Contemporary pain literature increasingly acknowledges the need of a multidimensional approach to pain, which accounts for its complex biological, psychological and social components. This is reflected in the recently revised definition of the International Association for the Study of Pain (IASP) and some contemporary philosophical positions. This paper addresses the need to offer a theoretical approach that integrates the biopsychosocial and qualitative multidimensionality of pain by developing the “social grounding view of pain”. My focus is on seeking a multidimensional philosophical (...) approach that accounts not only for its complex biological and psychological aspects but also and specifically does justice to its social dimension. I draw from some of the most recent multidimensional theoretical and methodological approaches that attempt to account for the social component of pain, including enactivism and interpretative phenomenological analysis (IPA), to propose the advancement of the social grounding view, which has a particular focus on socially shared linguistic concepts in relation to the meaning and modulation of pain. More specifically, the social grounding view is based on the argument that the meaning of the experience of pain is determined in part by socially shareable linguistic concepts habitually associated with pain. I test this view against empirical cases drawn from pain neuroscience education (PNE) and try to demonstrate how the modification of the linguistic concepts of pain could be used effectively to modulate its experience. (shrink)

The aim of this paper is to discuss popular conceptions of business ethics and their relationship to the problem of racial injustice by way of reviewing Spike Lee’s (1989) _Do the Right Thing_. Taking place on one day in late 80’s Bedford-Stuyvesant, and set against a tense decade of racial conflict in New York City, Spike Lee’s masterpiece has deeply influenced American discourse on race, capturing many of the complex interpersonal dynamics that are both constitutive and consequence of American racial (...) hierarchies. Instead of focusing on shareholders and stakeholders, I argue that _Do The Right Thing_ suggests a more political understanding of business’s ethical obligations: a business’s ethical obligations don’t emanate from internal relations but from its social and political position. I conclude by discussing a more recent film, Steve McQueen’s (2020) _Mangrove_. Like _Do the Right Thing_, _Mangrove_ also focuses on a business that is at the center of an urban racial conflict, but which stands in a very different relationship to this tension, providing an alternative illustration of business ethics informed by political and social positioning. (shrink)

Alexis de Tocqueville (1805–1859) was convinced that without a new possibility for transcendence, democracies would be ill-prepared to allow for actual freedom. In Democracy in America, his study of the United States, he explained that when self-interest was enlightened, individuals would tend to identify their personal benefits with the well-being of the community. By transcending their individualistic tendency to self-enclose, they would contribute to forming and maintaining a real sovereignty of the people. However, unless the “doctrine of self-interest well understood” (...) was aided by a higher ideal, by itself it would eventually fall short, thus paving the way for new forms of despotism. Religion, and more specifically, reformed versions of Christianity, seemed to effectively elevate the outlook of the early Americans. As I will argue, however, Tocqueville ultimately held that those versions lacked the profundity and stability required to resist the strong materialistic and individualistic tendencies of people living in a democracy. Tocqueville’s apparent, if anxious-ridden, preference for Catholicism as the more adequate civil religion resonates with important aspects of Augustine’s theory of the Two Cities, the earthly and the heavenly city. For both Tocqueville and Augustine, the Roman Church’s stable doctrine was what could more successfully teach mankind the truth about their limited condition, hence making them more capable of learning the “art of being free.”. (shrink)

A forcing poset of size 221 which adds no new reals is described and shown to provide a Δ22 definable well-order of the reals . The encoding of this well-order is obtained by playing with products of Aronszajn trees: some products are special while other are Suslin trees. The paper also deals with the Magidor–Malitz logic: it is consistent that this logic is highly noncompact.

