Here, the emerging data on DNA G‐quadruplexes (G4s) as epigenetic modulators are reviewed and integrated. This concept has appeared and evolved substantially in recent years. First, persistent G4s (e.g., those stabilized by exogenous ligands) were linked to the loss of the histone code. More recently, transient G4s (i.e., those formed upon replication or transcription and unfolded rapidly by helicases) were implicated in CpG island methylation maintenance and de novo CpG methylation control. The most recent data indicate that there are direct (...) interactions between G4s and chromatin remodeling factors. Finally, multiple findings support the indirect participation of G4s in chromatin reshaping via interactions with remodeling‐related transcription factors (TFs) or damage responders. Here, the links between the above processes are analyzed; also, how further elucidation of these processes may stimulate the progress of epigenetic therapy is discussed, and the remaining open questions are highlighted. (shrink)

This important new book by one of the world's leading political theorists boldly questions the moral justification for organizing our world as a territorial states-system and proposes major changes to states' sovereign powers.

This paper argues that the function of moral education in the biomedical context should be exactly the same as in a general, philosophical framework: it should not provide ready-to-use kits of moral principles; rather, it must show the history, epistemology and conceptual structure of moral theories that would enable those who have to make decisions to be as informed and as responsible as possible. If this complexity cannot be attained, an incomplete product—i.e. bioethics or bioethical principles—should not be seen as (...) a viable substitute. This theoretical position is subsequently illustrated by a case study involving research ethics committees. It is argued that within these committees, that are carefully formed multidisciplinary bodies, what makes competent decision-making possible is not a bioethical theory, nor even a sound philosophical ethics, but the dynamics of the discussion of a number of experts coming from different disciplines. This multidisciplinary expertise is necessary and sufficient to undertake the challenges of complex decisions in the biomedical context. (shrink)

Mental-content verbs such as think, believe, imagine and hope seem to pose special problems for the young language learner. One possible explanation for these diYculties is that the concepts that these verbs express are hard to grasp and therefore their acquisition must await relevant conceptual development. According to a diVerent, perhaps complementary, proposal, a major contributor to the diYculty of these items lies with the informational requirements for identifying them from the contexts in which they appear. The experiments reported here (...) explore the implications of these proposals by investigating the contribution of observational and linguistic cues to the acquisition of mental predicate vocabulary. We Wrst demonstrate that particular observed situations can be helpful in prompting reference to mental contents, speciWcally, contexts that include a salient and/or unusual mental state such as a false belief. We then compare the potency of such observational support to the reliability of alternate or concomitant syntactic information (e.g., sentential complementation) in tasks where both children and adults are asked to hypothesize the meaning of novel verbs. The Wndings support the eYcacy of false belief situations for increasing the saliency of mental state descriptions, but also show that.. (shrink)

This study examines the presence of ethical climates in skilled nursing facilities and identifies their antecedents (work group, job position, tenure). A cross-sectional survey design was implemented. A total of 359 facilities were selected in the Midwestern United States. Responses were received from nurses representing 100 of those facilities (28%). A total of 656 usable questionnaires were returned of the 3060 distributed (21.4% response rate). Descriptive statistics, confirmatory factor analysis, and multivariate and univariate analyses of variance were used. The results (...) confirmed the presence of five ethical climates. Significant differences between registered and licensed practical nurses with regard to egoistic and independence ethical climates were found. Furthermore, nurses in management and non-management positions differed significantly in their perceptions of caring and egoistic climates. The results suggest incongruence in value perceptions and imply that researchers and practitioners have to direct efforts towards preventing and identifying reasons behind this. (shrink)

