Through statistical analysis of datasets describing single cell shape following systematic gene depletion, we have found that the morphological landscapes explored by cells are composed of a small number of attractor states. We propose that the topology of these landscapes is in large part determined by cell‐intrinsic factors, such as biophysical constraints on cytoskeletal organization, and reflects different stable signaling and/or transcriptional states. Cell‐extrinsic factors act to determine how cells explore these landscapes, and the topology of the landscapes themselves. Informational (...) stimuli primarily drive transitions between stable states by engaging signaling networks, while mechanical stimuli tune, or even radically alter, the topology of these landscapes. As environments fluctuate, the topology of morphological landscapes explored by cells dynamically adapts to these fluctuations. Finally we hypothesize how complex cellular and tissue morphologies can be generated from a limited number of simple cell shapes. (shrink)

Dozens of countries have established Sovereign Wealth Funds (SWFs) in the last decade or so, in the majority of cases employing those funds to manage the large revenues gained from selling resources such as oil and gas on a tide of rapidly rising commodity prices. These funds have raised a series of ethical questions, including just how the money contained in such funds should eventually be spent. This article engages with that question, and specifically seeks to connect debates on SWFs (...) with debates onglobaljustice. Just how good are national claims to the great wealth contained in SWFs in the first place? Using the example of Norway's very large SWF – derived from selling North-Sea petroleum – I show that national claims are at least sometimes very weak, with the implication that the wealth in many such funds is ripe for redistribution in the interests of global justice. I conclude by offering some guidance for how the money contained in such funds could best be spent, with the goal of advancing global justice. (shrink)

According to Elizabeth Barnes’s minority body view, to say that a disability is value neutral is to say that it is neither automatically good nor bad, but rather can become good or bad depending on what it is combined with (including ableism and one’s aspirations, goals, and desires). Most people view dementia as intrinsically bad, that is, as something that makes one’s life go worse simply by its existence. In this paper, I argue that we are not currently able to (...) decide if dementia is value neutral or intrinsically bad. Arguments that say dementia is intrinsically bad are beset with problems such as negative feedback loops and a reliance on biased empirical evidence. Moreover, there are promising examples of people whose dementia is combined with certain traits that make their dementia good for them, which would undermine the intrinsic badness of dementia. (shrink)

This updated essay expands on the author's analysis of the complex social and psychological reasons for the inadequate response to the climate emergency. Recent reports by climate scientists quoted in the article suggest that the pace of climate change has already reached the point of irreversibility, triggering multiple tipping points with catastrophic implications for the future of life on this planet. Yet climate change denial, which as the author explains, takes many forms itself, both aggressive and passive, remains common at (...) all levels of human society, hindering effective action. Nevertheless, citing the growing number of legal cases being brought against both fossil fuel industries and state governments for not taking sufficient and verifiable measures for dealing with the crisis, the author finds positive signs that justice may be finally catching up with the culpable parties in both sectors. (shrink)

The impact of neoliberal reforms of education systems on the work of teachers and school leaders, particularly in relation to high-stakes accountability frameworks, has been extensively studied in recent decades. One significant aspect of neoliberal schooling is the emergence of quasi-autonomous public schools (such as Academies in England, Charter Schools in the USA and Independent Public Schools in Australia), characterised by heterarchical governance models, the promotion of entrepreneurial leadership cultures, and the promotion of a discourse of pursuing educational equity by (...) means of ‘achievement for all’. This paper explores the emergence of a mode of teacher professionalism characteristic of these quasi-autonomous schools, and conceptualises this as being ‘neo-performative’. The neo-performative profession is shaped by the shift in the focus of the regulation and management of schools from ‘governing to governance’, and the consequential rise of the ‘responsibilised profession’, and marked by the emergence of an entrepreneurial model of school leadership. The paper argues that this new conceptualisation of teacher professionalism requires further, more focused, empirical study in order to explore how neoperformative teachers and school leaders articulate their vision of educational equity and social justice, and how they enact this vision in an increasingly intensified high-stakes accountability culture. (shrink)

The Idea of Justice" summarizes and extends many of the themes Amartya Sen has been engaged with for the last quarter century: economic versus political rights, cultural relativism and the origin of notions such as human rights, and entitlements and their relation to gender equality.

