The term ‘breeding system’ is used to describe the morphological and behavioural aspects of the sexual life cycle of a species. The yeast breeding system provides three alternatives that enable hapoids to return to the diploid state that is necessary for meiosis: mating of unrelated haploids (amphimixis), mating between spores from the same tetrad (intratetrad mating, automixis) and mother daughter mating upon mating type switching (haplo‐selfing). The frequency of specific mating events affects the level of heterozygosity present in individuals and (...) the genetic diversity of populations. This review discuses the reproductive strategies of yeasts, in particular S. cerevisiae (Bakers' or budding yeast). Emphasis is put on intratetrad mating, its implication for diversity, and how the particular genome structure could have evolved to ensure the preservation of a high degree of heterozygosity in conjunction with frequent intratetrad matings. I also discuss how the ability of yeast to control the number of spores that are formed accounts for high intratetrad mating rates and for enhanced transmission of genomic variation. I extend the discussion to natural genetic variation and propose that a high level of plasticity is inherent in the yeast breeding system, which may allow variation of the breeding behaviour in accordance with the needs imposed by the environment. BioEssays 28: 696–708, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Beginning with Aristotle, philosophers have taken artifacts to be ontologically deficient. This paper proposes a theory of artifacts, according to which artifacts are ontologically on a par with other material objects. I formulate a nonreductive theory that regards artifacts as constituted by - but not identical to - aggregates of particles. After setting out the theory, I rebut a number of arguments that disparage the ontological status of artifacts.

This paper discusses varieties of normative phenomena, ranging from morality, to epistemic justification, to the rules of chess. It canvases a number of distinctions among these different normative phenomena. The most significant distinction is between formal and authoritative normativity. The prior is the normativity exhibited by any standard one can meet or fail to meet. The latter is the sort of normativity associated with phenomena like the "all-things-considered" ought. The paper ends with a brief discussion of reasons for skepticism about (...) authoritative normativity. (shrink)

No single theory so far proposed gives a wholly satisfactory account of the origin and maintenance of bird-song dialects. This failure is the consequence of a weak comparative literature that precludes careful comparisons among species or studies, and of the complexity of the issues involved. Complexity arises because dialects seem to bear upon a wide range of features in the life history of bird species. We give an account of the principal issues in bird-song dialects: evolution of vocal learning, experimental (...) findings on song ontogeny, dialect descriptions, female and male reactions to differences in dialect, and population genetics and dispersal.We present a synthetic theory of the origin and maintenance of song dialects, one that accommodates most of the different systems reported in the literature. The few data available suggest that large, regional dialect populations are genetically differentiated; this pattern is correlated with reduced dispersal between dialects, assortative mating by females, and male-male exclusion. At the same time, “subdialects” may be formed within regional dialects. Subdialect clusters are usually small and may represent vocal mimicry among a few adjacent territorial males. The relative importance of genetic and social adaptation may contribute to the emergence of subdialects; their distinctiveness may be correlated with the degree of polygyny, for example. Thus, subdialect formation is linked to one theory of the evolution of repertoire size, but data are too fragmentary to examine this idea critically. (shrink)

Kraut and other neo-Aristotelians have argued that there is no such thing as absolute goodness. They admit only good in a kind, e.g. a good sculptor, and good for something, e.g. good for fish. What is the view of Aristotle? Mostly limiting myself to the Nicomachean Ethics, I argue that Aristotle is committed to things being absolutely good and also to a metaphysics of absolute goodness where there is a maximally best good that is the cause of the goodness of (...) all other things in virtue of being their end. I begin by suggesting that the notion of good as an end, which is present in the first lines of the NE, is not obviously accounted for by good in a kind or good for something. I then give evidence that good in a kind and good for something can explain neither certain distinctions drawn between virtues nor the determinacy ascribed to what is good “in itself.” I argue contra Gotthelf that because several important arguments in the Nicomachean Ethics rely on comparative judgments of absolute value—e.g. “Man is the best of all animals”—Aristotle is committed to the existence of both absolute goodness and an absolutely best being. I focus on one passage, Aristotle’s division of goods in NE I 12, which presupposes this metaphysical picture. (shrink)

Collaborative remembering is essential to enabling teams to build shared understanding of projects and their progress. This article presents an analysis of collaborative remembering sequences in a corpus of interactions collected in a workplace where a team of designers developed a video television commercial. On the basis of coding and analysing linguistic and bodily behaviors in 158 such sequences, extracted from over 45 hours of video recordings, recurrent patterns of collaborative remembering processes were identified, relating to the interplay of work (...) roles. This article shows that collaborative remembering in the design studio is structured by behavioural, interactive and social factors. (shrink)

