Sight is undoubtedly the most crucial sense, and accidents resulting in its loss are a significant tragedy for individuals. The scientific community embarked on a journey of scientific innovation i...

It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3′ untranslated regions (UTRs). The functionality of sites in the coding domain sequence (CDS), on the other hand, remains under discussion. Such sites have limited impact on target mRNA abundance and recent work suggests that miRNAs bind in the CDS to inhibit translation. What then could be the regulatory benefits of translation inhibition through CDS targeting compared to mRNA degradation following 3′ UTR binding? We propose that these (...) domain‐dependent effects serve to diversify the functional repertoire of post‐transcriptional gene expression control. Possible regulatory benefits may include tuning the time‐scale and magnitude of post‐transcriptional regulation, regulating protein abundance depending on or independently of the cellular state, and regulation of the protein abundance of alternative splice variants. Finally, we review emerging evidence that these ideas may generalize to RNA‐binding proteins beyond miRNAs and Argonaute proteins. (shrink)

One of the major issues in the debate about the future of health care is how to keep costs under control while meeting growing demands for care. Addressing that, especially on an international scale, is far from easy. How are we to determine what the demands for care will most likely be? Even if it is not possible to estimate the future number of dependent elderly persons with any precision, it is hard to ignore the most probable scenario: a substantial (...) increase in the number of the oldest old. (shrink)

No presente artigo, pretende-se expor e analisar as críticas que Noam Chomsky dirige contra o materialismo em filosofia da mente. Para o referido autor, a rigor, não faria sentido questionar o estatuto ontológico da mente, na medida em que os próprios físicos e filósofos materialistas desconhecem 90% da matéria que constitui o universo. Deste modo, Chomsky dirá que no tempo de Descartes, da filosofia mecânica, o que se fazia era ciência normal, ao passo que após o advento das ideias de (...) Newton, o universo passa a ser antimaterialista. O presente trabalho pode ser útil/valioso à filosofia e história das ciências naturais, à física e à filosofia da mente.The aim of this paper is to expose and analyze Noam Chomsky’s criticisms against materialism in philosophy of mind. For this author, strictly speaking, questioning the ontological status of the mind would not make sense, considering that the materialistic physicists and philosophers themselves are unaware of 90% of the matter that constitutes the universe. Accordingly, Chomsky will say that in Descartes’ time, or in times of mechanical philosophy, what was done was normal science, while after the advent of Newton's ideas the universe becomes anti-materialist. This paper can be useful/valuable to philosophy and history of natural sciences, physics and philosophy of mind. (shrink)

Russell’s theory of memory as acquaintance with the past seems to square uneasily with his definition of acquaintance as the converse of the relation of presentation of an object to a subject. We show how the two views can be made to cohere under a suitable construal of ‘presentation’, which has the additional appeal of bringing Russell’s theory of memory closer to contemporary views on direct reference and object-dependent thinking than is usually acknowledged. The drawback is that memory as acquaintance (...) with the past falls short of fulfilling Russell’s requirement that knowledge by acquaintance be discriminating knowledge – a shortcoming shared by contemporary externalist accounts of knowledge from memory. (shrink)

Social fears emerging in adolescence can have negative effects on emotional well-being. Yet the mechanisms by which these risks occur are unknown. One possibility is that associative learning results in fears to previously neutral social stimuli. Such conditioned responses may alter subsequent processing of social stimuli. We used a novel conditioning task to examine how associative processes influence social fear and attention orienting in adolescents. Neutral photographs were paired with socially rewarding or aversive stimuli during conditioning; a dot-probe task then (...) assessed biases in attention orienting. The social conditioning task modified subjective ratings of the neutral stimuli. Moreover, for the neutral stimulus that was paired with the aversive stimulus, the strength of conditioning showed a relationship with subsequent attentional vigilance. The findings elucidate mechanisms by which negative peer experiences during adolescence may affect emotional processing. (shrink)

O objetivo deste artigo, que se insere no âmbito da filosofia da religião, é tratar o problema lógico do mal e mais concretamente a teoria da defesa do livre-arbítrio de Alvin Plantinga. Quero examinar se esta é uma teoria plausível e se resiste a algumas objeções. Pretendo defender que esta teoria parece resistir a certas objeções.

