Rejuvenation of cells by reprogramming toward the pluripotent state raises increasing attention. In fact, generation of induced pluripotent stem cells (iPSCs) completely reverses age‐associated molecular features, including elongation of telomeres, resetting of epigenetic clocks and age‐associated transcriptomic changes, and even evasion of replicative senescence. However, reprogramming into iPSCs also entails complete de‐differentiation with loss of cellular identity, as well as the risk of teratoma formation in anti‐ageing treatment paradigms. Recent studies indicate that partial reprogramming by limited exposure to reprogramming factors (...) can reset epigenetic ageing clocks while maintaining cellular identity. So far, there is no commonly accepted definition of partial reprogramming, which is alternatively called interrupted reprogramming, and it remains to be elucidated how the process can be controlled and if it resembles a stable intermediate state. In this review, we discuss if the rejuvenation program can be uncoupled from the pluripotency program or if ageing and cell fate determination are inextricably linked. Alternative rejuvenation approaches with reprogramming into a pluripotent state, partial reprogramming, transdifferentiation, and the possibility of selective resetting of cellular clocks are also discussed. (shrink)

Grau and Pury (Review of Philosophy and Psychology, 5, 155–168, 2014) reported that people’s views about love are related to their views about reference. This surprising effect was however not replicated in Cova et al.’s (in press) replication study. In this article, we show that the replication failure is probably due to the replication’s low power and that a metaanalytic reanalysis of the result in Cova et al. suggests that the effect reported in Grau and Pury is real. We then (...) report a large, highly powered replication that successfully replicates Grau and Pury 2014. This successful replication is a case study in the challenges involved in replicating scientific work, and our article contributes to the discussion of these challenges. (shrink)

This paper makes an attempt to philosophically re-construct what I have termed as a fundamental paradox at the heart of deontological liberalism. It is argued that liberalism attempts to create the possibilities of rational consensus and of bringing people together socially and politically by developing methodologies which overcome the divisive nature of essentially parochial substantive conceptions of the good. Such methodologies relying on the supposed universally valid dictates of reason and notions of procedural rationality proceed by disengaging men from the (...) divisive particularities of their plural value contexts. That disengagement is sought to be achieved by conceptualizing the individual as self sufficient in her moral and epistemic being thereby conceptually isolating individual man from the other. The liberal effort to create rational consensus which can bring people together then gets off the ground by isolating the individual from the other. This I have termed as the paradox of the self and the other or alternatively the paradox of social atomism and universalism. As a possible philosophical alternative this paper makes an attempt to re-construct Gandhi’s conceptualization of the relationship between swaraj as self rule and Satyagraha as non-violent resistance. This Gandhian connection, it is argued, has the potential to transform the moral psychology of our response to the other, thereby posing a challenge to the modern, predominantly liberal, conceptualization of such a response. (shrink)

Liberal theory and practice rests upon, and constantly re-affirms, a division between the secular/rational and the religious/faithful aspects of individual life. This paper will explore the philosophical implications of an alternative Gandhian understanding of the role of faith and reason in individual life. The paper will argue that M K Gandhi thought of moral life differently from both the religious traditionalist and the liberal. The distinctiveness of Gandhi’s vision came from the manner in which he could reconcile two very different (...) ways of thinking about the good human life. These could be simply put as the religious insight into the good life as an essentially integrated life and the alternative liberal insight that morality was better connected with the idea of universalizability/reciprocity. The first section of this paper entitled “An alternative Gandhian understanding of faith, reason, and the integrity of the good life” philosophically unpacks Gandhi’s arguments about the integrity between faith and reason in reading religious texts with a view to living a good life. The second section is entitled “On religious belief: Gandhi and liberalism”. It brings out the differences between Gandhi and liberals on faith, reason, and the truth of religious belief. Both Gandhi and the liberals agree that religious beliefs should be held with modesty. However, the liberal argument for modesty comes from an avowed skepticism about the truth of religious belief. It is such skepticism that philosophically grounds the liberal division between faith and reason. In this section, there will be an attempt to bring out Gandhi’s reasons for being modest about religious beliefs held with certitude. The paper ends with the thought that though one cannot say which of these positions on faith and reason—Gandhian or liberal—is more coherent, there is some reason for exploring the Gandhian position if only because religious persons can act on Gandhi’s arguments quite consistently with their faith. (shrink)