According to the Constitution View of persons, a human person is wholly constituted by (but not identical to) a human organism. This view does justice both to our similarities to other animals and to our uniqueness. As a proponent of the Constitution View, I defend the thesis that the coming-into-existence of a human person is not simply a matter of the coming-into-existence of an organism, even if that organism ultimately comes to constitute a person. Marshalling some support from developmental psychology, (...) I give a broadly materialistic account of the coming-into-existence of a human person. I argue for the metaphysical superiority of the Constitution View to Biological Animalism, Thomistic Animalism, and other forms of Substance Dualism. I conclude by discussing the single implication of the Constitution View for thinking about abortion. Footnotesa Thanks to Gareth Matthews and Catherine E. Rudder for comments. I am also grateful to other contributors to this volume, especially Robert A. Wilson, Marya Schechtman, David Oderberg, Stephen Braude, and John Finnis. (shrink)

Whereas professional persuasion is a means to an immediate and instrumental end, ethical persuasion must rest on or serve a deeper, morally based final end. Among the moral final ends of journalism, for example, are truth and freedom. There is a very real danger that advertisers and public relations practitioners will play an increasingly dysfunctional role in the communications process if means continue to be confused with ends in professional persuasive communications. Means and ends will continue to be confused unless (...) advertisers and public relations practitioners reach some level of agreement as to the moral end toward which their efforts should be directed. In this article we advance a five-part test that defines this moral end, establishes ethical boundaries that should guide persuasive practices, and serves as a set of action-guiding principles directed toward a moral consequence in professional persuasion. The TARES Test consists of five principles: Truthfulness, Authenticity, Respect, Equity and Social Responsibility. We provide checklists to guide the practitioner in moral reflection and application of TARES Test principles. (shrink)

A number of philosophers have offered quasi-perceptual theories of desire, according to which to desire something is roughly to “see” it as having value or providing reasons. These are offered as alternatives to the more traditional Humean Theory of Motivation, which denies that desires have a representational aspect. This paper examines the various considerations offered by advocates to motivate quasi-perceptualism. It argues that Humeanism is in fact able to explain the same data that the quasi-perceptualist can explain, and in one (...) case the Humean explanation is superior. Quasi-perceptual accounts of desire, the paper concludes, are for the most part unmotivated. (shrink)

Many accept the following three theses in animal ethics. First, although animal welfare should not be—or at least, need not be—our top moral priority, it is not a trivial one either. Second, if an animal is sentient, then it is a moral patient. Third, the extinction of an animal species is a tragic outcome that we have moral reason to prevent. I argue that a traditional (i.e., pre-modern) Buddhist perspective pushes against the first thesis and that a naturalized Buddhist perspective (...) is inconsistent with the latter two. (shrink)

Eric T. Olson has argued that any view of personal identity in terms of psychological continuity has a consequence that he considers untenable---namely, that he was never an early-term fetus. I have several replies. First, the psychological-continuity view of personal identity does not entail the putative consequence; the appearance to the contrary depends on not distinguishing between de re and de dicto theses. Second, the putative consequence is not untenable anyway; the appearance to the contrary depends on not taking seriously (...) an idea that underlies a plausible view of persons that I call ‘the Constitution View.’ Finally, Olson’s own “Biological View of personal identity” has liabilities of its own. (shrink)

The prevailing view of Christian philosophers today seems to be that Christianity requires a libertarian conception of free will. Focusing on Augustine’s mature anti-Pelagian works, I try to show that the prevailing view is in error. Specifically, I want to show that---on Augustine’s view of grace-a libertarian account of free will is irrelevant to salvation. On Augustine’s view, the grace of God through Christ is sufficient as weIl as necessary for salvation. Salvation is entirely in the hands of God, totally (...) independent of anything that any human being might do. And faith, the human response to salvation, is best understood in terms of a compatibilist account of freedom. (shrink)

If we divide our physical theories into theories of matter and theories of spacetime, quantum field theory is our most fundamental empirically successful theory of matter. As such, it has attracted increasing attention from philosophers over the past two decades, beginning to eclipse its predecessor theory of quantum mechanics in the philosophical literature. Here I survey some central philosophical puzzles about the theory's foundations.

