This article evaluates the political implications of Thomas Hobbes’s extensive treatment of religion by taking up the motif of the Eucharist (and accompanying doctrine of transubstantiation) in Leviathan. Hobbes holds out transubstantiation as an exemplar of absurdity and an historical outgrowth of Christianity’s inauspicious meeting with pagan practices. At the same time, Leviathan contains allusions to eucharistic imagery in its narration of the generation of the “Mortal God,” the commonwealth, as the incorporation of a civil body. These conflicting sentiments are (...) illustrative of a wider tension running through Hobbes’s thought. Although Hobbes’s repudiation of superstition is well-known, it stands in stark contrast to Leviathan’s treatment of Christianity as an exemplar of “true” religion. The varied allusions to eucharistic doctrine illustrate how proper use might be made of a persistent “natural religiosity.” Both in its consonance with reason and its political logic, Christianity remains a politically constructive expression of “power invisible.”. (shrink)

Recent scholarship has cast welcome light on the political relevance of Hobbes’s extensive treatment of theology and sacred history. Building on extant contributions, this article argues that God’s historical founding of a Kingdom lends insights into well-known difficulties attaching to Hobbes’s exposition of the Commonwealth by Institution. Although there are evident discrepancies between sacred history and man's natural estate, Abraham and Moses each faced political challenges that persist into the present. Acting as God’s authorized representatives not only allowed them to (...) assuage epistemic uncertainty, it enabled Moses to wield sovereign authority while preserving a claim to natural equality. I argue that Leviathan suggests this model of prophetic authority – conceived of as a particular kind of prudence – is key to meeting the challenges arising from the anthropological vulnerabilities of ignorance and fear. Hobbes’s interest in the role of founding prophets also helps to explain Leviathan’s novel inclusion of representation. This explication of prophetic authority reveals institution to be marked by a greater attention to legitimacy, epistemic authority, and divine sanction, and sheds light on the importance of sacred history for Hobbes’s broader political project. (shrink)

As Hume famously claimed, we are nowhere more free than in our imagination. While this feature of imagination suggests that imagination has a crucial role to play in modal epistemology, it also suggests that imagining cannot provide us with any non-modal knowledge about the world in which we live. This chapter rejects this latter suggestion. Instead it offers an account of “imagining under constraints,” providing a framework for showing when and how an imaginative project can play a justificatory role with (...) respect to our beliefs about the world. That we can be free in our imaginings does not show that they must proceed unfettered; as is argued, our ability to constrain our imaginings in light of facts about the world enables us to learn from them. The important upshot is that imagination has considerably more epistemic significance than previously thought. (shrink)

Though philosophers such as Wittgenstein and Sartre have dismissed imagination as epistemically irrelevant, this chapter argues that there are numerous cases in which imagining can help to justify our contingent beliefs about the world. The argument proceeds by the consideration of case studies involving two particularly gifted imaginers, Nikola Tesla and Temple Grandin. Importantly, the lessons that we learn from these case studies are applicable to cases involving less gifted imaginers as well. Though not all imaginings will have justificatory power, (...) the chapter shows how the sorts of cases in which imagining plays an epistemic role can be easily distinguished from the sorts of cases in which it does not. (shrink)

Intuitions about the transparency of experience have recently begun to play a key role in the debate about qualia. Specifically, such intuitions have been used by representationalists to support their view that the phenomenal character of our experience can be wholly explained in terms of its intentional content.[i] But what exactly does it mean to say that experience is transparent? In my view, recent discussions of transparency leave matters considerably murkier than one would like. As I will suggest, there is (...) reason to believe that experience is not transparent in the way that representationalism requires. Although there is a sense in which experience can be said to be transparent, transparency in this sense does not give us any particular motivation for representationalism—or at least, not the pure or strong representationalism that it is usually invoked to support. (shrink)

Empathy has for a long time, at least since the eighteenth century, been seen as centrally important in relation to our capacity to gain a grasp of the content of other people's minds, and predict and explain what they will think, feel, and do; and in relation to our capacity to respond to others ethically. In addition, empathy is seen as having a central role in aesthetics, in the understanding of our engagement with works of art and with fictional characters. (...) A fuller understanding of empathy is now offered by the interaction of research in science and the humanities. This volume draws together nineteen original chapters by leading researchers across several disciplines, together with an extensive Introduction by the editors. The individual chapters reveal how important it is, in a wide range of fields of enquiry, to bring to bear an understanding of the role of empathy in its various guises. It offers the ideal starting-point for the exploration of this intriguing aspect of human life. (shrink)

