Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses age‐associated molecular features, including elongation of telomeres, resetting of epigenetic clocks and age‐associated transcriptomic changes, and even evasion of replicative senescence. However, reprogramming into iPSCs also entails complete de‐differentiation with loss of cellular identity, as well as the risk of teratoma formation in anti‐ageing treatment paradigms. Recent studies indicate that partial reprogramming by limited exposure to reprogramming factors (...) can reset epigenetic ageing clocks while maintaining cellular identity. So far, there is no commonly accepted definition of partial reprogramming, which is alternatively called interrupted reprogramming, and it remains to be elucidated how the process can be controlled and if it resembles a stable intermediate state. In this review, we discuss if the rejuvenation program can be uncoupled from the pluripotency program or if ageing and cell fate determination are inextricably linked. Alternative rejuvenation approaches with reprogramming into a pluripotent state, partial reprogramming, transdifferentiation, and the possibility of selective resetting of cellular clocks are also discussed. (shrink)

Grau and Pury (Review of Philosophy and Psychology, 5, 155–168, 2014) reported that people’s views about love are related to their views about reference. This surprising effect was however not replicated in Cova et al.’s (in press) replication study. In this article, we show that the replication failure is probably due to the replication’s low power and that a metaanalytic reanalysis of the result in Cova et al. suggests that the effect reported in Grau and Pury is real. We then (...) report a large, highly powered replication that successfully replicates Grau and Pury 2014. This successful replication is a case study in the challenges involved in replicating scientific work, and our article contributes to the discussion of these challenges. (shrink)

Robert Kraut has proposed an analogy between valuing a loved one as irreplaceable and the sort of “rigid” attachment that (according to Saul Kripke’s account) occurs with the reference of proper names. We wanted to see if individuals with Kripkean intuitions were indeed more likely to value loved ones (and other persons and things) as irreplaceable. In this empirical study, 162 participants completed an online questionnaire asking them to consider how appropriate it would be to feel the same way about (...) a perfect replica of a loved one, as well as other questions about replaceability. Participants who previously had endorsed Kripkean reference (n = 96) rated loved ones as less replaceable on two different measures than participants who had previously endorsed Descriptivist reference (n = 66, t(160)> 2.27, p <.02, eta2> .03). Additional results suggest that this difference extends to other targets as well and is at least partially dependent on sentimental attachment. (shrink)

This essay discusses Rawls distinction between the reasonable and the rational in the context of the liberal effort to establish the priority of the right over the good. It argues that inarticulacy about the good makes it difficult for Rawls to find arguments in support of a minimal conception of the reasonable overlapping consensus. The essay examines Rawls’ arguments in support of the distinction between the rational and the reasonable. The paper suggests that in terms of these arguments, the term (...) reasonable seems to be a derivative of the rational. However, this does not stop Rawls from employing that term as if the distinction has been satisfactorily made. Therefore, the philosophical work expected from the term reasonable in Rawls is more than that term is legitimately able to do. Rawls’ arguments explaining reasonable and his arguments employing the term reasonable as a virtue of citizens begin to turn on an equivocation on the use of that term. The conclusion suggests that it is possible to reconstruct Rawls so that the term reasonable can be used in a substantive normative sense without endangering the stability of the overlapping consensus. This is possible if Rawls’ conception of the moral powers of citizens can be philosophically reconstructed as forming part of the basic moral potential of citizens as persons. Such moral potential can be conceived, as prior to and independent of, a complete/partial conception of the good in terms of which that potential might find a complete or partial articulation. (shrink)

Includes text of Patañjali's Yogasūtra in Sanskrit (Thai script).

