Rho proteins belong to the small GTPases superfamily. They function as molecular switches that, in response to diverse stimuli, control key signaling and structural aspects of the cell. Although early studies proposed a role for Rho GTPases in cellular transformation, this effect was underestimated due to the fact that no genetic mutations affecting Rho‐encoding genes were found in tumors. Recently, it has become evident that Rho GTPases participate in the carcinogenic process by either overexpression of some of the members of (...) the family with oncogenic activity, downmodulation of other members with suggested tumor suppressor activity, or by alteration of upstream modulators or downstream effectors. Thus, alteration of the levels of expression of different members of the family of Rho GTPases has been detected in many types of human tumors leading to a great interest in the cellular effects elicited by these oncoproteins. This essay reviews the current evidence of dysregulation of Rho signaling by overexpression in human tumors. BioEssays 27:602–613, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

En este artículo se analiza un conjunto de obras sobre ríos y represas que pertenece a la serie titulada Represa /Represión (2012-) de la artista colombiana Carolina Caycedo. La pregunta de la que se ocupa esta investigación es ¿cómo las estrategias estéticas de estas obras identifican los problemas socio-ecológicos generados por las represas y contribuyen a articular imaginarios políticos de sostenibilidad? El argumento principal es que las obras de Caycedo sobre el río Yuma o Magdalena contribuyen con la construcción (...) de una memoria histórica ambiental, a partir de saberes populares, campesinos y cosmovisiones indígenas. Con este fin, este texto caracteriza el problema de las represas a partir de los conceptos de ‘extractivismo’, de Macarena Gómez-Barris, y ‘desterritorialización’, de Rob Nixon, para luego realizar un recorrido por las obras de la artista, de cuyo análisis se va construyendo una caracterización de la memoria histórica ambiental de un segmento del río Yuma. El marco conceptual del trabajo incluye las nociones de ‘seres-tierra’, de Marisol de la Cadena y ‘territorio’, de Arturo Escobar, así como ‘memoria de los ríos’, de Kristina Lyons. La metodología se basa en el análisis conceptual y técnico de las piezas de Caycedo en el marco interdisciplinar de las humanidades ambientales. El análisis concluye que las obras de Caycedo generan espacios de memoria histórica ambiental desde perspectivas trasnacionales y, en estos espacios de encuentro que constituyen las obras, se relacionan y rearticulan los extremos de falsos antagonismos como naturaleza/cultura, humano/no humano y ciencia/arte. (shrink)

Carolina Sartorio argues that only the actual causes of our behaviour matter to our freedom. The key, she claims, lies in a correct understanding of the role played by causation in a view of that kind. Causation has some important features that make it a responsibility-grounding relation, and this contributes to the success of the view. Also, when agents act freely, the actual causes are richer than they appear to be at first sight; in particular, they reflect the agents' (...) sensitivity to reasons, where this includes both the existence of actual reasons and the absence of other reasons. So acting freely requires more causes and quite complex causes, as opposed to fewer causes and simpler causes, and is compatible with those causes being deterministic. The book connects two different debates, the one on causation and the one on the problem of free will, in new and illuminating ways. (shrink)