Animals, like humans, suffer and die from natural causes. This is particularly true of animals living in the wild, given their high exposure to, and low capacity to cope with, harmful natural processes. Most wild animals likely have short lives, full of suffering, usually ending in terrible deaths. This book argues that on the assumption that we have reasons to assist others in need, we should intervene in nature to prevent or reduce the harms wild animals suffer, provided that it (...) is feasible and that the expected result is positive overall. It is of the utmost importance that academics from different disciplines as well as animal advocates begin to confront this issue. The more people are concerned with wild animal suffering, the more probable it is that safe and effective solutions to the plight of wild animals will be implemented in the future. (shrink)

The construal of ‘exists’ as a first-order or real predicate is defended against prevailing orthodoxy.

Within an increasingly unequal, heterogeneous, and authoritarian Global North, a new global consumerism movement championed by activist consumers, together with academics, managers, and organizations, has emerged as the ultimate ethical management discourse for a better global future. NGC reframes Cold War official history of buycott consumerism by emancipating “passive” consumers and “insurgent” boycotts. Drawing on decolonial liberating transmodernity from Latin America, this paper shows how and why “old” and “new” dominant histories of consumerism deny the racialist/colonialist side of liberal capitalism. (...) The discussion involves transmodern and counter-transmodern mechanisms and overlooks everyday liberating boycott consumerism against the colonialism/racialism mobilized by subaltern victims of history. We problematize the re-appropriation of transmodernity as a potential path to decolonizing consumerism and management historiography from a majority perspective. (shrink)

We thank Parker and Wright for engaging in this roundtable debate in such a spirited way. The ‘Pharmacogenetic [test] to Avoid Loss of Hearing’ (PALOH) Trial is the first time a genetic point of care test has been applied in the acute neonatal setting; therefore, it is not surprising that questions have been raised which require debate, discussion and clarification. Parker and Wright misattribute several assumptions to the roundtable authors, which we would like to clarify here. Since they raise wider (...) questions about the PALOH trial itself, several of the roundtable discussants have made a joint response. (shrink)

Ideology and self-interest are often in tension. If positive political theorists assume broad self-interest as the standard of human behaviour, they can accommodate people’s ideological motivation to act for the common good. Yet, their theories may become tautological and empirically untestable. Conversely, if these theorists assume narrow self-interest, they increase testability. But because ideology seems incompatible with narrow self-interest, they often rule ideology out as a motivational driver. Positive political theorists can, however, combine ideology with narrow self-interest by assuming broad (...) egoism. And in so doing, they should assume that ideology motivates political agents until it becomes too costly for these agents’ material interests. (shrink)

Resumo O meu objetivo neste artigo é examinar criticamente o argumento de Kripke contra a teoria da identidade tipo-tipo. Assumindo a tese da necessidade da identidade, bem como a tese da designação rígida, Kripke sustenta que se a dor é idêntica à estimulação das fibras C, então a dor é necessariamente idêntica à estimulação das fibras C. No entanto, precisamente porque a proposição expressa pela frase “a dor não é idêntica à estimulação das fibras C” é uma possibilidade metafísica, Kripke (...) conclui, por modus tollens, que não há identidade entre dor e estimulação das fibras C. Por isso, a teoria da identidade tipo-tipo não é uma solução bemsucedida para o problema da mente-corpo. Este artigo tem duas partes. Na primeira parte, que é expositiva, apresento o argumento de Kripke contra a teoria da identidade tipo-tipo. Subsequentemente, ponho em causa o argumento de Kripke, argumentando que não é procedente, pois a nossa situação epistémica atual não nos permite determinar se é metafisicamente possível a dor não ser idêntica à estimulação das fibras C. Assim, Kripke não refuta a teoria da identidade tipo-tipo. Palavras-chave : designação rígida, filosofia da mente, identidade tipo-tipo, Kripke, necessidade da identidadeMy aim in this paper is to critically assess Kripke’s argument against the type-type identity theory. Assuming the thesis of the necessity of identity, as well as the thesis of rigid designation, Kripke holds that if pain is identical with C-fibre firing, then pain is necessarily identical with C-fibre firing. However, precisely because the proposition expressed by the sentence “pain is not identical with C-fibre firing” is a metaphysical possibility, Kripke concludes, by modus tollens, that pain and C-fibre firing are not identical. Therefore, the type-type identity theory is not a successful solution to the mind-body problem. So this paper has two parts. In the first part, which is expositive, I present Kripke’s argument against the type-type identity theory. After that, I will dispute Kripke’s argument, arguing that it is not sound, for our current epistemic situation does not allow us to determine whether it is a metaphysical possibility that pain is not identical with C-fibre firing. Thus, Kripke does not refute the type-type identity theory. Keywords : Kripke, necessity of identity, philosophy of mind, rigid designation, type-type identity. (shrink)

