BackgroundWhen conducting research with Indigenous populations consent should be sought from both individual participants and the local community. We aimed to search and summarise the literature about methods for seeking consent for research with Indigenous populations.MethodsA systematic literature search was conducted for articles that describe or evaluate the process of seeking informed consent for research with Indigenous participants. Guidelines for ethical research and for seeking consent with Indigenous people are also included in our review.ResultsOf 1447 articles found 1391 were excluded (...) ; 56 were relevant and included. Articles were categorised into original research that evaluated the consent process or publications detailing the process of seeking consent and guidelines for ethical research. Guidelines were categorised into international ; national and state/regional/local guidelines. In five studies based in Australia, Canada and The United States of America the consent process with Indigenous people was objectively evaluated. In 13 other studies interpreters, voice recording, videos, pictures, flipcharts and “plain language” forms were used to assist in seeking consent but these processes were not evaluated. Some Indigenous organisations provide examples of community-designed resources for seeking consent and describe methods of community engagement, but none are evaluated. International, national and local ethical guidelines stress the importance of upholding Indigenous values but fail to specify methods for engaging communities or obtaining individual consent. In the ‘Grey literature’ concerns about the consent process are identified but no solutions are offered.ConclusionConsultation with Indigenous communities is needed to determine how consent should be sought from the community and the individual, and how to evaluate this process. (shrink)

Researchers are required to seek consent from Indigenous communities prior to conducting research but there is inadequate information about how Indigenous people understand and become fully engaged with this consent process. Few studies evaluate the preference or understanding of the consent process for research with Indigenous populations. Lack of informed consent can impact on research findings. The Picture Talk Project was initiated with senior Aboriginal leaders of the Fitzroy Valley community situated in the far north of Western Australia. Aboriginal people (...) were interviewed about their understanding and experiences of research and consent processes. Transcripts were analysed using NVivo10 software with an integrated method of inductive and deductive coding and based in grounded theory. Local Aboriginal interpreters validated coding. Major themes were defined and supporting quotes sourced. Interviews with Aboriginal leaders were facilitated by a local Aboriginal Community Navigator who could interpret if necessary and provide cultural guidance. Participants were from all four major local language groups of the Fitzroy Valley; aged 31 years and above; and half were male. Themes emerging from these discussions included Research—finding knowledge; Being respectful of Aboriginal people, Working on country, and Being flexible with time; Working together with good communication; Reciprocity—two-way learning; and Reaching consent. The project revealed how much more there is to be learned about how research with remote Aboriginal communities should be conducted such that it is both culturally respectful and, importantly, meaningful for participants. We identify important elements in community consultation about research and seeking consent. (shrink)

The consent and community engagement process for research with Indigenous communities is rarely evaluated. Research protocols are not always collaborative, inclusive or culturally respectful. If participants do not trust or understand the research, selection bias may occur in recruitment, affecting study results potentially denying participants the opportunity to provide more knowledge and greater understanding about their community. Poorly informed consent can also harm the individual participant and the community as a whole. Invited by local Aboriginal community leaders of the Fitzroy (...) Valley, the Kimberley, Western Australia, The Picture Talk project explores the consent process for research. Focus groups of Aboriginal community members were conducted to establish preferences for methods of seeking individual consent. Transcripts were analysed through NVivo10 Qualitative software using grounded theory with inductive and deductive coding. Themes were synthesised with quotes highlighted. Focus groups with Aboriginal community members were facilitated by a Community Navigator as a cultural guide and interpreter and a researcher. Participants were recruited from all main language groups of the Fitzroy Valley – Gooniyandi, Walmajarri, Wangkatjungka, Bunuba and Nikinya. Participants were aged ≥18 years, with 5 female groups and one male group. Themes identified include: Reputation and trust is essential; The Community Navigator is key; Pictures give the words meaning – milli milli versus Pictures; Achieving consensus in circles; Signing for consent; and Research is needed in the Valley. Aboriginal communities of the Fitzroy Valley recommend that researchers collaborate with local leaders, develop trust and foster a good reputation in the community prior to research. Local Aboriginal researchers should be employed to provide cultural guidance throughout the research process and interpret local languages especially for elders. Pictures are preferred to written text to explain research information and most prefer to sign for consent. The Fitzroy Valley welcomes research when collaborative and for the benefit of the community. Future research could include exploring how to support young people, promote health screening and improve understanding of medical knowledge. (shrink)