The belief that the spirits of the dead can return to haunt the living exists either as a tenet or as a marginal conviction in all civilizations, whether ancient or modern. More often than not, the dead do not return to reunite the living with their loved ones but rather to lead them into some dreadful snare, entrapping them with disastrous consequences. To be sure, all the departed may return, but some are predestined to haunt: the dead who have been (...) shamed during their lifetime or those who took unspeakable secrets to the grave. From the brucolacs, the errant sprits of outcasts in ancient Greece, to the ghost of Hamlet’s vengeful father, and on down to the rapping spirits of modern times, the theme of the dead—who, having suffered repression by their family or society, cannot enjoy, even in death, a state of authenticity—appears to be omnipresent on the fringes of religions and, failing that, in rational systems. It is a fact that the “phantom,” whatever its form, is nothing but an invention of the living. Yes, an invention in the sense that the phantom is meant to objectify, even if under the guise of individual or collective hallucinations, the gap that the concealment of some part of a loved one’s life produced in us. The phantom is, therefore, also a metapsychological fact. Consequently, what haunts are not the dead, but the gaps left within us by the secrets of others.Because the phantom is not related to the loss of a loved one, it cannot be considered the effect of unsuccessful mourning, as is the case of melancholics or of all those who carry a tomb within themselves. It is the children’s or descendants’ lot to objectify these buried tombs through diverse species of ghosts. What comes back to haunt are the tombs of others. The phantoms of folklore merely objectify a metaphor active within the unconscious: the burial of an unspeakable fact within the loved one.Here we are in the midst of clinical psychoanalysis and still shrouded in obscurity, an obscurity, however, that the nocturnal being of phantoms can, paradoxically, be called upon to clarify. The most recently published book of essays by Nicolas Abraham is Rythmes de l’oeuvre, de la traduction et de la psychanalyse . “Notes on the Phantom” is the preliminary statement of his theory of transgenerational haunting. Nicholas Rand, assistant professor of French at the University of Wisconsin—Madison, is the English-language editor of Abraham’s works. (shrink)

Todos somos masoquistas. Esta afirmación puede ser entendida de dos maneras. En un sentido benigno o patológico. Según el primero, se trata de un hábito motivado por deseos masoquistas sin que éste constituya un perjuicio para la salud de las personas. En este sentido, todos, o casi todos, somos masoquistas. Este tipo de masoquismo puede constituir prácticas culturales, como comer comida picante, practicar deportes de contacto o participar en grupos BDSM. Por el contrario, el masoquismo patológico es aquel que, también (...) incentivado por deseos masoquistas, resulta en daños para la salud de las personas, ya sea a nivel biológico, psicológico o sociológico. Un deseo masoquista está constituido por la actitud en favor de experimentar algo desagradable, como un dolor, en virtud de la relación, ya sea causal o mereológica, que se le atribuye a esta experiencia con algo más. Es decir, podemos desear sentir dolor ya sea porque este es el medio para un fin que también queremos o porque es deseado en tanto que una parte constitutiva de un todo anhelado. Una taxonomía del masoquismo nos permite dar cuenta de la intrincada interacción que tenemos con experiencias desagradables. (shrink)

This paper explores the work of Nicolas Rashevsky, a Russian émigré theoretical physicist who developed a program in "mathematical biophysics" at the University of Chicago during the 1930s. Stressing the complexity of many biological phenomena, Rashevsky argued that the methods of theoretical physics -- namely mathematics -- were needed to "simplify" complex biological processes such as cell division and nerve conduction. A maverick of sorts, Rashevsky was a conspicuous figure in the biological community during the 1930s and early 1940s: he (...) participated in several Cold Spring Harbor symposia and received several years of funding from the Rockefeller Foundation. However, in contrast to many other physicists who moved into biology, Rashevsky's work was almost entirely theoretical, and he eventually faced resistance to his mathematical methods. Through an examination of the conceptual, institutional, and scientific context of Rashevsky's work, this paper seeks to understand some of the reasons behind this resistance. (shrink)

In the early twentieth century Walter Benjamin introduced the idea of epochal and ongoing progression in interaction between mind and the built environment. Since early antiquity, the present study suggests, Benjamin’s notion has been manifest in metaphors of gender in city-form, whereby edifices and urban voids have represented masculinity and femininity, respectively. At the onset of interaction between mind and the built environment are prehistoric myths related to the human body and to the sky. During antiquity gender projection can be (...) detected in western perceptions linking natural and built environments, commencing with Plato’s Atlantis and his Myth of Er, and later as a likely import of the Chinese yin-yang mythology. Culminating with the Age of Discovery, alongside advances in experiential awareness of the Earth’s sphericity, respective feminine and masculine earmarks can be detected in early modern perspicacity of the Earth’s southern and northern hemispheres. Our conceptions of natural and built environments inherently continue to contain gender traits. Yet urban voids, as the feminine face of city-form, have been severely understated in the built environment. Through design and configuration of urban voids, allegories of femininity in city-form ought to be celebrated, not discarded. (shrink)

Any model of ZFC + GCH has a generic extension (made with a poset of size ℵ 2 ) in which the following hold: MA + 2 ℵ 0 = ℵ 2 +there exists a Δ 2 1 -well ordering of the reals. The proof consists in iterating posets designed to change at will the guessing properties of ladder systems on ω 1 . Therefore, the study of such ladders is a main concern of this article.

