Pylyshyn defends a distinction between early visual perception and cognitive processing. But exactly where should the line between vision and cognition be drawn? Our research on object identification suggests that the construction of an object's visual description is isolated from contextually derived expectations. Moreover, the matching of constructed descriptions to stored descriptions appears to be similarly isolated.

Kant and Hegel have diametrically opposed views concerning the relationship between colour and drawing. For Hegel colour is all; while for Kant drawing is central. Through an analysis of both these positions the conclusion that is drawn is that colour and drawing have a necessary interrelation. One cannot be thought other than in relation to reach other. Taken together they are integral to the development of a philosophy of art.

. This paper explores the relationship between gift giving, guanxi and corruption through a study of the relationships between UK manufacturing companies in China and their local component suppliers. The analysis is based on interviews in the China-based operations of 49 UK companies. Interviews were carried out both with senior (often expatriate) staff and with local line managers who were responsible for everyday purchasing decisions and for managing relationships with suppliers. The results suggest that gift giving is perceived to be (...) a significant problem in UK-owned companies in China. However the relationship between these payments and established understanding of gift giving within guanxi-networks appears to be weak. Gift giving appears to be associated with illicit payments, corruption and the pursuit of self-interest. Firms seek to reduce the incidence of illicit transactions by changing staff roles, instituting joint responsibilities, which include the separation of different aspects of sourcing/purchasing, ineasing the involvement of senior staff in the process and through the education of employee and suppliers. (shrink)

Twenty-two experienced action video-game players (AVGPs) and 18 non-VGPs were tested on a pen-and-paper line bisection task that was untimed. Typically, right-handers bisect lines 2 % to the left of true centre, a bias thought to reflect the dominance of the right-hemisphere for visuospatial attention. Expertise may affect this bias, with expert musicians showing no bias in line bisection performance. Our results show that experienced-AVGPs also bisect lines with no bias with their right hand and a significantly reduced (...) bias with their left hand compared to non-AVGPs. Bisections by experienced-AVGPs were also more precise than those of non-AVGPs. These findings show the cognitive proficiencies of experienced-AVGPs can generalize beyond computer based tasks, which resemble their training environment. (shrink)

This paper discusses the question of when pain and distress relief known to hasten death would cross the line between permissible conduct and killing. The issue is discussed in the context of organ donation after cardiac death, and considers the administration of analgesics, sedatives, and the controversial use of paralysing agents in the provision and withdrawal of ventilation.

This article is intended as a response rather than counterpoint to Bennett's careful argument that amnesty cannot amount to an act of collective forgiveness. I agree that a state cannot forgive perpetrators of grave human rights violations. However, I am concerned that conceiving the question of amnesty strictly in terms of a choice between the Art of Compromise or the Hard Line of retribution may unduly limit our understanding of the potential relation between amnesty and forgiveness in politics. To show (...) this, I consider the question of amnesty in relation to the possibility of forgiving those ordinary citizens implicated in the perpetration of wrongs as bystanders and beneficiaries of an unjust regime. Following Arendt, I argue that political grounds for forgiveness in such circumstances are the frailty of the world and the natality of the other . On this account, forgiveness is not necessarily the final term in a process of reconciliation that restores a wrongdoer to the moral community. Rather, the disposition to forgive makes possible a politics in which members of a divided polity contest each other's understandings of the violence of the past and its significance for their political association. (shrink)

This article explores the contemporary ‘symptomatic’ position of radically excluded social groups through a critical engagement with the work of Žižek, Deleuze and Guattari. It begins with a presentation and critique of Žižek's theorisation, arguing that while he correctly perceives the symptomatic status of certain social groups and issues, his approach is insufficiently radical because of its reliance on inappropriate structuralist assumptions and metaphysical negativity. It then compares this theory to Deleuze and Guattari's theory of minoritarianism, viewed as a similar (...) attempt to engage with the symptomatic effects of exclusion. A political trajectory is derived from Deleuze and Guattari's theory which reconceives the politics of the excluded in terms of emancipatory lines of flight rather than gestures of identification. The article then explores social movements arising from the growing phenomenon of global exclusion in neoliberalism, looking at examples such as Somalia and Bolivia, and proposing autonomy and networked approaches to social life as responses to exclusion which reconfigure social space in affirmative ways. (shrink)

Almost everything Turing wrote is now accessible on-line in some form, much of it in the Turing Digital Archive, which makes available scanned versions of the physical papers held in the archive at King's College, Cambridge University. See..