The BTB domain is a protein–protein interaction motif that is found throughout eukaryotes. It determines a unique tri‐dimensional fold with a large interaction surface. The exposed residues are highly variable and can permit dimerization and oligomerization, as well as interaction with a number of other proteins. BTB‐containing proteins are numerous and control cellular processes that range from actin dynamics to cell‐cycle regulation. Here, we review findings in the field of transcriptional regulation to illustrate how the high variability of the BTB (...) has allowed related transcription factors to evolve different functional abilities. We then report how recent work has showed that, in spite of their high sequence divergence and apparently unrelated functions, many BTB‐containing proteins have at least one shared role: the recruitment of degradation targets to E3 ubiquitin ligase complexes. Taken together, these findings illustrate diverse and convergent functions of a versatile protein–protein interaction domain. BioEssays 28: 1194–1202, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Conformément au protocole défini avec les autorités chypriotes, une opération d’étude et de fouille de la zone du bassin naturel, à l’emplacement supposé du port interne d’Amathonte, a débuté en 2014. Une première campagne de fouilles s’est tenue du 15 septembre au 10 octobre 2014. Elle fut précédée d’une enquête géomorphologique au printemps de la même année. La seconde fouille a eu lieu du 31 août au 25 septembre 2015. Des campagnes intermédiaires d’étude du matériel, essentiellement sur le...

Based on multiDEVS formalism, we introduce multiPDEVS, a parallel and nonmodular formalism for discrete event system specification. This formalism provides combined advantages of PDEVS and multiDEVS approaches, such as excellent simulation capabilities for simultaneously scheduled events and components able to influence each other using exclusively their state transitions. We next show the soundness of the formalism by giving a construction showing that any multiPDEVS model is equivalent to a PDEVS atomic model. We then present the simulation procedure associated, usually called (...) abstract simulator. As a well-adapted formalism to express cellular automata, we finally propose to compare an implementation of multiPDEVS formalism with a more classical Cell-DEVS implementation through a fire spread application. (shrink)

We consider logical expressions built on the single binary connector of implication and a finite number of literals . We prove that asymptotically, when the number of variables becomes large, all tautologies have the following simple structure: either a premise equal to the goal, or two premises which are opposite literals.

Antoine Arnauld and Pierre Nicole were philosophers and theologians associated with Port-Royal Abbey, a centre of the Catholic Jansenist movement in seventeenth-century France. Their enormously influential Logic or the Art of Thinking, which went through five editions in their lifetimes, treats topics in logic, language, theory of knowledge and metaphysics, and also articulates the response of 'heretical' Jansenist Catholicism to orthodox Catholic and Protestant views on grace, free will and the sacraments. In attempting to combine the categorical theory of (...) the proposition with a Cartesian account of knowledge, their Logic represents the classical view of judgment which inspired the modern transformation in logic and semantic theory by Frege, Russell, Wittgenstein and recent philosophers. This edition presents a new translation of the text, together with a historical introduction and suggestions for further reading. (shrink)

İbâziyye hicrî birinci yüzyılda neş’et eden ilk kelâm fırkalarından birisidir. Birçok makâlât türü eserde İbâziyye’nin, Hariciliğin en mu’tedili ve günümüze ulaşan tek kolu olduğu ifade edilmektedir. Buna rağmen ilk dönem İbâzî âlimlerden günümüz İbâzîlerine kadar birçok kişi, İbâziyye’nin Haricî bir fırka olmadığını savunmaktadır. İbâzîler şirk ve isti’raz gibi bazı konularda Haricilerden farklı görüşlere sahip olmakla birlikte, iman-küfür, tevellâ-teberrî, imâmet, vb. birçok konuda ise Haricîlerin görüşlerine benzer görüşleri savunmaktadırlar. Bu çalışmamızda bizzat İbâzî kelâm metinlerinden hareketle İbâzîlerin Haricî bir fırka olup olmadığını (...) irdelemeye çalışacağız. (shrink)

Coordination of a power system with the phasor measurement devices in real time on the load and generation sides is carried out within the context of smart grid studies. Power systems equipped with information systems in a smart grid pace with external security threats. Developing a smart grid which can resist against cyber threats is considered indispensable for the uninterrupted operation. In this study, a two-way secure communication methodology underpinned by a chaos-based encryption algorithm for PMU devices is proposed. The (...) proposed system uses the IEEE-14 busbar system on which the optimum PMU placement has been installed. The proposed hyperchaotic system-based encryption method is applied as a new security methodology among PMU devices. The success of results is evaluated by the completeness of data exchange, durations, the complexity of encryption-decryption processes, and strength of cryptography using a microcomputer-based implementation. The results show that the proposed microcomputer-based encryption algorithms can be directly embedded as encryption hardware units into PMU and PDC devices which have very fast signal processing capabilities taking into considerations the acceptable delay time for power system protection and measuring applications and quality metering applications which is 2 ms and 10 ms, respectively. While proposed algorithms can be used in TCP or UDP over IP-based IEEE C37.118, IEC 61850, and IEC 61850-90-5 communication frameworks, they can also be embedded into electronic cards, smartcards, or smart tokens which are utilized for authentication among smart grid components. (shrink)

