An incoherent feed‐forward loop (FFL) is one of the most‐frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a ‘fast activation and delayed inhibition’. We find that the dynamics of various incoherent FFLs can be further classified into two types: time‐dependent biphasic responses and dose‐dependent biphasic responses. Why do the structurally identical incoherent FFLs play such different dynamical roles? Through computational studies, we show that (...) the dynamics of the two types of incoherent FFLs are mutually exclusive. Following from further computational results and experimental observations, we hypothesize that incoherent FFLs have been optimally designed to achieve distinct biological function arising from different cellular contexts. Additional Supporting Information may be found in the online version of the article. BioEssays 30:1204–1211, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Forecasting blood glucose values for patients can help prevent hypoglycemia and hyperglycemia events in advance. To this end, this study proposes an intelligent ensemble deep learning system to predict BG values in 15, 30, and 60 min prediction horizons based on historical BG values collected via continuous glucose monitoring devices as an endogenous factor and carbohydrate intake and insulin administration information as exogenous factors. Although there are numerous deep learning algorithms available, this study applied five algorithms, namely, recurrent neural network, (...) which is optimized for sequence data, and RNN-based algorithms, stacked LSTM, bidirectional LSTM, and gated recurrent unit). Then, a genetic algorithm was applied to the five prediction models to optimize their weights through ensemble techniques and to yield the final predicted BG values. The performance of the proposed model was compared to that of the autoregressive integrated moving average model as a baseline. The results show that the proposed model significantly outperforms the baseline in terms of the root mean square error and continuous glucose error grid analysis. For the valid 29 diabetic patients for the multivariate models, the RMSE was 11.08, 19.25, and 31.30 mg/DL for 15, 30, and 60 min PH, respectively. When the same data were applied to univariate models, the RMSE was 11.28, 19.99, and 33.13 mg/DL for 15, 30, and 60 min PH, respectively. Both the univariate and multivariate models showed a statistically significant difference compared with the baseline at a 5% statistical significance level. Instead of using a model with a single algorithm, applying a GA based on each output of a model with multiple algorithms was found to play a significant role in improving model performance. (shrink)

1. Yu Hyŏng-wŏn ŭi ppuri wa Pan'gyehak ŭl nonhada -- 1.1. Pan'gye Yu Hyŏng-wŏn kagye punsŏk -- 1.2. Chiyŏkhak ŭrosŏ Pan'gyehak yŏn'gu -- 2. Pan'gye Sŏnsaeng palchach'wi rŭl ch'aja kada -- 2.1. Sirhak ŭi mek'a, Puan Uban-dong -- 2.2. Pan'gye Sŏnsaeng i namgin palchach'wi -- 2.3. Puan chiyŏk Yugyo munhwa yusan ŭi hyŏnhwang kwa kwaje -- 3. Pan'gye Sŏnsaeng ŭl kirida -- 3.1. Puan Tongnim Sŏwŏn ŭi kŏllip kwa pyŏnch'ŏn e taehan yŏn'gu -- 3.2. Tŏkch'on Yang Tŭk-chung ŭi kagye wa (...) ch'usung e kwanhan yŏn'gu -- 3.3. Hong Kye-hŭi Kyŏngseron ŭi chaejijŏk kiban. (shrink)

Despite widespread discussion of the impact of corporate social responsibility activities on consumer perceptions, little research has examined how consumers cope with CSR-based crisis response messages as a bolstering strategy. To fill this gap, we propose a framework integrating situational crisis communication theory with the persuasion knowledge model, applying the model to an experiment with a 2 × 2 × 2 between-subjects factorial design. In Study 1, we found interaction effects between CSR motives and crisis type on word-of-mouth intention and (...) purchase intention. In addition, inferences about CSR motives interacted with perceptions about CSR history on purchase intention. In Study 2, we replicated study 1 and found that crisis responsibility mediated the main effect of crisis type on behavioral intentions, but neither the main effect of CSR motives and CSR history nor the interactions effects among those variables were mediated by crisis responsibility. Our results indicate that consumer inferences from a company’s CSR-based crisis communications play a significant role in increasing consumer behavioral intentions in two situations: when a crisis is accidental and when a CSR history is short. Ethical and theoretical implications are discussed. (shrink)