This article describes a survey among Finnish business students to find answers to the following questions: How do business students define a well-run company? What are their attitudes on the responsibilities of business in society? Do the attitudes of women students differ from those of men? What is the influence of business education on these attitudes? Our sample comprised 217 students pursuing a master's degree in business studies at two Finnish universities. The results show that, as a whole, students valued (...) the stakeholder model of the company more than the shareholder model. However, attitudes differed according to gender: women students were more in favor of the stakeholder model and placed more weight on corporate ethical, environmental, and societal responsibilities than their men counterparts - both at the beginning and at the end of their studies. Thus, no gender socialization effect of business school education could be observed in this sense. Business school education was found to shape women and men students' attitudes in two ways. Firstly, valuation of the shareholder model increased and, secondly, the importance of equal-opportunity employment decreased in the course of education. This raises the question whether the educational context is creating an undesirable tendency among future business professionals. The results further suggest that the sociocultural context can make a difference in how corporate social responsibility is perceived. The article also discusses possible ways to influence the attitudes of business students. (shrink)

The concept of “enhypostaton” was introduced into theological discourse during the sixth-century Christological debates with the aim of justifying the unitary subjectivity of Christ by reclassifying Christ’s human nature as ontically non-independent. The coinage of the term is commonly ascribed to Leontius of Byzantium. Its conceptual content has been recognized by contemporary scholarship as relevant to the core issues of Christology, as well as possessing significance for such philosophical questions as individuation and the nature of individual entityhood. Even so, despite (...) its role in the formation of classical Christological thought, the notion of “enhypostaton” is often regarded as obscure and not clearly defined. This paper aims to shed some light on the meaning of Leontius’ conception of it, in respect of its specifically philosophical import. (shrink)

De nos jours, les avocats et les juristes chinois sont très friands d'Internet. Pourtant, leur utilisation de la Toile n'a pas encore été l'objet de recherches. Cet article veut apporter un regard nouveau sur le lien entre avocats, internautes et société civile chinoise. Les juristes ont trouvé en Internet, en particulier sur les blogs, un lieu d'information et d'échange où ils peuvent se dédier aux sujets qui les intéressent . Les multiples démarches qu'ils ont initiées au sein du Réseau ont (...) abouti à une mobilisation des moyens numériques, permettant de mieux communiquer et informer sur le système légal et judiciaire chinois. Leur utilisation d'Internet a-t-elle catalysé l'initiative personnelle des utilisateurs et mobilisé l'opinion publique ? Cet article s'attache à démontrer comment par le biais d'Internet les avocats ont pu être des acteurs du développement de la société civile et participer ainsi à l'émergence d'une « communauté de critères » relevant du droit.Nowadays, lawyers and jurists Chinese are very fond of the Internet. However, their use of the Internet has not yet been investigated. This article will provide a new perspective on the relationship between lawyers, surfers and Chinese civil society. Lawyers found in the Internet, especially on blogs, a place to exchange information and where they can devote themselves to topics that interest them . Multiple steps they have initiated within the network led to a mobilization digital means to better communicate and inform the Chinese legal and judicial system. Internet use did catalyzed users personal initiative and mobilized public opinion? This article aims to demonstrate how through Internet lawyers have been involved in development of civil society and thus contribute to the emergence of a "community standards" under the law. (shrink)

Quantitative research has called attention to the burden associated with informal caregiving in home nursing arrangements. Less emphasis has been placed, however, on care recipients’ subjective feelings of being a burden and on caregivers’ willingness to carry the burden in home care. This article uses empirical material from semi‐structured interviews conducted with older people affected by multiple chronic conditions and in need of long‐term home care, and with informal and professional caregivers, as two groups of relevant others. The high burden (...) of home‐care arrangements is unanimously stressed by all three groups involved in the triangle of care. An empirical‐ethical investigation of what can be legitimately expected from family members and informal caregivers, informed by Frith's symbiotic empirical ethics approach, was undertaken. Key tenets from the special goods theory and nursing professionalism are used as analytical tools. The study concludes that the current situation may hinder professional development and can reinforce feelings of being a burden to relevant others. (shrink)

