The maintenance of genetic integrity is of vital importance to all living organisms. However, DNA – the carrier of genetic information – is continuously subject to damage induced by numerous agents from the environment and endogenous cellular metabolites. To prevent the deleterious consequences of DNA injury, an intricate network of repair systems has evolved. The biological impact of these repair mechanisms is illustrated by a number of genetic diseases that are characterized by a defect in one of the repair machineries (...) and in general predispose individuals to cancer. This article intends to review our current understanding of the complex nucleotide excision repair pathway, a universal repair system with a broad lesion specificity. Emphasis will be on the recent advances in the genetic analysis of this process in mammalian cells. (shrink)

This book brings together international experts on the application of Niklas Luhmann’s theory of society as autopoietic communication. Luhmann’s sociological systems theory is counter-intuitive and in its detached coolness difficult for many to understand and accept. Naturally they ask: is it really worth the trouble to learn? This book demonstrates what this combination of systems theory, Batesonian information theory, von Foerster’s second-order cybernetics, Maturana and Varela’s autopoiesis and Husserl’s phenomenology can offer. The book is produced in cooperation with the Sociocybernetic (...) Group and Copenhagen Business School. (shrink)

In the following study we shall investigate the ancient Greek ‘(all-)day runners’ (ήμεροδρόμοι) 2 from a historical as well as from a modern physiological perspective. Hemerodromoi were of some importance in Greek interstate communication, in particular in military long-distance communication, and are, accordingly, a subject of some interest for the study of interaction in the ancient Greek city-state culture. The investigation begins by considering the ancient evidence on these ‘(all-)day runners’ and moves on to a physiological consideration of this evidence, (...) with particular reference to the feat of the Athenian hemerodromos Pheidippides 3 who ran from Athens to Sparta in 490 BC, shortly before the famous battle of Marathon. (shrink)

Contributors consider the limits of our knowledge of a world of unlimited knowability by examining philosophical thought from the Classical Greeks to the present.

In this article, I argue that Barth resists the modern “turn to the subject” and that important features of his approach can be explained as being motivated by this resistance. Under the parameters of this “turn”, the human subject occupies a position which should be reserved for God. As an antidote to this turn, Barth suggests an exchange of subjects: The role that the subject occupies under subjectivist parameters should be taken over by a Trinitarian notion of God. This suggestion (...) explains to a great extent the approach he takes since his famous “breakthrough” and explains also his harsh rejection of Brunner. (shrink)

Self-deception entails apparent conceptual paradoxes and poses the dilemma between two competing needs: the need for stability of the self-concept, on the one hand, and the need to accept reality, on the other. It is argued, first, that conceptual difficulties can be avoided by distinguishing two levels of explanation. Whereas, in a personal language, “the person” deceives him- or her-self, a cognitive approach explains this self-deception by reference to the interplay of cognitive processes of which the person is not aware. (...) Second, the tension between stability and adjustment of the self can be resolved by self-immunization, which maintains the stability of central self-conceptions by adjusting peripheral aspects and their diagnostic value for the central concepts. Processes of self-immunization were investigated in a series of studies operating on both levels of explanation. Implications for psychological explanations of personal phenomena such as self-images and self-insight are discussed. (shrink)

A wide-ranging analysis of the economic world order and its ecological and theological dimensions, this unique and challenging work confronts us with the ...

Jonathan Wolff is Professor of Philosophy at University College London. He is the author of Robert Nozick (1991), An Introduction to Political Philosophy (1996) and Why Read Marx Today (2002). He is currently working on a number of topics at the intersection of political philosophy and public policy.

We show that it is impossible in quantum mechanics to describe two separated physical systems. This is due to the mathematical structure of quantum mechanics. It is possible to give a description of two separated systems in a theory which is a generalization of quantum mechanics and of classical mechanics, in the sense that this theory contains both theories as special cases. We identify the axioms of quantum mechanics that make it impossible to describe separated systems. One of these axioms (...) is equivalent to the superposition principle. We show how these findings throw a different light on the paradox of Einstein, Podolsky, and Rosen. (shrink)

Though capable of reproducing experimentally observed velocity profiles, the model proposed by Plamondon & Alimi (P&A) does not provide a viable theoretical framework for the understanding of trajectory formation and speed/accuracy trade-offs. The issues of variation and stability can be better understood by considering movement as resulting from an underlying dynamic rather than from an impulse-response of the system.

