IntroductionAutism spectrum disorder is a highly heterogeneous diagnosis. When a child is referred to autism services or receives a diagnosis of autism spectrum disorder it is not known what their potential adult outcomes could be. We consider the challenge of making predictions of an individual child’s long-term multi-facetted adult outcome, focussing on which aspects are predictable and which are not.MethodsWe used data from 123 adults participating in the Autism Early Diagnosis Cohort. Participants were recruited from age 2 and followed up (...) repeatedly through childhood and adolescence to adulthood. We predicted 14 adult outcome measures including cognitive, behavioral and well-being measures. Continuous outcomes were modeled using lasso regression and ordinal outcomes were modeled using proportional odds regression. Optimism corrected predictive performance was calculated using cross-validation or bootstrap. We also illustrated the prediction of an overall composite formed by weighting outcome measures by priorities elicited from parents.ResultsWe found good predictive performance from age 9 for verbal and non-verbal IQ, and daily living skills. Predictions for symptom severity, hyperactivity and irritability improved with inclusion of behavioral data collected in adolescence but remained modest. For other outcomes covering well-being, depression, and positive and negative affect we found no ability to predict adult outcomes at any age. Predictions of composites based on parental priorities differed in magnitude and precision depending on which parts of the adult outcome were given more weight.ConclusionVerbal and non-verbal IQ, and daily living skills can be predicted well from assessments made in childhood. For other adult outcomes, it is challenging to make meaningful predictions from assessments made in childhood and adolescence using the measures employed in this study. Future work should replicate and validate the present findings in different samples, investigate whether the availability of different measures in childhood and adolescence can improve predictions, and consider systematic differences in priorities. (shrink)

The purpose of cause-related marketing (CRM) is to publicise and capitalise on a firm's corporate social performance (CSP) by enhancing its legitimacy in the eyes of its stakeholders. This study focuses on the firm's internal stakeholders - i.e. its employees - and the extent of their involvement in the selection of social campaigns. Whilst the difficulties of managing a firm that has lost or damaged its legitimacy in the eyes of its employees are well known, little is understood about the (...) extent to which managers and their social partners listen to and involve their employees in the legitimation process. Through telephone interviews with non-profit organisations and senior managers of service sector firms, the extent of employee involvement in CRM campaigns and the perceived benefits of doing so are investigated. Amongst other things, we find that (i) the extent of employee participation varies significantly across firms; (ii) larger CRM campaigns tend to be managed centrally with relatively less employee participation than smaller ones and (iii) financial services firms are more likely to make CRM decisions centrally, with relatively less employee participation than retail services firms. (shrink)

CRISPR‐Cas technology accelerates development of fast, accurate, and portable diagnostic tools, typified by recent applications in COVID‐19 diagnosis. Parasitic helminths cause devastating diseases afflicting 1.5 billion people globally, representing a significant public health and economic burden, especially in developing countries. Currently available diagnostic tests for worm infection are neither sufficiently sensitive nor field‐friendly for use in low‐endemic or resource‐poor settings, leading to underestimation of true prevalence rates. Mass drug administration programs are unsustainable long‐term, and diagnostic tools – required to be (...) rapid, specific, sensitive, cost‐effective, and user‐friendly without specialized equipment and expertise – are urgently needed for rapid mapping of helminthic diseases and monitoring control programs. We describe the key features of the CRISPR‐Cas12/13 system and emphasise its potential for the development of effective tools for the diagnosis of parasitic and other neglected tropical diseases (NTDs), a key recommendation of the NTDs 2021–2030 roadmap released by the World Health Organization. (shrink)

An alternative to objectifying approaches to understanding Post-traumatic Stress Disorder grounded in hermeneutic phenomenology is presented. Nurses who provided care for soldiers injured in the Iraq and Afghanistan wars, and sixty-seven wounded male servicemen in the rehabilitation phase of their recovery were interviewed. PTSD is the one major psychiatric diagnosis where social causation is established, yet PTSD is predominantly viewed in terms of the usual neuro-physiological causal models with traumatic social events viewed as pathogens with dose related effects. Biologic models (...) of causation are applied reductively to both predisposing personal vulnerabilities and strengths that prevent PTSD, such as resiliency. However, framing PTSD as an objective disease state separates it from narrative historical details of the trauma. Personal stories and cultural meanings of the traumatic events are seen as epiphenomenal, unrelated to the understanding of, and ultimately, the therapeutic treatment of PTSD. Most wounded service members described classic symptoms of PTSD: flashbacks, insomnia, anxiety etc. All experienced disturbance in their sense of time and place. Rather than see the occurrence of these symptoms as decontextualized mechanistic reverberations of war, we consider how these symptoms meaningfully reflect actual war experiences and sense of displacement experienced by service members. (shrink)

