanced undergraduates in economics and mathematics. Topics covered include mathematical preliminaries, households and firms, existence of general equilibrium, Pareto efficiency of general equilibrium, the First and Second Fundamental Theorems of Welfare Economics, the core and core convergences, future markets over time and contingent commodity markets under uncertainty. Demand, supply, and excess demand appear first as functions, then optionally as correspondences. The (...) mathematics presented includes a real analysis, the Brouwer fixed point theorem, and separating and supporting hyperplane theorems. Optional chapters introduce the existence of equilibrium with set-valued supply and demand, the mathematics of upper and lower hemicontinuous correspondences, and the Kakutani fixed point theorem. The treatment emphasizes clarity and accessibility to the student through use of examples and intuition. (shrink)

This paper enlarges the analogy of meaning doctrine to show that it is a general, law-like linguistic phenomenon, and not peculiar to philosophy. The theory of forms, considered as active, repeatable, intelligible structures of things (accessible as such to intelligent beings alone), is basic to ground the sciences of nature and to an account of knowledge. Aquinas’s accounts of real natures, universals, natural and angelic things, causation, abstraction, knowledge, etc. are grounded in the theory of forms. The theory of forms (...) can be adapted to discern and even invent intelligible structures; thus we can account for real and common natures. Structures that are explanatory of the behavior of things, and are not themselves reductively explicable in terms of their own material components, are the constitutive structures of things and processes. There are real common natures of both things and processes, but ‘being common’ is the resultant of the physicalmultiplication of repeatable (because receivable) intelligible structure. Thus the commonness of a nature, like being human or being a chicken, is not antecedentto the individuals, as Plato thought, but consequent upon them. (shrink)

The psychosocial morbidity associated with HIV infection and responses to such infection may exceed morbidity associated with medical sequelae of such infection. This paper argues that negative judgements on those with HIV infection or in groups associated with such infection will cause avoidable psychological and social distress. Moral judgements made regarding HIV infection may also harm the common good by promoting conditions which may increase the spread of HIV infection. This paper examines these two lines of argument with regard to (...) the ethical aspects of psychological bases of health care, clinical contact, public perceptions of AIDS and the comparative perspective. It is concluded that the psychosocial aspects of HIV infection impose ethical psychological, as well as medical, obligations to reduce harm and prevent the spread of infection. (shrink)

The emotional strength of his mother, Margaret Douglas, and close kinship bonds, to some degree, compensated Adam Smith for the loss of his father. In addition, he was well prepared at the Kirkcaldy burgh school for his student years, and found his vocation as a moral philosopher, in an era marked by a strong drive for advance in agriculture and other economic sectors. Most important of all, his Presbyterian inheritance, together with training in the Latin and Greek classics, instilled in (...) him the values of self‐command of a Stoic cast, frugality, diligence in his calling, and strict justice towards others tempered with benevolence, which characterized his actions and his teaching. At the same time, he seemed to have developed an independence of mind, which led him to rebel against the strict controls of Calvinism meant to check human depravity, and to set store by human goodness, and the will to enjoy natural liberty. (shrink)

Now let us imagine, if you please, a tiny worm living in the blood, . . . . The worm would be living in the blood as we are living in our part of the universe, and it would regard each individual particle as a whole, not a part, and it would have no idea as to how all the parts are controlled by the overall nature of the blood and compelled to mutual adaptation as the overall nature of the (...) blood requires, so as to agree with one another in a definite relation. . . .Now all the bodies of Nature can and should be conceived in the same way as we have here conceived the blood; . . . . Now since the nature of the universe, unlike the nature of the blood, is not limited, but is absolutely infinite, its parts are modified by the nature of this infinite in infinite ways and are compelled to undergo infinite variations. (Spinoza, ESL, Letter 32, 245–6). (shrink)

