Sight is undoubtedly the most crucial sense, and accidents resulting in its loss are a significant tragedy for individuals. The scientific community embarked on a journey of scientific innovation i...

Animals, like humans, suffer and die from natural causes. This is particularly true of animals living in the wild, given their high exposure to, and low capacity to cope with, harmful natural processes. Most wild animals likely have short lives, full of suffering, usually ending in terrible deaths. This book argues that on the assumption that we have reasons to assist others in need, we should intervene in nature to prevent or reduce the harms wild animals suffer, provided that it (...) is feasible and that the expected result is positive overall. It is of the utmost importance that academics from different disciplines as well as animal advocates begin to confront this issue. The more people are concerned with wild animal suffering, the more probable it is that safe and effective solutions to the plight of wild animals will be implemented in the future. (shrink)

The UK Genethics Club was established in November 2001 in order to provide a national forum of ethics support for the profession of clinical genetics in the UK. The forum brings together health professionals, medical ethicists and lawyers and support is provided through detailed discussion of cases and sharing of good practice. Clinical genetics professionals had previously voiced concerns about making extremely difficult ethical decisions, with profound implications, in something of a vacuum. Professionals saw a lack of guidance in the (...) area and lack of time for discussion of difficult cases as reasons for this. This paper describes the origins of the group and gives (anonymized) examples of some of the types of issues discussed. (shrink)

Should Proverbs be read as prose or poetry? Considering the language craft is of essential significance for a hermeneutical enquiry into the biblical book of Proverbs. Five suppositions to support the presupposition that Proverbs is best read as poetry were considered.

One of the major issues in the debate about the future of health care is how to keep costs under control while meeting growing demands for care. Addressing that, especially on an international scale, is far from easy. How are we to determine what the demands for care will most likely be? Even if it is not possible to estimate the future number of dependent elderly persons with any precision, it is hard to ignore the most probable scenario: a substantial (...) increase in the number of the oldest old. (shrink)

Social fears emerging in adolescence can have negative effects on emotional well-being. Yet the mechanisms by which these risks occur are unknown. One possibility is that associative learning results in fears to previously neutral social stimuli. Such conditioned responses may alter subsequent processing of social stimuli. We used a novel conditioning task to examine how associative processes influence social fear and attention orienting in adolescents. Neutral photographs were paired with socially rewarding or aversive stimuli during conditioning; a dot-probe task then (...) assessed biases in attention orienting. The social conditioning task modified subjective ratings of the neutral stimuli. Moreover, for the neutral stimulus that was paired with the aversive stimulus, the strength of conditioning showed a relationship with subsequent attentional vigilance. The findings elucidate mechanisms by which negative peer experiences during adolescence may affect emotional processing. (shrink)

Cuando apareció Heidegger y el nazismo el mundo intelectual internacional habló de una «bomba», pese al tono mesurado y exacto del texto. El descubrimiento innegable de su vínculo con el nazi-fascismo, comprometía no sólo a su propio país, sino a toda la cultura del siglo XX. Esta discusión sigue viva. Por eso, Heidegger y su herencia: el neonazismo, el neofascismo y el fundamentalismo islámico compromete de modo sorprendente la proyección del pensamiento heideggeriano en el presente y el futuro. Con su (...) metodología estricta y sobria, su exposición clara, fundada siempre en hechos y textos, Víctor Farías pone de manifiesto la función vitalizadora que Heidegger tiene en las formas totalitarias y extremistas de la actualidad. Para todo lector será una sorpresa mayor descubrir su pensamiento en relación a la polémica antisemita y revisionista iniciada por su alumno Ernst Nolte, la función central de la filosofía heideggeriana en el programa y la praxis del NPD —el mayor partido neonazi alemán— y en el discurso teórico de los neofascistas más relevantes de Francia, Italia y Bélgica, fundamentando en él la xenofobia extrema y el antisemitismo. Aun los ecologistas fundamentalistas heideggerianos, con Rudolf Bahro a la cabeza, anhelan el advenimiento de un «Adolf verde». Sorprende también que los fundamentalistas islámicos vean en Martin Heidegger una suerte de icono en su lucha contra los «infieles», la modernidad y la democracia, se revela que Khomeini formó un grupo autodenominado «los heideggerianos» que recibieron la misión de articular la cultura y la legalidad islámica en Irán. Uno de sus miembros era Ahmadinezhad. El neomarxista populista Hugo Chávez, primitivo pero antisemita radical, tuvo como su asesor más importante a Norberto Ceresole, el neonazi heideggeriano más relevante de Argentina. Incluso los neoracistas indigenistas del Perú acuden a Heidegger para fundamentar su «lucha por su sangre inca y su suelo» en la autenticidad del «Ser-ahí» heideggeriano. (shrink)