In the history of Islam, many scholars who have contributed to Islamic sciences both with their works and their thoughts have been attributed to teşeyyuʻ (being inclined to Shi'ism). Dārakutnī (d. 385/995) is one of the scholars who were subjected to this accusation. Dārakutnī, who was considered one of the leading ḥadīth reciters of his period with his strong memory and deep understanding, wrote many works showing his competence in the science of ḥadīth He was also given the title of (...) “Amīr al-mu’minīn fi’l-hadīs”, a title bestowed upon very few people. The background behind Dārakutnī’s accusation of teşeyyuʻ is that he memorized the poems of Sayyid al-Himyerî (d. 173/789), a Shiite poet. In this article, the allegation of teşeyyu' attributed to Dārakutnī has been examined and the information that constitutes the source of the said accusation against him has been examined and whether this accusation has been handled on a solid basis has been examined. As a result of the research conducted on both Dārakutnī’s own words and works and the Ahl al-Sunnah and Shia rijāl literature, it was concluded that the accusation of teşeyyu' directed against Dārakutnī was merely an allegation and was not based on a scientific basis. In the research, the information in the relevant sources was examined and an attempt was made to present the information obtained in an objective manner. (shrink)

Bu makalede Erken dönem Eş‘ariyye’de dakîku’l-kelâm konusu izah edilmeye çalışılacaktır. Kelâm ilminin sistematik hale gelişinden itibaren konuları genellikle dakîku’l-kelâm ve celîlu’l-kelâm şeklinde ikili bir tasnifle ele alınmıştır. Dakîku’l-kelâm, konusu itibariyle âlem, âlemin unsurları, cevher, araz, cisim gibi fizik alanına tekabül ederken celîlu’l-kelâm ise uluhiyyet, nübüvvet ve sem’iyyât ile ilişkili olan metafizik alana tekabül etmektedir. Hicrî dördüncü asırda teşekkül eden Eş‘arî kelâm okulu varlık konusu başta olmak üzere fizik ve metafizik konuları sistematik bir şekilde ele almıştır. Erken dönem Eş‘arî kelâmında kelâm (...) ilminin fizik alanına tekabül eden dakîku’l-kelâm konularına epeyce yer verilmiştir. Bu çalışmada amacımız erken dönem Eş‘ariyye’nin Allah-âlem ilişkisi, âlemin hudûsu ve unsurları, cisim, cevher ve araz gibi meseleleri içeren dakîku’l-kelâm anlayışını sunmaktır. Allah-âlem ilişkisini ele almada daha önceleri Mu‘tezile tarafından kullanılan kelâm atomculuğunun Eş‘arî kelâmında da benimsenip benimsenmediğine değinilecektir. Aynı şekilde Âlemin işleyişinde bir zorunluluğun olup olmadığı meselesini konu edinen illiyet/nedensellik tartışmaları da ele alınacaktır. Bu çalışmanın erken dönem Eş‘arî kelâmının dakîku’l-kelâm alanındaki özgünlüğünü ortaya koymasını ve yeni çalışmalara kapı aralayarak literatüre bir katkı sunmasını umuyoruz. Çalışmada literatür taraması, mukayese ve metin analizi yöntemi kullanılmış olup konu erken dönem Eş‘ariyye ile sınırlandırılmıştır. (shrink)

Recent brain imaging studies using functional magnetic resonance imaging (fMRI) have implicated insula and anterior cingulate cortices in the empathic response to another’s pain. However, virtually nothing is known about the impact of the voluntary generation of compassion on this network. To investigate these questions we assessed brain activity using fMRI while novice and expert meditation practitioners generated a loving-kindness-compassion meditation state. To probe affective reactivity, we presented emotional and neutral sounds during the meditation and comparison periods. Our main hypothesis (...) was that the concern for others cultivated during this form of meditation enhances affective processing, in particular in response to sounds of distress, and that this response to emotional sounds is modulated by the degree of meditation training. The presentation of the emotional sounds was associated with increased pupil diameter and activation of limbic regions (insula and cingulate cortices) during meditation (versus rest). During meditation, activation in insula was greater during presentation of negative sounds than positive or neutral sounds in expert than it was in novice meditators. The strength of activation in insula was also associated with self-reported intensity of the meditation for both groups. These results support the role of the limbic circuitry in emotion sharing. The comparison between meditation vs. rest states between experts and novices also showed increased activation in amygdala, right temporo-parietal junction (TPJ), and right posterior superior temporal sulcus (pSTS) in response to all sounds, suggesting, greater detection of the emotional sounds, and enhanced mentation in response to emotional human vocalizations for experts than novices during meditation. Together these data indicate that the mental expertise to cultivate positive emotion alters the activation of circuitries previously linked to empathy and theory of mind in response to emotional stimuli.. (shrink)

This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

PLoS ONE 3(3): e1897. doi:10.1371/journal.pone.