Mental state reasoning or theory-of-mind has been the subject of a rich body of imaging research. Although such investigations routinely tap a common set of regions, the precise function of each area remains a contentious matter. With the help of functional magnetic resonance imaging (fMRI), we sought to determine which areas are involved when processing mental state or intentional metarepresentations by focusing on the relational aspect of such representations. Using non-intentional relational representations such as spatial relations between persons and between (...) objects as a contrast, the results ascertained the involvement of the precuneus, the temporal poles, and the medial prefrontal cortex in the processing of intentional representations. In contrast, the anterior superior temporal sulcus and the left temporo-parietal junction were implicated when processing representations that refer to the presence of persons in relational contexts in general. The right temporo-parietal junction, however, was specifically activated for persons entering spatial relations. The level of representational complexity, a previously unexplored factor, was also found to modulate the neural response in some brain regions, such as the medial prefrontal cortex and the right temporo-parietal junction. These findings highlight the need to take into account the critical roles played by an extensive network of neural regions during mental state reasoning. (shrink)

You and I are going to die. We are aware that it is going to happen, but not exactly when—in which there is relief, but also anxiety. What happens to us when we know with some precision what our last day will be? In this text, we discern the process of our own death, once we have reliable information about the approximate moment of the cessation of our life. Tú y yo vamos a morir. Estamos al tanto de que va (...) a ocurrir, pero no exactamente cuándo —en lo cual hay alivio, pero también angustia—. ¿Qué nos ocurre al saber con cierta precisión cuál será nuestro último día? En este texto, discernimos el proceso de nuestra propia muerte, una vez que tenemos información confiable sobre el momento aproximado del cese de nuestra vida. (shrink)

This paper seeks to explore the significance of a specific kind of religious experience for the rationality of religious belief. The context for this is a gap between what is often allowed as rational and what is embraced as certain in the life of faith. The claim to certainty at issue is related to the work and experience of the Holy Spirit; this experience has a structure which is explored phenomenologically. Thereafter various ways of cashing in the epistemic value of (...) the purported claim to certainty are examined. (shrink)

Mutual feedback between human-made environments and facets of thought throughout history has yielded two myths: the Garden and the Citadel. Both myths correspond to Jung’s feminine and masculine collective subconscious, as well as to Nietzsche’s premise of Apollonian and Dionysian impulses in art. Nietzsche’s premise suggests, furthermore, that the feminine myth of the Garden is time-bound whereas the masculine myth of the Citadel, or the Ideal City, constitutes a spatial deportment. Throughout history the two myths have continually molded the built (...) environment and thought, but the myth of the Ideal City – from Plato to Descartes to modernity – came to dominate city-form and ensuing aspects of contemplation. This relationship seems to have shifted during the twentieth century. Intellectual dispositions have begun to be largely nurtured by an incongruous city-form emerging from the gap between the incessant promise for an automated, well-functioning city, on the one hand, and looming alienation, coupled with the factual, malfunctioning city, on the other hand. Urban decay, a persisting and time-bound urban event that is a byproduct of this configuration, suggests the ascent of the Garden myth in post-modern city-form. (shrink)

Almost simultaneous emergence of Existentialism and Marxism at end of the Little Ice Age had coincided with rapid urbanization and prevalence of mood disorder in northern Europe. This historic configuration is cast against Relph’s notion of place in his critique of urban planning. During the LIA street walking had mitigated mood disorder triggered by sunlight deprivation of indoor spaces while, at the same time, it had also buoyed a place. It was the unplanned place in the open air—a dilapidated street (...) corner in St. Petersburg or Romanesque streetscape of Old Copenhagen—that offered authenticity, cerebral restitution, and for ardent minds also discernment and acumen. Relph’s critique continues to be of pressing relevance to winter-cities designed for automotive access, and also for the interpretation it offers on the thought and events of the late LIA and following it. (shrink)