There is a paucity of experimental data addressing how peers influence adolescent risk-taking. Here, we examined peer effects on risky decision-making in adults and adolescents using a virtual social context that enabled experimental control over the peer “interactions”. 40 adolescents (age 11-18) and 28 adults (age 20-38) completed a risk-taking (Wheel of Fortune) task under 4 conditions: in private; while being observed by (fictitious) peers; and after receiving ‘risky’ or ‘safe’ advice from the peers. For high-risk gambles (but not medium-risk (...) or even gambles), adolescents made more risky decisions under peer observation than adults. Adolescents, but not adults, tended to resist ‘safe’ advice for high-risk gambles. Although both groups tended to follow ‘risky’ advice for high-risk gambles, adults did so more than adolescents. These findings highlight the importance of distinguishing between the effects of peer observation and peer advice on risky decision-making. (shrink)

Stroke is one of the most common causes of acquired disability, leaving numerous adults with cognitive and motor impairments, and affecting patients’ capability to live independently. Virtual Reality (VR) based methods for stroke rehabilitation have mainly focused on motor rehabilitation but there is increasing interest toward the integration of cognitive training for providing more effective solutions. Here we investigate the feasibility for stroke recovery of a virtual cognitive-motor task, the Reh@Task, which combines adapted arm reaching, and attention and memory training. (...) 24 participants in the chronic stage of stroke, with cognitive and motor deficits, were allocated to one of two groups (VR, Control). Both groups were enrolled in conventional occupational therapy, which mostly involves motor training. Additionally, the VR group underwent training with the Reh@Task and the control group performed time-matched conventional occupational therapy. Motor and cognitive competences were assessed at baseline, end of treatment (1 month) and at a 1-month follow-up through the Montreal Cognitive Assessment, Single Letter Cancelation, Digit Cancelation, Bells Test, Fugl-Meyer Assessment Test, Chedoke Arm and Hand Activity Inventory, Modified Ashworth Scale, and Barthel Index. Our results show that both groups improved in motor function over time, but the Reh@Task group displayed significantly higher between-group outcomes in the arm subpart of the Fugl-Meyer Assessment Test. Improvements in cognitive function were significant and similar in both groups. Overall, these results are supportive of the viability of VR tools that combine motor and cognitive training, such as the Reh@Task. Trial Registration: This trial was not registered because it is a small clinical study that addresses the feasibility of a prototype device. (shrink)

It is well established that microRNAs (miRNAs) induce mRNA degradation by binding to 3′ untranslated regions (UTRs). The functionality of sites in the coding domain sequence (CDS), on the other hand, remains under discussion. Such sites have limited impact on target mRNA abundance and recent work suggests that miRNAs bind in the CDS to inhibit translation. What then could be the regulatory benefits of translation inhibition through CDS targeting compared to mRNA degradation following 3′ UTR binding? We propose that these (...) domain‐dependent effects serve to diversify the functional repertoire of post‐transcriptional gene expression control. Possible regulatory benefits may include tuning the time‐scale and magnitude of post‐transcriptional regulation, regulating protein abundance depending on or independently of the cellular state, and regulation of the protein abundance of alternative splice variants. Finally, we review emerging evidence that these ideas may generalize to RNA‐binding proteins beyond miRNAs and Argonaute proteins. (shrink)

A partir da leitura de contos do livro Ninguém é inocente em São Paulo, de Ferréz, o artigo investiga como a literatura marginal/periférica brasileira representa a experiência urbana por meio de personagens oriundos da periferia. Após essa investigação, o trabalho se desdobra sobre como conceitos de deslocamento e apropriação permitem articular a relação entre periferia e centro urbanos, com ênfase no processo de urbanização da cidade de São Paulo.

Th e a r ticl e e xplore s h o w globalizatio n i s assumin g a pr o g ress i v e emptyin g o f the s o v ereignt y o f natio n state s i n economic , political , institutional , social , cultura l an d l e gal aspects . Th e traditiona l l e ga l institution s ar e increasing ly g i vin g ris e (...) t o n ew non-stat e re- gulato r y source s (supranational , pr iv ate , technica l an d communitarian) . Th e resul t o f this po l ycentri c r e gulato r y compl e x i s th e co e xistenc e o f a d i v ersit y o f no r mat i v e order s and jurisdiction s i n v olvin g th e e xhaustio n o f th e l e ga l paradig m aroun d w hic h th e Stat e has st r ucture d it s institutions. (shrink)

We thank Parker and Wright for engaging in this roundtable debate in such a spirited way. The ‘Pharmacogenetic [test] to Avoid Loss of Hearing’ (PALOH) Trial is the first time a genetic point of care test has been applied in the acute neonatal setting; therefore, it is not surprising that questions have been raised which require debate, discussion and clarification. Parker and Wright misattribute several assumptions to the roundtable authors, which we would like to clarify here. Since they raise wider (...) questions about the PALOH trial itself, several of the roundtable discussants have made a joint response. (shrink)

