The Modern Synthesis has dominated biology for 80 years. It was formulated in 1942, a decade before the major achievements of molecular biology, including the Double Helix and the Central Dogma. When first formulated in the 1950s these discoveries and concepts seemed initially to completely justify the central genetic assumptions of the Modern Synthesis. The Double Helix provided the basis for highly accurate DNA replication, while the Central Dogma was viewed as supporting the Weismann Barrier, so excluding the inheritance of (...) acquired characteristics. This article examines the language of the Modern Synthesis and reveals that it is based on four important misinterpretations of what molecular biology had shown, so forming the basis of the four Illusions: 1. Natural Selection; 2. The Weismann Barrier; 3. The Rejection of Darwin’s Gemmules; 4. The Central Dogma. A multi-level organisation view of biology avoids these illusions through the principle of biological relativity. Molecular biology does not therefore confirm the assumptions of the Modern Synthesis. (shrink)

In evolutionary biology changes in population structure are explained by citing trait fitness distribution. I distinguish three interpretations of fitness explanations—the Two‐Factor Model, the Single‐Factor Model, and the Statistical Interpretation—and argue for the last of these. These interpretations differ in their degrees of causal commitment. The first two hold that trait fitness distribution causes population change. Trait fitness explanations, according to these interpretations, are causal explanations. The last maintains that trait fitness distribution correlates with population change but does not cause (...) it. My defense of the Statistical Interpretation relies on a distinctive feature of causation. Causes conform to the Sure Thing Principle. Trait fitness distributions, I argue, do not. *Received July 2009; revised October 2009. †To contact the author, please write to: Department of Philosophy/Institute for the History, Philosophy of Science and Technology, University of Toronto, Victoria College, 91 Charles Street West, Toronto, ON M5S 1K7, Canada; e‐mail: denis.walsh@utoronto.ca. (shrink)

What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, (...) that is life. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

In recent years, there has been an increasing interest among philosophers of memory in the questions of how to characterize and to account for the temporal phenomenology of episodic memory. One prominent suggestion has been that episodic memory involves a feeling of pastness, the elaboration of which has given rise to two main approaches. On the intentionalist approach, the feeling of pastness is explained in terms of what episodic memory represents. In particular, Fernández has argued that it can be explained (...) in terms of memory representing itself as being caused by a past perceptual experience. On the metacognitive approach, which we have recently developed in, the feeling of pastness results from the monitoring and interpretation of the processing features of episodic remembering. In this paper, we show that the metacognitive approach should be preferred over the intentionalist approach. We argue that intentionalism, and Fernández’ causal self-referential view in particular, ultimately fail as accounts of the feeling of pastness. The difficulties faced by intentionalism allows us to single out three constraints that any satisfactory account of the temporal phenomenology of episodic remembering needs to meet. We conclude by arguing that the metacognitive view satisfies those constraints in a neat way, and as such, that it should be preferred over intentionalism. (shrink)

This paper examines a doctrine which David Lewis has called 'Humean Supervenience' (hereafter 'HS'), and a problem which certain imaginary cases seem to generate for HS. They include rotating perfect spheres or discs, and flowing rivers, imagined as composed of matter which is perfectly homogeneous right down to the individual points. Before considering these examples, I shall introduce the doctrine they seem to challenge.

Over the past fifteen years there has been a considerable amount of debate concerning what theoretical population dynamic models tell us about the nature of natural selection and drift. On the causal interpretation, these models describe the causes of population change. On the statistical interpretation, the models of population dynamics models specify statistical parameters that explain, predict, and quantify changes in population structure, without identifying the causes of those changes. Selection and drift are part of a statistical description of population (...) change; they are not discrete, apportionable causes. Our objective here is to provide a definitive statement of the statistical position, so as to allay some confusions in the current literature. We outline four commitments that are central to statisticalism. They are: 1. Natural Selection is a higher order effect; 2. Trait fitness is primitive; 3. Modern Synthesis (MS)-models are substrate neutral; 4. MS-selection and drift are model-relative. (shrink)

April 15, 2024: This article published in Early View in error. The article will republish shortly.