Recasts Kantian philosophy along poststructuralist lines, particularly showing how Kantian ethics can be reformulated to take into account criticisms leveled by Foucault, Lacan, Deleuze, Derrida, and others.

Background Moral distress was first described by Jameton in 1984, and has been defined as distress experienced by an individual when they are unable to carry out what they believe to be the right course of action because of real or perceived constraints on that action. This complex phenomenon has been studied extensively among healthcare providers, and intensive care professionals in particular report high levels of moral distress. This distress has been associated with provider burnout and associated consequences such as (...) job attrition, with potential impacts on patient and family care. There is a paucity of literature exploring how middle and late career healthcare providers experience and cope with moral distress. Objectives We explore the experience of moral distress and the strategies and resources invoked to mitigate that distress in mid- and late-career healthcare providers practicing in paediatric intensive care, in order to identify ways in which the work environment can build a culture of moral resilience. Research design An exploratory, qualitative quality improvement project utilizing focus group and semi-structured interviews with pediatric intensive care front-line providers. Participants Mid-and-later career (10 + years in practice) pediatric intensive care front line providers in a tertiary pediatric hospital. Research context This work focuses on paediatric intensive care providers in a single critical care unit, in order to explore the site-specific perspectives of health care providers in that context with respect to moral distress coping strategies. Ethical considerations The study was approved by the Quality Management Office at the institution; consent was obtained from participants, and no identifying data was included in this project. Findings Participants endorsed perspective-building and described strategies for positive adaptation including; active, reflective and structured supports. Participants articulated interest in enhanced and accessible formal supports. Discussion Findings in this study resonate with the current literature in healthcare provider moral distress, and exposed ways in which the work environment could support a culture of moral resilience. Avenues are described for the management and mitigation of moral distress in this setting. Conclusion This exploratory work lays the groundwork for interventions that facilitate personal growth and meaning in the midst of moral crises in critical care practice. (shrink)

The term 'inter-faith' is a recent innovation in English that has gained significant traction in the discussion of religious diversity. This volume argues that the concept of faiths in the plural is deeply problematic for Christian theology and proposes a Hegelian alternative to the conventional bureaucratic notion of inter-faith dialogue. Hegel pioneered the systematic study of comparative religion. In line with Hegelian principle, Andrew Shanks identifies faith as an inflection of the will towards perfect truth-as-openness. In relation to other (...) religious traditions, this must involve the practice of a maximum xenophilia, or love for the unfamiliar, understood as a core Christian virtue. Shanks's neo-Hegelian theory recognises the potential for God's work in all religious traditions, which may be seen as divine experiments with human nature. This timely book discusses a wide range of interreligious encounters and will be an essential resource for studies in comparative theology and philosophy of religion. (shrink)

The influence that philosophy of science has had on scientific practice is as controversial as it is undeniable, especially in the case of biology. The dynamic between philosophy and biology as disciplines has developed along two different lines that can be characterized as 'paternal', on the one hand, and more 'fraternal', on the other. The role Popperian principles of demarcation and falsifiability have played in both the systematics community as well as the ongoing evolution-creation debates illustrate these contrasting forms (...) of interdisciplinary engagement, underscoring the influence philosophy of science in shaping our contemporary understanding of biology in the North American context. However, a strict disciplinary distinction between philosophy and science may itself be a false dichotomy that risks hampering future development of the biological sciences. By actively engaging with philosophical considerations as an integral part of their scientific practice, nineteenth-century biologists offer an interesting counterpoint to current trends of overspecialization and provide a model of scientists who avoided extremes of antagonism with, or subservience to, philosophy. (shrink)