In the past, biblical scholarship has neglected the hermeneutical contribution that an imaginal engagement with the text may make. The author’s aim in this article was to develop theological imagination as a hermeneutical device. This was done by briefly considering the concurrence in the hermeneutic contributions of three interpreters of biblical texts, with specific regard to their understanding of biblical imagination. These were Walter Brueggemann, Paul Ricoeur and Ignatius of Loyola. Their hermeneutical contributions concur in their understanding of a biblically (...) informed imagination, and it is specifically this aspect of the concurrence of their thought that was explored. An illustration from Proverbs 14:27, which draws on the metaphor and biblical motif of the fountain or source of life, was put forward to demonstrate how the concurrence in the contributions of these biblical interpreters may influence an imaginal engagement with the text.Keywords: Old Testament; Proverbs; Hermeneutics; The fear of the Lord/Yahweh; Walter Brueggemann; Paul Ricoeur; Ignatius of Loyola; Imaginal engagement. (shrink)

Our aim in this paper is to defend the reductionist (or deflationist) view on group testimony from the attacks of divergence arguments. We will begin by presenting how divergence arguments can challenge the reductionist view. However, we will argue that these arguments are not decisive to rule out the reductionist view; for, these arguments have false premises, assuming dubious epistemic principles that testimony cannot generate knowledge and understanding. The final part of this paper will be devoted to presenting the advantages (...) of the reductionist approach to explaining the phenomenon of group testimony. (shrink)

The Weatherall Report claims that research on non-human primates is permitted and morally required. The argument rests on the following thought experiment: > The hospital fire : A hospital is on fire. Some of the residents are humans and others are non-human animals. You can only save one group. What do you do? Some people have the intuition that we should rescue the humans. According to the report, if we accept that human lives have priority over non-human lives in this (...) case, consistency requires us to support the use of non-human animals in research. This is because both cases are about saving human lives at the expense of the lives of non-human animals. Two critical replies appeared in the literature, by E J Moore1 and Muireann Quigley.2 In a recent paper3 Gardar Arnason claims that such objections fail. I will argue, however, that his assessment is unconvincing. The first objection pressed by Moore is that there are fundamental disanalogies between The hospital fire and biomedical research. In that scenario we face a life-or-death emergency situation whereas in biomedical research we do not. In such situations it may be justified to prioritise those closest to us (eg, species …. (shrink)

Naturalist theories of representation have been attacked on the grounds of being too liberal on the minimal conditions for intentionality: they treat several states that are not representational as genuine representations. Behind this attack lies the problem of demarcation: what are the minimal conditions for intentionality that a state should satisfy to be genuinely representational? What are the limits of intentionality? This paper develops a dual proposal to solve this problem. First, I defend the explanatory role criterion in order to (...) assess proposals of minimal conditions for intentionality. I start by proposing the success pattern condition: a state represents a given external feature provided that there is a success pattern present in the behavioural output, and the system uses this state as a proxy for the presence of this external feature. However, this condition is not sufficient for minimal intentionality – there are both intentional and non-intentional success patterns. Another minimal condition is, hence, required to draw this distinction. I propose the constancy mechanism condition: a state is representational provided that the system employs a constancy mechanism in its production. The success pattern and constancy mechanism conditions jointly constitute the dual proposal for minimal intentionality. I argue that this proposal is explanatorily justified and, so, properly demarcates the limits of intentionality. (shrink)

Our ability to generate genomic data is currently well ahead of our ability to understand what they mean, raising challenges about how best to engage with them. This article considers ethical aspects of work with such data, focussing on research contexts that are intertwined with clinical care. We discuss the identifying nature of genomic data, the medical information intrinsic within them, and their linking of people within a biological family. We go on to consider what this means for consent, the (...) importance of thoughtful sharing of genomic data, the challenge of constructing meaningful findings, and the legacy of unequal representation in genomic datasets. We argue that the ongoing success of genomic data research relies on public trust in the enterprise: to justify this trust, we need to ensure robust stewarding, and wide engagement about the ethical issues inherent in such practices. (shrink)

Russell’s theory of memory as acquaintance with the past seems to square uneasily with his definition of acquaintance as the converse of the relation of presentation of an object to a subject. We show how the two views can be made to cohere under a suitable construal of ‘presentation’, which has the additional appeal of bringing Russell’s theory of memory closer to contemporary views on direct reference and object-dependent thinking than is usually acknowledged. The drawback is that memory as acquaintance (...) with the past falls short of fulfilling Russell’s requirement that knowledge by acquaintance be discriminating knowledge – a shortcoming shared by contemporary externalist accounts of knowledge from memory. (shrink)

O objetivo deste artigo, que se insere no âmbito da filosofia da religião, é tratar o problema lógico do mal e mais concretamente a teoria da defesa do livre-arbítrio de Alvin Plantinga. Quero examinar se esta é uma teoria plausível e se resiste a algumas objeções. Pretendo defender que esta teoria parece resistir a certas objeções.