This paper tackles the issue of the diversity of déjà experiences. According to the standard view in the neuropsychological literature, they should all be defined by means of a psychological criterion, by which they are experiences triggered by a perceived item and consist of a conscious clash between a first-order feeling of familiarity about the item and a second-order evaluation that assesses the first-order feeling as erroneous. This paper dismisses the standard view and contends there are two types of déjà (...) experiences, labeled déjà vu and déjà vécu respectively. But it also takes issue with the rare proponents of a distinct déjà vécu type. Contrary to their achievement view, it argues that recollection is not involved in déjà vécu experiences as an actual mental state or a component thereof. In our ability view, déjà vécu involves the feeling that one could recollect past occurrences of a currently lived episode of experience. (shrink)

Aesthetic theoriesmayclaim universality, but they are normally conditioned by the aesthetic issues and debates of their own times. Plato and Aristo- tle were motivated both to account for the Greek arts of their day and to connect aesthetics to their general metaphysics and theories of value. Closer to our time, asNo¨el Carroll observes, the theories of Clive Bell and R.G. Collingwood can be viewed as “defenses of emerging avant-garde practices— neoimpressionism, on the one hand, and the mod- ernist poetics of (...) Joyce, Stein, and Eliot on the other.”1 Susanne Langer can be read as provid- ing a justification for modern dance, while the ini- tial version of George Dickie’s institutional the- ory “requires something like the presupposition that Dada is a central form of artistic practice” in order to gain intuitive appeal. The. (shrink)

There are two general approaches to characterising biological functions. One originates with Cummins. According to this approach, the function of a part of a system is just its causal contribution to some specified activity of the system. Call this the ‘C-function’ concept. The other approach ties the function of a trait to some aspect of its evolutionary significance. Call this the ‘E-function’ concept. According to the latter view, a trait's function is determined by the forces of natural selection. The C-function (...) and E-function concepts are clearly quite different, but there is an important relation between them which heretofore has gone unnoticed. The purpose of this paper is to outline that relation.This is not the first paper to discuss the relation of C-function and E-function. Previous attempts all follow either one of two strategies. The first proposes that the two concepts are ‘unified.’ The other proposes that they are radically distinct and apply to wholly different fields within biology. (shrink)

Libertarian theories of the normative core of the corporation hold in common the view that is the responsibility of publicity held corporations to return profits to shareholders within the bounds of certain moral side-constraints. Side-constraints may be either weak (grounded in the rules of the game) or strong (grounded in rights). This essay considers libertarian arguments regarding the normative core of the corporation in the context of global capitalism and in the light of actual corporate behavior. First, it is argued (...) the weak side-constraints view is conceptually incoherent when applied in a global context. Second, it is argued that proponents of the libertarian strong side-constraints view lack an adequate theory of rights. Third, both the weak side-constraints view and the strong side-constraints view are shown to be unsatisfactory insofar as they fail to adequately address the coercive power of corporations. The main conclusion of this essay is that a viable libertarian theory of the corporation has yet to be articulated. (shrink)

Conscious Agency is a major driver of evolution. Artificial Selection (i.e. Conscious Selection by human breeders) was the foil against which Charles Darwin defined Natural Selection. In later work, he extended Artificial Selection to other species. That ability for social (e.g. sexual) selection must have evolved. Jablonka and Ginsburg identify markers of conscious agency, such as Unlimited Associative Learning (UAL), and show that it must have existed at the time of the Cambrian Explosion. To their insights, my commentary argues that (...) the harnessing of stochasticity was also involved in the evolution of the faculty of choice in organisms. (shrink)

The extensive range and depth of the twenty commentaries on my target article confirms that something has gone deeply wrong in biology. A wide range of biologists has more than met my invitation for “others to pitch in and develop or counter my arguments.” The commentaries greatly develop those arguments. Also remarkably, none raise issues I would seriously disagree with. I will focus first on the more critical comments, summarise the other comments, and then point the way forward on what (...) I view as a necessary and long-overdue transition in the foundations of biology. (shrink)