States claim the right to choose who can come to their country. They put up barriers and expose migrants to deadly journeys. Those who survive are labelled ‘illegal’ and find themselves vulnerable and unrepresented. The international state system advantages the lucky few born in rich countries and locks others into poor and often repressive ones. In this book, Christopher Bertram skilfully weaves a lucid exposition of the debates in political philosophy with original insights to argue that migration controls must be (...) justifiable to everyone, including would-be and actual immigrants. Until justice prevails, states have no credible right to exclude and no-one is obliged to obey their immigration rules. Bertram’s analysis powerfully cuts through the fog of political rhetoric that obscures this controversial topic. It will be essential reading for anyone interested in the politics and ethics of migration. (shrink)

Given the irrationality and failures of human behaviour in the face of ecocide, the majority of humankind appears either unable or unwilling to change self-destructive ways of life. Rejecting common accounts, the author suggests that the reasons for our stubborn resistance to change go well beyond cognitive dissonance or any standard political and economic explanations. Nor is the answer to be found in human history alone. The driving forces underlying that resistance, the author argues, originate far back in evolutionary time (...) to the impulses governing all sentient creatures. -/- NB: The copy of this article is the final, pre-production version of the article published in the Architectural Research Quarterly. (shrink)

This response to insightful commentaries on my book, from Richard Shusterman, Susan Dieleman, Raff Donelson, and Colin Koopman, takes up the recurring theme of the nature of normativity on a Rortyan view. To frame my individual replies, I revisit the Davidsonian account of epistemic interaction that influences Rorty’s mature view and suggest that the norms implicit in Davidsonian triangulation are insufficient to support Rorty’s antiauthoritarianism in ethics and epistemology. To address the resulting question of how to account for norms of (...) responsibility and obligation within Rorty’s thought, I highlight key strands of the pragmatic tradition, originating with Peirce but extending through James, Addams, and Dewey, that Rorty reconstructs in the process of developing the full implications of prioritizing democracy over philosophy. (shrink)

Three new books by Martha Nussbaum, Jeff Sebo, and Mark Rowlands seek to raise the profile of non-human animals within political theory. They present a series of compelling arguments for making animal flourishing central to discussions about the future, especially in a time of ecological crisis. All three offer important insights into what a genuinely non-anthropocentric political theory could look like. But while they converge in some ways – for instance, all recommend serious restrictions on the human industries that brutalise (...) other animals – they also paint quite different visions of the proper relationship between humans and other animals. This review essay assesses their distinctive visions of the future of human-animal relations. (shrink)

The original article was published without an acknowledgment section. The complete acknowledgment section is given.

Music’s sanctioned role in the day-to-day running of the ‘late-modern’ prison is to ensure wellbeing and compliance of prisoners, with most regimes facilitating access to music through the form of radios, cd’s, and cassette players. As a result, music often comes tied to judgements by the regime about prisoners’ conduct, with incentive systems allowing the regime to confiscate earned possessions under certain conditions. In this way, the role of music in prison is often continuous with the mechanisms of carceral control, (...) with its ‘humanising’ or ‘therapeutic’ effects being defined as a luxury to be earned through good behaviour and critical engagement with one’s moral and psychological treatment. By tracing the history of music during the birth of the modern prison in the nineteenth century, this paper asks how music became incorporated into the discourse and technology of the emerging carceral state. Drawing principally on the work of Michel Foucault, this paper seeks to explore the relationship between music and ‘the self’ as it is applied to carceral subjects. Foucault shows how the expansion of the carceral state at the end of the nineteenth century relied on the production of knowledge about the subject through the application of disciplinary techniques. By exploring the construction of the self through the discourse of music at the end of the eighteenth century and in the published works of carceral reformers at the end of the nineteenth century, this paper seeks to explore the role that music played within this period of carceral expansion. The discussion will focus on the ways in which music acts as a conduit for forms of carceral power through its relationship with the self. (shrink)