A generative grammar for a language L generates one or more syntactic structures for each sentence of L and interprets those structures both phonologically and semantically. A widely accepted assumption in generative linguistics dating from the mid-60s, the Generative Grammar Hypothesis, is that the ability of a speaker to understand sentences of her language requires her to have tacit knowledge of a generative grammar of it, and the task of linguistic semantics in those early days was taken to be that (...) of specifying the form that the semantic component of a generative grammar must take. Then in the 70s linguistic semantics took a curious turn. Without rejecting GGH, linguists turned away from the task of characterizing the semantic component of a generative grammar to pursue instead the Montague-inspired project of providing for natural languages the same kind of model-theoretic semantics that logicians devise for the artificial languages of formal systems of logic, and “formal semantics” continues to dominate semantics in linguistics. This essay argues that the sort of compositional meaning theory that would verify GGH would not only be quite different from the theories formal semanticists construct, but would be a more fundamental theory that supersedes those theories in that it would explain why they are true when they are true, but their truth wouldn’t explain its truth. Formal semantics has undoubtedly made important contributions to our understanding of such phenomena as anaphora and quantification, but semantics in linguistics is supposed to be the study of meaning. This means that the formal semanticist can’t be unconcerned that the kind of semantic theory for a natural language that interests her has no place in a theory of linguistic competence; for if GGH is correct, then the more fundamental semantic theory is the compositional meaning theory that is the semantic component of the internally represented generative grammar, and if that is so, then linguistic semantics has so far ignored what really ought to be its primary concern. (shrink)

My topic is the relation between nonsense and intelligibility, and the contrast between nonsense and falsehood which played a pivotal role in the rise of analytic philosophy. I shall pursue three lines of inquiry. First I shall briefly consider the positive case, namely linguistic understanding. Secondly, I shall consider the negative case—different breakdowns of understanding and connected forms of failure to make sense. Third, I shall criticize three important misconceptions of nonsense and unintelligibility: the austere conception of nonsense propounded by (...) the New Wittgensteinians ; the “no nonsense position” which roundly denies that there are cases of nonsense—Chomsky’s semantic anomalies or Ryle’s category mistakes–that are grammatically well-formed, without even having the potential for being used to make a truth-apt statement ; the individualistic conception of language and of semantic mistakes championed by Davidson. All three positions, I shall argue, ignore or deny combinatorial nonsense, the fact that perfectly meaningful sentence-components can be combined in a way that may be grammatical, yet without resulting in a sentence that is itself “meaningful”, i.e. endowed with linguistic sense. At a more strategic level, the first and the third position deny or ignore that natural languages are communal historical practices that go beyond idiolects and the employments of expressions in specific contexts and that are guided by semantic rules—standards for the meaningful use of words. (shrink)

This chapter contains sections titled: The Saying and the Said Subjectivity as Sensibility Ethics of Difference or an Ethics of Truths? Reading Levinas with Badiou: Impossibly Demanding? An Impossibly Demanding Education Notes.

This reflection contrasts the dominant imaginary underlying ‘lawofthe Anthropocene’ with an imaginary reaching towards ‘law/sforthe Anthropocene’. It does so primarily by contrasting two imaginaries of human embodiment—law’s existing imaginary of quasi-disembodiment and an alternative imaginary of embodiment as co-woven with the lively incipiencies and tendencies of matter. It draws on ‘transcorporeality’ and ‘sympoiesis’ as inspiration for ‘sympoietic normativities’ as ways of co-living and co-organizing in the face of the catastrophic implications of the Anthropocene emergency.

This commentary argues that the question of metalanguage is a key issue in emotion research. Izard (2010) ignores this issue (and all the earlier literature relating to it, including the debate in Emotion Review, 2009, 1[1]), and thus falls into the old traps of circularity, obscurity, and ethnocentrism. This commentary rejects Izard’s claim that “emotion” defies definition, and it offers a viable definition of “emotion” formulated in simple and universal human concepts, using the English version of the universal conceptual lingua (...) franca called Natural Semantic Metalanguage (NSM). Once again, this commentary draws attention to the centrality of the question of language in emotion research. (shrink)