When we see a child crying, the urge to help him and to comfort him comes to us spontaneously. We understand what he is experiencing, and feel in us something of his sadness, his distress: this is what we call empathy. This sense of the other is the fruit of our evolutionary history and is hardwired in our biology. Empathy has interested a lot of thinkers and in particular the Scottish philosophers of the Age of the Enlightenment such as Adam (...) Smith or Hume. More recently, the philosophers Robert Gordon and Alvin Goldman proposed the theory of simulation according to which when we understand the other, we simulate the other’s point of view and we use this prospective to understand the other and predict his behavior. The French neuropscyhologist Jean Decety adopted this point of view. He specifies that the empathy is the capacity to mentally simulate the subjectivity of the other, to put ourselves in the shoes of another: it lies on biological systems. (shrink)

Comment la philosophie de Hegel pourrait-elle encore promettre quelque chose puisqu'elle est apparue, aux yeux des lecteurs contemporains, comme une entreprise d'annulation du temps? Le savoir absolu n'est-il pas le resultat du processus dialectique par lequel l'esprit releve toute temporalite et par la toute surprise, l'evenement se produisant toujours trop tard? D'une absence de pensee de l'avenir dans la philosophie de Hegel decoulerait une absence d'avenir de la philosophie hegelienne elle-meme. C'est contre une telle assertion que le present ouvrage s'inscrit (...) en faux; il se propose pour cela de travailler le concept de plasticite, montrant comment il forme en profondeur, a la fois comme sa structure et comme son rythme, le contenu speculatif. Est plastique ce qui est susceptible de recevoir comme de donner la forme, mais aussi de l'aneantir. Hegel degage ce concept de son sol natal, l'art, pour le rendre a sa veritable origine : le developpement de la subjectivite. Est dit plastique, en effet, le rapport que la subjectivite entretient avec l'accident, avec ce qui arrive. L'auto-determination apparait comme proces de temporalisation au sein duquel la subjectivite, dans l'attitude contrastee d'un voir venir, se donne et par la recoit sa propre forme, anticipant son avenir tout en renoncant a en maitriser l'irruption. La plasticite du concept hegelien de temps est le foyer de resistance clandestin ou se prepare la reponse a l'accusation de vulgarite portee par Heidegger a l'encontre de ce meme concept. (shrink)

We discuss the relationship between the interpretative problems of quantum gravity and those of general relativity. We argue that classical and quantum theories of gravity resuscitate venerable philosophical questions about the nature of space, time, and change; and that the resolution of some of the difficulties facing physicists working on quantum theories of gravity would appear to require philosophical as well as scientific creativity.

I argue that there has been inadequate attention to and questioning of the dominance and normativity of whiteness in the cultural construction of bioethics in the United States. Therefore we risk reproducing white privilege and white supremacy in its theory, method, and practices. To make my argument, I define whiteness and trace its broader social and legal history in the United States. I then begin to mark whiteness in U.S. bioethics, recasting Renee Fox's sociological marking of its American-ness as an (...) important initial marking of its whiteness/WASP ethos. Furthermore, I consider the attempts of social scientists to highlight sociocultural diversity as a corrective in U.S. bioethics. I argue that because they fail to problematize white dominance and normativity and the white-other dualism when they describe the standpoints of African-American, Asian-American, and Native-American others, their work merely inoculates difference and creates or maintains minoritized spaces. Accordingly, the dominant white center of mainstream U.S. bioethics must be problematized and displaced for diversity research to make a difference. In conclusion, I give several examples of how we might advance the recommended endeavor of exploring our own ethnicity, class, and other social positioning and norms operating in U.S. bioethics, briefly highlighting "white talk" as one challenge. (shrink)

This chapter is concerned with the representation of time and change in classical (i.e., non-quantum) physical theories. One of the main goals of the chapter is to attempt to clarify the nature and scope of the so-called problem of time: a knot of technical and interpretative problems that appear to stand in the way of attempts to quantize general relativity, and which have their roots in the general covariance of that theory. The most natural approach to these questions is via (...) a consideration of more clear cases. So much of the chapter is given over to a discussion of the representation of time and change in other, better understood theories, starting with the most straightforward cases and proceeding through a consideration of cases that lead up to the features of general relativity that are responsible for the problem of time. (shrink)

This is the first of two papers responding to ‘recent’ commentary on various aspects of hyperplane dependence by several authors. In this paper I focus on the issues of the relations of HD to state reduction and unitary evolution. The authors who’s comments I address here are Maudlin and Myrvold. In the second paper of this set I focus on HD dynamical variables and localizable properties and measurements and address comments of de Koning, Halvorson, Clifton and Wallace. Each paper ends (...) with some reflections on the implications of HD for the ontology of Minkowski space-time. To set the stage for my responses, I begin this paper with some general position statements designed to correct what seem to be widespread and erroneous construals of some of my views. Two central points are argued for in this first paper. First, dynamical evolution occurs not only within foliations of Minkowski space-time. Rather the transition from the physical state of affairs on any one hyperplane to any other, whether the hyperplanes intersect or are parallel, is always an instance of dynamical evolution between them, generated by some active combination of boost-like transformations and/or time-like translations and/or state reductions and ‘reconstructions’. This point gives rise to a generalized conception of a history of dynamical evolution, allowing for the use of parameterized families of hyperplanes that multiply cover some portions of space-time. Nevertheless, and this is the second central point, for any two generalized histories, H and H’, the quantum states for a system on all the hyperplanes of H from the asymptotic past up to some hyperplane, h, determine the quantum states for the system on all the hyperplanes of H’ from the asymptotic past up to any hyperplane, h’, such that h’ lies to the past of all those state reduction regions that lie to the future of all hyperplanes of H that are ‘earlier’ than h. Consideration of these results should defuse concerns that have been voiced about the coherence and consistency of HD. A position closely related to the second point has already been argued for by Myrvold. (shrink)

Elaborates the author’s conception of plasticity by proposing a new way of thinking through Heidegger’s writings on change.