Narrativists about well-being claim that our lives go better for us if they make good stories—if they exhibit cohesion, thematic consistency, and narrative arc. Yet narrativism leads to mistaken assessments of well-being: prioritizing narrative makes it harder to balance and change pursuits, pushes us toward one-dimensionality, and can’t make sense of the diversity of good lives. Some ways of softening key narrativist claims mean that the view can’t tell us very much about how to live a good life that we (...) can’t find in other theories of well-being; while there are smaller-scale ways we can incorporate narrativist insights into our views of well-being, narrativism should not be a universal organizing principle for our lives. (shrink)

According to representationalism, the phenomenal character of a mental state reduces to its intentional content. Although representationalism seems plausible with respect to ordinary perceptual states, it seems considerably less plausible for states like moods. Here the problem for representationalism arises largely because moods seem to lack intentional content altogether. In this paper, I explore several possible options for identifying the intentional content of moods and suggest that none of them is wholly satisfactory. Importantly, however, I go on to argue that (...) the plausibility of representationalism should not be seen to rest on the question of whether moods have intentional content but rather on the question of whether the intentional content of moods, were there any, would be sufficient to determine their phenomenal character. As I argue, even if we concede to the representationalist that moods have intentional content, their phenomenal character outstrips their intentional content; thus, the representationalist reduction cannot succeed. Ultimately, then, I conclude that moods do indeed pose a serious objection to the representationalist theory. (shrink)

This paper addresses the issue of paternalism in child-rearing. Since the parent–child relationship seems to be the linguistic source of the concept, one may be tempted to assume that raising a child represents a particularly appropriate sphere for paternalism. The parent–child relationship is generally understood as a relationship that is supposed to promote the development and autonomy-formation of the child, so that the apparent source of the concept is a form of autonomy-oriented paternalism. Far from taking paternalism to be overtly (...) unproblematic in such paradigmatic, pedagogical settings, this article analyzes how an effort should be made to understand a child’s capacities and which standards parents should be held to when deciding whether interference truly serves the child’s interests. (shrink)

From the perspective of many philosophers of mind in these early years of the 21st Century, the debate between dualism and physicalism has seemed to have stalled, if not to have come to a complete standstill. There seems to be no way to settle the basic clash of intuitions that underlies it. Recently however, a growing number of proponents of Russellian monism have suggested that their view promises to show us a new way forward. Insofar as Russellian monism might allow (...) us to break out of the current gridlock, it's no wonder that it's become "hot stuff." To my mind, however, the excitement about Russellian monism is misplaced. Though some version of Russellian monism might well be true, I do not believe that it enables us to break free of the dualism/physicalism divide. As I will argue, once we properly understand what's required to flesh out an adequate monistic story, we will see that we are in an important way right back where we started. (shrink)

The early Confucians recognize that the exchanges and experiences of quotidian life profoundly shape moral attitudes, moral self-understanding, and our prospects for robust moral community. Confucian etiquette aims to provide a form of moral training that can render learners equal to the moral work of ordinary life, inculcating appropriate cognitive-emotional dispositions, as well as honing social perception and bodily expression. In both their astute attention to prosaic behavior and the techniques they suggest for managing it, I argue, the Confucians afford (...) a model useful for appropriation in contemporary efforts to address small but potent moral harms such as microinequities. (shrink)

This grounded study investigated the negotiation of authorship by faculty members, graduate student mentors, and their undergraduate protégés in undergraduate research experiences at a private research university in the northeastern United States. Semi-structured interviews using complementary scripts were conducted separately with 42 participants over a 3 year period to probe their knowledge and understanding of responsible authorship and publication practices and learn how faculty and students entered into authorship decision-making intended to lead to the publication of peer-reviewed technical papers. Herein (...) the theoretical model for the negotiation of authorship developed through the analysis of these interviews is reported. The model identifies critical causal and intervening conditions responsible for the coping strategies faculty and students employ, which, in our study, appear to often produce unfortunate consequences for all involved. The undergraduate student researchers and their graduate student mentors interviewed in this study exhibited a limited understanding of authorship and the requirements for authorship in their research groups. The power differential between faculty and students, the students’ limited epistemic development, the busy-ness of the faculty, and the faculty’s failure to prioritize authorship have been identified as key factors inhibiting both undergraduate and graduate students from developing a deeper understanding of responsible authorship and publication practices. Implications for graduate education and undergraduate research are discussed, and strategies for helping all students to develop a deeper understanding of authorship are identified. (shrink)