This article presents the results of an inductive, interpretive case study. We have adopted a narrative approach to the analysis of organizational processes in order to explore how individuals in a financial institution dealt with relatively novel issues of corporate social responsibility (CSR). The narratives that we reconstruct, which we label 'idealism and altruism', 'economics and expedience' and 'ignorance and cynicism' illustrate how people in the specific organizational context of a bank ('Credit Line') sought to cope with an attempt at (...) narrative imposition. In particular, our work exemplifies how people in organizations draw on shared discursive resources in order to make sense of themselves and their organizations. We illustrate how many people within the bank found it hard to integrate the normative case for CSR with their version of a narrative identity which had, and continued to be, centred on economic imperatives for new initiatives. Our article demonstrates both the value of the analysis of shared narratives, and represents an attempt to deal adequately with the polyphony of organizational voices, in case studies of CSR. (shrink)

Recently, a number of commentators on the early Wittgenstein have tried to make the Tractatus more palatable than it actually is; they have blurred the lines between exegesis and philosophical defense. As a corrective to this tendency, this paper attempts to retrieve the early Wittgenstein's true understanding of the ontology of possibility. Focusing upon the two kinds of metaphors he uses in the Tractatus, object-based and space ones, the first part of this paper emphasizes the philosophical problems that motivated (...) his ontology of possibility, especially the "Parmenidean" question of how false propositions make contact with reality. The second part addresses two novel interpretations of the early Wittgenstein's views of ontology and possibility—the non-ontological reading of McGuinness, Ishiguro and the "New" Wittgensteinians, and Raymond Bradley's "third degree possibilist" reading—and shows why they are exegetically unsound. (shrink)

De fato 35 is part of Cicero's argument against the Stoic theory of causation. He claims in general that the Stoic chain of causes consists of antecedent but not efficient causes. To the examples cited in the previous chapter he adds verses from the opening of Ennius’ Medea exul (lines 208–11 Jocelyn = FRL 2 and TRF 89.1–4) containing the Nurse's lamentation over the origins of the Argonautic expedition that led, ultimately, to Medea's current mental distress. Then follows the (...) question quorsum haec praeterita? and the answer quia sequitur illud, ‘nam numquam era errans mea domo ecferret pedem | Medea, animo aegro, amore saeuo saucia’, non ut eae res causam adferrent amoris, citing Ennius, Medea exul 215–16 Jocelyn = FRL 2 and TRF 89.8–9. Editors and commentators have struggled to explain the relation of the answer to the question. Here it is argued that the relation becomes clear if one adopts non for non and punctuates with a query after amoris. The sense will be: ‘Why have these past events been cited? In view of the sequel … was it not so that they bring on the cause of love?’ In other words, the Nurse, like the Stoics in Cicero's view, cites antecedent events as if they were efficient causes. (shrink)

A famous mathematical theorem says that the sum of an infinite series of numbers can depend on the order in which those numbers occur. Suppose we interpret the numbers in such a series as representing instances of some physical quantity, such as the weights of a collection of items. The mathematics seems to lead to the result that the weight of a collection of items can depend on the order in which those items are weighed. But that is very hard (...) to believe. A puzzle then arises: How do we interpret the metaphysical significance of this mathematical theorem? I first argue that prior solutions to the puzzle lead to implausible consequences. Then I develop my own solution, where the basic idea is that the weight of a collection of items is equal to the limit of the weights of its finite subcollections contained within ever-expanding regions of space. I show how my solution is intuitively plausible and philosophically motivated, how it reveals an underexplored line of metaphysical inquiry about quantities and locations, and how it elucidates some classic puzzles concerning supertasks. (shrink)

Against the growing trend in philosophy toward naturalistic analysis, Kant’s Critique of the Power of Judgment has gained significant attention. Some scholars suggest that Kant’s insights bear on our aesthetic appreciation of nature, others on our account of the life sciences. In this paper I draw these lines of inquiry together to identify two overlooked dimensions of Kant’s project: the role of moral hope in problematizing the limits of natural science and the role of culture in providing a solution. (...) Kant argues that we cannot think consistently unless we are able to conceive of nature as a domain that is hospitable to human freedom. His response is to identify the productive capacity of the imagination to transform the material of nature into something more. While the prevailing conception of nature today is at best indifferent and at worst antagonistic to human habitation, this dimension of Kant’s work has much to bear on contemporary thought. (shrink)