Cellular circuits have positive and negative feedback loops that allow them to respond properly to noisy external stimuli. It is intriguing that such feedback loops exist in many cases in a particular form of coupled positive and negative feedback loops with different time delays. As a result of our mathematical simulations and investigations into various experimental evidences, we found that such coupled feedback circuits can rapidly turn on a reaction to a proper stimulus, robustly maintain its status, and immediately turn (...) off the reaction when the stimulus disappears. In other words, coupled feedback loops enable cellular systems to produce perfect responses to noisy stimuli with respect to signal duration and amplitude. This suggests that coupled positive and negative feedback loops form essential signal transduction motifs in cellular signaling systems. BioEssays 29: 85–90, 2007. © 2006 Wiley Periodicals, Inc. (shrink)

There is a compassion crisis in healthcare negatively impacting patient outcomes. Little is known about the relationship of love as a motivating factor in healthcare. Our research exploring physician and nurse perspectives on what it means to love their patients elucidated substantive themes. Here we report findings from an exploratory follow-up qualitative study exploring patient perspectives on what it means to be loved by the healthcare team. Through convenience sampling, we conducted 21 structured interviews of patients exiting a family medicine (...) clinic. Nineteen of 21 patients unreservedly thought healthcare professionals should love their patients. Common themes emerged, which included being caring, trustworthy, empathetic, compassionate, conscientious, and a concern for the patient’s well-being. The characteristics and actions that reflect love were remarkably consistent with physician and nurse descriptions in our prior study. The nature of love described by patients, physicians and nurses could serve as a basis for high quality, compassionate, ethically sound healthcare. (shrink)

There is a compassion crisis in healthcare negatively impacting patient outcomes. Little is known about the relationship of love as a motivating factor in healthcare. Our research exploring physician and nurse perspectives on what it means to love their patients elucidated substantive themes. Here we report findings from an exploratory follow-up qualitative study exploring patient perspectives on what it means to be loved by the healthcare team. Through convenience sampling, we conducted 21 structured interviews of patients exiting a family medicine (...) clinic. Nineteen of 21 patients unreservedly thought healthcare professionals should love their patients. Common themes emerged, which included being caring, trustworthy, empathetic, compassionate, conscientious, and demonstrating concern for the patient's well-being. The characteristics and actions that reflect love were remarkably consistent with those mentioned by physicians and nurses in our prior study. The nature of love described by patients, physicians and nurses could serve as a basis for high quality, compassionate, ethically sound healthcare. (shrink)

The result of 2007’s presidential election in South Korea symbolizes the decline of the Left and the growth of the new Right. They say it goes with the global retrogression of democracy, or the consolidation of the hegemony of the rightist versions of democracy. According to Choi Jang-jip, the general public in Korea has thought that the Roh Moo-hyun’s administration had betrayed them, handing power over to the market, and seeking to form a coalition government with theconservatives. Similarly, Professor Jang (...) Ha-jun asserts that the democratic governments of Kim Dae-jung and Roh Moo-hyun have mistaken economic democratization for neo-liberalistic structural adjustment. (shrink)

This paper examines the internal dynamics of Korean political parties to understand why the minority coalition government of Kim Dae-jung suffered from political stalemate or deadlocks in the legislature. It shows that a focus on the size of the government in terms of a majority status in the legislature does not offer a convincing explanation of why the Kim Dae-jung administration slid towards ungovernability. Instead better insights come from an analysis of party organization, an aspect of party politics rarely examined (...) through in-depth analysis. The paper shows that in terms of the key dimensions of organization (leadership type, factionalism, funding, linkage role) Korean political parties fail to connect citizens to the political system. (shrink)

This paper considers the aporia in Dialectic of Enlightenment in two aspects of the self-destruction and self-critique of enlightenment and then emphasizes the dual vision which Horkheimer and Adorno hold on rationality. Firstly, it traces the explanation of the self-destruction of enlightenment so as to make explicit that it results in another form of the aporia, the self-critique of enlightenment. This is followed by formulating the criticism into two aspects, that Horkheimer and Adorno’s aporia leads them to be confronted by (...) a self-contradiction. I argue that the criticism neglects their narrative strategy of history as critique and the methodology of immanent critique of Horkheimer and Adorno. In conclusion, it is elucidated that Horkheimer and Adorno rightly posit their aporia and suggest a proper solution, by which we could take the dual vision on rationality and their own model of immanent critique as its significances. (shrink)