This essay provides a critical overview of the debate about corporate moral responsibility. Parties to the debate address whether corporations are the kinds of entities that can be blamed when they cause unjustified harm. Proponents of CMR argue that corporations satisfy the conditions for moral agency and so they are fit for blame. Their opponents respond that corporations lack one or more of the capacities necessary for moral agency. I review the arguments on both sides and conclude ultimately that what (...) divides the two is not so much competing conceptions of the corporation as it is disagreement about what moral agency requires. Homing in on the real site of contention will, it is hoped, allow future participants in the debate to focus their efforts more productively. (shrink)

The Zhuangzi offers two apparently incompatible models of bereavement. Zhuangzi sometimes suggests that the sage will greet loss with unfractured equanimity and even aplomb. However, upon the death of his own wife, Zhuangzi evinces a sorrow that, albeit brief, fits ill with this suggestion. In this essay, I contend that the grief that Zhuangzi displays at his wife’s death better honors wider values averred elsewhere in the text and, more generally, that a sage who retains a capacity for sorrow will (...) be better positioned for the robust joy so often identified as central to the Zhuangzi’s vision of flourishing. The sagely figures who entirely forego sorrow, I argue, achieve equanimity only through a sacrifice of the emotional range and responsiveness necessary not only for grief but also for the delight Zhuangzi recommends. (shrink)

The Analects appears to offer two bodies of testimony regarding the felt, experiential qualities of leading a life of virtue. In its ostensible record of Confucius’ more abstract and reflective claims, the text appears to suggest that virtue has considerable power to afford joy and insulate from sorrow. In the text’s inclusion of Confucius’ less studied and apparently more spontaneous remarks, however, he appears sometimes to complain of the life he leads, to feel its sorrows, and to possess some despair. (...) Where we attend to both of these elements of the text, a tension emerges. In this essay, I consider how Confucius’ complaints appear to complicate any clean conclusion that Confucius wins a good life, particularly where we attend to important pre-theoretical sensibilities regarding what a “good life” ought to include and how it ought to feel for the one who leads it. (shrink)

Hardt and Negri’s Empire series has inspired twenty years of debate and experimentation across the social sciences and humanities in fields as divergent as international re...

In this article, we examine the link between board composition and an enterprise strategy outcome, stakeholder relations. Because a firm’s enterprise strategy is set at the highest level of the organization, we expect the presence of stakeholder directors (suppliers, customers, employees, and community representatives) to be positively associated with stakeholder performance.Results from an analysis of 3,268 board members representing 250 firms are discussed in the context of both corporate governance and stakeholder management literatures.

My purpose in this essay is to suggest, via case study, that if Anglo-American philosophy is to become more inclusive of non-western traditions, the discipline requires far greater efforts at self-scrutiny. I begin with the premise that Confucian ethical treatments of manners afford unique and distinctive arguments from which moral philosophy might profit, then seek to show why receptivity to these arguments will be low. I examine how ordinary good manners have largely fallen out of philosophical moral discourse in the (...) west, looking specifically at three areas: conditions in the 18th and 19th centuries that depressed philosophical attention to manners; discourse conventions in contemporary philosophy that privilege modes of analysis not well fitted to close scrutiny of manners; and a philosophical culture that implicitly encourages indifference or even antipathy toward polite conduct. I argue that these three areas function in effect to render contemporary discourse inhospitable to greater inclusivity where Confucianism is concerned and thus, more broadly, that greater self-scrutiny regarding unexamined, parochial western commitments and practices is necessary for genuine inclusivity. (shrink)

Etiquette writer Judith Martin is frequently faced with “etiquette skeptics,” interlocutors who protest not simply that this or that rule of etiquette is problematic but complain that etiquette itself, qua a system of conventional norms for human conduct and communication, is objectionable. While etiquette skeptics come in a variety of forms, one of the most frequent skeptical complaints is that etiquette is artificial.The worries Martin canvasses are frequently also raised in more philosophical work as reasons to doubt the moral significance (...) of etiquette. See, e.g., Sarah Buss, “Appearing Respectful: The Moral Significance of Manners”, Ethics 109.4 : 795–826; Nancy Sherman, “The Look and Feel of Virtue”, in Christopher Gill, ed., Virtue, Norms, and Objectivity: Issues in Ancient and Modern Ethics ; and Karen Stohr, On Manners , especially Chapter 1. “Artificial” typically operates in this context as a catch-all te .. (shrink)

in The Case for Qualia,ed. by Edmond Wright , MIT Press (2008), pp. 285-298.