Should Proverbs be read as prose or poetry? Considering the language craft is of essential significance for a hermeneutical enquiry into the biblical book of Proverbs. Five suppositions to support the presupposition that Proverbs is best read as poetry were considered.

Dissertação: FARIA, Thiago Hot Pereira de. Mishná e Belo Horizonte: A influência da cultura oral na comunidade judaica belo-horizontina. 2014. Dissertação – Pontifícia Universidade Católica de Minas Gerais, Programa de Pós-graduação em Ciências da Religião, Belo Horizonte.

Our ability to generate genomic data is currently well ahead of our ability to understand what they mean, raising challenges about how best to engage with them. This article considers ethical aspects of work with such data, focussing on research contexts that are intertwined with clinical care. We discuss the identifying nature of genomic data, the medical information intrinsic within them, and their linking of people within a biological family. We go on to consider what this means for consent, the (...) importance of thoughtful sharing of genomic data, the challenge of constructing meaningful findings, and the legacy of unequal representation in genomic datasets. We argue that the ongoing success of genomic data research relies on public trust in the enterprise: to justify this trust, we need to ensure robust stewarding, and wide engagement about the ethical issues inherent in such practices. (shrink)

The UK Genethics Club was established in November 2001 in order to provide a national forum of ethics support for the profession of clinical genetics in the UK. The forum brings together health professionals, medical ethicists and lawyers and support is provided through detailed discussion of cases and sharing of good practice. Clinical genetics professionals had previously voiced concerns about making extremely difficult ethical decisions, with profound implications, in something of a vacuum. Professionals saw a lack of guidance in the (...) area and lack of time for discussion of difficult cases as reasons for this. This paper describes the origins of the group and gives (anonymized) examples of some of the types of issues discussed. (shrink)

There is a paucity of experimental data addressing how peers influence adolescent risk-taking. Here, we examined peer effects on risky decision-making in adults and adolescents using a virtual social context that enabled experimental control over the peer “interactions”. 40 adolescents (age 11-18) and 28 adults (age 20-38) completed a risk-taking (Wheel of Fortune) task under 4 conditions: in private; while being observed by (fictitious) peers; and after receiving ‘risky’ or ‘safe’ advice from the peers. For high-risk gambles (but not medium-risk (...) or even gambles), adolescents made more risky decisions under peer observation than adults. Adolescents, but not adults, tended to resist ‘safe’ advice for high-risk gambles. Although both groups tended to follow ‘risky’ advice for high-risk gambles, adults did so more than adolescents. These findings highlight the importance of distinguishing between the effects of peer observation and peer advice on risky decision-making. (shrink)

The documents published about sociology in the files between 1990 and 1999 are analyzed. The following topics are observed: distribution for years, countries, languages, types of documents, topics treated and journals in which the studies are published. At the same time the different institution..

Este trabalho é uma proposta de ensino de sintaxe para os cursos de Licenciatura em Letras. Os objetivos que me levaram a escrever este texto foram os seguintes: reabrir a discussão acerca da necessidade de revisar o que sugere a Nomenclatura Gramatical Brasileira no âmbito da análise sintática; reinvindicar o reconhecimento da noção de sintagma como unidade sintática construída hierarquicamente e localizada entre o vocábulo e a sentença; e reconhecer dois níveis de estruturação sintática – oracional e suboracional –, em (...) vez da tríplice partição da NGB – termos essenciais, termos integrantes e termos acessórios. As ideias aqui defendidas estão fundamentadas nos pressupostos teóricos da Gramática Gerativa, mais especificamente no modelo de Princípios e Parâmentros, bem como em propostas alicerçadas na Linguística de Texto. (shrink)