[First paragraphs] Reductionists about personal identity contend that there is nothing more to our survival than a series of causally related experiences and/or bodily continuities. Our belief in a separately existing self or subject of experiences is held to be unjustified, and we are recommended to reduce the conception of our own identity over time by jettisoning this belief. The particular form of reductionism that places the true view of our identity in a series of causally related experiences is usually (...) known as psychological reductionism or the psychological continuity approach. The version that gives prominence to the continuity of the body or human being, at least as it has been developed in recent years, is known as animalism or the biological approach. I shall concentrate on psychological reductionism because, of these two views, it seems to me the more intuitively appealing. But I shall also consider the animalist alternative, arguing that my main line of attack against psychological reductionism can be adapted against it. Both positions are mistaken in supposing that we have insufficient reason for believing in a separately existing subject of experiences. This conclusion is defended in the first section. In the second, I maintain that certain additional grounds that have been offered for accepting a reductionist position fail to do so. And, in the third, I examine a general objection to the conception of a subject of experiences that has been defended in the first two sections. (shrink)

Preface: The target of film theory -- Camera searching in the world -- Is a camera essential? -- Cahiers axiom -- Tracing Bazin's trace -- Images contested today -- Editor's discovery of form -- Bazin's forerunners -- Documentaries in the cauldron of history -- Cahiers line -- Pursuing cinema in the twenty-first century -- Projector as spectator's searchlight -- Power of projection -- Opening the screen's dimensions -- Frame as threshold -- Writing out of the frame -- Evolution of the (...) subjects of cinema -- Modern film: Between classic and avant-garde -- Ontogeny of cinema -- Credits and auteurs: An ecology of adaptation -- Fidelity: The economy of adaptation. (shrink)

Health is a central concept in Nietzsche’s work. Yet in the most philosophically sophisticated secondary literature on Nietzsche, there has been fairly little sustained treatment of just what Nietzschean health consists in. In this paper, I aim to provide an account of some of the central marks of this health: resilience, discipline, vitality, a certain positive condition of the will to power, a certain tendency toward integration, and so on. This exposition and discussion will be the main task of the (...) paper. Then in the concluding section of the paper, I consider a line taken in some related secondary literature, which would suggest that health might ultimately be understood in formal or dynamic terms, relating to one’s will to power and/or the unity of one’s drives. I will present the beginnings of an argument against such an account of health. In focusing on the formal and dynamic side exclusively, it cannot get the full story. In particular, it seems to me to miss the substantive dimension that is essential if we are to understand health properly. As I shall suggest, the core concept of Nietzschean health is not fully explicable except by reference to normative terms. (shrink)

Of all the crew to serve on a starship Enterprise, none has had such a convoluted line of existence as the venerable Mr. Spock. This chapter explores what the various incarnations of Mr. Spock can tell us about the nature of reality, existence, and personal identity. Lewis argues for the metaphysical theory of modal realism: all possible worlds are as real as the actual world. In science fiction parlance, this philosophical concept of world is more often called a universe. Thus, (...) Earth and Vulcan are both part of the same world depicted in Star Trek. The central question Lewis addresses is whether our world is the only real world, or whether other possible worlds could also be considered real. Lewis argues for the metaphysical theory of modal realism, all possible worlds are as real as the actual world. (shrink)

Pornography is everywhere, and it raises a host of difficult questions. What counts as pornography, first of all? When does material cross the line from being erotic to being objectionable? Where does a person's entitlement to sexual freedom end and another person's right not to feel objectified begin? How should rights be weighed against consequences in deciding what laws and policies ought to be adopted? Philosophers Andrew Altman and Lori Watson explore these and other issues in this succinct and (...) readable for-and-against volume. (shrink)

Decision theory is founded on the principle that we ought to take the action that has the maximum expected value from among actions we are in a position to take. But prior to the notion of expected value is the notion of the actual value of that action: roughly, a measure of the good outcomes you would in fact procure if you were to take it. Surprisingly many decision theories operate without an analysis of actual value. I offer a definition (...) of actual value, and show that a form of decision theory due to Stalnaker can be reformulated so as to be in line with the edict to maximize expected value. By contrast, I show that there is no quantity — given by my definition or otherwise — that plays the role of actual value in Jeffrey's decision theory. (shrink)