Professional philosophy in the United States has recently enjoyed a revival of discussion regarding the inclusion of Asian philosophies in the discipline, a revival that includes popular press articles, journal articles, books, and blog discussions.1 Such discussions can prompt hope that change is afoot and the discipline may, at long last, become more genuinely inclusive. However, for those of us who have been in the profession long enough, it is likewise difficult to resist a certain cynicism. After all, episodic bursts (...) of attention to Asian philosophy come around sufficiently often that new discussion can register as but rehearsals of familiar laments, laments that include, for example: the small numbers of... (shrink)

This paper examines whether, and how, Foucauldian genealogy travels to contexts and problematizations beyond the method's European site of articulation. Our particular focus is on the work of Colombian philosopher Santiago Castro-Gómez, whose work includes both a systematic defense of the usefulness of Foucauldian inquiry for decolonial study and genealogical inquiry in a Foucauldian spirit but in a context beyond Foucault's own horizon of study. We show that taking up Foucault's work in the context of Latin America leads Castro-Gómez to (...) significantly change Foucauldian concepts, categories, and methods. We further survey the potential synergies of decolonial thought and Foucauldian critique, while also highlighting how their joint mobilization requires a revision and problematization of key commitments of both approaches. (shrink)

Exemplars clearly play a significant role in the ethical vision of the Analects. However, while they are often treated as illustrations of the text’s more abstract ethical commitments, I argue that they are better understood to source those commitments. Such is to say that the conceptual schemata of the Analects – its account of human flourishing, the specific virtues it recommends, and its suggested path for self cultivation – originate in the people the text so vividly describes, in the unmediated (...) experiences of admiration and appreciation that these figures inspire. Theory is here an attempt to take our responses to exemplars and query just why we admire them, lifting from the examples they provide more general observations about virtue. Drawing on Linda Zagzebski’s’s recent work, I argue that there are both sound textual reasons and important prudential reasons to treat the Analects as exemplarist virtue ethic. (shrink)

I characterize the main approaches to the moral consideration of children developed in the light of the argument from 'marginal' cases, and develop a more adequate strategy that provides guidance about the moral responsibilities adults have towards children. The first approach discounts the significance of children's potential and makes obligations to all children indirect, dependent upon interests others may have in children being treated well. The next approaches agree that the potential of children is morally considerable, but disagree as to (...) whether and why children with intellectual disabilities are morally considerable. These approaches explore the moral significance of intellectual capacities, species membership, the capacity for welfare, and the interests of others. I argue that relationships characterized by reciprocity of care are morally valuable, that both the potential to be in such relationships and the actuality of being in them are morally valuable, and that many children with significant intellectual disabilities have this potential. (shrink)

Over the past few decades, as philosophers of mind have begun to rethink the sharp divide that was traditionally drawn between the phenomenal character of an experience (what it’s like to have that experience) and its intentional content (what it represents), representationalist theories of consciousness have become increasingly popular. On this view, phenomenal character is reduced to intentional content. This article explores a key motivation for this theory, namely, considerations of experiential transparency. Experience is said to be transparent in that (...) we ‘look right through it’ to the objects of that experience, and this is supposed to support the representationalist claim that there are no intrinsic aspects of our experience. (shrink)

In this article, I argue that persons suffering from Body Integrity Identity Disorder (BIID) can give informed consent to surgical measures designed to treat this disorder. This is true even if the surgery seems radical or irrational to most people. The decision to have surgery made by a BIID patient is not necessarily coerced, incompetent or uninformed. If surgery for BIID is offered, there should certainly be a screening process in place to insure informed consent. It is beyond the scope (...) of this work, however, to define all the conditions that should be placed on the availability of surgery. However, I argue, given the similarities between BIID and gender dysphoria and the success of such gatekeeping measures for the surgical treatment of gender dysphoria, it is reasonable that similar conditions be in place for BIID. Once other treatment options are tried and gatekeeping measures satisfied, A BIID patient can give informed consent to radical surgery. (shrink)

