In the Anthropology, the person has a self-organizing communicative structure, so person cannot be unique, lonely. This has been called by Polo: «Coexistence». It shows that the «Díada» (Duality) is richness, plenitude (fullness). This makes possible to mark the difference between two complementary person’s types: the male person and the female person. They could be called: «coexistence-from» and «coexistence-in».

The operational definition of a weak value for a quantum mechanical system involves the limit of the weak measurement strength tending to zero. I study how this limit compares to the situation for the undisturbed system. Under certain conditions, which I investigate, this limit is discontinuous in the sense that it does not merge smoothly to the Hilbert space description of the undisturbed system. Hence, in these discontinuous cases, the weak value does not represent the undisturbed system. As a result, (...) conclusions drawn from such weak values regarding the properties of the studied system cannot be upheld. Examples are given. (shrink)

The COVID-19 pandemic shocked the global economy, with numerous companies suffering losses and shutting down. However, some companies proved to be resilient, being able to sustain their economic performance despite the pandemic. The study aims to explain the sustainable economic performance of companies during the COVID-19 pandemic. The relationships between empowering leadership, innovative work behavior, organizational readiness to change, and sustainable economic performance were assessed. The data were collected via an online questionnaire from January 2021 to March 2021, during the (...) height of the COVID-19 pandemic in Russia. The respondents were Russian companies’ employees holding management positions, competent to objectively assess organizational circumstances during the COVID-19 pandemic. A sample of 337 was used in the analysis. Confirmatory factor analysis (CFA) with maximum likelihood estimation was conducted using SPSS AMOS. The structural model was tested with standardized parameter estimates, standard errors, and p-values calculated. The findings of the study suggest that innovative work behavior and organizational readiness to learn have a direct influence on sustainable economic performance. The findings also suggest that empowering leadership impacts innovative work behavior but not sustainable economic performance. The mediation analysis indicates that innovative work behavior is a mediator between empowering leadership and sustainable economic performance, whereas organizational readiness to learn is not a moderator. The study adds to the leadership and sustainability body of knowledge and contributes to the research on the COVID-19 pandemic in the organizational context. (shrink)

Variations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)

In the Anthropology, the person has a self-organizing communicative structure, so person cannot be unique, lonely. This has been called by Polo: "Coexistence". It shows that the "Díada" (Duality) is richness, plenitude (fullness). This makes possible to mark the difference between two complementary person's types: the male person and the female person. They could be called: "coexistence-from" and "coexistence-in".

Georgians' acquaintance with Islam was with the first Arab raids. From the first Muslim Arab domination, Georgians started to become Muslims with cultural interaction. Islam spread especially in Eastern Georgia during the time of Muslim Arabs, Seljuks and Mongols. The spread of Islam in Western Georgia started with the Ottomans. The Ottoman Empire's contact with Georgia begins with the conquest of Trabzon by Fatih Sultan Mehmed. When the Ottomans contacted the region, the geography of Georgia was divided into small kingdoms. (...) With the conquest of Trabzon, the Georgian border was reached and in 1479, Acaristan, Borcka and Maçahel surroundings joined the Ottoman lands. On the one hand, Sukhumi was captured from the north. Then, continuing to advance in the region, Yavuz Sultan Selim paid tribute to the Kingdom of Güryel and Imeret (Açıkbaş) in 1508 during his governorship of Trabzon. Thus, the Ottoman borders had reached beyond the Black Sea coast into Western Georgia. As a result of the increasing relations around Adjaria, which came under Ottoman rule, Islamization began to spread rapidly among the people. Contrary to what is claimed, the spread of Islam in the region did not spread from the ruling strata to the lower, but from the popular strata to the ruling strata. This process was surprisingly fast. In the process of Islamization, many mosques, masjids and schools were built in Adjara, especially with the help of the people. The foundations operating in the region and the mosques and masjids serving under them show that, contrary to the claims of Russian and Georgian historians, Islamization took place rapidly at the beginning of the 17th century in Adjara. In this process, many mosques, masjids and schools were built in the region. In this research, based on the numerous Hurufat records belonging to Adjara, Batumi, Gönye, Çürüksu and Maçahel, the Islamization process will be evaluated by making a social reading with the data obtained from the religious structures established in the rural settlements of the Adjara geography and their officials. Evaluations were made on the Islamization process in Adjara by making a social reading. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment containing the (...) 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