There is an initial presumption against disjunctive causes. First of all, for some people causation is a relation between events. But, arguably, there are no disjunctive events, since events are particulars and thus they have spatiotemporal locations, while it is unclear what the spatiotemporal location of a disjunctive event could be.1 More importantly, even if one believes that entities like facts can enter in causal relations, and even if there are disjunctive facts, it is still hard to see how disjunctive (...) facts could be causes. Imagine, for instance, the following scenario. I have a gun filled with red paint and another gun filled with blue paint, and I fire both guns at my neighbor’s white wall. A moment later, there is a graffiti on the wall and my neighbor notifies the police. He would have done so regardless of the graffiti’s color, since all he cares about is the existence of a graffiti on his wall. Is it plausible to claim that a disjunctive fact is a cause of his notifying the police? In particular, is it plausible to claim that he notified the police because I fired the red-paint gun or the blue-paint gun (the thought being that my firing paint of either color would have sufficed)? It seems not. The police was notified because of the actual graffiti on the wall, and the actual graffiti on the wall is made of a certain pattern of colored patches. Imagine, that, as it turns out, there are patches of both colors on the wall. Then it seems that both my firing the red-paint gun and my firing the blue-paint gun were causes of my neighbor’s notifying the police. In other words, my firing the red-paint gun and my firing the blue-paint gun jointly caused the outcome: each of them was a contributory cause of the outcome’s occurrence. On the other hand, imagine that there are only patches of one color on the wall. Then it seems that my firing only one of the guns was a cause. Either way, the disjunction fails to be a cause: either my firing the red-paint gun was a cause, or my firing the blue-paint gun was a cause, or they were both causes, but their disjunction was not.. (shrink)

Does a person's liability to attack during a war depend on the nature of their individual causal contribution to the (unjust) threat posed? If so, how? The recent literature on the ethics of war has become increasingly focused on questions of this kind. According to some views on these matters, your liability hinges on the extent of your causal contribution: the larger your contribution to an unjust threat, the larger the amount of harm that we can impose on you in (...) order to avert the threat. Some philosophers have suggested that we can ground a quite general principle of civilian immunity on this basis. But, do causal contributions really come in degrees? Can we make sense of a graded notion of causal contribution that can be relevant to debates about liability in war? I argue there is good reason to be sceptical. The appearance that causal contributions come in degrees is just an illusion that can be explained away. (shrink)

On the face of it, causal responsibility seems to be “additive” in the following sense: if I cause some effects, then it seems that I also cause the sum (aggregate, conjunction, etc.) of those effects. Let’s call the claim that causation behaves in this way, Additivity.

In this paper, we argue that there are epistemic norms on evidence-gathering and consider consequences for how to understand epistemic normativity. Though the view that there are such norms seems intuitive, it has found surprisingly little defense. Rather, many philosophers have argued that norms on evidence-gathering can only be practical or moral. On a prominent evidentialist version of this position, epistemic norms only apply to responding to the evidence one already has. Here we challenge the orthodoxy. First, we argue that (...) there is no significant normative difference between responding to evidence you have and gathering more evidence. Second, we argue that our practices of epistemically criticizing agents for their poor evidence-gathering indicate the existence of epistemic norms on evidence-gathering. Finally, we show that our thesis has important implications for recent debates about the relationship between epistemic norms and inquiry. (shrink)

The focus of this paper is an influential family of views in the ethics of self-defense and war: views that ground the agent’s liability to be attacked in self-defense in the agent’s moral responsibility for the threat posed (“Responsibility Views”). I critically examine the concept of responsibility employed by such views, by looking at potential connections with the contemporary literature on moral responsibility. I start by uncovering some of the key assumptions that Responsibility Views make about the relevant concept of (...) responsibility, and by scrutinizing those assumptions under the lens of more general theorizing about responsibility. I identify an important conflict that arises at that point. The problem is that the concept presupposed by Responsibility Views is in tension with the standard way of understanding the connection between the neutral and non-neutral forms of moral responsibility. I draw attention to a particular strategy that could be used to address this challenge, but I also identify some important obstacles that stand in the way. (shrink)

Midwest Studies In Philosophy, EarlyView.