Attention to internal body sensations is practiced in most meditation traditions. Many traditions state that this practice results in increased awareness of internal body sensations, but scientific studies evaluating this claim are lacking. We predicted that experienced meditators would display performance superior to that of nonmeditators on heartbeat detection, a standard noninvasive measure of resting interoceptive awareness. We compared two groups of meditators (Tibetan Buddhist and Kundalini) to an age- and body mass index-matched group of nonmeditators. Contrary to our prediction, (...) we found no evidence that meditators were superior to nonmeditators in the heartbeat detection task, across several sessions and respiratory modulation conditions. Compared to nonmeditators, however, meditators consistently rated their interoceptive performance as superior and the difficulty of the task as easier. These results provide evidence against the notion that practicing attention to internal body sensations, a core feature of meditation, enhances the ability to sense the heartbeat at rest. (shrink)

C’est en 1913 que sont publiées les Idées directrices pour une phénoménologie. Fruit d’une longue genèse, ce livre constitue un véritable manifeste pour une nouvelle science, la « science des phénomènes », décrivant les actes de la conscience et les structures de la subjectivité. Laurent Perreau, Antoine Grandjean et leurs contributeurs interrogent le projet et les méthodes de ce maître ouvrage : la réduction, le rapport à Descartes, l’intentionnalité, la notion d’évidence apodictique... Une étude majeure sur une oeuvre qui (...) a inspiré la philosophie moderne et marqué en profondeur la pensée de Max Scheler, Heidegger, Hannah Arendt, Merleau-Ponty, Paul Ricoeur... (shrink)

Ahlak, 21.yüzyıl insanının dikkate alması gereken temel bir varlık alanıdır. Bu alan içinde, bireysel ve toplumsal yaşamı yönlendiren erdem ve erdemsizlik tartışması önemli bir yer tutar. Bu makalede, Mevlana’nın görüşlerine özel atıfla, bir erdemsizlik örneği olarak vefasızlık üzerinde durulmaktadır.

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Laboratoire de Neurosciences Cognitives et Imagerie Ce´re´brale (LENA), Hoˆpital de La Salpeˆtrie`re, Centre National de la Recherche Scientifique (CNRS).

Interoperability across data sets is a key challenge for quantitative histopathological imaging. There is a need for an ontology that can support effective merging of pathological image data with associated clinical and demographic data. To foster organized, cross-disciplinary, information-driven collaborations in the pathological imaging field, we propose to develop an ontology to represent imaging data and methods used in pathological imaging and analysis, and call it Quantitative Histopathological Imaging Ontology – QHIO. We apply QHIO to breast cancer hot-spot detection with (...) the goal of enhancing reliability of detection by promoting the sharing of data between image analysts. (shrink)

Publie en 1683 comme un preambule a la refutation du Traite de la nature et de la grace de Nicolas Malebranche, l'ouvrage Vraies et fausses idees d'Antoine Arnauld (1612-1694) a connu un etonnant destin. Cette defense tres argumentee de la conception cartesienne des idees est peu a peu devenue un texte incontournable dans les debats de philosophie de la connaissance, cite et commente aussi bien par les auteurs classiques que dans les debats anglosaxons contemporains. Ce volume en propose la (...) premiere edition critique annotee en francais. Des annexes apportent en outre quelques outils pour se reperer dans l'important corpus de textes de philosophie de la connaissance rediges par Arnauld. (shrink)

NOTES: Based on the book Socrates on trial written by Andrew Irvine and published by the University of Toronto Press. Performed at the Chan Centre for the Performing Arts, University of British Columbia, Vancouver, Canada, May 31-June 7, 2008. CONTENTS: Trailer, Who was Socrates?, Selected scenes, The production, Credits. UBC Library Catalogue Permanent URL: http://resolve.library.ubc.ca/cgi-bin/catsearch?bid=3956307.

The institutional model as delineated by classical Public Administration has limited utility for public administration in the developing countries. There are unlikely to be any uniform structural remedies foradministrative defects in those countries. Similar relationships do not have similar consequences in different contexts. An increased awareness along these lines led to the emergence of Development Administration- an effort to relate structures to goals - and Comparative Public Administration - analysis of administrative structures in their own societal contexts. The basic argument (...) of the present articles is that despite our increased sophistication on these matters the relevance in Development Administration cannot be obtained if one relies only on theoretical knowledge. It is noted that in Development Administration thinking must descend from the heights of systematic theory to the open country of praxis. (shrink)