Europeans seeking to understand tribal arts face obvious problems of comprehending the histories, values, and ideas of vastly remote cultures. In this respect the issues faced in understanding tribal art (or folk art, primitive art, traditional art, third or fourth-world art — none of these designations is ideal) are not much different from those encountered in trying to comprehend the distant art of “our own” culture, for instance, the art of medieval Europe. But in the case of tribal or so-called (...) primitive art, there are special complications. First, objects of tribal art are sometimes so strange to us that we cannot tell immediately whether they are intended to be works of art (or some local analogue of what we would call art) at all.1An African head-rest I once came across had an odd, extravagant extrusion which made the whole piece reminiscent of Arp. It seemed to my baffled, ignorant eyes to be much more than a mere head-rest, but I couldn’t tell what more it was supposed to be. Maybe that extension on the side of the object had some purely utilitarian function, acting as a handle, or perhaps it was a natural part of the original block of wood, left there merely because it looked nice to the eye of the carver. Though the head-rest seemed beautiful, I still don’t know if I was admiring as an essentially expressive object some simple item of practical use, or something that combined expression and utility. (shrink)

A common view about the phenomenology of episodic remembering has it that when we remember a perceptual experience, we can relive or re-experience many of its features, but not its characteristic presence. In this paper, we challenge this common view. We first say that presence in perception divides into temporal and locative presence, with locative having two sides, an objective and a subjective one. While we agree with the common view that temporal and objective locative presence cannot be relived in (...) remembering, we argue that subjective locative presence – the feeling of being immersed in a certain scene – can be so. Our argument for this claim starts by determining independently the underpinning mechanisms of subjective locative presence in quasi-perceptual imagination. These mechanisms are self-projection, imaginative pretence, and attentional focus. We then proceed to establish that they have been found to underpin conscious states of episodic remembering too. We conclude that episodic remembering can bring us to relive the subjective locative presence characteristic of a perceptual experience, and that the common view is mistaken. Our view – ‘mnemonic immersivism’ – has important consequences regarding the relationships between memory and imagination and the phenomenology of episodic remembering. (shrink)

Judgments based on episodic memory are often thought to be immune to errors of misidentification (IEM). Yet there is a certain category of episodic memories, viz. observer memories, that seems to threaten IEM. In the resulting debate, some say that observer memories are a threat to the IEM enjoyed by episodic memory (Michaelian, 2021); others say that they pose no such threat (Fernández, 2021; Lin, 2020). In this paper, we argue for a middle way. First, we frame the debate, claiming (...) that the existing literature lacks a satisfying definition both of observer memories and of the precise issue of errors of identification in such memories. Then, we contribute to the debate by challenging an anti-separatist view about the relation between phenomenal and intentional features of observer memories that looms behind this debate. On this view, if the rememberer's self is a phenomenal feature of the memory, by implication it is also built into the intentional content. We reject this view and offer a moderate separatist account. Distinguishing between empirically-grounded species of observer memories, we say that the phenomenal self sometimes is, and sometimes is not built into the intentional content of the memory, and this results in different implications for IEM. (shrink)

This is a survey article in which I explore some important recent work on the topic in question, Kant’s formula of the end in itself (or “formula of humanity”). I first provide an overview of the formulation, including what the formula seems roughly to be saying, and what Kant’s main argument for it seems to be. I then call the reader’s attention to a variety of questions one might have about the import of and argument for this formula, alluding to (...) some of the works in which philosophers have recently raised or tried to answer these questions. Then, for the bulk of the paper, I focus my discussion on two issues of contention: the identity of the “end in itself” that the formula refers to, and the relation between the value of the end in itself and the value of other ends. I do not attempt to argue for a particular position of my own regarding these issues. Instead, I explain a number of the more interesting or influential recent attempts to answer these questions, compare these approaches in various ways, draw implications from them, and raise concerns about some of them. I also suggest that an important link connects the question about the identity of the end in itself and the question about the relation between the value of the end in itself in relation to the value of other ends: How one answers these questions commits one to a position on the thorny issue of whether, how, and how fully, autonomy is manifested through empirical (not simply pure) practical reason. (shrink)

