The maintenance of genetic integrity is of vital importance to all living organisms. However, DNA – the carrier of genetic information – is continuously subject to damage induced by numerous agents from the environment and endogenous cellular metabolites. To prevent the deleterious consequences of DNA injury, an intricate network of repair systems has evolved. The biological impact of these repair mechanisms is illustrated by a number of genetic diseases that are characterized by a defect in one of the repair machineries (...) and in general predispose individuals to cancer. This article intends to review our current understanding of the complex nucleotide excision repair pathway, a universal repair system with a broad lesion specificity. Emphasis will be on the recent advances in the genetic analysis of this process in mammalian cells. (shrink)

This book brings together international experts on the application of Niklas Luhmann’s theory of society as autopoietic communication. Luhmann’s sociological systems theory is counter-intuitive and in its detached coolness difficult for many to understand and accept. Naturally they ask: is it really worth the trouble to learn? This book demonstrates what this combination of systems theory, Batesonian information theory, von Foerster’s second-order cybernetics, Maturana and Varela’s autopoiesis and Husserl’s phenomenology can offer. The book is produced in cooperation with the Sociocybernetic (...) Group and Copenhagen Business School. (shrink)

In the following study we shall investigate the ancient Greek ‘(all-)day runners’ (ήμεροδρόμοι) 2 from a historical as well as from a modern physiological perspective. Hemerodromoi were of some importance in Greek interstate communication, in particular in military long-distance communication, and are, accordingly, a subject of some interest for the study of interaction in the ancient Greek city-state culture. The investigation begins by considering the ancient evidence on these ‘(all-)day runners’ and moves on to a physiological consideration of this evidence, (...) with particular reference to the feat of the Athenian hemerodromos Pheidippides 3 who ran from Athens to Sparta in 490 BC, shortly before the famous battle of Marathon. (shrink)

We performed an EEG graph analysis on data from 31 typical readers (22.27 ± 2.53 y/o) and 24 dyslexics (22.99 ± 2.29 y/o), recorded while they were engaged in an audiovisual task and during resting-state. The task simulates reading acquisition as participants learned new letter-sound mappings via feedback. EEG data was filtered for the delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), and beta (13–30 Hz) bands. We computed the Phase Lag Index (PLI) to provide an estimate of the (...) functional connectivity between all pairs of electrodes per band. Then, networks were constructed using a Minimum Spanning Tree (MST), a unique sub-graph connecting all nodes (electrodes) without loops, aimed at minimizing bias in between groups and conditions comparisons. Both groups showed a comparable accuracy increase during task blocks, indicating that they correctly learned the new associations. The EEG results revealed lower task-specific theta connectivity, and lower theta degree correlation over both rest and task recordings, indicating less network integration in dyslexics compared to typical readers. This pattern suggests a role of theta oscillations in dyslexia and may reflect differences in task engagement between the groups, although robust correlations between MST metrics and performance indices were lacking. (shrink)

Contributors consider the limits of our knowledge of a world of unlimited knowability by examining philosophical thought from the Classical Greeks to the present.

Enhancing brain activity and function is a very ancient practice which is usually accomplished by taking illegal drugs. Prescription medication is becoming more commonly used as a means of enhancing mood, and recently, it has become possible to modulate mood by applying magnetic or electrical current to the brain or by training the brain to work at predetermined oscillations. A summary of the available neuromodulation techniques will be presented associated with data from human subjects implanted with cortical and/or subcutaneous electrodes (...) that demonstrate the potential for electrical neuro-enhancement. (shrink)

In this article, I argue that Barth resists the modern “turn to the subject” and that important features of his approach can be explained as being motivated by this resistance. Under the parameters of this “turn”, the human subject occupies a position which should be reserved for God. As an antidote to this turn, Barth suggests an exchange of subjects: The role that the subject occupies under subjectivist parameters should be taken over by a Trinitarian notion of God. This suggestion (...) explains to a great extent the approach he takes since his famous “breakthrough” and explains also his harsh rejection of Brunner. (shrink)

A wide-ranging analysis of the economic world order and its ecological and theological dimensions, this unique and challenging work confronts us with the ...