El presente artículo es una elaboración teórica descriptiva que desarrolla una aproximación filosófica antropológica del símbolo-religioso. El objetivo de este artículo apunta a identificar que la simbología-religiosa es requerida por el ser humano de modo perenne, en relación a la búsqueda de significados suficientes para dotar de interpretación y valor a la realidad, con la finalidad de construir una cultura estable para el existir. En función de dicho propósito se establece que el símbolo adviene desde la dimensión imaginal (Chillón, 2010) (...) de la inteligencia, extendiéndose hacia sectores que los conceptos y la productividad racional no logran abordar. Al respecto, el manuscrito establece que, comprender la función de la simbología desde su procedencia original en la experiencia religiosa, significa contribuir a la comprensión del resurgir religioso manifestado en la posmodernidad, aún a las condiciones de cambio continuo y la ausencia de direcciones sólidamente definidas (Bauman, 1996). Se establece que las mediaciones simbólicas-religiosas, conservan intacta su tarea de transitar el vínculo entre el ser humano y el misterio trascendente (Chillón, 2010; Diez de Velasco, Méndez, & Maffesoli; 2007; Mardones, 1996), a objeto de orientar la vida humana integralmente. (shrink)

Joseph de Maistre's reputation as a writer is legendary. His style, unique and alive, moulded the French language anew. It sabotaged his attempts at anonymous publication and earned him, through the centuries, the praises of enemies and admirers. Yet the relationship between Maistre's thought and writing remains ill-known. This collection is the first to examine how Maistre's ideas - including his denunciation of the written word - intersected with his writing practices and personas. The essays disclose an author formed by (...) duty and affectionate relationships, by the conventions of public combat, by an intense sense of history, and by the imperatives of Revolution."--Series page. (shrink)

Some philosophers have claimed that causally determined agents are not morally responsible because they cannot make a difference in the world. A recent response by philosophers who defend the compatibility of determinism and responsibility has been to concede that causally determined agents are incapable of making a difference, but to argue that responsibility is not grounded in difference making. These compatibilists have rested such a claim on Frankfurt cases—cases where agents are intuitively responsible for acts that they couldn’t have failed (...) to perform. This essay argues, first, that the intuitive plausibility of the idea that responsibility is grounded in difference making is not completely put to rest by Frankfurt cases, even if those cases successfully show that responsibility is not grounded in difference making in the sense of access to alternative possibilities of action. It then goes on to develop a different compatibilist strategy, one according to which responsibility is grounded in difference making, but the type of difference making it is grounded in does not require access to alternative possibilities. Indeed, it is a form of difference making that is clearly compatible with determinism. (shrink)

En este trabajo se expone el debate entre Neurath y Horkheimer como ejemplo de recuperación de los aspectos políticos del Círculo de Viena, olvidados en la visión tradicional, que ayudarán a tener una mejor comprensión de las diversas posiciones de los miembros del Círculo. Se intenta mostrar que gran parte del debate se debe a las diferencias políticas entre los contendientes y a sus diferentes concepciones sobre la filosofía, la ciencia y la razón, pero no a la falta de intereses (...) políticos de Neurath y del Círculo de Viena. In this work we will summarize the Neurath-Horkheimer debate as an example of the recovery of the Vienna Circle's political aspects that were forgotten in the traditional view, so as to achieve a better understanding of the different positions assumed by the Circle's members. Our intention is to show that much of this debate stems from their political differences and the contenders' diverse conceptions of philosophy, science and reason, but not from the lack of political interests in Neurath and the Vienna Circle. (shrink)

En Chile, la filosofía en la segundaria, después de la última reforma a la educación, tiene un lugar contradictorio. Filosofía y globalización parecen no alcanzar un entendimiento. En los límites de la contradicción, se propone un espacio donde el diálogo con diversos conceptos trabajados por Derrida permiten entrar en la dimensión filosófica del problema político-educativo.