The sacrifices of nurses in hard-hit cities during the early stages of the COVID-19 pandemic and of family caregivers for people with late-stage Alzheimer’s disease present two puzzles. First, traditional accounts of supererogation cannot allow for the possibility of making enormous sacrifices that make one’s actions supererogatory simply to do what morality requires. These caregivers, however, are doing their moral duty, yet their actions also seem to be paradigmatic cases of supererogation. I argue that Dale Dorsey’s new account of supererogation (...) can solve this puzzle. Second, these caregivers often deny that they are heroic, but standard explanations of these assertions either diminish their sacrifice, say they are confused, or attribute to them a vice. If we want to understand them without diminishing them, we should instead see their denials as a response to what Beth DeVolder calls compulsory heroism. Compulsory heroism occurs when someone is foisted into the role of hero for doing their moral duty as a distraction from the social realities that make doing their duty involve inordinate sacrifice. (shrink)

Global distributive justice is now part of mainstream political debate. It incorporates issues that are now a familiar feature of the political landscape, such as global poverty, trade justice, aid to the developing world and debt cancellation. This is the first textbook to focus exclusively on issues of distributive justice on the global scale. It gives clear and up-to-date accounts of the major theories of global justice and spells out their significance for a series of important political issues, including climate (...) change, international trade, human rights and migration. These issues are brought to life through the use of case studies, which emphasise the connection of theories of justice to contemporary politics, and 'Further Issues' sections, which discuss emerging debates or controversies that are likely to command increasing attention in the coming years. (shrink)

What is the communicative value of negative polarity? That is, why do so many languages maintain a stock of special indefinites that occur only in a proper subset of the contexts in which ordinary indefinites can appear? Previous answers include: marking the validity of downward inferences; marking the invalidity of veridical inferences; or triggering strengthening implications. My starting point for exploring a new answer is the fact that an NPI must always take narrow scope with respect to its licensing context. (...) In contrast, ordinary indefinites are notorious for taking wide scope. So whatever other functions NPIs may have, they at least serve as an utterly reliable signal that an indefinite is taking narrow scope. As also proposed in recent work of Kusumoto and Tancredi, I will show that NPIs are only licensed in contexts in which the wide scope construal of an indefinite fails to entail the narrow scope. In other words, weak NPIs occur only in contexts in which taking narrow scope matters for interpretation. Thus one part of the explanation for the ubiquity and robust stability of negative polarity is that it signals scope relations. (shrink)

In recent years, the target of reaching “net zero” emissions by 2050 has come to the forefront of global climate politics. Net zero would see carbon emissions matched by carbon removals and should allow the planet to avoid dangerous climate change. But the recent prominence of this goal should not distract from the fact that there are many possible versions of net zero. Each of them will have different climate justice implications, and some of them could have very negative consequences (...) for the world's poor. This article demonstrates the many ambiguities of net zero, and argues in favor of a net zero strategy in which those who can reasonably bear the burden adopt early and aggressive mitigation policies. We also argue for a net zero strategy in which countries place the lion's share of their faith in known emissions reduction approaches, rather than being heavily reliant on as-yet-unproven “negative emissions techniques.” Our overarching goal is to put net zero in its place, by providing a clear-sighted view of what net zero will achieve, and where the “net” in net zero needs to be tightened further if the world is to achieve climate justice. (shrink)

When the history of life on earth is viewed as a history of cell division, all of life becomes a single cell lineage. The growth and differentiation of this lineage in reciprocal interaction with its environment can be viewed as a developmental process; hence the evolution of life on earth can also be seen as the development of life on earth. Here, in reviewing this field, some potentially fruitful research directions suggested by this change in perspective are highlighted. Variation and (...) selection become, for example, bidirectional information flows between scales, while the notions of “cooperation” and “competition” become scale relative. The language of communication, inference, and information processing becomes more useful than the language of causation to describe the interactions of both homogeneous and heterogeneous living systems at any scale. Emerging scale‐free theoretical frameworks such as predictive coding and active inference provide conceptual tools for reconceptualizing biology as the study of a unified, multiscale dynamical system. (shrink)