Na República Platão assume que a τέκνη é um fator fundamental para agregar as pessoas dentro de uma vida em comum e organiza as relações de modo que a cidade tenha o melhor sistema político possível, onde cada um exerce o ἒργον que lhe cabe. Para tanto o filósofo defende que a função exercida por cada membro da pólis esteja de acordo com a sua natureza. É a partir dessa premissa que se torna importante verificar dentro do texto platônico como (...) ele articula elementos importantes para defender tal pressuposto. Neste caso temos que verificar a relação da τέκνη com o ἒργον e da τέκνη com a ἐπιστήμη sem negligenciar como a τέκνη pode ser considerada algo que beneficia a cidade como um todo. Palavras-chave: República; Tékhne; érgon; platonismo. (shrink)

A epistemologia da crença religiosa é uma área da filosofia da religião que procura responder ao seguinte problema: haverá justificação para se ter fé sem provas, argumentos ou indícios? Ou formulando de outra forma: será epistemicamente legítimo acreditar em Deus sem provas, argumentos ou indícios? Além das respostas tradicionais de William Clifford e de William James a esse problema, há uma resposta mais contemporânea e filosoficamente prometedora: a epistemologia reformista de Alvin Plantinga (n. 1932). Chama-se “reformista” à sua epistemologia porque (...) este filósofo se identifica com o pensamento reformista, tradição protestante que remonta a João Calvino. (shrink)

The paper aims to review critically the concept of discipline and observe from it the classifications have been proposed to organize the subfields belonging to social sciences in Chile. Reflection begins by reviewing the concept of discipline, from its different meanings it has had to its current use in the academic world as a field or area of knowledge. Under the latter sense can be seen that there are two disputing senses, one with emphasis on epistemic order, and other on (...) factors of socio-historical nature. It analyses the different taxonomic proposals used to group and classify sub disciplines is social sciences by governmental institutions, as well as the Faculties of Social Sciences. Finally a review is made to studies on the development and establishment of social sciences in Chile, while excluding social work discipline. El artículo tiene como propósito hacer una revisión crítica en torno al concepto de disciplina y a partir de éste observar las clasificaciones que se han propuesto para organizar las subdisciplinas pertenecientes al campo de las ciencias sociales en Chile. Se inicia la reflexión revisando el concepto de disciplina, a partir de sus diferentes acepciones que ha tenido hasta su actual uso en el mundo académico, como campo o área del conocimiento. Bajo esta última acepción se aprecia la existencia de dos metasignificados que disputan su sentido, uno con énfasis en cuestiones de orden epistémico, y otro, en factores de naturaleza sociohistóricos. Se analiza las diferentes propuestas taxonómicas que se utilizan para agrupar y clasificar las subdiciplinas del área de las ciencias sociales por parte de instituciones gubernamentales encargadas del desarrollo de la educación y las ciencias del país, así como de las Facultades Universitarias de Ciencias Sociales. Finalmente se elabora una crítica a los estudios realizados sobre el desarrollo y constitución de las ciencias sociales en el Chile, en tanto se excluye al Trabajo Social como disciplina. (shrink)

Increasingly, biologists are using computers to model and to create biological representations. However, the exponential growth in available biological dataposes a challenge for experimental and theoretical researchers in both Biology and in Computer Science. In short, when even the simple retrieval of relevant biological information for a researcher becomes a complex task — its analysis and synthesis with other biological information will become even more daunting and unlikely. In this context, specially organized ‘structures of representation’ are needed for the efficient (...) interpretation of experimentally generated data. The “semantic Web” is a recent trend in networking techniques that we will examine here as a possible strategy for the computation of biological data — one that may allow us to take into account both the semiotic dimensions of biological processes, as well as their dynamic organization into stable and systemic levels. Thereupon, we propose that a semantic network for biology could benefit from principles rooted in such previous representation efforts as computer-generated ‘landscapes’ and ‘physical attractors’ — and that such principles could, in turn, then be better integrated into biological research through the development of a more semiotically informed user / computer interface design. (shrink)

We consider the simple case of a nonrelativistic charged harmonic oscillator in one dimension, to investigate how to take into account the radiation reaction and vacuum fluctuation forces within the Schrödinger equation. The effects of both zero-point and thermal classical electromagnetic vacuum fields, characteristic of stochastic electrodynamics, are separately considered. Our study confirms that the zero-point electromagnetic fluctuations are dynamically related to the momentum operator p=−i ℏ ∂/∂ x used in the Schrödinger equation.