Cet article traite de la question méta-sémantique de ce qui permet au souvenir épisodique d’avoir le contenu sémantique qui est le sien. Il adopte une position singulariste quant au contenu du souvenir et critique la justification méta-sémantique relationnaliste de cette position. Selon celle-ci, le contenu du souvenir est singulier parce que le souvenir consiste en une relation d’accointance avec l’événement passé. L’article oppose un argument causal et un argument sémantique à cette analyse puis montre que les deux traits du souvenir (...) que l’idée d’accointance est censée expliquer – la phénoménologie et la singularité du souvenir – peuvent l’être au moyen de modèles singularistes non fondés sur l’accointance. (shrink)

The concept of the environment appears to be indispensably involved in adaptive explanation. Quite what its role is, however, is a matter of some dispute. The environment is customarily viewed as the dual of the organism; a wholly external, discrete, autonomous cause of evolution. On this view, the external environment is the principal cause of the adaptedness of form, and the determinant of what it is to be an adaptation. I argue that this conception of the environment neither adequately explains (...) nor individuates evolutionary adaptations. Instead, adaptation, properly construed, is an evolutionary response to affordances. The environment, traditionally construed, underdetermines an organism’s affordances. Instead, I argue that the environment takes its place in evolutionary models not as a discrete causal entity, but as an abstraction. (shrink)

According to a prominent view of evolutionary theory, natural selection and the processes of development compete for explanatory relevance. Natural selection theory explains the evolution of biological form insofar as it is adaptive. Development is relevant to the explanation of form only insofar as it constrains the adaptation-promoting effects of selection. I argue that this view of evolutionary theory is erroneous. I outline an alternative, according to which natural selection explains adaptive evolution by appeal to the statistical structure of populations, (...) and development explains the causes of adaptive evolution at the level of individuals. Only together can a statistical theory of selection and a mechanical theory of development explain why populations of organisms comprise individuals that are adapted to their conditions of existence. (shrink)

Cholak, Goncharov, Khoussainov, and Shore [1] showed that for each k > 0 there is a computably categorical structure whose expansion by a constant has computable dimension k. We show that the same is true with k replaced by ω. Our proof uses a version of Goncharov's method of left and right operations.

There has been increasing interest over the last few decades in the study of the effective content of Mathematics. One field whose effective content has been the subject of a large body of work, dating back at least to the early 1960s, is model theory. Several different notions of effectiveness of model-theoretic structures have been investigated. This communication is concerned withcomputablestructures, that is, structures with computable domains whose constants, functions, and relations are uniformly computable.In model theory, we identify isomorphic structures. (...) From the point of view of computable model theory, however, two isomorphic structures might be very different. For example, under the standard ordering of ω the success or relation is computable, but it is not hard to construct a computable linear ordering of type ω in which the successor relation is not computable. In fact, for every computably enumerable degree a, we can construct a computable linear ordering of type ω in which the successor relation has degree a. It is also possible to build two isomorphic computable groups, only one of which has a computable center, or two isomorphic Boolean algebras, only one of which has a computable set of atoms. Thus, for the purposes of computable model theory, studying structures up to isomorphism is not enough. (shrink)

Psychological individualism is motivated by two taxonomic principles: (i) that psychological states are individuated by their causal powers, and (ii) that causal powers supervene upon intrinsic physiological state. I distinguish two interpretations of individualism--the 'orthodox' and the 'alternative'--each of which is consistent with these motivating principles. I argue that the alternative interpretation is legitimately individualistic on the grounds that it accurately reflects the actual taxonomic practices of bona fide individualistic sciences. The classification of homeobox genes in developmental genetics provides an (...) illustration. When applied to the taxonomy of psychological kinds, alternative individualism has some surprising consequences. In particular, externalist taxonomies of thought are consistent with the alternative interpretation, and hence consistent with individualism. I conclude, on this basis, that the individualism/externalism dispute which has long preoccupied philosophy of psychology is an empty one. (shrink)

Formal systems are standardly envisaged in terms of a grammar specifying well-formed formulae together with a set of axioms and rules. Derivations are ordered lists of formulae each of which is either an axiom or is generated from earlier items on the list by means of the rules of the system; the theorems of a formal system are simply those formulae for which there are derivations. Here we outline a set of alternative and explicitly visual ways of envisaging and analyzing (...) at least simple formal systems using fractal patterns of infinite depth. Progressively deeper dimensions of such a fractal can be used to map increasingly complex wffs or increasingly complex 'value spaces', with tautologies, contradictions, and various forms of contingency coded in terms of color. This and related approaches, it turns out, offer not only visually immediate and geometrically intriguing representations of formal systems as a whole but also promising formal links (1) between standard systems and classical patterns in fractal geometry, (2) between quite different kinds of value spaces in classical and infinite-valued logics, and (3) between cellular automata and logic. It is hoped that pattern analysis of this kind may open possibilities for a geometrical approach to further questions within logic and metalogic. (shrink)

We show that there are models and such that elementarily embeds into but their ultrafilter extensions and are not elementarily equivalent.

