Signaling complexes and networks are being intensely studied in an attempt to discover pathways that are amenable to therapeutic intervention. A challenge in this search is to understand the effect that the modulation of a target will have on the overall function of a cell and its surrounding neighbors. Protein‐interaction mapping reveals relationships between proteins and their impact on cellular processes and is being used more widely in our understanding of disease mechanisms and their treatment. The review discusses challenges and (...) breakthroughs in this new and evolving area and its impact on medicine. BioEssays 27:958–969, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Current national and international guidelines for the ethical design and development of artificial intelligence (AI) and robotics emphasize ethical theory. Various governing and advisory bodies have generated sets of broad ethical principles, which institutional decisionmakers are encouraged to apply to particular practical decisions. Although much of this literature examines the ethics of designing and developing AI and robotics, medical institutions typically must make purchase and deployment decisions about technologies that have already been designed and developed. The primary problem facing medical (...) institutions is not one of ethical design but of ethical deployment. The purpose of this paper is to develop a practical model by which medical institutions may make ethical deployment decisions about ready-made advanced technologies. Our slogan is “more process, less principles.” Ethically sound decisionmaking requires that the process by which medical institutions make such decisions include participatory, deliberative, and conservative elements. We argue that our model preserves the strengths of existing frameworks, avoids their shortcomings, and delivers its own moral, practical, and epistemic advantages. (shrink)

“What is it that agitates you, my dear Victor? What is it you fear?” -/- “The monster now becomes more vengeful. He murders Victor’s friend Henry Clerval and his wife Elizabeth on the night of her wedding to Victor, and Victor sets out in pursuit of the friend across the icy Artic regions. The monster is always ahead of him, leaving tell tale marks behind and tantalizing his creator. Victor meets with his death in the pursuit of the monster he (...) had created with a noble objective.” [ http://philpapers.org/profile/112741] . (shrink)

"Then to this earthen Bowl did I adjourn My Lip the secret Well of Life to learn: And Lip to Lip it murmur'd-"While you live Drink!-for once dead you never shall return." " [http://philpapers.org/profile/112741] .

The poem, has also highlighted the theme of isolation. The Darkling Thrush is the symbol of perseverance. Men at times is all by himself. There is none around. The frail, gaunt, aged , weather-beaten bird has stood against all odds. There is an air of self doubt and the poet is in a dilemma how to welcome the advent of a new era. It has endured all the odds of time and is happy today singing its joyful song.

“Three poets in three distant ages born Greece, Italy and England did adorn; The first in loftiness of thought surpassed. The second in majesty; in both the last.” (http://philpapers.org/profile/112741).

( http://philpapers.org/profile/112741 )"Let generation know to procure the love, the concept, knowledge and ideas with thoughts they are acquiring on versatile English Language, instead of making themselves to be felt dealing with only burden." -/- I too realize, -/- "Literature is not merely going through a book, It is the moment of definition of per feeling that : I am acquiring through an imagery.".