This book examines the way in which new discoveries about genetic and neuroscience are influencing our understanding of human behaviour. As scientists unravel more about the ways in which genes and the environment work together to shape the development of our brains, their studies have importance beyond the narrow confines of the laboratory. This emerging knowledge has implications for our notions of morality and criminal responsibility. The extent to which "biological determinism" can be used as an explanation for our behaviour (...) is of interest to philosophers reflecting on the free will versus determinism debate. It also has repercussions for the criminal justice system; in courtrooms around the world, defence lawyers are beginning to appeal to genetic and brain imaging data as grounds for finding their clients not guilty. Can a defendant's genes or the structure of his brain be used as an excuse for his behaviour? Is criminality "hardwired"? Is it legitimate to claim "I couldn't help it, my genes made me do it"? This book appeals to anyone interested in the link between behaviour and genetics, the science and philosophy of moral responsibility and/or criminal law. (shrink)

In the ‘ordinary business of life’, everyone makes claims about what there is. For instance, we say things like: ‘There are some beautiful chairs in my favourite furniture shop’. Within the context of philosophical debate, some philosophers also make claims about what there is. For instance, some ontologists claim that there are chairs; other ontologists claim that there are no chairs. What is the relation between ontologists’ philosophical claims about what there is and ordinary claims about what there is? According (...) to Cian Dorr, ontologists’ claims and denials of existence belong to ‘a sort of professional jargon’. Dorr claims, for example, that ‘There are prime numbers between 20 and 30’ can be used superficially or used fundamentally. Ordinary uses of are superficial: we use the sentence to assert a boring, well-known truth. But in the ontology room, is used fundamentally, to assert that numbers are ‘part of the ultimate furniture of reality’: and this is a substantial metaphysical doctrine, not a boring truth. In this paper, we will show that none of Dorr’s arguments for these claims succeeds. (shrink)

... and the baby has a large VSD. Otherwise appears well, gaining weight, smiling. No apnea, never been on ventilator. Local cardiac surgeon refused to operate, saying that surgery would be inappropriate. Have reached out to other centers, and some state that they never perform what they said was “futile” heart surgery on children with Trisomy 18, while other sites say they have and will continue to perform these operations. Can someone explain to me what is going on? In the (...) realm of medical care—given enough patients, clinicians, and time—conflict is inevitable. Someone will want to do something, such as give a drug or start a new form of technologic support, and someone else will think that this is a... (shrink)

ABSTRACTIn 1991 the Dutch government released the results of the first national investigation into the nature and extent of decisions concerning end of life including euthanasia. A significant finding was that most cases of euthanasia were not reported. This prompted us to ask what effect, if any, not reporting caused. More specifically, we asked whether reporting has a positive or negative impact on the experiences of friends or relatives of patients who have received euthanasia. In cases of euthanasia, complications of (...) both process and experience can deter from a minimally complicated death. These difficulties arise when either the family or physician does not perceive the freedom to disclose euthanasia openly. On the basis of interviews with family members and patients, we illustrate that they generally benefit from reporting. Our premise is that reporting fosters open discussion of euthanasia. We further suggest physicians and society benefit from a milieu of openness initiated by reporting cases of euthanasia. (shrink)

Pessimism about the stability of intra-personal relationships runs deeply in the philosophy of Jean-Paul Sartre. I begin by examining how this pessimism arises from Sartre’s ontology, particularly considering the attitude of love towards the Other. I then suggest that there may be space within Sartre’s philosophy for a defense of love as a positive relation to the Other which need not be destined to cycle into attitudes toward the Other such as hate or masochism.

It is a real pleasure to reply to so many thoughtful and probing responses to my book. In what follows, I will focus on six key themes that emerge across the various pieces. Some of them call into question core commitments of my theory, and in those cases I will try to show what might be said in its defence. Quite a number of the critics, however, present what we might call expansionist arguments: though they endorse some of the arguments (...) I make, that is – or pick up some of its key concepts – they seek to push them in new and interesting directions. I will suggest that many of those arguments look likely to be successful, though I will also express caution about one or two of them. I doubt, however, that I will be the final judge of their success. Early on in the book I express the hope that it might provide a set of conceptual tools capable of advancing discussions about resource justice more broadly, even for scholars who reject my own idiosyncratic approach. Having made that gambit, I cannot now claim to have a monopoly on the use of the tools in question. Witnessing the use that others have already made of them has been a refreshing and rewarding experience. (shrink)