If, as Axel Honneth has recently argued, critical theory needs psychoanalysis for meta-normative and explanatory reasons, this does not settle the question of which version of psychoanalysis critical theorists should embrace. In this paper, I argue against Honneth's favoured version – an intersubjectivist interpretation of Winnicott's object-relations theory – and in favour of an alternative based on the drive-theoretical work of Melanie Klein. Klein's work, I argue, provides critical theorists with a more realistic conception of the person and a richer (...) explanatory account of human aggression and destructiveness than does Honneth's intersubjectivist view. As such, it better serves the ends for which Honneth claims that critical theory should turn to psychoanalysis in the first place. (shrink)

Work in philosophy of mind often engages in descriptive phenomenology, i.e., in attempts to characterize the phenomenal character of our experience. Nagel’s famous discussion of what it’s like to be a bat demonstrates the difficulty of this enterprise (1974). But while Nagel located the difficulty in our absence of an objective vocabulary for describing experience, I argue that the problem runs deeper than that: we also lack an adequate subjective vocabulary for describing phenomenology. We struggle to describe our own phenomenal (...) states in terms we ourselves find adequately expressive. This paper aims to flesh out why our phenomenological vocabulary is so impoverished – what I call the impoverishment problem. As I suggest, this problem has both practical and philosophical import. After fleshing out the problem in more detail, I draw some suggestive morals from the discussion in an effort to point the way forward towards a solution. (shrink)

Traditionally, imagination has been considered to be a primitive mental state type (or group of types), irreducible to other mental state types. In particular, it has been thought to be distinct from other mental states such as belief, perception, and memory, among others. Recently, however, the category of imagination has come under attack, with challenges emerging from a multitude of different directions. Some philosophers have argued that we should not recognize belief and imagination as distinct states but rather on a (...) continuum, whereas other philosophers have argued something similar with respect to belief and memory. And some philosophers have suggested that we can reduce imagination to other mental states, whether mental imagery, belief, supposition, or some combination. In this paper, I address some of these challenges in an attempt to show we need to maintain imagination as a distinct – and indeed, robust – category in our taxonomy of mind. (shrink)

Recent treatments of imagination have increasingly treated imagining as a skill. Insofar as imaginative accuracy is one of the factors that underwrites this skill, it is important to understand what it means to say that an imagining is accurate. This paper takes up that task. The discussion proceeds in four parts. First, I address two worries that may naturally arise about the coherence ofthe notion of imaginative accuracy. Second, with those worries addressed, I turn to an exploration of what is (...) meant by imaginative accuracy. My discussion relies on two key points: first, that accuracy is best understood in terms of aim; and second, that imaginings aim at the representation of fictional states of affairs. I call this line of thought _the fictionality approach_. Third, I look more closely at six different types of imaginings in an effort to develop and clarify the fictionality approach. Finally, I turn to what I call the calibration objection. Given the nature of imagination, there seems to be no way to calibrate one’s judgments of imaginative accuracy. After showing how much of the force of the calibration objection can be defused, I offer some brief concluding remarks. (shrink)

In The Matter of Consciousness, in the course of his extended discussion and defense of Frank Jackson’s famous knowledge argument, Torin Alter dismisses some objections on the grounds that they are cases of cheating. Though some opponents of the knowledge argument offer various scenarios in which Mary might come to know what seeing red is like while still in the room, Alter argues that the proposed scenarios are irrelevant. In his view, the Mary case is offered to defend the claim (...) that phenomenal facts cannot be a priori deduced from physical facts. Thus, a proposed scenario constitutes an objection to the knowledge argument only if it presents a case in which Mary’s learning inside the room comes about via a priori deduction from physical facts. Call this the deducibility standard. In what follows, I’ll explore a series of relevant cases in an effort to clarify this standard. Doing so enables us to better understand how cheating should be assessed in this context and thereby also to get clearer on the argumentative dialectic surrounding the Mary case. (shrink)

Hope has been neglected as a topic by philosophers interested in families, children, and children's autonomy. Hope may be confused with adjacent phenomena, such as optimism and wishful thinking. However, hope, when understood to involve goals, exploration of pathways to achieving those goals, and motivation to explore the pathways, is necessary for autonomy. It is also importantly related to children's resilience in response to challenges and stressors. In the course of explaining what I take autonomy to involve, why I think (...) children can have areas of local autonomy, and connections between hope, autonomy and resilience, I examine evidence that supports my claims about these connections. I then conclude with a brief discussion of implications of these connections for social policy, especially in the educational context, and for personal interactions with children. (shrink)