This paper critically supports the modern evolutionary explanation of religion popularised by David Sloan Wilson, by comparing it with those of his predecessors, namely Emile Durkheim and Thomas Hobbes, and to some biological examples which seem analogous to religions as kinds of superorganisms in their own right. The aim of the paper is to draw out a theoretical pedigree in philosophy and sociology that is reflected down the lines of various other evolutionarily minded contributors on the subject of religion. (...) The general theme is of evolved large-scale cooperative structures. A scholarly concern is as follows: Wilson draws on Durkheim, using Calvinism as an example without mentioning Hobbes, but it was Thomas Hobbes who used Calvinism as an example of a leviathanesque religious structure—which is not acknowledged by either Wilson or Durkheim. If there are even any similarities between these authors, there appears to be an omission somewhere which should rightly be accounted for by giving credit to Hobbes where it is due. I issue on conclusion, what it is that makes Wilson’s approach radically different to that it skates on. I also issue it with a cautionary word. (shrink)

Semiotic Theory of Learning asks what learning is and what brings it about, challenging the hegemony of psychological and sociological constructions of learning in order to develop a burgeoning literature in semiotics as an educational foundation. Drawing on theoretical research and its application in empirical studies, the book attempts to avoid the problematization of the distinction between theory and practice in semiotics. It covers topics such as signs, significance and semiosis; the ontology of learning; the limits of learning; ecosemiotics; ecology (...) and sexuality. -/- The book is written by five of the key figures in the semiotics field, each committed to the belief that living is a process of interaction through acts of signification with a signifying environment. While the authors are agreed on the value of semiotic frameworks, the book aims not to present an entirely coherent line in every respect, but rather to reflect ongoing scholarship and debates in the area. In light of this, the book offers a range of possible interpretations of major semiotic theorists, unsettling assumptions while offering a fresh, and still developing, series of perspectives on learning from academics grounded in semiotics. -/- Semiotic Theory of Learning is a timely and valuable text that will be of great interest to academics, researchers and postgraduates working in the fields of educational studies, semiotics, psychology, philosophy, applied linguistics and media studies. (shrink)

Nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels that bring about a diversity of fast synaptic actions. Analysis of the Caenorhabditis elegans genome has revealed one of the most‐extensive and diverse nAChR gene families known, consisting of at least 27 subunits. Striking variation with possible functional implications has been observed in normally conserved motifs at the acetylcholine‐binding site and in the channel‐lining region. Some nAChR subunits are particular to neurons whilst others are present in both neurons and muscles. The localization (...) of subunits in non‐synaptic regions suggests novel roles for nAChRs. Genetic and heterologous expression studies have identified a subset of nAChR subunits that are important drug targets while the study of mutants has identified genes functionally‐linked to nAChRs. Future studies using C. elegans offer the prospect of increasing our understanding of the functional diversity of a complex nAChR gene family as well as addressing the role of nAChRs and associated proteins in human disorders. BioEssays 26:39–49, 2004.© 2003 Wiley Periodicals, Inc. (shrink)

In this first book-length liberal reply to CLS, Andrew Altman systematically examines the philosophical underpinnings of the CLS movement and exposes the deficiencies in the major lines of the CLS argument against liberalism.

Ever since the great Florida meltdown in the presidential election of 2000, Americans have had reason to suspect they may not, after all, live in the greatest democracy on the planet. We have seen breakdowns at every level of the system, from voter registration to voting machine software to provisional balloting to dubious purges of supposedly ineligible voters. Despite the lip service paid to the genius of the American system, the reality is that elections in this country have rarely been (...) about transparency and fair play; they are not about who deserves to win so much as how much each side is prepared to do to push and scrape its way over the finish line. The United States has a history of electoral malfeasance and fraud unrivalled in the rest of the western world -- a result of the unique circumstances of its democratic deve;lopment. Its claims to democratic greatness are themselves fraudulent, and now subject to closer scrutiny than ever before. (shrink)

