“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)

Background: Funding organisations and research ethics committees should play a part in strengthening attention to gender equality in clinical research. In the research policy of European Union , funding measures have been taken to realise this, but such measures are lacking in the EU policy regarding RECs.Objective: To explore how RECs in Austria, Germany, Ireland, The Netherlands and Sweden deal with gender equality issues by asking two questions: Do existing procedures promote representation of women and gender expertise in the committee? (...) How are sex and gender issues dealt with in protocol evaluation?Methods: Two RECs were selected from each country. Data were obtained through interviews with key informants and content analysis of relevant documents .Results: All countries have rules to ensure the presence of women on RECs; gender expertise is not required. Drug study protocols are carefully evaluated, sometimes on a formal basis, as regards the inclusion of women of childbearing age. The reason for excluding either one of the sexes or including specific groups of women or making a gender-specific risk–benefit analysis are investigated by some RECs. Such measures are, however, neither defined in the regulations nor integrated in review tools.Conclusions: The RECs investigated in five European member states are found to pay limited attention to gender equality in their working methods and, in particular in protocol evaluation. Policy and regulations of EU are needed to strengthen attention to gender equality in the work of RECs. (shrink)

In this article, we discuss the continued circulation and use of retracted science as a complex problem: Multiple stakeholders throughout the publishing ecosystem hold competing perceptions of this problem and its possible solutions. We describe how we used a participatory design process model to co-develop recommendations for addressing this problem with stakeholders in the Alfred P. Sloan-funded project, Reducing the Inadvertent Spread of Retracted Science (RISRS). After introducing the four core RISRS recommendations, we discuss how the issue of retraction-related stigma (...) gives rise to recommendation #4, Educate stakeholders about retraction and pre- and post-publication stewardship of the scholarly record. This recommendation is important for training publishing professionals and realizing this recommendation will require further collaborative design work across scholarly communications. We highlight ongoing stakeholder work which is now re-starting the design cycle. We conclude with a discussion of ongoing activities facilitating uptake and refinement of RISRS research and the implementation agenda. (shrink)

We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2 < z < 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

There are many connections among artificial intelligence, learning, reasoning and ontologies. The Ontology Summit 2017 explored, identified and articulated the relationships among these areas. As p...

There are many connections among artificial intelligence, learning, reasoning and ontologies. The Ontology Summit 2017 explored, identified and articulated the relationships among these areas. As p...

Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p < 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:186 HISTORY OF PHILOSOPHY direction and made meaningful, whereas for Fichte they are the cognitively recognized goals of human activity. Nonetheless, I still find Lacroix' thoroughgoing teleological interpretation of Kant a bit bothersome, at points strained, although there is little doubt that teleology plays a large part in Kant's thought with respect to the realm of reason. Moreover, I'm not convinced that Kant's thought is as unified and internally (...) consistent as Lacroix would like to find it. In all fairness, however, it should be mentioned that he does not ignore the inconsistencies in Kant's thought. Lacroix' Kant interpretation certainly warrants serious consideration, for it has at least two outstanding features: It makes Kant's doctrine of the noumenal realm much more palatable than most other interpretations. Secondly, it goes a long way toward drawing out the full significance of Kant's comment, "I have therefore found it necessary to deny knowLedr in order to make room for jaith." And it is only by bringing out the significance of this statement that Kant's work can be shown to be primarily metaphysical in intention. Finally, the work's greatest virtue may be that it pulls the shroud of formalism off Kant's thought and shows it to possess a dynamic concern for living man, a concern that few, if any, have seen in it before. Incidentally, Lacroix' book is full of observations on the reception and interpretation of Kant's thought by various twentieth-century French philosophers, and these offer some nice insights into the different directions French thought is taking today. TED B. HUMPHREY Arizona State University Wordsworth--A Philosophical Approach. By Melvin Rader. (Oxford: The Clarendon Press, 1967. Pp. x -4-217.38s.) Wordsworth's poems have brought tears to many a rational mind, but Melvin Rsder manages to keep sane and sober while he expounds the poet's ideas in plain prose and interprets critically the wealth of feeling, imagination, metaphor and myth in which the ideas are clothed. This rendering of Wordsworth's mind is eloquent in its own way, sad performs a useful service to readers who are apt to miss the train of thought within the flow of poetry and of communion with the landscapes of the English Lakes. The analysis shows how, after an early enthusiasm for Locke's and Hartley's "chemistry" of experience, the poet expresses philosophically dimensions of human nature and experience that had been neglected by the more clinical models of "association~sm." Wordsworth's own statement reveals this aspect of his thinking: "Imagination...is that chemical faculty by which elements of the most different nature and distant origin are blended together into one harmonious and homogeneous whole" (p. 139). Here the words "different" and "d'tstant," as Racier points out, exclude the types of association by resemblance and contiguity that are basic to Locke and Hartley. The hberation of Coleridge, and the imaginative transcendence of Wordsworth from these limitations of rationalistic empiricism is a major theme of Rader's work. However, Ruder shows that much of Wordsworth's naturalism is traceable to Hartley's influence. Cudworth's "dynamic idealism" which pictured nature as alive and insisted on the power of ideas, was another major source. Shaftesbury's analysis of the emotional aspects of human nature which his tutor, John Locke, excluded from his Essay because they are not in "the understanding" was also an inspiration to Wordsworth. The definite conversion to transcendentalism was completed by the Kantian romanticists, who suggested to Coleridge that the categorical imperative could be transformed into an a pr/or/gospel. The subsequent divergence of Coleridge and Wordsworth is described in detail by Ruder, and reveals the fact that naturalism retained a stronger hold on Wordsworth than it did on Coleridge. Wordsworth did not follow Coleridge into his romantic spiritual nationalism, but developed a nature-mysticism and "animism" (to use Rader's term). Though this mysticism is not an articulate philosophy, Rader follows it with sympathy and under- BOOK REVIEWS 187 standing. He picks his way philosophicelly ~darough the many preludes, interludes and epilogues of the long, autobiographical poem, The Prelude. He succeeds in interpreting philosophically.Wordsworth's absorption in "the... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:112 HISTORY OF PHILOSOPHY Gallie's Peirce and Pragmatism (1952). She believes that the translation of Peirce's theory of the categories into the conceptual framework of British empiricism and naturalism misrepresents Peirce's cosmology which had very peculiar traits--traits which the author associates with the Platonic tradition. She shows in detail how Peirce tried at first (1868) to relate his three categories to the Scotist, Scholastic, concepts of "essence" and "substance," (...) and how, in his various phaneroscopic experiments, he gradually repudiated the Scholastic languages and by 1902 was ready to interpret his three categories as an adequate ontology. What led Peirce in this direction was his critique of perceptual judgment. He realized that subject and object are in dynamical, social, and historical relation to each other. A logical object is, therefore, also a "dynamic object" or objective. This insight led him at first to regard his doctrine of signs and their interpretation as a humanist or idealist doctrine, for the idealists had also recognized objects as objectives. Nynfa Bosco is quick to appreciate that this interpretation of acts of knowing is closely related to Gentile's idealism. But gradually a more ontological and Platonic interpretation emerges in Peirce, until in the end "thirdness" is a modernist version of the reality of universals. She believes Peirce's greatest achievement was his exposition of "thirdness" as an ontological mediation between modern idealism and Scholastic realism and his theory of evolution as a continuity of physical and mental events. The volume closes with chapters on Peirce's mathematics, ethics, esthetics, philosophy of religion, theology, and psychology. Those chapters are not mere expositions but critical evaluations. To review Nynfa Bosco's criticisms would take us far beyond the limits of an historical review. Suffice it to say that her criticisms are acute as well as sympathetic, and that they reflect well some of the differences