I examine the metaphysical issue of the nature of color. I argue that there are two distinct ranges of colors, namely, physical colors, which are disjunctive monadic physical properties of physical objects, and mental colors, which are properties of neural processes. ;A pair of claims provide the motivation for subjectivist and dispositionalist proposals about the nature of color, proposals which I reject. The first claim holds that a description of colors according to our ordinary experience of color provides a specification (...) of some aspects of the nature of color. The second holds that our ordinary experience of color provides access to the nature of color. ;In chapter 1, I argue that visual experiences have mental colors, neural properties which importantly determine our color categories. However, I reject C. L. Hardin's and James A. McGilvray's arguments for the subjectivist claim that the colors we attribute to physical objects are mental colors. ;In chapter 2, I show that Paul A. Boghossian and J. David Velleman's arguments in support of subjectivism rely on the assumption that visual experience provides unqualified access to the nature of color. I argue, however, that objections to their projectivism about color perception provide strong reasons to reject subjectivism as well as their assumption that visual experience provides unqualified access to the nature of color. ;In chapters 3 and 4, I examine Mark Johnston's and Christopher Peacocke's dispositionalist proposals about the nature of physical colors, which are founded on the claim that ordinary visual experience provides access to an aspect of the nature of color. I undercut dispositionalism by rejecting their arguments for the claim that ordinary visual experience provides such access. ;In chapter 5, I show that Evan Thompson's proposal that the colors of objects are relations between properties of perceivers and objects assumes that a description of color according to our ordinary experience specifies some aspects of the nature of color. I reject this assumption by distinguishing between mental color and physical color. I conclude that rather than specifying the nature of color, descriptions of colors according to our ordinary experience merely serve to fix the reference of color terms. (shrink)

The fundamental faith of the metaphysicians is the faith in opposite values. . . .For one may doubt, first, whether there are any opposites at all, and secondly whether these popular valuations and opposite values on which the metaphysicians put their seal, are not perhaps merely foreground estimates, only provisional perspectives, perhaps even from some nook, perhaps from below, frog perspectives, as it were, to borrow an expression painters use. For all the value that the true, the truthful, the selfless (...) may deserve, it wouldstill be possible that a higher and more fundamental value for life might have to be ascribed to deception, selfishness, and lust. . . .Maybe! (Nietzsche, BGE, #2). (shrink)

Has there already been a Grotian Moment for corruption? If not, what would it take for new legal rules and doctrines on corruption to crystallise? This article seeks to answer these two questions by reviewing the relevant history of international legal scholarship, the current public international law framework for anticorruption, and recent developments in international legal practice. We conclude that a Grotian Moment may have been reached for a narrow concept of corruption, focused on petty corruption and bribery, with the (...) proliferation of international anticorruption law following the Cold War. However, a Grotian Moment for a broadened understanding of corruption, based on other forms such as institutional, political, and grand corruption, ought to emerge to comprehensively address all forms of corruption. Given the range of challenges, including resistance from political elites and the indeterminacy of criminal liability, a Grotian Moment for a broadened concept of corruption remains improbable. (shrink)

A giving which gives only its gift, but in the giving holds itself back and withdraws, . . . . (Heidegger, TB, 8)the Forgotten is . . . the Law. (Lyotard, “HJ," 147)how could this thought (Heidegger’s), a thought so devoted to remembering that a forgetting (of Being) takes place in all thought, in all art, in all “representation” of the world, how could it possibly have ignored the thought of [that] which, in a certain sense, thinks, tries to think, (...) nothing but that very fact? . . . to the point of suppressing and foreclosing to the very end the horrifying (and inane) attempt at exterminating, at making us forget forever what, in Europe, reminds us, ever since the beginning, that “there is” the Forgotten? (Lyotard, HJ, 4)[I]n witnessing, one also exterminates. The witness is a traitor. (Lyotard, I, 204)The Other becomes my neighbour precisely through the way the face summons me, calls for me, begs for me, and in so doing recalls my responsibility, and calls me into question.. . . as if I had to answer for the other’s death even before being. (83). (shrink)