THE IMMORTAL FLY: ETERNAL WHISPERS. WHO IS SHE? Author: Rituparna Ray Chaudhuri. Hello, Recently my book named, ‘The Immortal Fly: Eternal Whispers : Based On True Events of a Family' been published from Partridge (USA) In Association with Penguin Random House (UK) and achieved a separate Google identity. -/- As being # the author of the book, I thought to define self in the book what is definition of 'Depression'. I wanted to explain self in many ways, but the (...) best quotation appeared to me : “My life will end someday, but it will end at my convenience.’’ -/- ***** I am missing "her". By now, years passed without 'her' . Even though, unlike before, everything is becoming to be more scattered, gloomy and desolate. She is no-where whom I share my feelings. Even now, when I do close my eyes, I can visualize the same that I had left years since on 7th February, 2019 at 8.20 A.M. in the hospital struggling a continuous period of fifty days : on the fifty one day, my father said, ”The End of our Fifty Years relationship has been completed with the Fifty Days”….’Whoever’ she was to others , but she is our legend…To me, she is ‘My Ma’. -/- The story could begin, 'I failed preciously on success of my life.' Simplicity, Innocence, Belief, Faith and Personality met unknowingly with filthy waves skillfully immersed in Betray, Sorcery, Jealousy, Greediness, Revenge, Lie... ‘’ ******* The Daughter writes, “I had asked Ma many times, but her ‘impenetrable personality’ and dynamic words to everyone with a tinge of smile as reflected on her face, she was reluctant to continue her conversation with me. I had thought, hence, I must not be indefinite on my spoken words. Who shall I blame!” Based on true story of a family came from South Calcutta (India) to a suburb, on staying at home of the Daughter’s maternal grandmother’s house, this book reveals in facts and true events how Destiny had unknowingly ‘further’ played an abominable role to Fate of The Daughter, when eventually one day on 7th February, 2019 everything was finished within 8.20A.M. The Daughter is, therefore, left alone on terrestrial with immortal words as written in her Diary, ‘Eternal Whispers’: “My words to self that I am to fulfill my Ma’s - wish. ’’ ‘’ -/- • Keywords: 1. Diary and True Events 2. The Chaotic Society 3. Fatality 4. Of A-Family 5. Science , Philosophy and Literature 6. Severe Depression 7. Medical Journey. -/- The Alternative Title of the Book: The Greatest Mistake or Fortune:: The book is mainly carrying with intense words of a journey of the relationship between a Mother with her Daughter has left readers in an abrupt situation where ,perhaps, I can define "Man is the innocent creature with 'his' personality under circumstances..." -/- . (shrink)

Marriage distance is an important variable in human genetics. The distribution of marriage distance has been studied among the Santals, a large agricultural tribe of eastern India, in the neighbourhood of Giridih, Bihar. A Type III Pearsonian curve was fitted to the observed distribution; the fit was found to be good. Possible explanations have been suggested for the distribution pattern among the Santals and for the difference with respect to this pattern between the Santals and other populations.

"Who can tell us more about a man's character than his wife? Shakespeare allows Lady Macbeth to explain her husband's character as she understands it, and although she cannot see the "whole" truth, she tells us a great deal about Macbeth...." http://philpapers.org/profile/112741.

The Problem of Love I would like to say a word about the psychological approach to love and to Erich Fromm's little classic, ...

This book provides an introduction to Newtonian and relativistic mechanics. Unlike other books on the topic, which generally take a 'top-down' approach, it follows a novel system to show how the concepts of the 'science of motion' evolved through a veritable jungle of intermediate ideas and concepts. Starting with Aristotelian philosophy, the text gradually unravels how the human mind slowly progressed towards the fundamental ideas of inertia physics. The concepts that now appear so obvious to even a high school student (...) took great intellectuals more than a millennium to clarify. The book explores the evolution of these concepts through the history of science. After a comprehensive overview of the discovery of dynamics, it explores fundamental issues of the properties of space and time and their relation with the laws of motion. It also explores the concepts of spatio-temporal locality and fields, and offers a philosophical discussion of relative motion versus absolute motion, as well as the concept of an absolute space. Furthermore, it presents Galilean transformation and the principle of relativity, inadequacy of Galilean relativity and emergence of the spatial theory of relativity with an emphasis on physical understanding, as well as the debate over relative motion versus absolute motion and Mach's principle followed by the principle of equivalence. The natural follow-on to this section is the physical foundations of general theory of relativity. Lastly, the book ends with some new issues and possibilities regarding further modifications of the laws of motion leading to the solution of a number of fundamental issues closely connected with the characteristics of the cosmos. It is a valuable resource for undergraduate students of physics, engineering, mathematics, and related disciplines. It is also suitable for interdisciplinary coursework and introductory reading outside the classroom. (shrink)

"The theory of Darwin was improved upon by Lamarck. He laid down the principle that living organisms change because they want to. Lamarck , while making this statement, actually, introduced the Element of Mind in the universe. He observed that every cell or unit of life has a will, a purpose, a design and a hope. In other words, he came to the conclusion that everything has a soul. In this regard, there was a sort of conflict between the believers (...) in Darwinian-ism and Lamarck-ism. Shaw supported the views of Lamarck."..... -/- ( http://philpapers.org/profile/112741 ). (shrink)