Pour certains interprètes des Recherches philosophiques , Wittgenstein souscrit à l'idée que l'emploi d'un langage est une institution sociale et que suivre une règle est nécessairement une pratique partagée ; d'autres estiment au contraire — à mon avis avec raison — qu'il admet la possibilité d'un langage parlé par un seul individu et des règles non communes. Je défends l'interprétation selon laquelle la question importante dans les Recherches n'est pas tellement de savoir si un idiolecte est possible que de savoir (...) ce qui découle, pour nos concepts de signification, de compréhension linguistique et de « suivre une règle », du fait que la communication verbale soit — comme c'est normalement le cas — une pratique commune.According to some interpreters of the Philosophical Investigations , Wittgenstein thinks that language-use is a social institution and that rule following is a shared practice. Others hold the opposite view and rightly so. They argue that Wittgenstein thinks there could be a language which is spoken by only one individual and unshared rules. In this paper I defend the following interpretation: The important question raised in the Investigations is not whether or not an idiolect is possible , it is rather what follows with respect to our concepts of meaning , understanding and rule-following from the fact that verbal communication is indeeed a shared practice. (shrink)

Mathematical models of the heart have developed over a period of about 40 years. Cell types in all regions of the heart have been modelled and they are now being incorporated into anatomically detailed models of the whole organ. This combination is leading to the creation of the first ‘virtual organ,’ which is being used in drug discovery and testing, and in simulating the action of devices, such as cardiac defibrillators. Simulation is a necessary tool of analysis in attempting to (...) understand biological complexity. We often learn as much from the failures as from the successes of mathematical models. It is the iterative interaction between experiment and simulation that is important. Examples are given where this process has been instrumental in some of the major advances in the field. BioEssays 24:1155–1163, 2002. © 2002 Wiley‐Periodicals, Inc. (shrink)

Theoria, Volume 87, Issue 1, Page 109-135, February 2021.

We commonly hear it said that a work of art must be understood “on its own terms,” and that phrase is used in other contexts as well; people, especially people very different from ourselves, are said to have to be understood on their own terms. But what is the meaning of the expression “on its/their own terms?” Note that we do not say of every possible object of understanding that it must be understood on its own terms. The statement, “Chemistry (...) must be understood on its own terms,” sounds odd. The “on its own terms” appears to lack point. It invites the retort, “Good grief, on what other terms had you expected to understand it?!” We seem to be brought to this: where the exhortation “understand it on its own terms” is to be used in reference to some object, there must be some reasonable way of understanding that object alternative to understanding it on its own terms. We may ask the child its own childish reasons why it keeps clobbering little sister (“She took my dolly!”), or we may account for its actions in terms the child does not comprehend (“sibling rivalry”). We may on occasion even do the same sort of thing with adults, perhaps giving a reason out of Freud for something done by a person who never heard of Freud or psychoanalysis. But naturally, distinctions between “their terms” and “our terms” become of extreme importance when we attempt to understand the peoples of other cultures. In such cases there literally are different systems of terms, that is, different languages, within which we must make sense of activities. (shrink)

Wittgenstein écrit dans les Recherches philosophiques: «Pour une large part des cas d'emploi du mot “signification” — bien que ce ne soit pas pour tous les cas — on peut l'expliquer ainsi: la signification d'un mot est son usage dans le langage». Le slogan «La signification, c'est l'usage» a servi de signe de ralliement à toute une génération de philosophes, mais la question de savoir quel sens lui donne Wittgenstein — mise à part celle de savoir quel sens il avait (...) pour ces philosophes — pose encore un problème aujourd'hui. (shrink)