This essay will examine Gandhian ahimsa in its inseparability from truth. In this context, it will take issue with those who have argued that Gandhian ahimsa was either (entirely or in part) drawn from Tolstoy or (entirely or in part) from the anekantavada of the Jains; arguing that while Gandhi was influenced by both these sources, his ahimsa was drawn (in his own admission) from an altogether different source, i.e. from the metaphysics and ethics of the Bhagavad Gita. Even if (...) one were to disregard for the moment the differences between Gandhi and the other interpreters of the Gita (specially from those who were his contemporaries), Gandhi’s drawing of ahimsa as non-violence and a non-passionate universal love from the context of the war between cousins in the Gita might seem surprising. Gandhi’s contemporaries like Tilak and Sri Aurobindo (among others) had argued that the Gita had justified the exception to the law of harmlessness for the sake of duty and suggested that the aim of the Gita was to undertake a critique of the ethical and confirm it’s subordination to the political. Gandhi however had argued (to the contrary) that the metaphysics of oneness in the Gita brought out in the vision of Sri Krishna’s divine form recommended both desireless action and absolute ahimsa; given that to harm anyone or anything in the universe was, quite literally, to harm oneself. (shrink)

Misophonia is a condition characterized by defensive motivational system emotional responding to repetitive and personally relevant sounds. Preliminary research suggests misophonia may be associated with a range of psychiatric disorders, including personality disorders. However, very little research has used clinician-rated psychometrically validated diagnostic interviews when assessing the relationship between misophonia and psychopathology. The purpose of this study was to extend the early research in this area by examining the relationship between symptoms of misophonia and psychiatric diagnoses in a sample of (...) community adults, using semi-structured diagnostic interviews. Results indicated higher misophonia symptoms were associated with more clinician-rated symptoms of personality disorders, but not other disorders. Anxiety partially mediated the relationship between personality disorder symptoms and misophonia. These results suggest misophonia may be associated with a range of psychiatric symptoms and highlight the role of anxiety in this poorly understood condition. (shrink)

In this 60th anniversary of Business & Society essay, we seek to make three main contributions at the intersection of governance and artificial intelligence. First, we aim to illuminate some of the deeper social, legal, organizational, and democratic challenges of rising AI adoption and resulting algorithmic power by reviewing AI research through a governance lens. Second, we propose an AI governance framework that aims to better assess AI challenges as well as how different governance modalities can support AI. At the (...) heart of our framework lies the governance forces that apply to institutions, organizations, and individuals, who ultimately provide, regulate, and use AI decision-making. We discuss how businesses may harness AI’s economic power through governance solutions without creating or amplifying societal biases and inequalities. Third, as part of our section on future research, we identify a set of governance trade-offs in AI adoption, suggest future research avenues to conceptually strengthen research on the governance of AI, and lay out key policy recommendations. (shrink)

In matters of discontinuation of life-sustaining treatment, traditional role of the family to speak on behalf of the incompetent patient is questionable. We explore the reasons why physicians perceive patient autonomy to be transferrable to family members. Principle of patient autonomy may not suffice when futile treatment is demanded and may serve to erode the ethical integrity of medical profession. An enhanced role for bioethics committees is proposed when physicians propose to discontinue life-sustaining treatment against the wishes of the patient (...) or their families. (shrink)

This collection of essays by eminent scholars on the reconstruction and critique of Kant's transcendental philosophy in the Indian context specifically discusses moral philosophy, philosophical psychology, religion, and aesthetics.

Innovations in aligning investment with sustainability led to impact investing, enabling investors to achieve conventional financial returns and measurable social and environmental returns. Since its inception in 2007, it has grown manifolds, with significant efforts being made to create a global ecosystem. However, due to limited academic literature, the theme is yet to garner the scholarly interest it deserves. In this study, we analyse and visualise a knowledge map of the impact investment research field through a comprehensive bibliometric analysis by (...) employing a research corpus of 421 studies sourced from Web of Science and Scopus. We identify the growth trajectory, geographical concentration, productive and influential authors, journals and significant articles and examine the inter-disciplinarity of the field. The major research themes interlinked with impact investing included; social entrepreneurship, social innovation, social finance, impact investment market, innovative financial instruments, financialisation of essential services and impact reporting. To drive the field forward, future research needs to develop an impact investment ecosystem, address behavioural issues, stakeholder management and institutional context in impact investment theme, develop and diffuse innovative financial instruments, develop a framework for standardised accounting and reporting practices to measure financial and non-financial dimensions, tackle impact washing by fund managers, address lack of financial access to the third sector and develop the legal and regulatory framework for third sector organisations. (shrink)

This book discusses the work of four different kinds of artists from four different countries to examine how they create a space for politics in their work.