This study on Kant’s moral anthropology examines the conditions for achieving moral action, and strives to expand our understanding of Kantian moral philosophy. According to Kant, building moral character is not limited to developing rational capacities but also includes developing emotional capacities, and responsibly managing and deliberately cultivating emotional dispositions. / -/- Award: Förderpreis der Freiburger Kant-Stiftung und der Kant-Gesellschaft 2016 / -/- Anna Wehofsits’ Studie zu Kants moralischer Anthropologie untersucht die Realisierungsbedingungen moralischen Handelns. Die historische Rekonstruktion und systematische (...) Diskussion dieser Bedingungen zielt auf ein erweitertes Verständnis der Kantischen Ethik: Moralische Charakterbildung nach Kant ist nicht auf die Entwicklung rationaler Fähigkeiten beschränkt, sondern schließt die Entwicklung emotionaler Fähigkeiten ein, den verantwortlichen Umgang mit emotionalen Dispositionen und ihre gezielte Kultivierung. -/- . (shrink)

Authors of chapters: J. Blanc, D. Blitman, F. Couturier, P. Fasula, R. Lamarche-Perrin, D. Ross, R. Sandoz, S. Troubé .

Unlike the question of whether self-deception can be understood on the model of other-deception, the relationship between the two phenomena at the level of practice is hardly ever explored. Other-deception can support self-deception and vice versa. Self-deception often affects not only the beliefs and behavior of the self-deceiving person but also the beliefs and behavior of others who may become accomplices of self-deception. As I will show, however, it is difficult to describe this supportive relationship between self-deception and the deception (...) of others without conceptual contradiction. While “deflationary” approaches offer a convincing way to avoid the so-called paradoxes of self-deception, they do not resolve the conceptual tensions that arise here. I conclude by outlining a solution. (shrink)

Abstractabstract There are estimated to be five million vegetarians in the United Kingdom and another four million in the United States. There are numerous vegetarians elsewhere in the world: around fifteen million, for instance, in India. Some of these vegetarians are parents. And some of the vegetarian parents will bring up their children to be vegetarian, too. Is this a permissible course of action? Or should vegetarian parents raise omnivorous offspring? In this article, I consider three arguments that aim to (...) show that a parent should not raise a child on a vegetarian diet. None of these arguments are convincing and I know of no better ones — so I conclude that it is permissible for a parent to raise her child as a vegetarian. (shrink)

According to the contemporary consensus, when reaching in the lexicon grammar looks for items like nouns, verbs, and prepositions while logic sees items like predicates, connectives, and quantifiers. In fact, there doesn’t seem to be a single lexical category contemporary grammar and logic both make use of. I hope to show that while a perfect match between the lexical categories of grammar and logic is impossible there can be a substantial overlap. I propose semantic definitions for all the major parts (...) of speech. I argue that the differences among these categories can be captured in terms of distinctions recognized in logic. (shrink)

Davidsonian analyses of action reports like ‘Alvin chased Theodore around a tree’ are often viewed as supporting the hypothesis that sentences of a human language H have truth conditions that can be specified by a Tarski-style theory of truth for H. But in my view, simple cases of adverbial modification add to the reasons for rejecting this hypothesis, even though Davidson rightly diagnosed many implications involving adverbs as cases of conjunct-reduction in the scope of an existential quantifier. I think the (...) puzzles in this vicinity reflect “framing effects,” which reveal the implausibility of certain assumptions about how linguistic meaning is related to truth and logical form. We need to replace these assumptions with alternatives, instead of positing implausible values of event-variables or implausible relativizations of truth to linguistic descriptions of actual events. (shrink)