I explore the question of how to ground the responsibility of agents in some tricky cases involving multiple agents who act in a non-coordinated fashion. These are scenarios where no single agent has the individual ability to make a difference to a harmful outcome, but where the outcome would have been avoided if they had all acted as they should have (thus, the agents collectively made a difference to the outcome’s occurrence). I argue that an important source of the problem (...) is that it’s hard to motivate a concept of cause that can be behind the agents’ responsibility in these cases. I illustrate the problem with a particular example: Yablo’s proportionality criterion on causation. I then sketch a possible solution. (shrink)

Beliefs can be resistant to evidence. Nonetheless, the orthodox view in epistemology analyzes beliefs as evidence-responsive attitudes. I address this tension by deploying analytical tools on capacities and masking to show that the cognitive science of evidence-resistance supports rather than undermines the orthodox view. In doing so, I argue for the claim that belief requires the capacity for evidence-responsiveness. More precisely, if a subject believes that p, then they have the capacity to rationally respond to evidence bearing on p. Because (...) capacities for evidence-responsiveness are fallible and may be masked, beliefs can be held in the face of counter-evidence. Indeed, I will argue that our best science of belief supports the claim that evidence-resistant beliefs result from masks on evidence-responsiveness capacities. This account of belief not only allows for resistance to evidence, but provides us with a framework for describing and explaining actual cases of evidence-resistance. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:632 Feminist Studies 44, no. 3. © 2018 by Feminist Studies, Inc. Achilles Sees Life Leaving from His Heel Carolina Hotchandani The nurse asked me if I could raise my legs yet. I watched my feet to see if they’d move when I tried. The right one twitched a bit. The little one must have been taken somewhere before then to get a shot or have blood drawn. (...) Later, I would see how they draw blood from a baby. A needle stuck in the heel, of all places. All I know is her cry was not in the room as I tried to find my will in my legs. Sometimes I think she took it away. My baby, my will. As if she drew it out of my bony heel.... (shrink)

Long known solely as fascism s precursor, Joseph de Maistre (1753-1821) re-emerges in this volume as a versatile thinker with a colossally diverse posterity whose continuing relevance in Europe is ensured by his theorization of the ...

Este texto apresenta resultados de um levantamento sobre os principais autores que tratam sobre a epistemologia da educação física e suas principais contribuições no desenvolvimento da pesquisa sobre a formação profissional. A síntese apresentada integra a pesquisa: “A produção do conhecimento sobre a formação profissional em educação física: realidade e perspectivas superadoras”. Apontamos que os balanços teóricos das produções científicas da área estão provocando a busca de maiores níveis de qualidade nas novas pesquisas. Concluímos que as avaliações epistemológicas são pertinentes (...) como referência básica para novos estudos sobre a formação profissional no campo de Educação Física, Esporte e Lazer. (shrink)

In this paper I reexamine the debate between two contrasting conceptions of free will: the classical model, which understands freedom in terms of alternative possibilities, and a more recent family of views that focus only on actual causes, and that were inspired by Frankfurt’s famous attack on the principle of alternative possibilities. I offer a novel argument in support of the actual-causes model, one that bypasses the popular debate about Frankfurt-style cases.

This is a case study of the birth of conservative historicism out of the Jacobin Terror. The historical rupture represented by the French Revolution provoked reflections on the course and meaning of history among those who, opposed to the Revolution, would become heralds of conservatism. Highly significant -- and heretofore neglected -- among these reflections were those that the Savoyard thinker Joseph de Maistre developed in De la Souverainete du peuple, the precipitate critique of Rousseau's Du Contrat social that he (...) composed during the years 1794 to 1796. This paper contends that De la Souveraineté introduced an influential and original form of historicism founded on a combinatorial theory of political constitutions. It likewise demonstrates that, in devising a model for the history of nations, Maistre also defined concepts that would become integral to nineteenth-century positivism, to the then- nascent science of moral statistics, and to French sociology. (shrink)