This book examines reason and unreason in the legal and political responses to terrorism. Terrorism is often perceived as sheer madness, unreasonable use of extreme violence and senseless, futile political action. These assertions are challenged by this book. Combining ‘traditional’ thought on reason and unreason in terrorism with empirical explorations of post-modern terrorism and its use of communication platforms the work uses interdisciplinary and cross disciplinary dimensions to provide a multidimensional picture of critical issues in current politics and a deeper (...) examination of their implications than previously available. The book looks at various aspects of modern politics, from terrorism to protest, from decision-making to political discourse, applying the perspective of philosophical thought. To do so, political issues and actions are examined by using concepts such as reason, emotions, madness, magic, morality, absolutism, extremism, psychopathology, rationality and others. The analysis is rooted in theories and concepts derived from history, philosophy, religion, art, sociology, psychology, and political science. This book, which was mostly written by the late Abraham Kaplan, an American philosopher, and edited and updated by Gabriel Weimann, will be of much interest to students of political violence/terrorism, philosophy, war and conflict studies and political science in general. (shrink)

Including the first English edition of the Treatise of the Three Impostors since 1904, this book examines the treatise in its literary, political, and philosophical context.

Complex dynamical systems theory is an evolution of nonlinear dynamics, developed for modeling and simulation of biological systems. Here, we speculate on the potential of this strategy for the emerging theory of social systems, and the implications for the future of our own planetary society.

Scaling of pattern with size has been described and studied for over a century, yet its molecular basis is understood in only a few cases. In a recent, elegant study, Inomata and colleagues proposed a new model explaining how bone morphogenic protein (BMP) activity gradient scales with embryo size in the early Xenopus laevis embryo. We discuss their results in conjunction with an alternative model we proposed previously. The expansion‐repression mechanism (ExR) provides a conceptual framework unifying both mechanisms. Results of (...) Inomata and colleagues implicate the chordin‐stabilizing protein sizzled as the expander molecule enabling scaling, while we attributed this role to the BMP ligand Admp. The two expanders may work in concert, as suggested by the mathematical model of Inomata et al. We discuss approaches for differentiating the contribution of sizzled and Admp to pattern scaling. (shrink)

Clinical medicine is an inexact science. In situations of uncertainty, we often ask an experienced colleague for a second opinion. But what if one could effectively call upon the experience of thou...

We propose a class [I,S] of loss functions for modeling the imprecise preferences of the decision maker in Bayesian Decision Theory. This class is built upon two extreme loss functions I and S which reflect the limited information about the loss function. We give an approximation of the set of Bayes actions for every loss function in [I,S] and every prior in a mixture class; if the decision space is a subset of R, we obtain the exact set.

The discovery, made in Oxford, that crude penicillin could cure systemic and life‐threatening bacterial infections was followed by attempts to purify penicillin, to determine its structure and then to produce it by total chemical synthesis. The β‐lactam structure of the molecule, first proposed in October 1943, was a source of controversy until 1945. However, no useful chemical synthesis was achieved and fermentation became the commercial source of the antibiotic.In 1953, one of the products of a Cephalosporium sp. from Sardinia was (...) shown to be a new and hydrophilic penicillin (penicillin N). This was contaminated with a substance having the same side‐chain but a characteristic absorption spectrum. The latter, cephalosporin C, showed antibacterial activity but was not inactivated by a penicillinase. The determination of its β‐lactam structure and isolation of its nucleus enabled pharmaceutical companies to produce many semisynthetic cephalosporins.A new tripeptide was later found to be an intermediate in the biosynthesis of both penicillin N and cephalosporin C, and this was followed by the complete elucidation of the biosynthetic pathways leading to these compounds and to benzylpenicillin. (shrink)

Canonical theists insist that the Church initially canonized a Trinitarian ontology, leaving epistemic convictions to speak for themselves. Pursuing epistemology is a vital exercise in its own right. Within this, particularism is compatible with metaknowledge, with a doctrine of analogy, and with the propositional content of Christian theism. We can also build on past insights and accommodate ordinary believers who have no idea what epistemology is. This program overlaps with the work of Plantinga but differs in its analysis of the (...) Holy Spirit and argues that a diachronic account of warrant can better handle the problems to be faced. (shrink)