Rational choice theory enjoys unprecedented popularity and influence in the behavioral and social sciences, but it generates intractable problems when applied to socially interactive decisions. In individual decisions, instrumental rationality is defined in terms of expected utility maximization. This becomes problematic in interactive decisions, when individuals have only partial control over the outcomes, because expected utility maximization is undefined in the absence of assumptions about how the other participants will behave. Game theory therefore incorporates not only rationality but also common (...) knowledge assumptions, enabling players to anticipate their co-players' strategies. Under these assumptions, disparate anomalies emerge. Instrumental rationality, conventionally interpreted, fails to explain intuitively obvious features of human interaction, yields predictions starkly at variance with experimental findings, and breaks down completely in certain cases. In particular, focal point selection in pure coordination games is inexplicable, though it is easily achieved in practice; the intuitively compelling payoff-dominance principle lacks rational justification; rationality in social dilemmas is self-defeating; a key solution concept for cooperative coalition games is frequently inapplicable; and rational choice in certain sequential games generates contradictions. In experiments, human players behave more cooperatively and receive higher payoffs than strict rationality would permit. Orthodox conceptions of rationality are evidently internally deficient and inadequate for explaining human interaction. Psychological game theory, based on nonstandard assumptions, is required to solve these problems, and some suggestions along these lines have already been put forward. Key Words: backward induction; Centipede game; common knowledge; cooperation; epistemic reasoning; game theory; payoff dominance; pure coordination game; rational choice theory; social dilemma. (shrink)

Kris McDaniel has recently proposed an interpretation of the distinction between conventional truth and ultimate truth, as that distinction is made within Abhidharma metaphysics. According to McDaniel's proposal, the distinction between conventional truth and ultimate truth is closely connected with a similar distinction between conventional existence and ultimate existence. What is more, the distinction between conventional existence and ultimate existence should be interpreted along ontological pluralist lines: the difference between things that ultimately exist and things that merely conventionally exist (...) amounts to a difference in the modes of being enjoyed by the things in question.One... (shrink)

In the foreground of Father Lonergan's analysis of the cognitional process are insight and the heuristic structures it employs. A close study of paradigms of insight exhibits mental acts apprehending intelligibilities logically distinct from, though psychologically conveyed by sense data and images. Because these intelligibilities, e.g., in contemporary physics, bear witness to entities which are unimaginable, knowing is not merely looking. Knowing involves entertaining intelligible meanings and reflecting on them, and though it exists, for men at least, within the boundaries (...) of sensible experience, knowing in its primary activity as insight goes beyond the empirical presentations to grasp intelligible meanings and to judge reflectively their truth or falsity. When judging, a rational self-consciousness affirms a proposition, i.e., an intelligible meaning, in view of its sufficient reason or grounds. In this sense affirmative judgment renders the conditioned "virtually unconditioned" by linking it up with its conditions, as structures immanent and operative within the cognitional process effectuate this linkage of the conditioned with its conditions. These structures, which Father Lonergan supposes he can express as rules for the construction of situations which give rise to insight so that method and not genius suffices to gain truth, are held to be constitutive of the acts of insight and understanding. Accordingly, the positive content of Insight is summed up in the slogan: "Thoroughly understand what it is to understand, and not only will you understand the broad lines of all there is to be understood but also you will possess a fixed base, an invariant pattern, opening upon all further developments of understanding". (shrink)

In this paper I argue that William Harvey believed in a form of astrology. It has long been known that Harvey employed a macrocosm–microcosm analogy and used alchemical terminology in describing how the two types of blood change into one another. This paper then seeks to examine a further aspect of Harvey in relation to the magical tradition. There is an important corollary to this line of thought, however. This is that while Harvey does have a belief in astrology, it (...) is strongly related to Aristotle's views in this area and is quite restricted and attenuated relative to some contemporary beliefs in astrology. This suggests a more general thesis. While Harvey was amenable to ideas which we associate with the natural magic tradition, those ideas had a very broad range of formulation and there was a limit to how far he would accept them. This limit was largely determined by Harvey's adherence to Aristotle's natural philosophy and his Christian beliefs. I argue that this is also the case in relation to Harvey's use of the macrocosm–microcosm analogy and of alchemical terminology, and, as far as we can rely on the evidence, this informs his attitudes towards witches as well. Understanding Harvey's influences and motives here is important in placing him properly in the context of early seventeenth-century thought. (shrink)