[Esotericism. One-day Workshop about the Annale n. 25 of the Storia d'Italia Einaudi]. This section contains the proceedings of the one-day workshop on the book Esoterismo, published as the Annale n. 25 in the collection "History of Italy" by Einaudi. The workshop was organized by ISPF on the October 26, 2011 to promote the discussion on the significance of Western esotericist traditions in Italian history. S. Caianiello’s introduction highlights some major concepts and goals of the recent field of studies about (...) Western Esotericism, and some open problems about its definition. M. Cambi comments on the substantial transformation of esotericist themes in Giordano Bruno’s natural philosophy, whereby the sources of the magician’s power are completely enclosed in the realm of nature, thus rejecting any transcendent foundation. M. Conforti focuses on "the function and opportunities" offered by the Western Esotericism approach "to the genesis and development of early modern science" and comments from this perspective on different contributions in the volume, emphasizing however the importance of largely pre-existing traditions in the history of science and medicine which have long challenged the wiggish separation between science and magic, rational and irrational thought. L. Simonutti provides new material to the general theme, with a historical-philosophical analysis of the esotericist elements in Picart’s iconography of the 18th Century edition of "Cymbalum mundi". F. Sofia discusses the effective role of esotericist traditions in the attempts to establish a "civil religion" in Italy from Risorgimento to Fascism, a history in which, she argues, it is difficult to establish "how much esotericism was an intentional choice or the product of an unavoidable nicodemism". C. Castellano reviews the contributions dedicated to the "political teology" of Italian Risorgimento, dealing in depth with the complex relationship between Freemasonry and Carbonari in Italy – in her view, more of a cultural than of a strictly political connection – and highlights the relevance of the anticurial component in their esotericist inspiration. G.M. Cazzaniga, author and editor of the Annale, beyond reacting to the different stimuli offered by the discussion, provides a brief history of Western Esotericism studies in Europe and of the reasons of their difficult reception in Italy. (shrink)

The orthodox view in epistemology is that belief is constitutively evidence-responsive. I offer a novel argument for a version of this view, one that appeals to capacities to rationally respond to evidence. I do so by developing the Sellarsian idea that the concept of belief functions to mark the space of reasons in a non-intellectualist and naturalistic direction. The resulting view does justice to the role of belief in social interactions, joint deliberation, and rational persuasion, while including evidence-resistant beliefs and (...) animal beliefs as genuine beliefs. It has a range of further benefits: it helps us account for epistemic normativity, paves the way for better psychological models of belief revision, distinguishes beliefs from imaginings and mere acceptances, and helps us avoid noxious simplistic takes on human irrationality. (shrink)

Delusions are standardly defined as attitudes that are not amenable to change in light of conflicting evidence. But what evidence do people with delusion have for and against it? Do delusions really go against their total evidence? How are the answers affected by different conceptions of evidence? -/- This chapter focuses on how delusions relate to evidence. I consider what delusions-relevant evidence people with delusions have. I give some reasons to think that people typically have evidence for their delusions, and (...) that the evidence they have against them is often overstated. I draw on this discussion to consider whether delusions are evidentially supported and epistemically rational. Finally, I discuss implications for the nature of delusion, responsibility, and treatment and suggest directions for future research. Throughout, the discussion is sensitive to different conceptions of evidence and rationality in epistemology. -/- A central upshot is that what we should say about the epistemic standing of delusions depends substantively on our positions in epistemology, in particular, on the debate between internalists and externalists about evidence. If we want clarity on the epistemic standing of delusions, we need to incorporate more sophisticated tools from epistemology. (shrink)

Over the years, two models of freedom have emerged as competitors: the alternative-possibilities model, which states that acting freely consists in being able to do otherwise, and, more recently, the actual-sequence model, which states that acting freely is exclusively a function of the actual sequence of events issuing in our behavior. In general, a natural strategy when trying to decide between two models of a certain concept is to look for examples that support one model and undermine the other. Frankfurt-style (...) cases have been used for this kind of purpose, to challenge the alternative-possibilities view and support the actual-sequence view. In this paper I examine the prospects of the counterparts of Frankfurt-style cases: “PAP-style” cases, or cases that could be used to support the alternative-possibilities view and challenge the actual-sequence view. I argue that there are no successful PAP-style cases. (shrink)