This introduction to philosophy offers a selection of readings based on an interdisciplinary, applied approach and illustrating the challenges religion, science, and morality pose to one another. It demonstrates to readers how philosophy is practiced today, rather than in years past, and engages them in a relevant and immediately comprehensible manner. The book maintains the critical, rational edge of traditional philosophical writing, while at the same time incorporating material and approaches not usually found in introductory volumes. Reason sections provide traditional (...) philosophical truth claims made in each subject; Culture sections investigate the social issues that arise from these claims. What Is Morality? Morality and the Good Life. Morality in Higher Education. Morality in Film. Morality in Law. Morality in Markets. Morality and Rational Self-Interest. Classical Theories of Morality. Critical Perspectives on Morality. Feelings and Reason in Morality. What Is Science? Science and a Meaningful Life. The Scientific World View and Its Critics. Science, Technology and the Transformation of Culture. Biology and Ethics. Scientific Determinism and Human Responsibility. Objectivity and Values in Science. Truth and Progress in Science. How Much Can Science Explain? What Is Religion? Religion and the Meaning of Life. Pluralism and Religious Diversity. Religion and Politics. Religion and Education. Evidence for the Existence of God? Evidence Against the Existence of God? Faith and Reason? Religious Practice without God? For anyone interested in philosophy. (shrink)

In their contribution to the rapidly developing field of research on psychedelic medicine, Glenn Cohen and Mason Marks shed light on a frequently overlooked but critical aspect of ethical considera...

In its roughly 25 years of existence, the trial consulting profession has grown dramatically in membership, recognition, and breadth of practice. What began as a small activist group of social scientists volunteering their expertise to assist in the defense of Vietnam War protestors has evolved into a diverse set of professionals from a range of educational and professional backgrounds. In spite of such enormous growth, the work of trial consultants has gone largely unexamined. Trial Consulting takes an in-depth look at (...) the primary activities of trial consultants, including witness preparation, focus groups and mock trials, jury selection, change of venue surveys, and attorney presentation style. It also examines the profession's struggle to define itself, resisting certification and licensure requirements and settling instead for a set of practice standards. The authors draw upon empirical and other scholarly work in the social sciences, recommended "best practices" from trial lawyers, and the written and spoken recommendations and reflections of the trial consultants themselves. Addressing a broad spectrum of topics ranging from handwriting analysis to medical malpractice cases, they also suggest reforms for improving the profession and the efficacy of the trial consultant in the courtroom. The result is a critical analysis of what trial consulting truly adds to, and detracts from, the administration of justice. This book is an indispensable guide for practicing and aspiring trial consultants as well as the judges, attorneys, and psychologists who work with them. Trial Consulting provides a thought-provoking statement on the state of the profession, and students and professionals alike will benefit from the challenges it offers. (shrink)

Latin American Immigration Ethics advances philosophical conversations and debates about immigration by theorizing migration from the Latin American and Latinx context.

Lower plasma levels of high-density lipoproteins in adolescents with type 2 diabetes have been associated with a higher pulse wave velocity, a marker of arterial stiffness. Evidence suggests that HDL proteins or particle subspecies are altered in T2D and these may drive these relationships. In this work, we set out to reveal any specific proteins and subspecies that are related to arterial stiffness in youth with T2D from proteomics data. Plasma and PWV measurements were previously acquired from lean and T2D (...) adolescents. Each plasma sample was separated into 18 fractions and evaluated by mass spectrometry. Then, we applied a validated network-based computational approach to reveal HDL subspecies associated with PWV. Among 68 detected phospholipid-associated proteins, we found that seven were negatively correlated with PWV, indicating that they may be atheroprotective. Conversely, nine proteins show positive correlation with PWV, suggesting that they may be related to arterial stiffness. Intriguingly, our results demonstrate that apoA-I and histidine-rich glycoprotein may reverse their protective roles and become antagonistic in the setting of T2D. Furthermore, we revealed two arterial stiffness-associated HDL subspecies, each of which contains multiple PWV-related proteins. Correlation and disease association analyses suggest that these HDL subspecies might link T2D to its cardiovascular-related complications. (shrink)