Until 1996, poor single mothers in the United States could claim welfare benefits for themselves and their children under the Aid to Families with Dependent Children (AFDC) program if they had no other source of income. With the 1996 passage of the Personal Responsibility Work Opportunity Reconciliation Act (PRWORA), paid work and work-related activities became a mandatory condition for receiving aid. At the same time, the law promotes marriage as a route out of poverty. Using a feminist reinterpretation of Althusser’s (...) concept of interpellation, I turn to Job Clubs, mandatory week-long workshops that teach job search skills, to analyze the citizen-subject generated by front-line representatives of the state in the context of this new legislation. Based on participant-observation, I conclude that while PRWORA ostensibly promotes both marriage and paid employment, Job Club trainers enforced a masculine worker-citizen subject through the deployment of three discursive strategies. These discursive strategies 1) promoted paid work over welfare-receipt as both a pragmatic and moral choice, 2) posited an individual-psychological account of women’s welfare receipt, and 3) portrayed parenting skills as marketable skills. In the conclusion, I speculate that current welfare reform efforts require the generation of a self-reproducing worker-citizen and that workshops like Job Club become a site in which the existence of this autonomous citizen is affirmed. (shrink)

The main goal of this paper is to exhibit the role of the concept of human nature for the ethical orientation of organizational life. Therefore, after presenting some definitions of the concepts of human nature, which depict the complexity of these phenomena, some models of the concepts of human nature are described. Furthermore, the setting of the concepts of human nature in the organizational life is discussed. Those concepts can be perceived as a deep-structure of the organizational life, having an (...) impact not only on the individual behaviour of employees and managers (like sensibility for human emotions, pro-social engagement, communication style), but also affecting their moral competence and influencing whole organizational culture – image of the organization, preferred management strategies and the way of perceiving justice. Those elements play crucial role in ethical attitude of the organization because all those variables support the efficacy of ethical rules and most of them are part of ethical code and corporate ethical code. Therefore, it is necessary for an organization to consider implicit and explicit concepts of human nature on which the organizational culture is based and support those concepts, which enables the ethical conduct of the organization and being alert especially to the consequences of materialistic/egoistic and competitive concepts of human nature. The theses discussed in the paper are supported by some empirical research studies conducted in this field. (shrink)

Traditionally, scholars have taken homoiôsis theôi in the Theaetetus digression to require neglect of particulars, but they have noted that although Socrates advocates it, he does not live such a life. To explain the discrepancy, Mahoney and Rue both argue that we need to reinterpret godlikeness to require active engagement in the city. I reject their reinterpretations and I revise the traditional view, arguing that godlikeness is not a single ideal. Instead, I argue, Plato provides several different portraits of godlikeness (...) that together suggest interest in particulars makes the person neither better nor worse as a philosopher. (shrink)

Among the myriad longstanding political, socioeconomic, and moral debates focused on the fair distribution of health-care resources within the United States, those addressing intergenerational justice tend to produce the most heat and, often, the least amount of light. The familiar narratives tend to be binary ones of opposing generational stakeholders. While a great number of proposed solutions focus on reconfiguring rationing priorities, this paper will instead shift the discourse to intergenerational interdependence, suggesting that these conflict-born moral dilemmas are in important (...) ways false. The alternative view of intergenerational relations defended here is grounded in an interdependent, rather an oppositional, model of human relationships. I argue that this interdependence can best be realized through a deliberate movement toward intergenerational narrative understandings, as well as through physical proximities. I conclude by considering several ongoing intergenerational projects directed at just such a goal. (shrink)

The last financial crisis combined with some recent social trends (like growing inequality or environmental problems) inspired many contemporary economists to the re-evaluation of actual economic knowledge in the search for solutions to these problems. Modern economic schools (especially heterodox ones) stress the meaning of ethical issues in economics more often. The thesis of the paper is that this revival of the ethical face of present economics depends very strongly on the changing assumptions of human nature within economics and other (...) disciplines which work alongside economics, such as social psychology or business ethics, for instance. In order to prove the thesis, the paper provides an evaluation of current economic schools, especially within the heterodoxy, in search of their ethical aspects, and presents them as a result of the changing assumptions about human beings within those schools. This ethical dimension of human beings manifests itself in different ways, which can be perceived as a result of it being based on different ethical schools and different psychological and philosophical assumptions about human nature. Therefore, the paper also considers the current developments of the view on human beings in contemporary schools of economic ethics. (shrink)