The argument that automatic processes are responsible for affective/evaluative priming effects has been primarily based on studies that have manipulated the stimulus onset asynchrony (SOA; i.e., the interval between the onset of the prime and the onset of the target). Moreover, these SOA studies provide an insight in the time course of the activation processes underlying automatic affect/attitude activation. Based on a fine-grained manipulation of the SOA employing either the evaluative decision task (Experiment 1) and the pronunciation task (Experiment 2) (...) we concluded that affective priming, and hence automatic affect activation, is based on fast-acting automatic processes. The results of Experiment 3 provide a valid explanation for an apparent discrepancy between the results of Experiments 1 and 2 and previous findings. Finally, the results of Experiment 3 support the prediction of Jarvis and Petty (1996) that affective priming effects should be stronger for participants who are more chronically engaged in conscious evaluations. (shrink)

This Element lays the foundation, introduces a framework, and sketches the program for a systematic study of mathematical notations. It is written for everyone who is curious about the world of symbols that surrounds us, in particular researchers and students in philosophy, history, cognitive science, and mathematics education. The main characteristics of mathematical notations are introduced and discussed in relation to the intended subject matter, the language in which the notations are verbalized, the cognitive resources needed for learning and understanding (...) them, the tasks that they are used for, their material basis, and the historical context in which they are situated. Specific criteria for the design and assessment of notations are discussed, as well as ontological, epistemological, and methodological questions that arise from the study of mathematical notations and of their use in mathematical practice. (shrink)

Moritz Pasch (1843ber neuere Geometrie (1882), in which he also clearly formulated the view that deductions must be independent from the meanings of the nonlogical terms involved. Pasch also presented in these lectures the main tenets of his philosophy of mathematics, which he continued to elaborate on throughout the rest of his life. This philosophy is quite unique in combining a deductivist methodology with a radically empiricist epistemology for mathematics. By taking into consideration publications from the entire span of Paschs (...) highly original, but virtually unknown, philosophy of mathematics is presented. (shrink)

Das voruegende Buch verfolgt ein systematisches und philologisches Anuegen gleichermassen, weshalb es auch in verschiedener Weise gelesen werden kann. Der systematisch interessierte Leser wird sich mehr durch den ersten Teil angesprochen fuhlen, in dem ein Interpretationsansatz zu Hegels Idee einer Realphilosophie vorgestellt wird. Das philologische Interesse wird dann eher im zweiten Hauptteil befriedigt, der eine ausfuhruche Detailanalyse der Philosophie des subjektiven Geistes" durchfuhrt. Trotzdem uegen hier nicht zweierlei Bucher vor, die man gut auch getrennt hatte pubuzieren konnen, denn der systematische (...) Interpretationsansatz wird erst durch die anschuessende Detailanalyse belegt sowie auch die komparatorische Form der Kommentierung, die in der Einleitung" nahere Erlauterung finden wird, sich erst vor dem Hintergrund jenes Interpretationsansatzes als sinnvoll erweist. Auch wenn sich also beide Hauptteile mit einem fokussierten Interesse getrennt voneinander lesen lassen, so bedarf doch die Argumentation dieses Buches beider Teilstucke, um vollstandig zu sein.". (shrink)

Emerging technologies such as artificial intelligence, gene editing, nanotechnology, neurotechnology and robotics, which were originally unrelated or separated, are becoming more closely integrated. Consequently, the boundaries between the physical-biological and the cyber-digital worlds are no longer well defined. We argue that this technological convergence has fundamental implications for individuals and societies. Conventional domain-specific governance mechanisms have become ineffective. In this paper we provide an overview of the ethical, societal and policy challenges of technological convergence. Particularly, we scrutinize the adequacy of (...) domain-specific governance mechanisms in the face of such integrated technologies and highlight their growing ineffectiveness. Furthermore, we propose a comprehensive governance framework that is anticipatory, inclusive, and resilient. Central to this framework is the principle of participatory governance, which calls for a proactive engagement of all stakeholders, including those from marginalized and vulnerable populations, ensuring that their voices and concerns shape the trajectory of technological development. The framework emphasizes the need for protective measures that preemptively address potential risks and inequities that may arise from the adoption and integration of emerging technologies. Based on a detailed analysis of case studies and current governance models, we present and discuss a set of ten actionable recommendations. These are designed to facilitate the transition towards a governance approach that not only respects individual autonomy and privacy, but also fosters a collective responsibility towards sustainable and fair technological progress. By placing human dignity, societal welfare and the protection of the most vulnerable at the center of technological innovation, we advocate for a future where convergence is synonymous with progress that is both ethically grounded and universally beneficial. (shrink)