Lambek elegantly characterized part of natural language. As is well-known, his substructural logic L, and its non-associative version NL, handle basic function/argument composition well, but not scope taking and syntactic displacement—at least, not in their full generality. In previous work, I propose $$\text {NL}_\lambda $$, which is NL supplemented with a single structural inference rule (“abstraction”). Abstraction closely resembles the traditional linguistic rule of quantifier raising, and characterizes both semantic scope taking and syntactic displacement. Due to the unconventional form of (...) the abstraction inference, there has been some doubt that $$\text {NL}_\lambda $$ should count at a legitimate substructural logic. This paper argues that $$\text {NL}_\lambda $$ is perfectly well-behaved. In particular, it enjoys cut elimination and an interpolation result. In addition, perhaps surprisingly, it is decidable. Finally, I prove that it is sound and complete with respect to the usual class of relational frames. (shrink)

Journal of Social Philosophy, Volume 52, Issue 1, Page 10-16, Spring 2021.

Hope is like water, existing in different states, exhibiting different properties.In the solid form, hope is manifest as specific hopes: I hope for this, I hope for that. In these concrete forms, solidified hope can become firm and fixed, for better and for worse. Dogged determination aimed at achieving a fixed hope is a very good characteristic—that is, until the continued pursuit of this specific solid hope becomes foolish, harmful, unwise. At the other end of the spectrum, in the gaseous (...) form, hope is amorphous, a glowing feeling that one has to tune into to detect, akin to optimism. In between these two states, hope is liquid. Flowing. Assuming the shape of whatever holds it. Carving, eroding, even dissolving.. (shrink)

Classical deviance theories about metaphor argue that the metaphorical sense of a word or expression, w, deviates from the sense of the word or expression interpreted literally. Developments in lexical pragmatics challenge these theories by claiming that deviance pervades (nearly) all aspects of linguistic communication. If deviance is the norm, then classical explanans offer little to no insight. In fact, many theorists have abandoned the idea of the literal-metaphorical distinction. This move carries significant consequences for theories of language and communication. (...) We argue against this move and in favour of a linguistically robust literal-metaphorical distinction. We have three goals: The first is to argue that the literal-metaphorical distinction is important for theories of language and communication. The second is to assess Allott and Textor’s Non-Conformity View of deviance which gives up the idea that deviance is marked by a departure from conventional word meaning. Pace Allott and Textor, we claim that the literal-metaphorical distinction must ultimately be couched in some account of lexicalised meaning. Our third goal is to develop a form of qualified deviance that avoids what we take to be shortcomings of the Non-Conformity View. (shrink)

Calling someone fat is not only cruel and unkind—it also subordinates them. While the sharpest and most immediate harms of fatphobic bullying are emotional and psychological, these vary according to the resilience of the target. What one person can laugh off, another feels deeply, perhaps for years. But ‘fat-calling’ does not only have individual harms—it also perpetuates a subordinating social structure ranking fat people as inferior. Despite recent work on obesity and fatphobia, the conversational dynamics of ascribing fatness to someone (...) else (rather than oneself) are relatively unexplored, especially in philosophy. This paper argues that fat-calling assigns its target a subordinate discourse role, constraining their subsequent conversational behaviour and permitting further discriminatory behaviour from interlocutors. And these conversational norm-changes alter the initial permissibility conditions of future conversations to the detriment of fat people. This is not to say that fat-calling is morally equivalent to slurs and hate speech—but it does show that it leverages similar conversational mechanisms to entrench injustice. (shrink)

Metaphilosophy, Volume 53, Issue 2-3, Page 185-198, April 2022.

This article looks at how the category of female fighters in the Sierra Leone civil war (1991–2002) was interpreted by the local population and by the international humanitarian community. The category of the female fighter both challenges and confuses the gendered stereotypes of ‘woman the victim’ and ‘man the perpetrator’ on multiple levels. Most research on ‘women and war’ focuses on women either as inherently more peaceful or merely as victims, and often unwittingly reproduces in ‘war-affected women’ a corresponding lack (...) of ‘agency’. In this article, I criticize such theorizing by demonstrating the diversity and specificity of Sierra Leonean women's war experiences, while also examining how the notion of and discourse about war itself is gendered. While it has become necessary to expand the inquiries into what women do in war and to critically analyse women's roles as perpetuators and perpetrators of war and conflict, this article maintains that in situations where one can talk about the violence of women, as in the example of female combatants, one often finds violence against women as well. (shrink)