Shortages of generic, injectable chemotherapeutics have been increasing in prevalence since 2006. Due to the lack of access to first-line, lifesaving treatments, physicians have been forced to ration chemotherapy between patients. Although the scarcity has been managed with good intentions, it has been done in an ad hoc manner, without the benefit of an ethically grounded and standardized schema. Using an approach based on the “accountability for reasonableness” method by Daniel and Sabin, I establish a framework and protocol for rationing (...) that is specific to chemotherapy. Prior to the state of true shortage, I present guidelines for the use of an adequate supply of chemotherapy with knowledge of upcoming scarcity. Within the rationing framework itself, I first prioritize emergency use of chemotherapeutics and those already receiving treatment at the time of shortage. I advocate for stratifying patients based on the prognostic indicators of their cancer type, using a combination of clinical-trial-based initial response and longer term survival, followed by the patients’ line of treatment. All patients who are not able to receive their “best” treatment must receive a sequent, next-best treatment, and their treatment team must have the ability to appeal to a rationing committee in special circumstances. I reject the ideas of stratification based on the intention of the treatment, perceived quality of life, pre-existing condition not impacting performance status, the classical “sickest first” argument, and giving preference to pediatric cases. Lastly, I advocate for any system of rationing to be transparent to those it affects and acknowledge the difficulties it presents to patients and physicians alike. (shrink)

: This essay addresses the difficulties that sociology as a discipline continues to experience in grasping the relations between technology, science and the social. I argue that these difficulties stem from a resolute centering of sociology on the social, which follows a generically Durkheimian blueprint. I elaborate a response to these difficulties which derives from recent lines of work in science and technology studies, and which entails a decentering of the social relative to the material and the conceptual, in (...) terms of both objects of analysis and explanatory formats. In order to display the direct sociological relevance of this approach, I move to the macro level, developing the conceptual apparatus of a decentered social theory via the discussion of a historical example of major sociological significance—the systematic gearing together of scientific research, technological innovation and industrial production that originated in the synthetic dye industry in the second half of the nineteenth century. Besides the interest of the topic itself, the aim is thus to exemplify in some detail what a decentered sociology might look like, both empirically and conceptually. (shrink)

One of the fundamental questions in post-Fregean philosophy is how to account for the normativity involved in assertoric claims once the traditional subject-object view of thinking is rejected. One of the more productive lines of inquiry in the contemporary literature attributes normativity to second nature, which is presented as a sui generis space of reason giving and receiving distinct from the space of nature studied by the natural sciences. In this paper I suggest an alternative account by drawing from (...) Castoriadis’s philosophical interpretation of autopoiesis. For Castoriadis, the idea of second nature protects the modern conception of nature from undergoing the radical critique it requires, for it restricts normativity to the anthropic sphere. In contrast, he proposes an autopoietic account of the subject that grounds the capacity to know that one knows in the activity of the living being. Castoriadis demonstrates that the normativity of assertoric claims is not a vertical break from nature but rather a horizontal transformation of the biological capacity for self-referentiality. (shrink)

Evidence-based medicine (EBM) has long deemphasized mechanistic reasoning and pathophysiological rationale in assessing the effectiveness of interventions. The EBM+ movement has challenged this stance, arguing that evidence of mechanisms and comparative studies should both be seen as necessary and complementary. Advocates of EBM+ provide a combination of theoretical arguments and examples of mechanistic reasoning in medical research. However, EBM+ proponents have not provided recent examples of how downplaying mechanistic reasoning resulted in worse medical results than would have occurred otherwise. Such (...) examples are necessary to make the case that EBM+ responds to a problem in clinical practice that urgently demands a solution. In light of this, we examine the failed rollout of efavirenz as a first-line HIV treatment in Zimbabwe as evidence of the importance of mechanistic reasoning in improving clinical practice and public health policy decisions. We suggest that this case is analogous to examples commonly given to support EBM. (shrink)

Rustin Cohle, or Rust, is identifiable as being one character by looking at the script of True Detective and seeing the lines of text that only Rust will say. It would appear that the brute physicalist account is not sufficient for understanding how there are three different Rusts while each possesses many of the same physical characteristics as the others. In fact, one identifies at least three distinct non‐identical Rusts namely: Taxman, Belligerent, and Patient. Since they are mental instantiations (...) and not physical bodies, it is possible to have all three Rusts existing in the same body and, oddly, at the same time. By appealing to the psychological account, there is no restriction on how many Rusts there can be in a single body at any moment. Rust continues to be Rust so long as he has the same body, which can be identified as the body with the bird tattoo on the right arm. (shrink)