between Italian and American tendencies in philosophical analysis. For several reasons, in short, this work deserves to be known internationally. It probably deserves also to be translated, though a translator would find it difficult to maintain the liveliness of her Italian style, which makes reading the book a pleasure as well as an instruction. HERBERT W. SCHNEIDER Claremont, Calilornia L'Iddalism de Lachelier. By Gaston Mauchaussat. (Paris: Presses Universitaires, Biblioth6que de Philosophie Contemporaine [N.F. 18], 1961. Pp. 224.) This is really an intellectual biography of Jules Lachelier (1832-1918); it traces the development of his idealism from 1866 to 1913 and of his moral BOOK REVIEWS I13 philosophy from 1868 to 1918. According to Lachelier himself, there was a significant change in his thinking when, in 1875, he ceased being a teacher, but M. Mauchaussat finds significant elements of the later development even in his earliest works. In general, according to this account, there was a continuous development from subjective to Platonic idealism and from empirical ethics to his axiological theodicy. The documentation and exposition are detailed and precise. The figure of Lachelier emerges as an important historical link between the romantic idealism of the early nineteenth century and the objective value theory or "philosophie de l'esprit" of the twentieth. Though Lachelier himself seems to have forgotten or discounted the early influence on him of Maine de Biran, the author of this biography finds good evidence that his early "Berkeleyan" idealism was derived largely from Maine de Biran and led him to make a careful study of the empirical psychology of thinking and of the importance of habit. D~s 1858, lisant l'introduction du M6moire de Maine de Biran sur l'influence de I'habitude, il en tire cette cons6quence que les esprits ne peuvent d6velopper leurs diverses puissances que par leur union avec le corps et qu'en somme l'homme pense parce qu'il parle (p. 13). It is evident that Lachelier's primary concern was to find in an empirical idealism a mediator between dogmatic naturalism and the equally dogmatic "spiritualism" which the school of Victor Cousin had established in academic circles. It was Ravaisson who guided him in this search. His course at the Ecole Normale Superieur, to which he was called in 1864, gave him an opportunity to work... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 97 Unity and Reform: Selected Writings of Nicholas de Cusa. Edited by John P. Dolan. (Notre Dame, Indiana: University of Notre Dame Press, 1962. Pp. viii -I- 260. $6.50.) This volume was designed to serve both the cause of historical instruction and the cause of "unity and reform" as it has been stimulated by the present ecumenical movement and Council. Professor Dolan's Introduction emphasizes the practical aspects (...) of the Bishop's career, especially his efforts to combat the disintegration of the Respublica Christiana of the fifteenth century. He explains the Bishop's achievements, both ecclesiastical and philosophical, in terms of the problems of his own time. However, the reader soon discovers in the narrative of the Introduction as well as in the selections from Cusanus's works that the current revival of interest in this theologian and philosopher is due to the important bearing which he has on the Catholic efforts toward reunion and reform today. Only Book III of Learned Ignorance is included; then follow in their entirety Concerning Wisdom, The Vision of God or the Icon, Concerning Concord in Religious Belief (De Pace Fidei); and to illustrate Nicholas of Cusa's interest in mathematics and physics, the volume concludes with a dialogue on experiments in weighing. Hrne~a~T W. Sca~NEm~tt Claremont, California La cosmologie de Giordano Bruno. By Paul-Henri Michel. (Paris: Editions Hermann, 1962. Pp. 341.) Malgr~ les excellents travaux d~j~ publi~s (ceux d'Emile Namer, d'Augusto Guzzo et d'autres ~minents sp~cialistes bruniens), Giordano Bruno demeure une figure historique la lois tr~s c~l~bre et bien myst~rieuse au demeurant. L'exceUent ouvrage de Paul-Henri Michel rendra ainsi les plus grands services aux historiens de la pens~e qui se penchent avec curiosit~ sur la d~concertante p~iode de transition qui s~pare les philosophes de la Renaissance de l'av~nement en Europe d'attitudes proprement modernes devant la r~alit~ ext~rieure et l'homme. S'appuyant sans cesse sur les textes originaux de Bruno lui-mdme, pourvu d'un index complet, le bel ouvrage du Pr. Michel ne d~cevru passes lecteurs ~xudits. Comme il se dolt, rauteur commence par faire le point sur l'homme Bruno, s'attachant faire la distinction qui s'impose entre l'histoire et la l~gende--car la k~gende s'est empar ~e de ce philosophe, consid~r~ volontiers comme un athfie materialiste total ayant voulu d~truire la religion catholique, attitude louse ou vilipendfie selon clue Bruno sera vu comme un h~r~tique pervers ou, au contraire, comme un glorieux martyr de la "librepens ~" rationaliste. On appr~.iera tout sp~cialement les pages (p. 10 et suivantes) darts lesquelles M. Michel s'efforce de faire toute la lumi~re ~, propos du proc~s ecd~iastique de Giordano Bruno--sur lequel toute la lumi~re souhaitable n'avait pas encore ~t~ faite. Mais la majeure paxtie du volume est consacr~e ~ un expos~ m~thodique du syst~me du monde, telle clue l'~tude minutieuse de tousles textes accessibles permet de le structurer. En dix chapitres, l'auteur passe minutieusement--mais toujours d'une mani~re remarquablement logique et claire--les grandes articulations autour desquelles tourne toute la cosmologie brunienne: Le monde comme objet de connaissance, Cosmogonic, Ens mobile, LAme du Monde, La mati~re et l'univers infini, Le systkme solaire, Les mondes innombrables, L'univers vivant, Temps et dternit~. Le grand nombre des citations ~tendues faisant de cette belie ~tude une sorte de fort commode anthologie m~thodique de la pens~e brunienne. 98 HISTORY OF PHILOSOPHY I1 est incontestable que nous autres contemporains sommes toujours endins 5. voir en Giordano Bruno un penseur franchement "moderne," et le fait est qu'il brave volontiers, prenant intrdpidement parti pour le syst~me de Copernic, la philosophie scolastique et la th~ologie scripturaire; son grandiose hymne mdtaphysique 5. l'infini de l'univers et 5. la r6partition innombrable des syst~mes plan~taires rend be1 et bien un son r~volutionnaire pour son temps. Ce n'est d'ailleurs pas pour rien que Bruno rut mis 5. l'index pour... (shrink)