Predatory journals and conferences are an emerging problem in scientific literature as they have financial motives, without guaranteeing scientific quality and exposure. The main objective of the ASGLOS project is to investigate the predatory e‐email characteristics, management, and possible consequences and to analyse the extent of the current problem at each academic level. To collect the personal experiences of physicians’ mailboxes on predatory publishing, a Google Form® survey was designed and disseminated from September 2021 to April 2022. A total of (...) 978 responses were analysed from 58 countries around the world. A total of 64.8% of participants indicated the need for 3 or fewer emails to acquire a criticality view in distinguishing a real invitation from a spam, while 11.5% still have doubt regardless of how many emails they get. The AGLOS Study clearly highlights the problem of academic e‐mail spam by predatory journals and conferences. Our findings signify the importance of providing academic career‐oriented advice and organising training sessions to increase awareness of predatory publishing for those conducting scientific research. (shrink)

Development of methods to reawaken the semi‐dormant regenerative potential that lies within adult human tissues would hold promise for the restoration of diseased or damaged organs and tissues. While most of the regeneration potential is suppressed in many vertebrates, including humans, during adult life, urodele amphibians (salamanders) retain their regenerative ability throughout adulthood. Studies in newts and axolotls, two salamander models, have provided significant knowledge about adult limb regeneration. In this review, we present a comparative analysis of salamander and mammalian (...) regeneration and discuss how evolutionarily altered properties of the regenerative environment can be exploited to restore full regenerative potential in the human body. (shrink)

This book discusses the work of four different kinds of artists from four different countries to examine how they create a space for politics in their work.

Differential scanning calorimetry (DSC) has been employed to investigate the glass transition activation energy E g, thermal stability and glass-forming ability (GFA) of Se90In10− x Sb x (x = 0, 2, 4, 6, 8, 10) chalcogenide glasses. DSC runs were performed at six different heating rates. Well-defined endothermic and exothermic peaks were obtained at glass transition and crystallization temperature. The dependence of glass transition temperature T g on heating rate (α), as well as composition of Sb, has been studied. From (...) the dependence of glass transition temperature on heating rate, the E g has been calculated on the basis of the Kissinger [Anal. Chem. 29 (1957) p.1702] and Moynihan [J. Phys. Chem. 78 (1974) p.267] models. Thermal stability has been monitored through the calculation of temperature differences T c–T g, the stability parameter S, and the enthalpy released during crystallization H c. The GFA has been investigated on the basis of the Hruby parameter H r, which is strong indicator of GFA. Results for GFA are in good agreement with fragility index F i calculations, indicating that Se90In6Sb4 is an excellent glass-former. (shrink)

This book examines the centrality of ideas such as satya (truth), ahimsa (non-violence), humility, and respect for understanding moral life in the complex milieu of human existence. It provides a comprehensive view of how Gandhian ideas have both a temporal and spatial universality significantly different from Western modern philosophy's universality claims. The chapters represent different styles of philosophy but with a common purpose, offering insights into how the global debates on religion, morality, and politics are assessed from Gandhi's point of (...) view. Written in language accessible to general readers with an interest in Gandhian thinking, the book will appeal to academics and philosophers. (shrink)