One recent trend in the philosophy of mathematics has been to approach the central epistemological and metaphysical issues concerning mathematics from the perspective of the applications of mathematics to describing the world, especially within the context of empirical science. A second area of activity is where philosophy of mathematics intersects with foundational issues in mathematics, including debates over the choice of set-theoretic axioms, and over whether category theory, for example, may provide an alternative foundation for mathematics. My central claim is (...) that these latter issues are of direct relevance to philosophical arguments connected to the applicability of mathematics. In particular, the possibility of there being distinct alternative foundations for mathematics blocks the standard argument from the indispensable role of mathematics in science to the existence of specific mathematical objects. (shrink)

Drawing upon contemporary virtue ethics theory, The Model of The Principled Advocate and The Pathological Partisan is introduced. Profiles are developed of diametrically opposed archetypes of public relations and advertising practitioners. The Principled Advocate represents the advocacy virtues of humility, truth, transparency, respect, care, authenticity, equity, and social responsibility. The Pathological Partisan represents the opposing vices of arrogance, deceit, secrecy, manipulation, disregard, artifice, injustice, and raw self-interest. One becomes either a Principled Advocate or a Pathological Partisan by habitually enacting or (...) embodying the virtues or vices in the context of professional practices. (shrink)

Nature seems to be such that we can describe it accurately with quantum theories of bosons and fermions alone, without resort to parastatistics. This has been seen as a deep mystery: paraparticles make perfect physical sense, so why don’t we see them in nature? We consider one potential answer: every paraparticle theory is physically equivalent to some theory of bosons or fermions, making the absence of paraparticles in our theories a matter of convention rather than a mysterious empirical discovery. We (...) argue that this equivalence thesis holds in all physically admissible quantum field theories falling under the domain of the rigorous Doplicher–Haag–Roberts approach to superselection rules. Inadmissible parastatistical theories are ruled out by a locality-inspired principle we call charge recombination. 1 Introduction2 Paraparticles in Quantum Theory3 Theoretical Equivalence3.1 Field systems in algebraic quantum field theory3.2 Equivalence of field systems4 A Brief History of the Equivalence Thesis4.1 The Green decomposition4.2 Klein transformations4.3 The argument of Drühl, Haag, and Roberts4.4 The Doplicher–Roberts reconstruction theorem5 Sharpening the Thesis6 Discussion6.1 Interpretations of Quantum Mechanics6.2 Structuralism and haecceities6.3 Paraquark theories. (shrink)

The term ‘natural theology’ provokes a variety of reactions, spanning from whole-hearted endorsement to passionate rejection. Charged as it is with polemical and pejorative undertones, this debate begs for an intervention. If the scholarly community is to engage constructively with the concept and practice of natural theology — either by way of acceptance, rejection, or something in between — clarity in its definition and identification is imperative. The aim of this paper, then, is to try to shed some light on (...) three of the most common definitions of ‘natural theology’ in contemporary scholarship, to provide clarity about the ways in which they differ, and to propose some conceptual refinements in the hope that, if adopted, more fruitful discourse may take place in relation to this much-debated and interdisciplinary phrase. (shrink)

Byrne offers a novel interpretation of the idea that the mind is transparent to its possessor, and that one knows one’s own mind by looking out at the world. This paper argues that his attempts to extend this picture of self-knowledge force him to sacrifice the theoretical parsimony he presents as the primary virtue of his account. The paper concludes by discussing two general problems transparency accounts of self-knowledge must address.

Just as tariffs lead to economic distortions and provide incentives for corruption, so do patent monopolies on prescription drugs, except the impact is often an order of magnitude larger.

Nonphilosophers, if they think of philosophy at all, wonder why people work in metaphysics. After all, metaphysics, as Auden once said of poetry, makes nothing happen.1 Yet some very intelligent people are driven to spend their lives exploring metaphysical theses. Part of what motivates metaphysicians is the appeal of grizzly puzzles (like the paradox of the heap or the puzzle of the ship of Theseus). But the main reason to work in metaphysics, for me at least, is to understand the (...) shared world that we all encounter and interact with. And the shared world that we all encounter includes us self-conscious beings and our experience. The world that we inhabit is unavoidably a temporal world: the signing of the Declaration of Independence is later than the Lisbon earthquake; the Cold War is in the past; your death is in the future. There is no getting away from time. (shrink)

A decade ago some members of the American Society for Bioethics and the Humanities (ASBH) concluded that the society's reluctance to develop a code of professional ethics, although a tolerable anom...