The age of maturity of children to consent for medical research is under debate, as different authorities regard the capacity of young teenagers as either satisfactory or not to grant consent without parental participation in the process. The present paper contrasts the generally accepted guideline for ethics in paediatric research in Canada with what the same children are allowed and expected to be able to do as babysitters. This comparison reveals deep incongruences in the way the maturity of the same (...) children is appreciated for two different tasks. (shrink)

PURPOSE:To report the localization of a gene causing drusen and macular degeneration in a previously undescribed North American family. METHODS:Genetic mapping studies were performed using linkage analysis in a single family with drusen and atrophic macular degeneration. RESULTS:The clinical manifestations in this family ranged from fine macular drusen in asymptomatic middle-aged individuals to atrophic macular lesions in two children and two elderly patients. We mapped the gene to chromosome 6q14 between markers D6S2258 and D6S1644. CONCLUSIONS:In a family with autosomal dominant (...) drusen and atrophic macular degeneration, the gene maps to a 3.2-cM region on chromosome 6q14. This locus appears to be distinct from, but adjacent to, the loci for cone-rod dystrophy 7 (CORD7) and North Carolina macular dystrophy (MCDR1). Future identification of the gene responsible for the disease in this family will provide a better understanding of macular degeneration. (shrink)

We study the minimal enumeration degree problem in models of fragments of Peano arithmetic () and prove the following results: in any model M of Σ2 induction, there is a minimal enumeration degree if and only if M is a nonstandard model. Furthermore, any cut in such a model has minimal e-degree. By contrast, this phenomenon fails in the absence of Σ2 induction. In fact, whether every Σ2 cut has minimal e-degree is independent of the Σ2 bounding principle.

The article is devoted to dynamic processes in the field of artificial intelligence, namely in the tasks of neurodynamics. The problems of stability of transient processes in neural networks, which dynamics can be described by systems of weakly nonlinear difference equations, are considered. Conditions are formulated in terms of the direct Lyapunov method.

How international research might contribute to justice in global health has not been substantively addressed by bioethics. This article describes how the provision of ancillary care can link international clinical research to the reduction of global health disparities. It identifies the ancillary care obligations supported by a theory of global justice, showing that Jennifer Ruger’s health capability paradigm requires the delivery of ancillary care to trial participants for a limited subset of conditions that cause severe morbidity and mortality. Empirical research (...) on the Shoklo Malaria Research Unit’s (SMRU) vivax malaria treatment trial was then undertaken to demonstrate whether and how these obligations might be upheld in a resource-poor setting. Our findings show that fulfilment of the ancillary care obligations is feasible where there is commitment from chief investigators and funders and is strongly facilitated by SMRU’s dual role as a research unit and medical non-governmental organization. (shrink)