This book is one of the most important recent books on Hegel, a philosopher who has had a crucial impact on the shape of continental philosophy. Published here in English for the first time, it includes a substantial preface by Jacques Derrida in which he explores the themes and conclusions of Malabou's book. _The Future of Hegel: Plasticity, Temporality and Dialectic_ restores Hegel's rich and complex concepts of time and temporality to contemporary philosophy. It examines his concept of time, relating (...) it to perennial topics in philosophy such as substance, accident and the identity of the subject. Catherine Malabou's also contrasts her account of Hegelian temporality with the interpretation given by Heidegger in _Being and Time_, arguing that it is the concept of 'plasticity' that best describes Hegel's theory of temporality. The future is understood not simply as a moment in time, but as something malleable and constantly open to change through our interpretation. The book also develops Hegel's preoccupation with the history of Greek thought and Christianity and explores the role of theology in his thought. Essential reading for those interested in Hegel and contemporary continental philosophy, _The Future of Hegel _is also fascinating to those interested in the ideas of Heidegger and Derrida. (shrink)

Since mitochondrial replacement techniques were developed and clinically introduced in the United Kingdom, there has been much discussion of whether these lead to children borne of three parents. In the UK, the regulation of MRT has dealt with this by stipulating that egg donors for the purposes of MRT are not genetic parents even though they contribute mitochondrial DNA to offspring. In this paper, I examine the way that the Human Fertilisation and Embryology Act in the UK manages the question (...) of parentage. I argue that the Act breaks the link typically made between genetic causation and genetic parenthood by redefining genetic causation solely in terms of nuclear genetics. Along with this, mtDNA is construed as a kind of supplement to the nuclear family. Drawing on the account of the supplement developed by Jacques Derrida, I argue that mtDNA and the women who donate it are seen as both essential to establishing the nuclear family but also exterior to and insignificant for it. (shrink)

Current Legal Issues, like its sister volume Current Legal Problems, is based upon an annual colloquium held at University College London. Each year, leading scholars from around the world gather to discuss the relationship between law and another discipline of thought. Each colloqium examines how the external discipline is conceived in legal thought and argument, how the law is pictured in that discipline, and analyses points of controversy in the use, and abuse, of extra-legal arguments within legal theory and practice.Law (...) and Psychology, the latest volume in the Current Legal Issues series, contains a broad range of essays by scholars interested in the interactions between law and psychology. The volume includes studies of jury trials in terrorism cases, psychological evidence in family law cases, child witness testimony and the role of psychology in punishment theory. (shrink)

Belief is a species of mere conception, and is modifiable, rather than bivalent (believing or disbelieving). The attendant-impression theory of transformation of conception into belief expresses the moral dimension of one and the same thing, of which the manner-of-conception (without attendant impression) theory of the transformation refers to the epistemic dimension of that same thing. These two aspects of the transformation of conception into belief point to an ambiguity in Hume's use of the term IDEA: as act and as content. (...) The act of conception, its content, and the pedigree of that content are all mutually indeterminate. The imagination conceives, constructs contents, and transforms conception into belief. The foundation of the role of mere conception in belief is the mind's "native situation of indifference", which makes it possible for Hume to account not only for warranted but also unwarranted belief. Hume is interested not only in what should actuate the soul but what does so in fact. Hume's real innovation lies in a theory of belief unburdened by traditional representation and in the effects rather than the external foundations of certitude. (shrink)

This article describes and evaluates the application of an explicitly critical realist methodology to a quantitative doctoral research project on the causes of family homelessness in Australia. It...

Robust stakeholder engagement in health research requires broad communicative integration, not only of patients but also other stakeholders such as health system leaders, clinicians, and researcher...

The article develops an Ignatian perspective, from within which it then interprets and amplifies Bernard Lonergan's intellectual project. Exploiting recent analyses of medieval memorial culture and the rhetorical dynamicsof monastic spiritual practice, the article highlights the performative quality of key Ignatian texts, paying particular attention to the categories of ornamentation and ordering . Appreciating the vantage afforded by heightened self-presence, reflexive knowledge and intentional praxis, the article then explores Lonergan's project, employing the rubric of ornamentation and ordering to investigate the (...) interaction between cognitional activity and the matrix of desire informed by unbounded wonder, specific desires and distorting bias. Formative self-appropriation is then considered as a religious process, in which the self gathers the resources of Scripture and tradition to compose a creative faith response to the divine initiative of transforming love, a response that unfolds more fully in the co-development of personal, social and cultural activity. (shrink)