This dialogue addresses the global risk that broke out of the North Korean development of nuclear weapons and missiles. It starts from the brutal consequences of the national division for Korea and asks why North Korea has been so preoccupied with nuclear projects as has been found to be the case since the 1990s, and how much and why Kim Jung-un today differs from his father in terms of his future, and where the fundamental limit lies in Moon Jae-In’s as (...) well as Trump’s approaches to Korean denuclearization and peace. The highlight of this dialogue is to explain the intrinsic difficulties for Donald Trump and Kim Jung-un in finding a reasonable solution to their respective demands for denuclearization and regime security, and explore the likely future of the Korean Peninsula from the vantage point of Kim Dae-jung’s Sunshine Policy and metamorphosis. (shrink)

This eighth volume of Collected Papers includes 75 papers comprising 973 pages on (theoretic and applied) neutrosophics, written between 2010-2022 by the author alone or in collaboration with the following 102 co-authors (alphabetically ordered) from 24 countries: Mohamed Abdel-Basset, Abduallah Gamal, Firoz Ahmad, Ahmad Yusuf Adhami, Ahmed B. Al-Nafee, Ali Hassan, Mumtaz Ali, Akbar Rezaei, Assia Bakali, Ayoub Bahnasse, Azeddine Elhassouny, Durga Banerjee, Romualdas Bausys, Mircea Boșcoianu, Traian Alexandru Buda, Bui Cong Cuong, Emilia Calefariu, Ahmet Çevik, Chang Su Kim, Victor (...) Christianto, Dae Wan Kim, Daud Ahmad, Arindam Dey, Partha Pratim Dey, Mamouni Dhar, H. A. Elagamy, Ahmed K. Essa, Sudipta Gayen, Bibhas C. Giri, Daniela Gîfu, Noel Batista Hernández, Hojjatollah Farahani, Huda E. Khalid, Irfan Deli, Saeid Jafari, Tèmítópé Gbóláhàn Jaíyéolá, Sripati Jha, Sudan Jha, Ilanthenral Kandasamy, W.B. Vasantha Kandasamy, Darjan Karabašević, M. Karthika, Kawther F. Alhasan, Giruta Kazakeviciute-Januskeviciene, Qaisar Khan, Kishore Kumar P K, Prem Kumar Singh, Ranjan Kumar, Maikel Leyva-Vázquez, Mahmoud Ismail, Tahir Mahmood, Hafsa Masood Malik, Mohammad Abobala, Mai Mohamed, Gunasekaran Manogaran, Seema Mehra, Kalyan Mondal, Mohamed Talea, Mullai Murugappan, Muhammad Akram, Muhammad Aslam Malik, Muhammad Khalid Mahmood, Nivetha Martin, Durga Nagarajan, Nguyen Van Dinh, Nguyen Xuan Thao, Lewis Nkenyereya, Jagan M. Obbineni, M. Parimala, S. K. Patro, Peide Liu, Pham Hong Phong, Surapati Pramanik, Gyanendra Prasad Joshi, Quek Shio Gai, R. Radha, A.A. Salama, S. Satham Hussain, Mehmet Șahin, Said Broumi, Ganeshsree Selvachandran, Selvaraj Ganesan, Shahbaz Ali, Shouzhen Zeng, Manjeet Singh, A. Stanis Arul Mary, Dragiša Stanujkić, Yusuf Șubaș, Rui-Pu Tan, Mirela Teodorescu, Selçuk Topal, Zenonas Turskis, Vakkas Uluçay, Norberto Valcárcel Izquierdo, V. Venkateswara Rao, Volkan Duran, Ying Li, Young Bae Jun, Wadei F. Al-Omeri, Jian-qiang Wang, Lihshing Leigh Wang, Edmundas Kazimieras Zavadskas. (shrink)