Tagore and Gandhi shared a relationship across 26 years. They argued about many things including the means for the attainment of swaraj/freedom. In terms of this central concern with the nature of freedom they came fairly close to an issue that has perhaps dominated the (European) Enlightenment. For the Enlightenment has sought to clarify what is meant by individual freedom and attempted to secure such freedom to the individual. This article argues that the Tagore-Gandhi debate can perhaps be reconstructed around (...) the issue of freedom and the collective. Gandhi was able to employ the idea of collective action with conceptual and practical ease. He seemed to have felt no tension between individual freedom and the notion of the collective of which an individual becomes a part in his/her attempt to deal with the contending ‘other’ and secure his /her freedom/swaraj. To understand Tagore’s opposition to the Gandhian idea of swaraj this article draws a philosophical parallel between Tagore and Kant on individual freedom as primarily the freedom to reason. Tagore’s argument seemed to have centered on the insight that the location of the individual in a collective hypostatized self in order to protect his or her freedom from ‘others’ reaffirms the self other divide. The insider-outsider exclusionary dynamics that are generated not only consolidate such distinctions as external to (and outside of) the collective self, but they also initiate internal dynamics that create the ‘silenced insider.’. (shrink)

In this 60th anniversary of Business & Society essay, we seek to make three main contributions at the intersection of governance and artificial intelligence. First, we aim to illuminate some of the deeper social, legal, organizational, and democratic challenges of rising AI adoption and resulting algorithmic power by reviewing AI research through a governance lens. Second, we propose an AI governance framework that aims to better assess AI challenges as well as how different governance modalities can support AI. At the (...) heart of our framework lies the governance forces that apply to institutions, organizations, and individuals, who ultimately provide, regulate, and use AI decision-making. We discuss how businesses may harness AI’s economic power through governance solutions without creating or amplifying societal biases and inequalities. Third, as part of our section on future research, we identify a set of governance trade-offs in AI adoption, suggest future research avenues to conceptually strengthen research on the governance of AI, and lay out key policy recommendations. (shrink)

Robert Kraut has proposed an analogy between valuing a loved one as irreplaceable and the sort of “rigid” attachment that (according to Saul Kripke’s account) occurs with the reference of proper names. We wanted to see if individuals with Kripkean intuitions were indeed more likely to value loved ones (and other persons and things) as irreplaceable. In this empirical study, 162 participants completed an online questionnaire asking them to consider how appropriate it would be to feel the same way about (...) a perfect replica of a loved one, as well as other questions about replaceability. Participants who previously had endorsed Kripkean reference (n = 96) rated loved ones as less replaceable on two different measures than participants who had previously endorsed Descriptivist reference (n = 66, t(160)> 2.27, p <.02, eta2> .03). Additional results suggest that this difference extends to other targets as well and is at least partially dependent on sentimental attachment. (shrink)

This essay discusses Rawls distinction between the reasonable and the rational in the context of the liberal effort to establish the priority of the right over the good. It argues that inarticulacy about the good makes it difficult for Rawls to find arguments in support of a minimal conception of the reasonable overlapping consensus. The essay examines Rawls’ arguments in support of the distinction between the rational and the reasonable. The paper suggests that in terms of these arguments, the term (...) reasonable seems to be a derivative of the rational. However, this does not stop Rawls from employing that term as if the distinction has been satisfactorily made. Therefore, the philosophical work expected from the term reasonable in Rawls is more than that term is legitimately able to do. Rawls’ arguments explaining reasonable and his arguments employing the term reasonable as a virtue of citizens begin to turn on an equivocation on the use of that term. The conclusion suggests that it is possible to reconstruct Rawls so that the term reasonable can be used in a substantive normative sense without endangering the stability of the overlapping consensus. This is possible if Rawls’ conception of the moral powers of citizens can be philosophically reconstructed as forming part of the basic moral potential of citizens as persons. Such moral potential can be conceived, as prior to and independent of, a complete/partial conception of the good in terms of which that potential might find a complete or partial articulation. (shrink)

Includes text of Patañjali's Yogasūtra in Sanskrit (Thai script).