The essay reads as a moment of alliance – a moment of reading of two disparate things together. The event of alliance remains inspired by Gilles Deleuze's theorisations of becoming. This marks the coming together of unrelated things – one into the fold of another – without being subordinated in the process. It reads an anime, Kiki's Delivery Service, with Deleuze and Guattari's writings on ‘the girl’ – where the girl represented as ‘real’ in a fantasy meets the girl written (...) as a metaphor in a theoretical intervention. This inflicts a sense of violence, of abstraction, to both the figures of ‘girl’. On the one hand, Miyazaki's work, removed from the discourse of anime, is placed under a feminist scrutiny, while on the other hand, Deleuze and Guattari's notion of the ‘girl’, extracted from the logic of the original texts, is reinserted into feminist renditions. The two readings are coordinated by a specific intention. This is to imagine the feminist potential of the ‘girl’. Occasionally the two works appear to talk to each other, yet sometimes they stand incommensurable. The texts animate each other without being subsumed by each other – inhabiting and following the movements to trace the other as fields of singularities which cannot be reduced to fixed identities or parallels. This transversal act of reading does not aim at coercing the Deleuzian notion of the girl upon Kiki, but rather looks forward to the conversations generated between the two narratives. (shrink)

Crop cultivation is one of the oldest activities of civilization. For a long time, crop production was carried out based on knowledge passed from generation to generation. However, due to the rapid growth in the human population of the world, human knowledge-based cultivation is not enough to meet the demanding need. To address this issue, the usage of machine learning-based tools has been studied in this paper. An experiment has been carried out over 0.3 million data. This dataset identifies 46 (...) prominent parameters for cultivation, which is collected from the Department of Agriculture Extension, Bangladesh. Comparison between neural networks and numbers of machine learning algorithms has been carried out in this research. It is observed that the neural network outperforms the other methods by maintaining an average prediction accuracy of 96.06% for six different crops. Other contemporary machine learning algorithms, namely, support vector machine, random forest, and logistic regression, have average prediction accuracy of around 68.9%, 91.2%, and 62.39%, respectively. (shrink)

Finding the Raga is more than a book that tries to make sense of the raga, of Indian classical music, and of how Indian music challenges Western notions of what music might be. It is a work of self-inquiry, as might be expected from Amit Chaudhuri, a musician who is also a novelist; a novelist who is also a critic and essayist; a trained and recorded performer in the Indian classical vocal tradition who was also, once, a guitarist and (...) songwriter in the American folk music style and is now a composer and recorded performer in experimental music. Each one of these undertakings and selves signifies turns at different points in life, and each turn and change of direction brings a fresh perspective on music, writing, and what it means to take on and do these things. No category-Indian, Western-is a given in this book. Partly a record of one of the most important turns in the author's life, toward North Indian music, and of its long aftermath, Finding the Raga is also part autobiography set in 1970s Bombay, part essay, and part detailed analysis of how we might grasp the conceptual underpinnings as well as the experience of music. It explores the different ways in which music relates to the world-whether it's through representation or evocation, as in Western music, or through the raga being sung at different times of day and in different seasons, as in Indian music-and also tries to understand what the act of listening involves for individuals and cultures. (shrink)

Dr Chaudhury is concerned to defend what is responsible and hopeful in contemporary ecological thinking, but to avoid the trap of denying that any positive contribution can be made by western science and technology. Critical rationalists do not need to agree with her suggestions and recommendations in order to welcome her positioning of environmental issues alongside the traditional human and political debates about freedom. The Indian perspective that informs this book is particularly impressive and interesting. David Miller (University of Warwick) (...) Professor Mahasweta Chaudhury is Professor for Philosophy at Calcutta University in India. In the late sixties she studied at the London School of Economics under Karl Popper, John Watkins, Alan Musgrave and Imre Lakatos. (shrink)

In this book the author brings to bear the collected wisdom of a life spent as a dispassionate scholar and a political engage, on one of the recurring concerns of our fin de siecle-the decline of western civilization.