This article originated in a “cultural futures” course I taught in Seoul in 2007.1 As part of their semester project, students interviewed friends and family to identify futures that were likely to precipitate profound cultural shifts in their lives. Not surprisingly, “Korean unification” was at the top of students’ lists. After all, then-president Roh Moo-hyun had in many ways continued the “Sunshine” policies of his predecessor, President Kim Dae-jung, culminating in a largely symbolic train journey from the South to the (...) North in May 2007 and, perhaps more meaningfully, a new wave of emotional “separated family reunions” (isan’gajok sangbong). But what cultural and societal shifts might unification bring? Here .. (shrink)

We now have a fairly good understanding of the economic causes of the 1977 Asian financial crisis. There is as yet, however, little understanding of the politics behind the crisis. Not only did various political systems in Asia play a significant role in fomenting the crisis, they have also demonstrated remarkable capacities in dealing with its aftermath. Nowhere is this more evident than in the far‐reaching economic reforms implemented by the Kim Dae‐Jung administration in South Korea. The key to Korea's (...) success in weathering the crisis lay in the decisive leadership of Kim Dae‐Jung and in the “developmental state” structures and institutions he inherited—both of which exemplify the autonomy of a putatively democratic state from societal, especially elite, pressures. (shrink)

Given its close ties with Confucianism, East Asian exceptionalism could be defined as the inversion of Max Weber's doctrine that Confucian values inhibit rationality and lead to economic stagnation. That revaluation, which has contributed to an inversion of `Orientalism' as it relates to East Asia, becomes a core premise of what may be called the Singapore model of East Asian development theory. Another premise of that model is the primacy given to economic over political development, i.e., over democracy. In opposition (...) to this reactionary turn, and in the light of current revisionism in Japanese studies, this article follows Kim Dae Jung in positing a `Korean model' which challenges prevailing assumptions of East Asian exceptionalism. It is argued that Korea's record of democratic development over the last 15 years deserves a more affirmative response than has been allowed by some of the most vocal American Koreanists. This model, moreover, affirms Kim's belief in an organic rather than exogenous explanation of Korea's political development. It is argued that Korea, rather than Japan, offers the best available prototype for Asian political development in its `post-exceptional' phase, and that Korea's emerging political culture - in striking contrast to Singapore's - bears witness to the fact that economic development can be consistent with liberal-democratic objectives. In Kim Dae Jung's opposition politics, and now in his presidency, one finds a rare balance of political and economic priorities. In the long run the `Korean Model' could prove far more important for East Asia than anything the IMF has to offer. (shrink)

The Asian Debt Crisis of 1997–2001 led to drastically higher levels of unemployment, resulting in enormous social anxiety and shock. For the first time in its history, South Korea's attention was forcibly drawn to homeless people. Both the new government of the first civilian president, Kim Dae Jung, and an emerging civil society began to pay unprecedented attention to homeless issues. In this new context, homelessness was constructed as a product of the economic crisis. However, although certain homeless men who (...) fit the category of employability and rehabilitation were considered ‘deserving’, long-term street living people and homeless women were disregarded and further marginalized through specific gendered processes. In particular, homeless women were rendered invisible and considered ‘undeserving’ because they fell outside of normative gender expectations, including the idea that a woman's place was in the home, regardless of their ability or desire to work. Building upon ‘needs-talk’ analysis created by Nancy Fraser, this paper exposes the important role of gender norms in the making of a neoliberal welfare citizenship in South Korea, by arguing that the narratives of homeless policy administrators and shelter managers designated homeless women as ‘undeserving’ welfare citizens. (shrink)

"This is a fine volume that clarifies, defends, and moves beyond the views that Kim presented in Mind in a Physical World.