I set out four general facts about things that we can refer to and talk about, whether they exist or not. Then, I set out an argument for the existence of God. Myargument, like Anselm’s original argument, is a reductio ad absurdum: It shows that the assumption that God does not exist leads to a contradiction. Theargument is short and in ordinary language. Each line of the argument, other than the reductio premise, is justified by one of the general facts. (...) Finally, I consider some traditional objections to Anselm’s argument, and show how my updated version avoids them. (shrink)

Zarathustra initially describes churches as the stale caves of world-denying priests. However, following his encounter with the eternal return of the same, Zarathustra overcomes this resentful atheism. The pure sky that Zarathustra desires above all else, a sky emptied of the gods, is not visible again through the holes in ruined church roofs, but really thanks to these holes. The pure sky is an image of the world liberated from the teleological time of theistic providence, indeed even from the divine (...) necessity that pantheism attributes to the world. Yet for all that it is god-less, the pure sky is acknowledged to be a gift of the same metaphysical-Christian history of God that it only seems to negate: the sky’s pure eye peers through holes in church roofs. Zarathustra, though an “old atheist,” can now love “even churches.” I call this Zarathustra’s affirmative atheism. I also link affirmative atheism to the conception of eternal recurrence as a self-abolishing anti-teaching. In the eternal return, Zarathustra’s atheism is finally indistinguishable from a history of churches and therefore negates itself. But although it is not a new teaching, affirmative atheism points to something novel. This is an atheism that can no longer be taught in doctrines but must be lived as fate. (shrink)

Any artefact – a hammer, a telescope, an artificial hip – may malfunction. Conceptually speaking, artefacts have an inherent normative aspect. I argue that the normativity of artefacts should be understood as part of reality, and not just “in our concepts.” I first set out Deflationary Views of artefacts, according to which there are no artefactual properties, just artefactual concepts. According to my contrasting view – the Constitution View – there are artefactual properties that things in the world really have. (...) For example, there is a property of being a telephone per se; we apply our concept telephone to things that have that property. Things that have the property of being a telephone are constituted by, but not identical to, aggregates of particles. To be an artefact, an object must have an intended function, among other things. Telephones – in virtue of being the kind of objects that they are – are always subject to malfunction. And malfunctions, when they occur, are just as much part of the world as telephones are. The example of artefacts shows that what is in the world – what really exists – need not be “mind-independent” nor independent of our concepts. (shrink)

Many have suggested that, unlike the so-called higher-senses, the lower-senses are not capable of providing aesthetic experience. Supporting this is, what I will call, the Transparency-Exteroceptivity Argument, which says that a necessary feature for aesthetic experience is lacking in the case of the lower-senses, namely transparency/exteroceptivity. I argue, contrary to the Transparency-Exteroceptivity Argument, that olfaction can provide transparent access to the properties of particular external objects. I argue that the Transparency-Exteroceptivity Argument relies on a misleading visuocentric and unimodal view of (...) the senses, is guilty of hasty generalization, and should be rejected. (shrink)

The possibility of using private military and security companies to bolster the capacity to undertake intervention for human rights purposes has been increasingly debated. The focus of such discussions has, however, largely been on practical issues and the contingent problems posed by private force. By contrast, this article considers the principled case for privatising humanitarian intervention. It focuses on two central issues. First, does outsourcing humanitarian intervention to private military and security companies pose some fundamental, deeper problems in this context, (...) such as an abdication of a state's duties? Second, on the other hand, is there a case for preferring these firms to other, state-based agents of humanitarian intervention? For instance, given a state's duties to their own military personnel, should the use of private military and security contractors be preferred to regular soldiers for humanitarian intervention? (shrink)

Motile bacteria respond to environmental cues to move to more favorable locations. The components of the chemotaxis signal transduction systems that mediate these responses are highly conserved among prokaryotes including both eubacterial and archael species. The best‐studied system is that found in Escherichia coli. Attractant and repellant chemicals are sensed through their interactions with transmembrane chemoreceptor proteins that are localized in multimeric assemblies at one or both cell poles together with a histidine protein kinase, CheA, an SH3‐like adaptor protein, CheW, (...) and a phosphoprotein phosphatase, CheZ. These multimeric protein assemblies act to control the level of phosphorylation of a response regulator, CheY, which dictates flagellar motion. Bacterial chemotaxis is one of the most‐understood signal transduction systems, and many biochemical and structural details of this system have been elucidated. This is an exciting field of study because the depth of knowledge now allows the detailed molecular mechanisms of transmembrane signaling and signal processing to be investigated. BioEssays 28:9–22, 2006. © 2005 Wiley Periodicals, Inc. (shrink)