Misophonia is a condition characterized by defensive motivational system emotional responding to repetitive and personally relevant sounds. Preliminary research suggests misophonia may be associated with a range of psychiatric disorders, including personality disorders. However, very little research has used clinician-rated psychometrically validated diagnostic interviews when assessing the relationship between misophonia and psychopathology. The purpose of this study was to extend the early research in this area by examining the relationship between symptoms of misophonia and psychiatric diagnoses in a sample of (...) community adults, using semi-structured diagnostic interviews. Results indicated higher misophonia symptoms were associated with more clinician-rated symptoms of personality disorders, but not other disorders. Anxiety partially mediated the relationship between personality disorder symptoms and misophonia. These results suggest misophonia may be associated with a range of psychiatric symptoms and highlight the role of anxiety in this poorly understood condition. (shrink)

Increasing university students’ engagement with ethics is becoming a prominent call to action for higher education institutions, particularly professional schools like business and engineering. This paper provides an examination of student attitudes regarding ethics and their perceptions of ethics coverage in the curriculum at one institution. A particular focus is the comparison between results in the business college, which has incorporated ethics in the curriculum and has been involved in ethics education for a longer period, with the engineering college, which (...) is in the nascent stages of developing ethics education in its courses. Results show that student attitudes and perceptions are related to the curriculum. In addition, results indicate that it might be useful for engineering faculty to use business faculty as resources in the development of their ethics curricula. (shrink)

Innovations in aligning investment with sustainability led to impact investing, enabling investors to achieve conventional financial returns and measurable social and environmental returns. Since its inception in 2007, it has grown manifolds, with significant efforts being made to create a global ecosystem. However, due to limited academic literature, the theme is yet to garner the scholarly interest it deserves. In this study, we analyse and visualise a knowledge map of the impact investment research field through a comprehensive bibliometric analysis by (...) employing a research corpus of 421 studies sourced from Web of Science and Scopus. We identify the growth trajectory, geographical concentration, productive and influential authors, journals and significant articles and examine the inter-disciplinarity of the field. The major research themes interlinked with impact investing included; social entrepreneurship, social innovation, social finance, impact investment market, innovative financial instruments, financialisation of essential services and impact reporting. To drive the field forward, future research needs to develop an impact investment ecosystem, address behavioural issues, stakeholder management and institutional context in impact investment theme, develop and diffuse innovative financial instruments, develop a framework for standardised accounting and reporting practices to measure financial and non-financial dimensions, tackle impact washing by fund managers, address lack of financial access to the third sector and develop the legal and regulatory framework for third sector organisations. (shrink)

This book discusses the work of four different kinds of artists from four different countries to examine how they create a space for politics in their work.

This volume discusses the development of the dialogue between Tagore (1861-1941) and Gandhi (1869-1948) during 1915 and 1941, about many things of personal, national, and international significance---satyagraha, non-cooperation, the boycott and burning of foreign cloth, the efficacy of fasting as a means of resistance and Gandhi's mantra connecting "swaraj" and "charkha". The author, Bindu Puri, argues that the debate was about more fundamental issues, such as the nature of truth and swaraj/freedom and the possibilities of untruth that Tagore saw (...) in Gandhi's movements for truth and freedom. Puri shows that the differences between the two men's perspectives came from differently negotiated relationships to (and understandings of) tradition and modernity. Tagore was part of the Bengal renaissance and powerfully influenced by the idea that the Enlightenment consisted in the freedom of the individual to reason for herself. Gandhi, on the other hand, remained close to the Indian philosophical tradition which linked individual freedom to moral progress. Puri points out that Tagore cannot, however, be unreflectively assimilated to the Enlightenment project of Western modernity, for he came fairly close to Gandhi in rejecting the anthropocentricism of modernity and shared Gandhi's belief in an enchanted cosmos. The only single-authored volume on the Tagore-Gandhi debate, this book is a welcome addition to the existing literature. (shrink)

Predatory journals and conferences are an emerging problem in scientific literature as they have financial motives, without guaranteeing scientific quality and exposure. The main objective of the ASGLOS project is to investigate the predatory e‐email characteristics, management, and possible consequences and to analyse the extent of the current problem at each academic level. To collect the personal experiences of physicians’ mailboxes on predatory publishing, a Google Form® survey was designed and disseminated from September 2021 to April 2022. A total of (...) 978 responses were analysed from 58 countries around the world. A total of 64.8% of participants indicated the need for 3 or fewer emails to acquire a criticality view in distinguishing a real invitation from a spam, while 11.5% still have doubt regardless of how many emails they get. The AGLOS Study clearly highlights the problem of academic e‐mail spam by predatory journals and conferences. Our findings signify the importance of providing academic career‐oriented advice and organising training sessions to increase awareness of predatory publishing for those conducting scientific research. (shrink)