Recent studies in semantics of modal and superintuitionistic predicate logics provided many examples of incompleteness, especially for Kripke semantics. So there is a problem: to find an appropriate possible- world semantics which is equivalent to Kripke semantics at the propositional level and which is strong enough to prove general completeness results. The present paper introduces a new semantics of Kripke metaframes' generalizing some earlier notions. The main innovation is in considering "n"-tuples of individuals as abstract "n"-dimensional vectors', together with some (...) transformations of these vectors. Soundness of the semantics is proved to be equivalent to some non- logical properties of metaframes; and thus we describe the maximal semantics of Kripke- type. (shrink)

We report the results of a randomized trial to assess the impact of an innovative ethics curriculum on the knowledge and confidence of 85 medical house officers in a university hospital programme, as well as their responses to a simulated clinical case. Twenty-five per cent of the house officers received a lecture series, 25 per cent received lectures and case conferences, with an ethicist in attendance, and 50 per cent served as controls. A post-intervention questionnaire was administered. Knowledge scores did (...) not differ among the groups. Confidence regarding ethical issues was significantly greater in the aggregate intervention group compared to the control group. Confidence regarding procedural issues related to ethics was significantly higher for the EI group than for the controls. Responses to a simulated case showed that significantly fewer house officers in the EI group would intubate a patient for whom such therapy would be futile. We conclude that ethics education can have an impact on house officers' confidence and their responses to a simulated case, and that the EI was more effective than the LI. Such results have implications regarding the implementation of ethics education during residency. (shrink)

Many medical ethicists accept the thesis that there is no moral difference between withholding and withdrawing life-sustaining therapy. In this paper, we offer an interesting counterexample which shows that this thesis is not always true. Withholding is distinguished from withdrawing by the simple fact that therapy must have already been initiated in order to speak coherently about withdrawal. Provided that there is a genuine need and that therapy is biomedically effective, the historical fact that therapy has been initiated entails a (...) claim to continue therapy that cannot be attributed to patients who have not yet received therapy. This intrinsic difference between withholding and withdrawing therapy is of moral importance. In many instances, patients will waive this claim. But when one considers withdrawing therapy from one patient to help another in a setting of scarce resources, this intrinsic moral difference comes into sharp focus. In an era of shrinking medical resources, this difference cannot be ignored. (shrink)

Ethical decision making measures are widely applied as the principal dependent variable used in studies of research integrity. However, evidence bearing on the internal and external validity of these measures is not available. In this study, ethical decision making measures were administered to 102 graduate students in the biological, health, and social sciences, along with measures examining exposure to ethical breaches and the severity of punishments recommended. The ethical decision making measure was found to be related to exposure to ethical (...) events and the severity of punishments awarded. The implications of these findings for the application of ethical decision making measures are discussed. (shrink)

First published in 1966. Professor Dryer has furnished a highly illuminating account of Kant’s _Critique of Pure Reason _by unfolding its central argument. _Kant’s Solution for Verification in Metaphysics _brings out the light which Kant has to throw on central topics of philosophy. It takes its place as an indispensable guide to every student of the _Critique of Pure Reason. _.