Though capable of reproducing experimentally observed velocity profiles, the model proposed by Plamondon & Alimi (P&A) does not provide a viable theoretical framework for the understanding of trajectory formation and speed/accuracy trade-offs. The issues of variation and stability can be better understood by considering movement as resulting from an underlying dynamic rather than from an impulse-response of the system.

Jonathan Wolff is Professor of Philosophy at University College London. He is the author of Robert Nozick (1991), An Introduction to Political Philosophy (1996) and Why Read Marx Today (2002). He is currently working on a number of topics at the intersection of political philosophy and public policy.

We show that it is impossible in quantum mechanics to describe two separated physical systems. This is due to the mathematical structure of quantum mechanics. It is possible to give a description of two separated systems in a theory which is a generalization of quantum mechanics and of classical mechanics, in the sense that this theory contains both theories as special cases. We identify the axioms of quantum mechanics that make it impossible to describe separated systems. One of these axioms (...) is equivalent to the superposition principle. We show how these findings throw a different light on the paradox of Einstein, Podolsky, and Rosen. (shrink)

Das voruegende Buch verfolgt ein systematisches und philologisches Anuegen gleichermassen, weshalb es auch in verschiedener Weise gelesen werden kann. Der systematisch interessierte Leser wird sich mehr durch den ersten Teil angesprochen fuhlen, in dem ein Interpretationsansatz zu Hegels Idee einer Realphilosophie vorgestellt wird. Das philologische Interesse wird dann eher im zweiten Hauptteil befriedigt, der eine ausfuhruche Detailanalyse der Philosophie des subjektiven Geistes" durchfuhrt. Trotzdem uegen hier nicht zweierlei Bucher vor, die man gut auch getrennt hatte pubuzieren konnen, denn der systematische (...) Interpretationsansatz wird erst durch die anschuessende Detailanalyse belegt sowie auch die komparatorische Form der Kommentierung, die in der Einleitung" nahere Erlauterung finden wird, sich erst vor dem Hintergrund jenes Interpretationsansatzes als sinnvoll erweist. Auch wenn sich also beide Hauptteile mit einem fokussierten Interesse getrennt voneinander lesen lassen, so bedarf doch die Argumentation dieses Buches beider Teilstucke, um vollstandig zu sein.". (shrink)

With the proliferation of networked electronic communication came daunting capabilities to collect, process, combine and store data, resulting in hitherto unseen transformational pressure on the concepts of trust, security and privacy as we know them. The Future Internet will bring about a world where real life will integrate physical and digital life. Technology development for data linking and mining, together with unseen data collection, will lead to unwarranted access to personal data, and hence, privacy intrusion. Trust and identity lie at (...) the basis of many human interactions and transactions, and societies have developed legitimate concern for privacy being essential for freedom and creativity. The burgeoning development of the Information Society, particularly during the past fifteen years, transcended the societal readiness to respond to the transformational change evoked by ICT. We have reached the eleventh hour for the preservation of trust and privacy as elements that can be transposed into our digital future. Europe has been at the forefront in recognizing the importance of privacy protection in relation to digital data, witness the advanced European legislation in this domain. The European Commission recognizes that appropriate measures need to combine technology development with legal means, user awareness and tools supporting data controllers to comply with law in an accountable and transparent way, and that empower users with a controlling stake in managing their personal data. Activities are underway at many levels. European RTD programmes play their role in supporting research in trustworthy ICT, privacy enhancing technologies, privacy-by-design in service layers as well as in networks, enabling technologies such as cryptography, and in generalized frameworks for trust and privacy-protective identity management. (shrink)

In the context of some criticism about social responsibility education in business schools, the paper reports findings from a survey of CSR education (teaching and research) in Europe. It analyses the extent of CSR education, the different ways in which it is defined and the levels at which it is taught. The paper provides an account of the efforts that are being made to mainstream CSR teaching and of the teaching methods deployed. It considers drivers of CSR courses, particularly the (...) historical role of motivated individuals and the anticipation of future success being dependent on more institutional drivers. Finally it considers main developments in CSR research both by business school faculty and PhD students, tomorrow''s researchers and the resources devoted to CSR research. The conclusion includes questions that arise and further research directions. (shrink)

This text provides an introduction to the history and current state of theories of word meanings.