Its oft I had been asked by students and many of others of the given topic. What I personally felt be its answer, referring obviously standard books, I answered my seekers including also analyzing myself many times just twelve lines of the opening scene, which is in fact, later I thought, is containing a very ‘partial fulfillment’ of the conversation among the witches- perhaps that figures out the destiny of a mortal being, destiny of our tragic hero, full of “profound- (...) mature -complexity of human materialistic nature’’. ( http://philpapers.org/profile/112741 ). (shrink)

The objective of this paper is to discuss some of the foundational issues centering around the question of integrating education in human values with professional engineering education: its necessity and justification. The paper looks at the efforts in ‘tuning’ the technical education system in India to the national goals in the various phases of curriculum development. The contribution of the engineering profession in national development and India’s self-sufficiency is crucially linked with the institutionalization of expertise and the role of morality (...) and responsibility. This linkage can be created through a proper understanding of the social role of the profession—what motivates the professionals and what makes professional life meaningful. Value education facilitates the process of moral maturity and the development of a ‘holistic’ mindset. This paper deals with the need to create such a mindset, the human values associated with it and gives examples of efforts to impart such education through ‘action-oriented’ programmes introduced in some institutes of engineering in India. (shrink)

In some families, there is an inseparable connection between showing love, caring, and providing food. These conceptual connections can create tension between families and care teams over end-of-life care for critically ill late-stage cachexic patients with cancer when families demand that their loved one receive feeds. This case study describes how to dissolve these tensions without compromising the family’s values or the medical team’s ethical duty of nonmaleficence.

This book explores a vital but neglected element in the philosophy of social science - the complex nature of the social world. By a systematic philosophical engagement, it conceives the social world in terms of three basic concerns: epistemic, methodological and ethical. It examines how we cognize, study and ethically interact with the social world. As such, it demonstrates that a discussion of ethics is epistemically indispensable to the making of the social world. The book presents a new interpretation of (...) philosophy of social science and addresses a series of related topics, including the role of the human subject in the context of scientific knowledge, objectivity, historicity, meaning and nature of social reality, social and literary theory, scientific methodology and fact/value dichotomy, human and collective agency and the limits to relativism. Examining each in turn, it argues that the social world is constructed through human actions and becomes significant because we ascribe meaning to it. This is organized around discussions on the meaning, agency and the making of a social world. The book will be useful to scholars and researchers of philosophy of social science, political philosophy and sociology. ficant because we ascribe meaning to it. This is organized around discussions on the meaning, agency and the making of a social world. The book will be useful to scholars and researchers of philosophy of social science, political philosophy and sociology. (shrink)

Although social scientists have identified diverse behavioral patterns among children from dissimilarly structured families, marketing scholars have progressed little in relating family structure to consumption-related decisions. In particular, the roles played by members of single-mother families—which may include live-in grandparents, mother’s unmarried partner, and step-father with or without step-sibling(s)—may affect children’s influence on consumption-related decisions. For example, to offset a parental authority dynamic introduced by a new stepfather, the work-related constraints imposed on a breadwinning mother, or the imposition of adult-level (...) household responsibilities on children, single-mother families may attend more to their children’s product preferences. -/- Without a profile that includes socio-economic, behavioral, and psychological aspects, efficient and socially responsible marketing to single-mother households is compromised. Relative to dual-parent families, single-mother families tend to have fewer resources and less buying power, children who consume more materialistic and compulsively, and children who more strongly influence decision making for both own-use and family-use products. Timely research would ensure that these and other tendencies now differentiate single-mother from dual-parent families in ways that marketers should address. Hence, our threefold goal is (1) to consolidate and highlight gaps in existing theory applied to studying children’s influence on consumption-related decision making in single-mother families, and (2) to propose a hybrid framework that merges two theories conducive to such research, and (3) to identify promising research propositions for future research. (shrink)

Presents Of Late Prof. Pravas Jivan Chaudhury (Born 1916 Died In 1961) On Various Subjects Like Aesthetics, Science And Philosophy. 8 Chapters - Nature, Scope And Value Of Philosophy Of Science - The Method Of Science - Problems Of Scientific Method 3 Chapters - Human Aspect Of Science - Science And Human Values - Science And Metaphysics. Without Dustjacket.

Documenting the dark side : fictional and documentary treatments of torture and the 'war on terror' -- History lessons : what audiences (could) learn about genocide from historical drama -- The art of disappearance : remembering political violence in Argentina and Chile -- Uninvited visitors : immigration, detention and deportation in science fiction -- Architectures of enmity : the Israeli-Palestinian conflict through a cinematic lens.

Mainly papers presented at a conference held at Jadavpur University in 2000.