Temporal Changes in Ovarian Gonadotropin-Releasing Hormone mRNA Levels by Gonadotropins in the Rat Sung Ho Lee, Eun-Seob Song, Sun Kyeong Yu, Changmee Kim, Dae Kee Lee, Wan Sung Choi l and Kyungjin Kim* Department of Molecular Biofogy and SRC for Cell Differentiation, Seoul National University, Seoul 150-742, Korea; IDepartment of Anatomy, College of Medicine, Gyeongsanf; National University, Chinju 660-280, Korea (Recei·. cd on December 29, 1993) The present study examines whether gonadotropins are involved in the regulation of ovarian GnRH gene (...) expression and how ovarian GnRH gene expression temporalJy correlates with alterations in hypothalamic GnRH, pituitary LH~ gene expression in respons to gonadotropins. Hypothalamic and ovarian GnRH mRNA and pituitary LH~ mRNA levels were determined by respective RNA-blot hybridizations, and ovarian GnRH and estradiol contents and serum LH levels were measured by respective radioimmunoassays. Three animal models such as 1) PMSG-treated, 2) PMSG and heG-treated immature rats and 3) proestrous stage of adult rats were used. Immature rats (25-days old) were administered with PMSG (10 iu) at 10:00 hand 48 h later with heG (10 iu) to induce ovulation. In the PMSG-injected model, hypothalamic GnRH mRNA levels were markedly augmented about 9-fold at 50 h, and pituitary LH mRNA 3-fold at 52 h after PMSG administration. Serum LH levels were increased to the preovulatory surge levels at 56 h, and ovarian GnRH mRNA levels were augmented 4-fold at 60 h after PMSG injection. Administration of heG also induced a marked enhancement in ovarian GnRH mRNA levels in comparison to the values shown in both intact and PMSGtreated rats at 52 hand 54 h, respectively. In the proestrous stage of normal adult rats, pituitary LH~ mRNA levels were peaked at 16:00 h. The preovulatory LH surge was evident at 4 h before increment in ovarian GnRH mRNA levels as shown in PMSG-treated rats. The present study clearly showed the sequential increase in hypothalamic GnRH mRNA, pituitary LH~ mRNA and ovarian GnRH mRNA levels, indicating that ovarian GnRH may play a possible role in the control of follicular maturation and the ovulation process. (shrink)

We provide new findings that add to the growing body of empirical evidence that important epistemic intuitions converge across cultures. Specifically, we selected three recent studies conducted in the US that reported surprising effects of knowledge attribution among English speakers. We translated the vignettes used in those studies into Mandarin Chinese and Korean and then ran the studies with participants in Mainland China, Taiwan, and South Korea. We found that, strikingly, all three of the effects first obtained in the US (...) also emerged in the East Asian cultures we studied. Our findings not only cohere with but also provide—at least moderate—support for the existence of extensive convergences of important epistemic intuitions across cultures. (shrink)

This paper analyzes and evaluates quine's influential thesis that epistemology should become a chapter of empirical psychology. quine's main point, it is argued, is that normativity must be banished from epistemology and, more generally, philosophy. i claim that without a normative concept of justification, we lose the very concept of knowledge, and that belief ascription itself becomes impossible without a normative concept of rationality. further, the supervenience of concepts of epistemic appraisal shows that normative epistemology is indeed possible.

In “Normativity and Epistemic Intuitions”, Weinberg, Nichols and Stich famously argue from empirical data that East Asians and Westerners have different intuitions about Gettier -style cases. We attempted to replicate their study about the Car case, but failed to detect a cross - cultural difference. Our study used the same methods and case taken verbatim, but sampled an East Asian population 2.5 times greater than NEI’s 23 participants. We found no evidence supporting the existence of cross - cultural difference about (...) the intuition concerning the Gettier car case. Taken together with the failures of both of the existing replication studies, our results provide strong evidence that the purported cross - cultural difference in Gettier intuitions does not exist. (shrink)

Xenophobia is conceptually distinct from racism. Xenophobia is also distinct from nativism. Furthermore, theories of racism are largely ensconced in nationalized narratives of racism, often influenced by the black-white binary, which obscures xenophobia and shelters it from normative critiques. This paper addresses these claims, arguing for the first and last, and outlining the second. Just as philosophers have recently analyzed the concept of racism, clarifying it and pinpointing why it’s immoral and the extent of its moral harm, so we will (...) analyze xenophobia and offer a pluralist account of xenophobia, with important implications for racism. This analysis is guided by the discussion of racism in recent moral philosophy, social ontology, and research in the psychology of racism and implicit attitudes. (shrink)