Stoicism was one of the new philosophical movements of the Hellenistic period. The name derives from the porch (stoa poikilê) in the Agora at Athens decorated with mural paintings, where the members of the school congregated, and their lectures were held. Unlike ‘epicurean,’ the sense of the English adjective ‘stoical’ is not utterly misleading with regard to its philosophical origins. The Stoics did, in fact, hold that emotions like fear or envy (or impassioned sexual attachments, or passionate love of anything (...) whatsoever) either were, or arose from, false judgements and that the sage—a person who had attained moral and intellectual perfection—would not undergo them. The later Stoics of Roman Imperial times, Seneca and Epictetus, emphasise the doctrines (already central to the early Stoics' teachings) that the sage is utterly immune to misfortune and that virtue is sufficient for happiness. Our phrase ‘stoic calm’ perhaps encapsulates the general drift of these claims. It does not, however, hint at the even more radical ethical views which the Stoics defended, e.g. that only the sage is free while all others are slaves, or that all those who are morally vicious are equally so. Though it seems clear that some Stoics took a kind of perverse joy in advocating views which seem so at odds with common sense, they did not do so simply to shock. Stoic ethics achieves a certain plausibility within the context of their physical theory and psychology, and within the framework of Greek ethical theory as that was handed down to them from Plato and Aristotle. It seems that they were well aware of the mutually interdependent nature of their philosophical views, likening philosophy itself to a living animal in which logic is bones and sinews; ethics and physics, the flesh and the soul respectively (another version reverses this assignment, making ethics the.. (shrink)

Wann immer wir etwas sehen, hören, fühlen oder riechen, erscheint uns etwas. Was aber bedeutet es, dass jemandem etwas erscheint? Was ist der mentale Zustand, in dem sich jemand befindet, wenn ihm etwas erscheint (der Zustand des Erscheinens)? Diese nur scheinbar harmlose Frage steht im Zentrum der vorliegenden Untersuchung. Die Antwort, die verteidigt wird, lautet: Zustände des Erscheinens sind ihrem Wesen nach transparent. D. h. in einem Zustand des Erscheinens sind dem Subjekt dieses Zustandes ausschließlich die Gegenstände dieser Zustände präsent, (...) niemals aber das Subjekt oder der Zustand selbst (zumindest nicht als solche). Diese Antwort widerspricht einigen in der Philosophie des Geistes tief verwurzelten Auffassungen. Eine davon ist die Auffassung, das phänomenale Bewusstsein von Zuständen des Erscheinens bestünde in irgendeiner unmittelbaren Bekanntschaft mit eben diesen Zuständen. In Wahrheit, so wird argumentiert, hat das fragliche Bewusstsein eine auf die Welt gerichtete Struktur. Es ist nichts anderes als das Präsent-Sein von Gegenständen in Zuständen des Erscheinens. Dieses Ergebnis hat bedeutende Konsequenzen. Es stellt insbesondere die klassische Taxonomie mentaler Zustände in Frage. Einerseits lässt sich die Unterscheidung von intentionalen und phänomenalen Eigenschaften nicht aufrechterhalten. Denn das phänomenale Bewusstsein von Zuständen des Erscheinens ist eine Art der Intentionalität. Andererseits lässt sich die Einheit des Merkmals der Intentionalität nicht aufrechterhalten. Denn die Intentionalität von Zuständen des Erscheinens ist von grundsätzlich anderer Art als die Intentionalität propositionaler Einstellungen. Es wird daher vorgeschlagen, nicht weiter zwischen intentionalen und phänomenalen Zuständen zu unterscheiden, sondern zwischen verschiedenen Arten intentionaler Zustände. (shrink)

Current descriptivist accounts of proper names entail two claims: that the expressions we know as different proper names are the bearers of different meanings and that the descriptions corresponding to these meanings contain quotations of the expressions whose meanings they are taken to be. While is the source of a number of intractable problems, descriptivists feel committed to it because it is the only available option to adhere to, which they use to take as a matter of course. In the (...) present paper I will bring up for discussion a, to my knowledge, new descriptivist account, inter-nominal descriptivism, which avoids the commitment to by rejecting. According to this account, all tokens of the expressions known as different proper names express the same descriptive mode of presentation and this descriptive mode of presentation is akin to the character of an indexical. I will try to show that, contrary to first appearance, this idea can be developed in a consistent and plausible manner. (shrink)