Development of methods to reawaken the semi‐dormant regenerative potential that lies within adult human tissues would hold promise for the restoration of diseased or damaged organs and tissues. While most of the regeneration potential is suppressed in many vertebrates, including humans, during adult life, urodele amphibians (salamanders) retain their regenerative ability throughout adulthood. Studies in newts and axolotls, two salamander models, have provided significant knowledge about adult limb regeneration. In this review, we present a comparative analysis of salamander and mammalian (...) regeneration and discuss how evolutionarily altered properties of the regenerative environment can be exploited to restore full regenerative potential in the human body. (shrink)

Differential scanning calorimetry (DSC) has been employed to investigate the glass transition activation energy E g, thermal stability and glass-forming ability (GFA) of Se90In10− x Sb x (x = 0, 2, 4, 6, 8, 10) chalcogenide glasses. DSC runs were performed at six different heating rates. Well-defined endothermic and exothermic peaks were obtained at glass transition and crystallization temperature. The dependence of glass transition temperature T g on heating rate (α), as well as composition of Sb, has been studied. From (...) the dependence of glass transition temperature on heating rate, the E g has been calculated on the basis of the Kissinger [Anal. Chem. 29 (1957) p.1702] and Moynihan [J. Phys. Chem. 78 (1974) p.267] models. Thermal stability has been monitored through the calculation of temperature differences T c–T g, the stability parameter S, and the enthalpy released during crystallization H c. The GFA has been investigated on the basis of the Hruby parameter H r, which is strong indicator of GFA. Results for GFA are in good agreement with fragility index F i calculations, indicating that Se90In6Sb4 is an excellent glass-former. (shrink)

This study examined video game–playing aggression among graduate and undergraduate students at Rochester Institute of Technology in upstate New York. The following three research questions were posed: In the context of video game playing, what differences are there in levels of aggression in relation to sex? What differences are there in levels of aggression and type of video games played? Are aggression and length of video game playing related? A nonprobability sample of students (N = 175) was selected and electronically (...) surveyed. The Buss–Perry Aggression Questionnaire, a widely used self-reported measure, was used to assess aggression. No significant difference was found between men and women with regard to levels of aggression, and no statistically significant relationship was found between aggression and length of video game playing (r = −.05, p =.52). However, significant differences were found in levels of aggression between playing and nonplaying respondents of action role-playing (t = −1.48, df = 175, p =.01) and role-playing video games (t = −1.24, df = 175, p =.02). Players of role-playing games had lower levels of aggression than nonplayers. Since role-playing requires one to take the part of another person, empathy might play a role in reduced levels of aggression. Although exposure to violent video games has been related to decreased empathy, role-playing games show just the opposite. It is suggested that controversies regarding violent video games might best be explained by moral panic theory and that competitive games may attract more aggressive players. (shrink)

This essay will examine Gandhian ahimsa in its inseparability from truth. In this context, it will take issue with those who have argued that Gandhian ahimsa was either (entirely or in part) drawn from Tolstoy or (entirely or in part) from the anekantavada of the Jains; arguing that while Gandhi was influenced by both these sources, his ahimsa was drawn (in his own admission) from an altogether different source, i.e. from the metaphysics and ethics of the Bhagavad Gita. Even if (...) one were to disregard for the moment the differences between Gandhi and the other interpreters of the Gita (specially from those who were his contemporaries), Gandhi’s drawing of ahimsa as non-violence and a non-passionate universal love from the context of the war between cousins in the Gita might seem surprising. Gandhi’s contemporaries like Tilak and Sri Aurobindo (among others) had argued that the Gita had justified the exception to the law of harmlessness for the sake of duty and suggested that the aim of the Gita was to undertake a critique of the ethical and confirm it’s subordination to the political. Gandhi however had argued (to the contrary) that the metaphysics of oneness in the Gita brought out in the vision of Sri Krishna’s divine form recommended both desireless action and absolute ahimsa; given that to harm anyone or anything in the universe was, quite literally, to harm oneself. (shrink)