In 1999, the Journal of Business Ethics published its 1 500th article. This article commemorates the journal's quest "to improve the human condition" (Michalos, 1988, p. 1) with a summary and assessment of the first eighteen volumes. The first part provides an overview of JBE, highlighting the journal's growth, types of methodologies published, and the breadth of the field. The second part provides a detailed account of the quantitative research findings. Major research topics include (1) prevalence of ethical behavior, (2) (...) ethical sensitivities, (3) ethics codes and programs, (4) corporate social performance and policies, (5) human resource practices and policies, and (6) professions – accounting, marketing/sales, and finance/strategy. Much remains to be done. (shrink)

Denis Worrall draws on 20th century South African history and his own experience as a South African to show some of the less obvious but extremely important facets of apartheid that directly impact its dissemination.

David Pietraszewski's theory of social groups offers a developmentally plausible account of how we reason about group membership, as it delineates clear boundaries to the hypothesis space that children must navigate. Merits notwithstanding, the account remains silent with respect to the arbitration problem: It does not explain how children can appropriately select among competing frames when interpreting social interactions.

The Theory and Philosophy of Organisations assesses and analyzes the assumptions upon which our understanding of organizations is based and in doing so aims to redirect the ways in which organizational research is conceived and executed. Contributions to the volume emphasize how all approaches to the study of organizations are influenced by deep metatheoretical assumptions about the nature of science and society. It is argued that these differences create a spectrum of valid perspectives and methods, and the book outlines how (...) conceptual problems in the field have given rise to innovative forms of empirical enquiry such as symbolism, postmodernism, ethnomethodology and structuralism. Criticizing the conservatism which has characterized much of the work in this field, the authors offers this range of methods as a starting point for obtaining richer and more grounded explanations of organizations. (shrink)

Given a class $$\mathcal {C}$$ of models, a binary relation $$\mathcal {R}$$ between models, and a model-theoretic language L, we consider the modal logic and the modal algebra of the theory of $$\mathcal {C}$$ in L where the modal operator is interpreted via $$\mathcal {R}$$. We discuss how modal theories of $$\mathcal {C}$$ and $$\mathcal {R}$$ depend on the model-theoretic language, their Kripke completeness, and expressibility of the modality inside L. We calculate such theories for the submodel and the quotient (...) relations. We prove a downward Löwenheim–Skolem theorem for first-order language expanded with the modal operator for the extension relation between models. (shrink)

The argument of J. M. E. McTaggart in ‘The Unreality of Time’ (Mind 1908) fails logically. There is no A series as such, but there is a shifting past-present-future arrangement within and consistent with the earlier-later B series, past being always earlier, future always later, present always a position earlier or later. An exactly similar logical structure is constructible within the number series, by making each number as one goes up it in turn (it does not matter what ‘it’, or (...) ‘present’, means, ontologically). The subsequent argument that past-present-future time falls into contradiction then fails also, and proves to be equivocal. (shrink)

Michael Psellos ist ein Philosoph, der wie kein anderer für die byzantinische Epoche steht. Das Denken dieses Großintellektuellen – der in subtilen Auseinandersetzungen mit antiken und spätantiken Positionen in Theologie, Ontologie und Ethik eine selbständige christliche Philosophie formuliert – findet in diesem Band erstmalig eine monographische Gesamtdarstellung. Die Arbeit liefert durch ihren systematischen Charakter, durch die Einbeziehung bisher nicht interpretierter Texte, durch die Darlegung der bisherigen Forschungsergebnisse und durch die Aufdeckung von Traditioinslinien eine wichtige Grundlage für die weitere Erforschung der (...) byzantinischen Philosophie. (shrink)

The central goal of this paper is to investigate the injustices that can occur with the use of new technologies, especially Artificial Intelligence (AI), focusing on the issues concerning respect to human rights and the protection of victims and the most vulnerable. We aim to study the impacts of AI in daily life and the possible threats to human dignity imposed by it, such as discrimination based on prejudices, identity-oriented stereotypes, and unequal access to health services. We characterize such cases (...) as algorithmic injustices. In the final part of the text, we propose some strategies to confront this specific type of injustice. (shrink)