Pathological tremor is a common but highly complex movement disorder, affecting ~5% of population older than 65 years. Different methodologies have been proposed for its quantification. Nevertheless, the discrimination between Parkinson’s disease tremor and essential tremor remains a daunting clinical challenge, greatly impacting patient treatment and basic research. Here, we propose and compare several movement-based and electromyography-based tremor quantification metrics. For the latter, we identified individual motor unit discharge patterns from high-density surface electromyograms and characterized the neural drive to a (...) single muscle and how it relates to other affected muscles in 27 Parkinson’s disease and 27 essential tremor patients. We also computed several metrics from the literature. The most discriminative metrics were the symmetry of the neural drive to muscles, motor unit synchronization, and the mean log power of the tremor harmonics in movement recordings. Noteworthily, the first two most discriminative metrics were proposed in this study. We then used decision tree modelling to find the most discriminative combinations of individual metrics, which increased the accuracy of tremor type discrimination to 94%. In summary, the proposed neural drive-based metrics were the most accurate at discriminating and characterizing the two most common pathological tremor types. (shrink)

Scholarly papers by Gėlėgzhamt︠s︡yn Luvsant︠s︡ėrėn on Mādhyamika, Buddhist philosophy, Mongolian philosophy and Buddhist studies in Mongolia.

L'incommensurable fait apparaître qu'il est des fêlures irréductibles dans notre expérience révélant de l'infini du sein même de cette expérience: entre le plaisir et la jouissance ou bien le rapport social et l'intime. L'inouï dit, non pas l'extraordinaire ou l'insolite, mais ce qui peut être au contraire le plus commun de notre expérience--mais que nous n'entendons pas parce que nous ne savons pas déborder les cadres figés de cette expérience. La vraie vie fait signe vers ce que, tout en étant (...) en vie, nous risquons de n'être toujours que dans une apparence de vie, ou pseudo-vie, sans accéder à vraiment vivre. Trois concepts proposés par François Jullien pour ne pas laisser rabattre notre vie, mais la porter à son déploiement. Contre les facilités du prêche et du marché du Bonheur, il faut penser ces concepts comme outils pour 'changer la vie.'"--Page 4 of cover. (shrink)

Selected articles of Ēṭukūru Balarāmamūrti on Marxist philosophy; includes contributed on his life and work.

E. Rae Harcum argues that Christians do not have to give up their religious faith to keep the contributions of science. He confronts the relation between the human body and its non-material parts—the mind and spirit—and provides a way of looking at these metaphysical issues.

Robert E. Butts (1928-1997) was a philosopher and historian of science whose central concerns were the distinction between the rational and the irrational. He viewed scientific rationality as our major defence against the various conditions that encourage witch hunts and similar outbursts of irrationality, with all their attendant pain and terror. Butts saw himself as a pragmatic realist, combining what he took to be the best aspects of logical empiricism with a historically informed pragmatism, deeply appreciative of the methods of (...) science, trying to describe a kind of rationality essential in the struggle to preserve human values. This volume gathers previously unpublished essays and lectures with some previously published, thematically related essays. It includes essays and lectures on philosophical aspects of the European witch hunt, on scientific rationality and methodology, and on the relationships between science and philosophy exhibited in the writings of such historically significant figures as Leibniz, D'Alembert, Hume, Kant, Carnap and Kuhn. (shrink)

Can there be such a thing as moral science, or a science of morality? And if so, what sense has the word science in such a connection? In the middle of the last century such a question would probably have seemed superfluous. Utilitarians, Comtists, and not a few “evolutionists” would all have claimed to be moralists, with this advantage over the metaphysical or theological moralists of an earlier day that their own moral doctrines were “scientific”.

Part two of the proceedings of the fifth International Congress of Logic, Methodology and Philosophy of Science, London, Ontario, Canada, August 27 - September 2, 1975.

Ecclesia and Ethics considers the subject of Ecclesial Ethics within its theological, theoretical and exegetical contexts. Part one presents the biblical-theological foundations of an ecclesial ethic – examining issues such as creation, and Paul's theology of the Cross. Part two moves on to examine issues of character formation and community. Finally, part three presents a range of exegetical applications, which examine scripture and ethics in praxis. These essays look at hot-button issues such as the 'virtual self' in the digital age, (...) economics, and attitudes to war. The collection includes luminaries such as N.T. Wright, Michael J. Gorman, Stanley Hauerwas and Dennis Hollinger, as well as giving space to new theological and exegetical voices. As such Ecclesia and Ethics provides a challenging and contemporary examination of modern ethical debates in the light of up-to-date theology and exegesis. (shrink)