The aim of this paper is to relate two trending topics in contemporary epistemology: the discussion of group knowledge and the discussion of knowledge-first approach. In social epistemology no one has seriously applied and developed Williamson’s theory of knowledge-first approach to the case of group knowledge yet. For example, scholars of group knowledge typically assume that knowledge is analyzed in terms of more basic concepts, such as group belief or acceptance, group justification, and so on. However, if Williamson’s theory of (...) knowledge is correct, these are not good analyzes for understanding group knowledge. For, in such framework, knowledge is not analyzed in terms of belief and justification, and the same should apply to group knowledge. Thus, we propose to analyze which consequences Williamson’s theory has for social epistemology, namely for an understanding of group knowledge. The questions that will guide this article are the following: What is a knowledge-first approach to group knowledge? And what does a knowledge-first approach teach us with regard to one of the most pressing issues of social epistemology, namely the dispute between summativists and non-summativists accounts of groups? We claim that a knowledge-first account of group knowledge can be offered and that it favors non-summativism. (shrink)

Parenting is a transforming experience for the life of parents that brings joy and satisfaction as well as challenges, frustration, and demands. The aim of this study was to determine the relationship between “parental stress and satisfaction” and work-home conflict, perceived social support, and global satisfaction with life, and to determine the moderating role of the parent's gender. A sample of 244 participants was studied: 49.6% (121) mothers and 50.4% (123) fathers with children between 2 and 12 years of age. (...) The data was analysed by means of multiple linear regression models and Beta regression for stress and parental satisfaction, respectively, and they were complemented with general and conditional dominance analyses to estimate the relevance of the predictors. Mothers presented higher levels of parental stress and satisfaction than fathers. Being female, having two children, and home-work conflict were predictors of a higher parental stress. Age was also a predictor, as younger parents and also those older than 37 years of age showed more parental stress. Having no partner and being male was associated to lower parental satisfaction. In conclusion, parental stress and satisfaction emerge as clearly differentiated dimensions of parenting experience. The gender gap in parental stress could be linked to the persistence of traditional roles regarding the care of the children, in agreement with the findings in other research. (shrink)

In this paper I present a proposal to reformulate the argument of Alvin Plantinga (2011) against metaphysical naturalism. Contrary to Plantinga’s argument, in this new version I propose to consider the probability of the reliability of cognitive faculties, not with regard to any kind of beliefs, but only with respect to metaphysical beliefs. I claim that those who accept naturalism have a defeater for the belief that their cognitive faculties are reliable with respect to metaphysical beliefs and, thus, they have (...) a defeater for any of their metaphysical beliefs, including the belief in metaphysical naturalism. Therefore, those who accept naturalism have a defeater for naturalism; in other words, metaphysical naturalism is self-defeating. (shrink)

In his 1903 Syllabus, Charles S. Peirce makes a distinction between icons and iconic signs, or hypoicons, and briefly introduces a division of the latter into images, diagrams, and metaphors. Peirce scholars have tried to make better sense of those concepts by understanding iconic signs in the context of the ten classes of signs described in the same Syllabus. We will argue, however, that the three kinds of hypoicons can better be understood in the context of Peirce's sixty-six classes of (...) signs. We analyze examples of hypoicons taken from the field of information design, describing them in the framework of the sixty-six classes, and discuss the consequences of those descriptions to the debate about the order of determination of the 10 trichotomies that form those classes. (shrink)

Na filosofia de Levinas, o conceito de infinito é, por excelência, uma categoria ética. O artigo investiga a possibilidade de pensar o infinito como categoria estética, elegendo, para tanto, dois textos particularmente significativos para a compreensão da evolução estética do pensamento levinasiano: La réalité et son ombre e Autrement qu’être ou au-delà de l’essence. A arte é analisada sob o ponto de vista da linguagem, sendo a crítica da ontologia o motivo fundamental do discurso ético e estético. PALAVRAS-CHAVE – Infinito. (...) Estética. Ética. Linguagem. (shrink)