Though courage is widely regarded as a core virtue there is controversy over what kinds of acts are courageous. Moreover, some see courageous acts as necessarily good, whereas others believe that some acts can be both courageous and bad. We examine this disagreement and argue that it largely rests on two sorts of confusion or misunderstanding. We examine this disagreement and argue that it largely rests on two sorts of confusion or misunderstanding. One regards differences in the descriptor under which (...) the act is seen: acts can be comprehended under several different descriptors, all of which may be appropriate but support different courage evaluations. The other involves differences in uses of the term courage: the term serves two fundamentally different functions and involves two different concepts. One, process courage, is the use of the term to refer to the psychological mechanisms or processes whereby people act in the face of risk for perceived good. The other, accolade courage, is a form of acknowledgment - the use of the term to draw attention to the action or the actor and commend one or the other. We identify various sorts of support for this process/accolade distinction. We then conclude by outlining several important contributions these distinctions offer for research and social debate. Attention to differences in descriptors and functions of the term courage will improve both research and social discourse on the virtue of courage. (shrink)

Increasing university students’ engagement with ethics is becoming a prominent call to action for higher education institutions, particularly professional schools like business and engineering. This paper provides an examination of student attitudes regarding ethics and their perceptions of ethics coverage in the curriculum at one institution. A particular focus is the comparison between results in the business college, which has incorporated ethics in the curriculum and has been involved in ethics education for a longer period, with the engineering college, which (...) is in the nascent stages of developing ethics education in its courses. Results show that student attitudes and perceptions are related to the curriculum. In addition, results indicate that it might be useful for engineering faculty to use business faculty as resources in the development of their ethics curricula. (shrink)

This paper will consider the ideas of absolute equality and absolute difference that are part of Gandhi’s vision on the plurality of religions. It will fall into three sections. The first section is entitled “Thinking samadarshana through samabhava-Gandhi on “equimindedness” and religious ‘others’”. It will seek to bring out the central ideas in Gandhi’s thoughts on the plurality of religions. In this context the paper will briefly examine the difference between Gandhi’s arguments for absolute equality and the liberal position on (...) religious toleration. The second section will elaborate Gandhi’s reasons for thinking the absolute equality of all religions and will be entitled “The Religion at the heart of all religions- Truth or God”. The third section will be entitled “The truth-untruths of religious others and the duty of resistance: Difficulties with a relativist reading of Gandhi”. It will recapitulate the different strands of the argument in the paper and bring out the implications of ahimsa as love as it transforms resistance to what one thinks of as the truth-untruths of religious ‘others’ in a plural context. It will also take issue with an important contemporary reading of Gandhi, that of Professor Akeel Bilgrami, who reads Gandhi’s position along the lines of a “thorough going relativism about Truth”. In the course of the paper it is hoped to unpack the absolute equality in absolute difference that constituted Gandhi’s vision on the plurality of religions. (shrink)

This paper is in conversation with Richard Sorabji’s reading of the Gandhi Tagore debate. On Sorabji’s account freedom was an important issue in that debate as Gandhi was unable to appreciate Tagore’s emphasis on individual freedom as creativity. While I agree that freedom was an important issue, I argue that Gandhi understood and employed the resources made available by individual creativity. The differences arose because Gandhi thought of freedom as creativity primarily in moral rather than aesthetic terms.

This article examines the role of Harlequin and Mills and Boon romance novels in the lives of young, single, middle-class women readers in urban India. The article focuses on the readers' interpretations of the novels given the differences in the sites of production of the romance novels and the sociocultural context of reception. Three themes are explored in this study: the influence of romance novels on the readers' expectations of marital sexuality and gender role patterns, the limitations of novels in (...) dealing with the social uncertainties that face the readers as young women in Indian culture, and the generation of readers' social anxieties due to the difference between the content of the novels and the sociocultural context in which they are read. The article concludes with a discussion of its implications for understanding global forms of culture, contested meanings of culturally transposed texts, and the shaping of popular cultural practices in a transnational arena around vectors of gender and socioeconomic class. (shrink)