In folk songs, which can be described as melodies reflecting the feelings and thoughts of the people, it is possible to find all kinds of events experienced by the person or society, all kinds of emotions that can be felt, in other words, the joy, sadness, life and beliefs of individuals and/or society, in short, all elements of life. Folk songs are one of the most important sources in which society's perception of religion, religious life, and how religion is theoretically (...) or practically embodied in daily life can be determined. With this study, it is aimed to determine the reflections of the subject of “religion (Islam)” in the folk songs of Âşık Veysel, (the existence of the subject of religion, how it takes place theoretically and practically), and to classify and evaluate the materials found. Before moving on to the main topic in the study, brief and concise information was given about Âşık Veysel and his folk songs/poems. In the main part of the study, the religious elements contained in the lyrics of Âşık Veysel's compositions/adaptations and lyrics in a total of thirty-seven pieces of broken air style procedural (rhythmic) works belonging to him were examined in the form of substances. The works belonging to him that he sang as poems without melody, the works that were in a unmetered folk song style (uzun hava, rhythmless) and free rhythm, and the works whose lyrics belonged to other bards/poets and were performed by Âşık Veysel were not subjected to examination. This limitation of the scope of the study is due to the fact that Veysel's folk songs are more widespread, visible and listened to, as well as the fact that the analysis of all his works exceeds the volume of the article. Based on the saying “what is inside the cube seeps out of it”, a number of results have been achieved as a result of studying the religious elements found in the lyrics of the songs composed and sung by Âşık Veysel in the metered folk song style(kırık hava, rhythmic) style. Many religious and mystical topics such as Allah, prophets, holy books, worldly life, the hereafter, heaven, hell, death, mourning, fate, spiritual/luminous beings, sacrifice, prayer, curse, martyrdom, veteran, sects, loyalty and dhikr have been directly or indirectly included in folk songs, which are usually seen to be sung/written in an admonitory style. Prayer, zakat, fasting, hajj, etc. practical issues have not been included at all. (shrink)

Arte, educación y comunidad en la estética pedagógica Resumen: Una de las corrientes estéticas contemporáneas más pujantes, la «estética pedagógica», planteó desde sus comienzos la combinación entre el arte y la educación. Las creaciones respaldadas por esta orientación se basan en muchas de las ideas de las pedagogías críticas de los años 60 e igualmente en los presupuestos de las llamadas últimas vanguardias artísticas. Todas ellas comparten un mismo espíritu emancipador en sintonía con las teorías más críticas con la sociedad (...) de producción capitalista. Pero en los últimos años la «estética pedagógica» se ha visto empujada a problematizar la cuestión de la «comunidad» desde diferentes puntos de vista, partiendo de la base de que no puede haber educación ni arte sin un replanteamiento del espacio en común que ambos ponen en juego. Palabras clave: Arte. Educación. Política. Comunidad. Art, Education and Community in Pedagogical Aesthetics: one of the most thriving contemporary aesthetic trends, «Pedagogical Aesthetics», raised from its beginnings the combination between art and education. The creations supported by this orientation are based on many of the ideas of the critical pedagogies of the 60s and also on the budgets of the so-called latest artistic avant-gardes. All of them share the same emancipatory spirit in tune with the most critical theories with the capitalist production society. But in recent years the «pedagogical aesthetic» has been pushed to problematize the question of «community» from different points of view, based on the fact that there can be no education or art without a rethinking of the common space that both put into play. Keywords: Art. Education. Politics. Community Arte, educação e comunidade em estética pedagógica Resumo: uma das tendências estéticas contemporâneas mais prósperas, a «estética pedagógica», levantou desde o início a combinação entre arte e educação. As criações apoiadas por essa orientação baseiam-se em muitas das idéias das pedagogias críticas dos anos 60 e também nos orçamentos das chamadas vanguardas artísticas mais recentes. Todos eles compartilham o mesmo espírito emancipatório em sintonia com as teorias mais críticas da sociedade capitalista de produção. Mas, nos últimos anos, a «estética pedagógica» foi levada a problematizar a questão da «comunidade» de diferentes pontos de vista, com base no fato de que não pode haver educação ou arte sem repensar o espaço comum que ambos Eles colocam em jogo. Palavras-chave: Arte. Educação. Política. Comunidade. Data de registro:16/06/2020 Data de aceite: 22/07/2020. (shrink)

In this chapter we extend earlier work (Vinuesa et al., Nat Commun 11, 2020) on the potential of artificial intelligence (AI) to achieve the 17 Sustainable Development Goals (SDGs) proposed by the United Nations (UN) for the 2030 Agenda. The present contribution focuses on three SDGs related to healthy and sustainable societies, i.e., SDG 3 (on good health), SDG 11 (on sustainable cities), and SDG 13 (on climate action). This chapter extends the previous study within those three goals and goes (...) beyond the 2030 targets. These SDGs are selected because they are closely related to the coronavirus disease 19 (COVID-19) pandemic and also to crises like climate change, which constitute important challenges to our society. (shrink)