The analysis focuses on the centrality of the mind and the mental, and their relationship with the notion of discourse in International Relations theorizing. While many forms of discourse theory ar...

In the context of some criticism about social responsibility education in business schools, the paper reports findings from a survey of CSR education (teaching and research) in Europe. It analyses the extent of CSR education, the different ways in which it is defined and the levels at which it is taught. The paper provides an account of the efforts that are being made to mainstream CSR teaching and of the teaching methods deployed. It considers drivers of CSR courses, particularly the (...) historical role of motivated individuals and the anticipation of future success being dependent on more institutional drivers. Finally it considers main developments in CSR research both by business school faculty and PhD students, tomorrow''s researchers and the resources devoted to CSR research. The conclusion includes questions that arise and further research directions. (shrink)

On the basis of a wide range of historical examples various features of axioms are discussed in relation to their use in mathematical practice. A very general framework for this discussion is provided, and it is argued that axioms can play many roles in mathematics and that viewing them as self-evident truths does not do justice to the ways in which mathematicians employ axioms. Possible origins of axioms and criteria for choosing axioms are also examined. The distinctions introduced aim at (...) clarifying discussions in philosophy of mathematics and contributing towards a more refined view of mathematical practice. (shrink)

Three different ways in which systems of axioms can contribute to the discovery of new notions are presented and they are illustrated by the various ways in which lattices have been introduced in mathematics by Schröder et al. These historical episodes reveal that the axiomatic method is not only a way of systematizing our knowledge, but that it can also be used as a fruitful tool for discovering and introducing new mathematical notions. Looked at it from this perspective, the creative (...) aspect of axiomatics for mathematical practice is brought to the fore. (shrink)

Two recent articles [Gronchi et al., Citation2018. Automatic and controlled attentional orienting in the elderly: A dual-process view of the positivity effect. Acta Psychologica, 185, 229–234; Wirth & Wentura, Citation2020. It occurs after all: Attentional bias towards happy faces in the dot-probe task. Attention, Perception, & Psychophysics, 82(5), 2463–2481] report attentional biases for happy facial expressions in the dot-probe paradigm, albeit in different directions. While Wirth and Wentura report a bias towards happy expressions, Gronchi et al. found a reversed effect. (...) A striking difference between the studies was the task performed by the participants. While in Wirth and Wentura, participants performed a discrimination task, they performed a location task in Gronchi et al. In Experiment 1, we directly compared the two versions of the dot-probe paradigm. With the discrimination task, the bias towards happy faces was replicated. However, the location task yielded a null effect. In Experiment 2, we found a cueing effect with an abrupt onset cue in both tasks. However, for the location task a congruence-sequence effect (a typical characteristic of response-priming processes) occurred. This result suggests that in the location task, attentional processes are confounded with response-priming processes. We recommend to generally use discrimination tasks. (shrink)

Well over a century after its introduction, Frege's two-dimensional Begriffsschrift notation is still considered mainly a curiosity that stands out more for its clumsiness than anything else. This paper focuses mainly on the propositional fragment of the Begriffsschrift, because it embodies the characteristic features that distinguish it from other expressively equivalent notations. In the first part, I argue for the perspicuity and readability of the Begriffsschrift by discussing several idiosyncrasies of the notation, which allow an easy conversion of logically equivalent (...) formulas, and presenting the notation's close connection to syntax trees. In the second part, Frege's considerations regarding the design principles underlying the Begriffsschrift are presented. Frege was quite explicit about these in his replies to early criticisms and unfavorable comparisons with Boole's notation for propositional logic. This discussion reveals that the Begriffsschrift is in fact a well thought-out and carefully crafted notation that intentionally exploits the possibilities afforded by the two-dimensional medium of writing like none other. (shrink)