In a recent article in this journal our unit was accused of a number of errors of judgment in applying covert video surveillance (CVS) to infants and children suspected of life-threatening abuse. The article implied, that on moving from the Royal Brompton Hospital in London to North Staffordshire Hospital, we failed to present our work to the Research Ethics Committee (REC). We did send our protocol to the REC though we did not consider that, after a total of 16 patients (...) had been documented as being the subject of life-threatening abuse, this was research. The REC in Staffordshire agreed with us. We were also accused of undertaking work that should be pursued by the Police. We agree with this. However, unlike the Metropolitan Police the Staffordshire Police would not undertake CVS. We fail to agree that 'working together' with parents is necessarily practical or safe when trying to protect children from life-threatening abuse of this kind. (shrink)

A recently formulated concept of stochastic localizability is shown to be consistent with a concept of stochastic microcausality, which avoids the conclusions of Hegerfeldt's no-go theorem as to the inconsistency of sharp localizability of quantum particles and Einstein causality. The proposed localizability on quantum space-time is shown to lead to strict asymptotic causality. For finite time evolutions, upper bounds on propagation to the exterior of stochastic light cones are derived which show that the resulting probabilities are too small to be (...) actually observable in a realistic context. (shrink)

A laboratory-testable, solid-state Maxwell demon is proposed that utilizes the electric field energy of an open-gap p-n junction. Numerical results from a commercial semiconductor device simulator (Silvaco International–Atlas) verify primary results from a 1-D analytic model. Present day fabrication techniques appear adequate for laboratory tests of principle.

Anselm saw theology as fides quaerens intellectum, faith searching for understanding. Theology concerns itself with human awareness of something that transcends humanity. It starts where we are and involves a given-ness which forms its fundamental basis. Human experience or awareness of God is interpreted from within this agreed framework. Theology is a way of experiencing and interpreting life but it is also dynamic body of knowledge. Within the Christian tradition, this can be seen in the theologies from the so-called ‘margins’. (...) The study of such a dynamic body of knowledge has been the concern of theology and religious studies degree programmes in modern Universities. Theology is however, not the preserve of the elite professionals. The professional theologians need to stand alongside ordinary people and learning from their experiences as much as theirs. (shrink)

This paper considers the research contribution of OCMS as reflected in the theses presented for higher degrees by its students. This does not therefore include the very significant research productivity of OCMS staff. The OCMS processes and procedures for admitting, supervising and examining research students are first reviewed. The statistical evidence relating to successful completions is then presented and analysed. The scope of the research undertaken is examined in relation to the stated aims of OCMS, and this leads to the (...) conclusion that in general these aims have been impressively met, both academically and in serving the needs of the worldwide Church. (shrink)

We argue that artificial networks are explainable and offer a novel theory of interpretability. Two sets of conceptual questions are prominent in theoretical engagements with artificial neural networks, especially in the context of medical artificial intelligence: Are networks explainable, and if so, what does it mean to explain the output of a network? And what does it mean for a network to be interpretable? We argue that accounts of “explanation” tailored specifically to neural networks have ineffectively reinvented the wheel. In (...) response to, we show how four familiar accounts of explanation apply to neural networks as they would to any scientific phenomenon. We diagnose the confusion about explaining neural networks within the machine learning literature as an equivocation on “explainability,” “understandability” and “interpretability.” To remedy this, we distinguish between these notions, and answer by offering a theory and typology of interpretation in machine learning. Interpretation is something one does to an explanation with the aim of producing another, more understandable, explanation. As with explanation, there are various concepts and methods involved in interpretation: Total or Partial, Global or Local, and Approximative or Isomorphic. Our account of “interpretability” is consistent with uses in the machine learning literature, in keeping with the philosophy of explanation and understanding, and pays special attention to medical artificial intelligence systems. (shrink)