Richard Gale, in On the Nature and Existence of God, offers several reasons why an “historical-cum-indexical” theory of reference cannot be appropriate in explaining how people refer to God. The present paper identifies five distinct lines of argument in Gale, attempts to clarify several important desiderata for a successful theory of reference, and argues that Gale fails to discharge the burden of proof he has assumed, leaving the most important features of Alston’s “direct reference” theory untouched. Nevertheless, it is (...) conceded that some consequences of Alston’s theory are quite counter-intuitive. The paper therefore concludes with a consideration of two alternatives: either taking a hard, Alstonian line in conflict with people’s linguistic intuitions, or striking a compromise with descriptivism along lines similar to those found in Gareth Evans’s paper, “The Causal Theory of Names.”. (shrink)

Veterinarians serve on the front lines working to prevent animal suffering and abuse. For centuries, their compassion and expertise have improved the quality of life and death for animals in their care. However, modern interest in animal rights has led more and more people to ask questions about the ethical considerations that lie behind common veterinary practices. This Common Threads volume, drawn from articles originally published in the Journal of Animal Ethics (JAE), offers veterinarians and other interested readers a (...) primer on key issues in the field. Essays in the first section discuss aspects of veterinary oaths, how advances in animal cognition science factor into current ethical debates, and the rise of complementary and alternative veterinary medicine and its relationship to traditional veterinary medicine. The second section continues with an essay that addresses why veterinarians have an obligation to educate animal caregivers to look past "cuteness" in order to treat all animals with dignity. The collection closes with three short sections focusing on animals in farming, trade, and research ”areas where veterinarians encounter conflicts between their job and their duty to advocate and care for animals. Contributors: Judith Benz-Schwarzburg, Vanessa Carli Bones, Grace Clement, Simon Coghlan, Priscilla N. Cohn, Mark J. Estren, Elisa Galgut, Eleonora Gullone, Matthew C. Halteman, Andrew Knight, Drew Leder, Andrew Linzey, Clair Linzey, Kay Peggs, Megan Schommer, Clifford Warwick, and James W. Yeates. (shrink)

The Principle of the Fixity of the Past (FP) holds that the past is ‘fixed’ in evaluating what we are free to do, and it is frequently invoked by incompatibilists when arguing that freedom and determinism are incompatible. However, several authors have argued that incompatibilists ought to abandon FP for a different principle, sometimes called the Principle of the Fixity of the Independent (FI). According to this principle, it is not the past in its entirety that is fixed, but only (...) those parts of the past that are independent of our current choices. But a question remains: What about authors who are not friendly to incompatibilism in the first place? Is there any reason to think that compatibilists should also abandon their preferred interpretation of FP for something along the lines of FI? I examine perhaps the most influential version of (classical or leeway) compatibilism, David Lewis's ‘local-miracle compatibilism’. I argue that although Lewis's version of local-miracle compatibilism avoids being committed to anything like FI, his version faces a number of objections. Once we revise Lewis's version to avoid these objections, we arrive at a version of local-miracle compatibilism that is committed to FI, or at least something very close. (shrink)

Ethical deliberations are unfolding for potentially controversial organoid‐entities such as brain organoids and embryoids. Much of the ethical deliberation centers on the questionable moral status of such organoid‐entities. However, while such work is important and appropriate, ethical deliberations may become too exclusively rooted in moral status and potentially overshadow other relevant moral dilemmas. The ethical discussion on organoid models can benefit from insights brought forth by both Judith Jarvis Thomson and Don Marquis in how they attempted to advance the abortion (...) debate. To discuss other abortion ethical issues more fully, both Thomson and Marquis assumed differing moral status positions of the conceptus and followed lines of reasoning based on these moral status assumptions. We suggest a similar approach with controversial organoid‐entities like brain organoids and embryoids. To avoid overshadowing or overlooking other relevant ethical issues, ethicists ought to first assume an organoid‐entity moral status position (such as a high moral status or no moral status) and explore any possible arguments that may result from such a position. While we ought not to copy the content of Thomson and Marquis' arguments exactly for organoid‐entities, it is worthwhile to translate their arguments' overarching structures. This paper explores the relevant insights of Thomson and Marquis, how they can be translated into the organoid ethics debate, and what possible lines of inquiry may be worth exploring based on particular moral status assumptions. (shrink)