Trata-se de relato de experiência sobre a rede de atençao psicossocial com populaçoes vulneraveis, populaçoes de imigrantes africanos e estrangeiros em geral que vivem no contexto francês através do Centro de Acolhimento a Refugiados. A reflexao busca estabelecer um eixo de consideraçao sobre a realidade do nordeste brasileiro com as perspectivas da epistemologia da Terapia Comunitaria criada pelo professor e médico psiquiatra Adalberto Barreto, e consideraçoes da pedagogia de Paulo Freire a fim de exercer o cuidado em saude mental para (...) pessoas expostas a extremas violências de ordem étnica, cultural, psiquica, econômica, social e moral. O relato revela que os conhecimentos e experiência brasileira estao sendo aprofundados e desenvolvidos por profissionais da saude mental no contexto francês através da clinica da antropologia médica, junto ao Polo de Pesquisa Médica Psicologica Associaçao Minkoviska em Paris com apoio do Ministerio da Saude da França. (shrink)

Increasingly, biologists are using computers to model and to create biological representations. However, the exponential growth in available biological dataposes a challenge for experimental and theoretical researchers in both Biology and in Computer Science. In short, when even the simple retrieval of relevant biological information for a researcher becomes a complex task — its analysis and synthesis with other biological information will become even more daunting and unlikely. In this context, specially organized ‘structures of representation’ are needed for the efficient (...) interpretation of experimentally generated data. The “semantic Web” is a recent trend in networking techniques that we will examine here as a possible strategy for the computation of biological data — one that may allow us to take into account both the semiotic dimensions of biological processes, as well as their dynamic organization into stable and systemic levels. Thereupon, we propose that a semantic network for biology could benefit from principles rooted in such previous representation efforts as computer-generated ‘landscapes’ and ‘physical attractors’ — and that such principles could, in turn, then be better integrated into biological research through the development of a more semiotically informed user / computer interface design. (shrink)

This book assesses the evolutionary sustainability of liberalism. The book’s central claim is that liberal institutions ultimately weaken their social groups in the evolutionary process of inter-group competition. In this sense, institutions relying on the liberal satisfaction of preferences reveal maladaptive tendencies. Based on the model of multilevel selection, this work appraises the capacity of liberal democracy and free markets to satisfy preferences. In particular, the book re-evaluates public choice theory’s classic postulate that free markets are a suitable alternative to (...) the shortcomings of western liberal democracies regarding preference satisfaction. Yet, the book concludes that free markets are not a solution to the problems of liberal democracy because both market and democratic liberal institutions rest on the liberal satisfaction of preferences, an ethic which hurts group evolutionary fitness. This volume is of interest to political theorists, evolutionary ethicists, political economists and to general readers interested in the future of liberalism. (shrink)

In the past, biblical scholarship has neglected the hermeneutical contribution that an imaginal engagement with the text may make. The author’s aim in this article was to develop theological imagination as a hermeneutical device. This was done by briefly considering the concurrence in the hermeneutic contributions of three interpreters of biblical texts, with specific regard to their understanding of biblical imagination. These were Walter Brueggemann, Paul Ricoeur and Ignatius of Loyola. Their hermeneutical contributions concur in their understanding of a biblically (...) informed imagination, and it is specifically this aspect of the concurrence of their thought that was explored. An illustration from Proverbs 14:27, which draws on the metaphor and biblical motif of the fountain or source of life, was put forward to demonstrate how the concurrence in the contributions of these biblical interpreters may influence an imaginal engagement with the text.Keywords: Old Testament; Proverbs; Hermeneutics; The fear of the Lord/Yahweh; Walter Brueggemann; Paul Ricoeur; Ignatius of Loyola; Imaginal engagement. (shrink)

A Ricoeurian hermeneutic affords readers of the Old Testament an opportunity to access the biblical text anew as a source and norm for faith. Reese gave a convenient summarising description of Ricoeur’s hermeneutical approach. Ricoeur organised his considerations around four poles, namely distanciation, objectification, projecting of a world, and appropriation. These operate as the structuring considerations of a Ricoeurian hermeneutic and were illustrated with a sample proverb from the collection Proverbs 10:1–15:33.