As is fairly well-known several issues raised by Tagore became a subject of some debate between Gandhi and him during the years between 1915 and 1941 (Puri, 2015). These issues could be broadly categorized into two, those concerning an uncritical adoption of the western modular nation as the end/goal by those engaged in the movement for India’s freedom and those concerning satyagraha (in the form of non-cooperation, boycott, fasting, etc.) as the unquestioned “moral” (Bhattacharya, 2008: 49) means to that (...) end. This essay will examine the first set of issues and argue that though Tagore had difficulties with what he described as “the nation of the west” (Tagore, 1996: 425) these difficulties did not amount to a rejection of the “case for self-determination-the forging of the national links” (Berlin, 1999: 264) or of an independent politically reorganized Indian nation but were targeted at the uncritical acceptance of “the nation of the west” (Tagore, 1996. 425)/“cruel epidemic of evil” (ibid., 424) which was “sweeping over the human world” (ibid.); as the goal of India’s struggle for freedom/swaraj. This essay will take issue with scholars who argue that Tagore’s arguments against the western nation did not distance him from Gandhi because both shared insights into the illegitimacy of the nation-state. It will suggest, to the contrary, that what these thinkers had rejected was the modular western nation-state which they saw as a product of enlightenment modernity, and that this was not a rejection of the nation per se. Gandhi and Tagore came together in their “love of country” (Bhattacharya, 2008: 70), expressed in/by a resolve of building a praja or great eastern nesan in continuity with the premodern communities of India’s past. One which was modelled closely along the lines of harmony in diversity and in the spirit of Tagore’s swadeshi samaj/indigenous Indian society. (shrink)

This paper will consider the ideas of absolute equality and absolute difference that are part of Gandhi’s vision on the plurality of religions. It will fall into three sections. The first section is entitled “Thinking samadarshana through samabhava-Gandhi on “equimindedness” and religious ‘others’”. It will seek to bring out the central ideas in Gandhi’s thoughts on the plurality of religions. In this context the paper will briefly examine the difference between Gandhi’s arguments for absolute equality and the liberal position on (...) religious toleration. The second section will elaborate Gandhi’s reasons for thinking the absolute equality of all religions and will be entitled “The Religion at the heart of all religions- Truth or God”. The third section will be entitled “The truth-untruths of religious others and the duty of resistance: Difficulties with a relativist reading of Gandhi”. It will recapitulate the different strands of the argument in the paper and bring out the implications of ahimsa as love as it transforms resistance to what one thinks of as the truth-untruths of religious ‘others’ in a plural context. It will also take issue with an important contemporary reading of Gandhi, that of Professor Akeel Bilgrami, who reads Gandhi’s position along the lines of a “thorough going relativism about Truth”. In the course of the paper it is hoped to unpack the absolute equality in absolute difference that constituted Gandhi’s vision on the plurality of religions. (shrink)

This paper is in conversation with Richard Sorabji’s reading of the Gandhi Tagore debate. On Sorabji’s account freedom was an important issue in that debate as Gandhi was unable to appreciate Tagore’s emphasis on individual freedom as creativity. While I agree that freedom was an important issue, I argue that Gandhi understood and employed the resources made available by individual creativity. The differences arose because Gandhi thought of freedom as creativity primarily in moral rather than aesthetic terms.

This article examines the role of Harlequin and Mills and Boon romance novels in the lives of young, single, middle-class women readers in urban India. The article focuses on the readers' interpretations of the novels given the differences in the sites of production of the romance novels and the sociocultural context of reception. Three themes are explored in this study: the influence of romance novels on the readers' expectations of marital sexuality and gender role patterns, the limitations of novels in (...) dealing with the social uncertainties that face the readers as young women in Indian culture, and the generation of readers' social anxieties due to the difference between the content of the novels and the sociocultural context in which they are read. The article concludes with a discussion of its implications for understanding global forms of culture, contested meanings of culturally transposed texts, and the shaping of popular cultural practices in a transnational arena around vectors of gender and socioeconomic class. (shrink)

This collection of essays by eminent scholars on the reconstruction and critique of Kant's transcendental philosophy in the Indian context specifically discusses his ideas on perpetual peace, universal history, and critical philosophy.

This review discussion examines two recent works on Gandhi, Richard Sorabji’s Gandhi and the Stoics: Modern Experiments on Ancient Values, and Ram Guha’s Gandhi Before India. The review makes the point that we can see Gandhi’s unusual philosophical method at work if the two books are read together. Sorabji has argued that it is essential to understand Gandhi’s philosophy before we can assess the consistency between what he thought, believed and did. Guha has recorded events in Gandhi’s early years that (...) can provide readers with details of Gandhi’s practise and experiments. (shrink)